IMP

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Homo sapiens

3 genes annotated in human

Multi-species View

negative regulation of stem cell proliferation

GO:2000647

Any process that stops, prevents or reduces the frequency, rate or extent of stem cell proliferation.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of stem cell proliferation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of stem cell proliferation" (in gray)

Name	Description	Probability	Func Analog Organism
CCT8	chaperonin containing TCP1, subunit 8 (theta)	0.960
PPP2CB	protein phosphatase 2, catalytic subunit, beta isozyme	0.746	Fly
NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	0.615	Fly
JUP	junction plakoglobin	0.543
TCP1	t-complex 1	0.451
FSTL1	follistatin-like 1	0.392
BMPR1A	bone morphogenetic protein receptor, type IA	0.353
COX6C	cytochrome c oxidase subunit VIc	0.325
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.304
SMARCA4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	0.283	Fly
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.245
SMARCE1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1	0.184
REL	v-rel reticuloendotheliosis viral oncogene homolog (avian)	0.184
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.172
YAP1	Yes-associated protein 1	0.164
CCT4	chaperonin containing TCP1, subunit 4 (delta)	0.154
ATP5I	ATP synthase, H+ transporting, mitochondrial Fo complex, subunit E	0.131
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.130
MED29	mediator complex subunit 29	0.126
MED28	mediator complex subunit 28	0.123
PPP2R2A	protein phosphatase 2, regulatory subunit B, alpha	0.122
ETFA	electron-transfer-flavoprotein, alpha polypeptide	0.120
PPP2R1B	protein phosphatase 2, regulatory subunit A, beta	0.119
APC	adenomatous polyposis coli	0.097
FZD1	frizzled homolog 1 (Drosophila)	0.080
ARID1B	AT rich interactive domain 1B (SWI1-like)	0.079
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.078
BTRC	beta-transducin repeat containing	0.076
MED30	mediator complex subunit 30	0.074
PPP2R2C	protein phosphatase 2, regulatory subunit B, gamma	0.071	Fly
ENG	endoglin	0.063
PARD6G	par-6 partitioning defective 6 homolog gamma (C. elegans)	0.062
SMARCD1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1	0.056
SMARCC1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1	0.054	Fly
WFIKKN2	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	0.052
ZFYVE9	zinc finger, FYVE domain containing 9	0.050
PPP4C	protein phosphatase 4, catalytic subunit	0.049
COX5B	cytochrome c oxidase subunit Vb	0.049
PARD6B	par-6 partitioning defective 6 homolog beta (C. elegans)	0.045
SKA3	spindle and kinetochore associated complex subunit 3	0.045
MED27	mediator complex subunit 27	0.044
PPP2CA	protein phosphatase 2, catalytic subunit, alpha isozyme	0.043	Fly
TCF7L2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.043
SMARCB1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	0.038
LRP6	low density lipoprotein receptor-related protein 6	0.036
AR	androgen receptor	0.035
MAP3K8	mitogen-activated protein kinase kinase kinase 8	0.034
NDUFB8	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa	0.034
NDUFS4	NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase)	0.033
EMD	emerin	0.033
VDAC2	voltage-dependent anion channel 2	0.032
TGFBR1	transforming growth factor, beta receptor 1	0.032
FBXW11	F-box and WD repeat domain containing 11	0.032
COX7C	cytochrome c oxidase subunit VIIc	0.031
MECP2	methyl CpG binding protein 2 (Rett syndrome)	0.030
ATP5O	ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit	0.030
GLIS2	GLIS family zinc finger 2	0.030
PARD3	par-3 partitioning defective 3 homolog (C. elegans)	0.028
CHD4	chromodomain helicase DNA binding protein 4	0.027
TGFB2	transforming growth factor, beta 2	0.027
PPME1	protein phosphatase methylesterase 1	0.027
XRCC6	X-ray repair complementing defective repair in Chinese hamster cells 6	0.026
NCOR1	nuclear receptor corepressor 1	0.026
EIF3K	eukaryotic translation initiation factor 3, subunit K	0.026
TCF4	transcription factor 4	0.025
SERTAD4	SERTA domain containing 4	0.025
NFIA	nuclear factor I/A	0.025
PRKCZ	protein kinase C, zeta	0.025
NDUFA1	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa	0.025
AMOTL1	angiomotin like 1	0.024
NDUFB1	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa	0.024
UQCR11	ubiquinol-cytochrome c reductase, complex III subunit XI	0.023
TGFB3	transforming growth factor, beta 3	0.023
SP1	Sp1 transcription factor	0.023
NFKBIE	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon	0.023
MEIS2	Meis homeobox 2	0.023
SLC25A3	solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3	0.022
PSEN1	presenilin 1	0.022
ZC3HAV1	zinc finger CCCH-type, antiviral 1	0.022
SDHA	succinate dehydrogenase complex, subunit A, flavoprotein (Fp)	0.022
ECI1	enoyl-CoA delta isomerase 1	0.021
PPP2R2D	protein phosphatase 2, regulatory subunit B, delta	0.021	Fly
FZD8	frizzled homolog 8 (Drosophila)	0.021
CDK8	cyclin-dependent kinase 8	0.021
PPP2R2B	protein phosphatase 2, regulatory subunit B, beta	0.021	Fly
AXIN1	axin 1	0.021
SGOL1	shugoshin-like 1 (S. pombe)	0.021
DIP2A	DIP2 disco-interacting protein 2 homolog A (Drosophila)	0.020
CDH2	cadherin 2, type 1, N-cadherin (neuronal)	0.020
PBX1	pre-B-cell leukemia homeobox 1	0.020
CREBBP	CREB binding