IMP

Process View

Homo sapiens

30 genes annotated in human

cellular amino acid biosynthetic process

The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "cellular amino acid biosynthetic process"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "cellular amino acid biosynthetic process" (in gray)

Name	Description	Probability	Func Analog Organism
GCLC	glutamate-cysteine ligase, catalytic subunit	0.780
AARS	alanyl-tRNA synthetase	0.768
ALDH2	aldehyde dehydrogenase 2 family (mitochondrial)	0.758	Yeast
ALDH1A1	aldehyde dehydrogenase 1 family, member A1	0.713	Yeast
GCLM	glutamate-cysteine ligase, modifier subunit	0.577
RAB10	RAB10, member RAS oncogene family	0.572
ALDOB	aldolase B, fructose-bisphosphate	0.498
GARS	glycyl-tRNA synthetase	0.433
TOM1L1	target of myb1 (chicken)-like 1	0.400
CYP2E1	cytochrome P450, family 2, subfamily E, polypeptide 1	0.262
GLUD1	glutamate dehydrogenase 1	0.238
TFG	TRK-fused gene	0.217
GOT1	glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)	0.203	Yeast Mouse
CDK2AP2	cyclin-dependent kinase 2 associated protein 2	0.197
SOD1	superoxide dismutase 1, soluble	0.185
GLUD2	glutamate dehydrogenase 2	0.178
CRY1	cryptochrome 1 (photolyase-like)	0.164
USP46	ubiquitin specific peptidase 46	0.159
AIFM1	apoptosis-inducing factor, mitochondrion-associated, 1	0.130
CALCA	calcitonin-related polypeptide alpha	0.126
DLG2	discs, large homolog 2 (Drosophila)	0.114
MARS	methionyl-tRNA synthetase	0.109
GLYAT	glycine-N-acyltransferase	0.105
CRAT	carnitine O-acetyltransferase	0.101
SARS	seryl-tRNA synthetase	0.101
GCAT	glycine C-acetyltransferase	0.086
FH	fumarate hydratase	0.081
METRN	meteorin, glial cell differentiation regulator	0.081
BBS1	Bardet-Biedl syndrome 1	0.078
NARS	asparaginyl-tRNA synthetase	0.073
IDH3A	isocitrate dehydrogenase 3 (NAD+) alpha	0.072
MAGEA11	melanoma antigen family A, 11	0.067
NUDT18	nudix (nucleoside diphosphate linked moiety X)-type motif 18	0.063
NECAP2	NECAP endocytosis associated 2	0.062
MTHFD2	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase	0.056
LHX3	LIM homeobox 3	0.055
RHOXF2	Rhox homeobox family, member 2	0.055
PPP3CA	protein phosphatase 3, catalytic subunit, alpha isozyme	0.053
SLC7A1	solute carrier family 7 (cationic amino acid transporter, y+ system), member 1	0.052
GOT2	glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2)	0.050	Fly
YARS	tyrosyl-tRNA synthetase	0.046
PLSCR4	phospholipid scramblase 4	0.045
PDHA1	pyruvate dehydrogenase (lipoamide) alpha 1	0.044
PRDX2	peroxiredoxin 2	0.042
DLG1	discs, large homolog 1 (Drosophila)	0.042
PSAT1	phosphoserine aminotransferase 1	0.040
C2orf18	chromosome 2 open reading frame 18	0.040
SLC2A2	solute carrier family 2 (facilitated glucose transporter), member 2	0.039
BHMT	betaine--homocysteine S-methyltransferase	0.039
GRM7	glutamate receptor, metabotropic 7	0.038
HADH	hydroxyacyl-CoA dehydrogenase	0.037
OCLN	occludin	0.036
SRSF5	serine/arginine-rich splicing factor 5	0.036
SORD	sorbitol dehydrogenase	0.036
NMI	N-myc (and STAT) interactor	0.035
CASP7	caspase 7, apoptosis-related cysteine peptidase	0.035
MBNL1	muscleblind-like (Drosophila)	0.033
DBT	dihydrolipoamide branched chain transacylase E2	0.033
CYP4F2	cytochrome P450, family 4, subfamily F, polypeptide 2	0.033
PCK2	phosphoenolpyruvate carboxykinase 2 (mitochondrial)	0.032
GSR	glutathione reductase	0.031
EIF2AK2	eukaryotic translation initiation factor 2-alpha kinase 2	0.030
PCK1	phosphoenolpyruvate carboxykinase 1 (soluble)	0.030
CARS	cysteinyl-tRNA synthetase	0.029
HPD	4-hydroxyphenylpyruvate dioxygenase	0.028
LNX1	ligand of numb-protein X 1	0.028
G6PC	glucose-6-phosphatase, catalytic subunit	0.027
METAP1	methionyl aminopeptidase 1	0.027
NTN4	netrin 4	0.027
NUPR1	nuclear protein, transcriptional regulator, 1	0.026
GCDH	glutaryl-CoA dehydrogenase	0.026
SLC25A10	solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10	0.026
TCTN3	tectonic family member 3	0.026
TST	thiosulfate sulfurtransferase (rhodanese)	0.025
PINK1	PTEN induced putative kinase 1	0.025
HAAO	3-hydroxyanthranilate 3,4-dioxygenase	0.025
ECHS1	enoyl CoA hydratase, short chain, 1, mitochondrial	0.025
MAPK3	mitogen-activated protein kinase 3	0.025
MVK	mevalonate kinase	0.025
TMEM120A	transmembrane protein 120A	0.025
KHK	ketohexokinase (fructokinase)	0.024
NME4	non-metastatic cells 4, protein expressed in	0.024
SEPT11	septin 11	0.024
PON1	paraoxonase 1	0.024
COX5A	cytochrome c oxidase subunit Va	0.024
CCDC78	coiled-coil domain containing 78	0.024
ARG1	arginase, liver	0.024
QDPR	quinoid dihydropteridine reductase	0.024
VPS25	vacuolar protein sorting 25 homolog (S. cerevisiae)	0.024
EIF2S3	eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa	0.023
ABHD14A	abhydrolase domain containing 14A	0.023
NAT2	N-acetyltransferase 2 (arylamine N-acetyltransferase)	0.023
PAH	phenylalanine hydroxylase	0.023	Rat
PRDX1	peroxiredoxin 1	0.023
FABP1	fatty acid binding protein 1, liver	0.023
ACLY	ATP citrate lyase	0.022
AGXT	alanine-glyoxylate aminotransferase	0.022
COX5B	cytochrome c oxidase subunit Vb	0.022
OGFOD1	2-oxoglutarate and iron-dependent oxygenase domain containing 1	0.022
DNAJA3	DnaJ (Hsp40) homolog, subfamily A, member 3	0.022
HAL	histidine ammonia-lyase	0.022
AKR7A3	aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)	0.022
OSBPL8	oxysterol binding protein-like 8	0.022
APOO	apolipoprotein O	0.021
DCXR	dicarbonyl/L-xylulose reductase	0.021
ALDH4A1	aldehyde dehydrogenase 4 family, member A1	0.021	Yeast
SNF8	SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae)	0.021
SFXN2	sideroflexin 2	0.021
NQO1	NAD(P)H dehydrogenase, quinone 1	0.020
CYP26A1	cytochrome P450, family 26, subfamily A, polypeptide 1	0.020
ATP5B	ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide	0.020
SLC7A11	solute carrier family 7, (cationic amino acid transporter, y+ system) member 11	0.020
ADCY7	adenylate cyclase 7	0.020
LASP1	LIM and SH3 protein 1	0.020
EPHX1	epoxide hydrolase 1, microsomal (xenobiotic)	0.020
BDH1	3-hydroxybutyrate dehydrogenase, type 1	0.020
IGSF21	immunoglobin superfamily, member 21	0.019
PFKFB1	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1	0.019
HRSP12	heat-responsive protein 12	0.019
GPT2	glutamic pyruvate transaminase (alanine aminotransferase) 2	0.019
ARF6	ADP-ribosylation factor 6	0.019
ALDH1L1	aldehyde dehydrogenase 1 family, member L1	0.019
PCBD1	pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha	0.019
DPYS	dihydropyrimidinase	0.019
ADAM17	ADAM metallopeptidase domain 17	0.018
RYR2	ryanodine receptor 2 (cardiac)	0.018
PNLIPRP1	pancreatic lipase-related protein 1	0.018
PC	pyruvate carboxylase	0.018
C1orf109	chromosome 1 open reading frame 109	0.018
MECR	mitochondrial trans-2-enoyl-CoA reductase	0.018
ACADS	acyl-CoA dehydrogenase, C-2 to C-3 short chain	0.018
PLG	plasminogen	0.018
IVD	isovaleryl-CoA dehydrogenase	0.018
ME1	malic enzyme 1, NADP(+)-dependent, cytosolic	0.018
SARDH	sarcosine dehydrogenase	0.017
RGN	regucalcin (senescence marker protein-30)	0.017
MAT1A	methionine adenosyltransferase I, alpha	0.017	Yeast
STARD7	StAR-related lipid transfer (START) domain containing 7	0.017
NFE2L2	nuclear factor (erythroid-derived 2)-like 2	0.017
MINPP1	multiple inositol-polyphosphate phosphatase 1	0.017
TM7SF2	transmembrane 7 superfamily member 2	0.017
CYB5B	cytochrome b5 type B (outer mitochondrial membrane)	0.017
CAT	catalase	0.017
MBL2	mannose-binding lectin (protein C) 2, soluble	0.017
GHITM	growth hormone inducible transmembrane protein	0.017
ZFAND2B	zinc finger, AN1-type domain 2B	0.017
ISOC1	isochorismatase domain containing 1	0.017
EPHX2	epoxide hydrolase 2, cytoplasmic	0.017
PHGDH	phosphoglycerate dehydrogenase	0.017
HBXIP	hepatitis B virus x interacting protein	0.017
ROGDI	rogdi homolog (Drosophila)	0.017
KNG1	kininogen 1	0.017
LARS2	leucyl-tRNA synthetase 2, mitochondrial	0.017
SLC37A4	solute carrier family 37 (glucose-6-phosphate transporter), member 4	0.016
SIRT3	sirtuin 3	0.016
BNIPL	BCL2/adenovirus E1B 19kD interacting protein like	0.016
ICMT	isoprenylcysteine carboxyl methyltransferase	0.016
GLRX3	glutaredoxin 3	0.016
ATP1B1	ATPase, Na+/K+ transporting, beta 1 polypeptide	0.016
PIR	pirin (iron-binding nuclear protein)	0.016
DHRS1	dehydrogenase/reductase (SDR family) member 1	0.016
ALDH3A2	aldehyde dehydrogenase 3 family, member A2	0.016
RAB26	RAB26, member RAS oncogene family	0.016
PEBP1	phosphatidylethanolamine binding protein 1	0.016
SERPINA6	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6	0.016
COQ9	coenzyme Q9 homolog (S. cerevisiae)	0.016
C14orf1	chromosome 14 open reading frame 1	0.015
CTH	cystathionase (cystathionine gamma-lyase)	0.015
KRTAP4-12	keratin associated protein 4-12	0.015
TAT	tyrosine aminotransferase	0.015
OTC	ornithine carbamoyltransferase	0.015
CYP1A2	cytochrome P450, family 1, subfamily A, polypeptide 2	0.015
CYP7A1	cytochrome P450, family 7, subfamily A, polypeptide 1	0.015
WWP1	WW domain containing E3 ubiquitin protein ligase 1	0.015
SLC25A15	solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15	0.015
IGF2BP1	insulin-like growth factor 2 mRNA binding protein 1	0.015
SERPINC1	serpin peptidase inhibitor, clade C (antithrombin), member 1	0.015
HAO1	hydroxyacid oxidase (glycolate oxidase) 1	0.014
ADH5	alcohol dehydrogenase 5 (class III), chi polypeptide	0.014
CALM1	calmodulin 1 (phosphorylase kinase, delta)	0.014
JMJD1C	jumonji domain containing 1C	0.014
SUOX	sulfite oxidase	0.014
ORM2	orosomucoid 2	0.014
ACAA1	acetyl-CoA acyltransferase 1	0.014
C16orf59	chromosome 16 open reading frame 59	0.014
ATG12	ATG12 autophagy related 12 homolog (S. cerevisiae)	0.014
TLX3	T-cell leukemia homeobox 3	0.014
FAM203A	family with sequence similarity 203, member A	0.014
PRDX6	peroxiredoxin 6	0.014
GSTZ1	glutathione transferase zeta 1	0.014
MTTP	microsomal triglyceride transfer protein	0.014
NAT8B	N-acetyltransferase 8B (GCN5-related, putative, gene/pseudogene)	0.014
GAMT	guanidinoacetate N-methyltransferase	0.013
B3GAT1	beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)	0.013
MORF4L1	mortality factor 4 like 1	0.013
APOA5	apolipoprotein A-V	0.013
PCYT2	phosphate cytidylyltransferase 2, ethanolamine	0.013
PSPH	phosphoserine phosphatase	0.013
FAM113A	family with sequence similarity 113, member A	0.013
BRI3BP	BRI3 binding protein	0.013
SLC6A1	solute carrier family 6 (neurotransmitter transporter, GABA), member 1	0.013
SLC4A7	solute carrier family 4, sodium bicarbonate cotransporter, member 7	0.013
BANP	BTG3 associated nuclear protein	0.013
C10orf10	chromosome 10 open reading frame 10	0.013
CRIM1	cysteine rich transmembrane BMP regulator 1 (chordin-like)	0.013
UGDH	UDP-glucose 6-dehydrogenase	0.013
NR1I2	nuclear receptor subfamily 1, group I, member 2	0.013
BAG2	BCL2-associated athanogene 2	0.013
MIPEP	mitochondrial intermediate peptidase	0.013
CHRNB2	cholinergic receptor, nicotinic, beta 2 (neuronal)	0.013
CYP4A11	cytochrome P450, family 4, subfamily A, polypeptide 11	0.013
MAX	MYC associated factor X	0.013
IARS	isoleucyl-tRNA synthetase	0.013
NR3C1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	0.013
ALAS1	aminolevulinate, delta-, synthase 1	0.013
TNNT3	troponin T type 3 (skeletal, fast)	0.013
GAD1	glutamate decarboxylase 1 (brain, 67kDa)	0.013	Rat
HAGH	hydroxyacylglutathione hydrolase	0.013
BAAT	bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)	0.013
SERPINB1	serpin peptidase inhibitor, clade B (ovalbumin), member 1	0.013
CASK	calcium/calmodulin-dependent serine protein kinase (MAGUK family)	0.013
CYP2F1	cytochrome P450, family 2, subfamily F, polypeptide 1	0.013
CALCOCO2	calcium binding and coiled-coil domain 2	0.013
GNAO1	guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O	0.013
OPLAH	5-oxoprolinase (ATP-hydrolysing)	0.013
MYLPF	myosin light chain, phosphorylatable, fast skeletal muscle	0.012
FAH	fumarylacetoacetate hydrolase (fumarylacetoacetase)	0.012
PNPO	pyridoxamine 5'-phosphate oxidase	0.012
RAB8A	RAB8A, member RAS oncogene family	0.012
DLGAP2	discs, large (Drosophila) homolog-associated protein 2	0.012
ANGPTL3	angiopoietin-like 3	0.012
FXN	frataxin	0.012
XPOT	exportin, tRNA (nuclear export receptor for tRNAs)	0.012
ACMSD	aminocarboxymuconate semialdehyde decarboxylase	0.012
ITIH1	inter-alpha (globulin) inhibitor H1	0.012
IGFBP2	insulin-like growth factor binding protein 2, 36kDa	0.012
ARL15	ADP-ribosylation factor-like 15	0.012
SLC1A2	solute carrier family 1 (glial high affinity glutamate transporter), member 2	0.012
EMX1	empty spiracles homeobox 1	0.012
SLC22A7	solute carrier family 22 (organic anion transporter), member 7	0.012
RPS27	ribosomal protein S27	0.012
F12	coagulation factor XII (Hageman factor)	0.012
NXPH1	neurexophilin 1	0.012
SULT2A1	sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1	0.012
TMEM161A	transmembrane protein 161A	0.012
GPR6	G protein-coupled receptor 6	0.012
TFR2	transferrin receptor 2	0.012
NEU4	sialidase 4	0.012
MCCC2	methylcrotonoyl-CoA carboxylase 2 (beta)	0.012
ATXN10	ataxin 10	0.012
CYP27A1	cytochrome P450, family 27, subfamily A, polypeptide 1	0.012
ACAT1	acetyl-CoA acetyltransferase 1	0.012
PIPOX	pipecolic acid oxidase	0.012
RPS6KA3	ribosomal protein S6 kinase, 90kDa, polypeptide 3	0.012
CCDC106	coiled-coil domain containing 106	0.012
RPUSD1	RNA pseudouridylate synthase domain containing 1	0.012
WDYHV1	WDYHV motif containing 1	0.012
CBS	cystathionine-beta-synthase	0.012
SLC6A12	solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12	0.011
REG1A	regenerating islet-derived 1 alpha	0.011
MAP3K1	mitogen-activated protein kinase kinase kinase 1	0.011
CYP2C9	cytochrome P450, family 2, subfamily C, polypeptide 9	0.011
AKR1C2	aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)	0.011
NHLH2	nescient helix loop helix 2	0.011
PCCB	propionyl CoA carboxylase, beta polypeptide	0.011
FECH	ferrochelatase	0.011
SDCBP	syndecan binding protein (syntenin)	0.011
PPA1	pyrophosphatase (inorganic) 1	0.011
MTHFD1	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase	0.011
CYP4F11	cytochrome P450, family 4, subfamily F, polypeptide 11	0.011
PKP4	plakophilin 4	0.011
SNTA1	syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component)	0.011
NR1I3	nuclear receptor subfamily 1, group I, member 3	0.011
OMP	olfactory marker protein	0.011
NDUFC2	NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa	0.011
CHD1L	chromodomain helicase DNA binding protein 1-like	0.011
CA5A	carbonic anhydrase VA, mitochondrial	0.011
AFF2	AF4/FMR2 family, member 2	0.011
B9D1	B9 protein domain 1	0.011
KCND2	potassium voltage-gated channel, Shal-related subfamily, member 2	0.011
CYB5A	cytochrome b5 type A (microsomal)	0.011
ALDH6A1	aldehyde dehydrogenase 6 family, member A1	0.011
ORM1	orosomucoid 1	0.011
B4GALT2	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2	0.011
SULT1B1	sulfotransferase family, cytosolic, 1B, member 1	0.011
AHR	aryl hydrocarbon receptor	0.011
DAPK1	death-associated protein kinase 1	0.011
FBP1	fructose-1,6-bisphosphatase 1	0.011
RASD1	RAS, dexamethasone-induced 1	0.011
MARCKS	myristoylated alanine-rich protein kinase C substrate	0.011
MTMR7	myotubularin related protein 7	0.011
PLSCR3	phospholipid scramblase 3	0.011
CYFIP1	cytoplasmic FMR1 interacting protein 1	0.011
LECT2	leukocyte cell-derived chemotaxin 2	0.011
MOSC1	MOCO sulphurase C-terminal domain containing 1	0.011
PTPLAD1	protein tyrosine phosphatase-like A domain containing 1	0.011
TIFA	TRAF-interacting protein with forkhead-associated domain	0.010
ESRRA	estrogen-related receptor alpha	0.010
HPX	hemopexin	0.010
DDX3X	DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked	0.010
HRG	histidine-rich glycoprotein	0.010
OGT	O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)	0.010
NARS2	asparaginyl-tRNA synthetase 2, mitochondrial (putative)	0.010
FAM103A1	family with sequence similarity 103, member A1	0.010
RWDD2B	RWD domain containing 2B	0.010
CAMK2N2	calcium/calmodulin-dependent protein kinase II inhibitor 2	0.010
CPB2	carboxypeptidase B2 (plasma)	0.010
UBB	ubiquitin B	0.010
TRIB3	tribbles homolog 3 (Drosophila)	0.010
LBP	lipopolysaccharide binding protein	0.010
SLC27A5	solute carrier family 27 (fatty acid transporter), member 5	0.010	Human
NECAB2	N-terminal EF-hand calcium binding protein 2	0.010
RBBP7	retinoblastoma binding protein 7	0.010
FAM3C	family with sequence similarity 3, member C	0.010
KIAA0090	KIAA0090	0.010
OSTF1	osteoclast stimulating factor 1	0.010
TNP2	transition protein 2 (during histone to protamine replacement)	0.010
DENND4A	DENN/MADD domain containing 4A	0.010
SGMS1	sphingomyelin synthase 1	0.010
ALDH1B1	aldehyde dehydrogenase 1 family, member B1	0.010	Yeast
GRIA1	glutamate receptor, ionotropic, AMPA 1	0.010
TMEM38B	transmembrane protein 38B	0.010
KCNJ11	potassium inwardly-rectifying channel, subfamily J, member 11	0.010
ASS1	argininosuccinate synthase 1	0.010
SPR	sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)	0.010
PYCR1	pyrroline-5-carboxylate reductase 1	0.010
NDUFA2	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa	0.010
GLRX	glutaredoxin (thioltransferase)	0.010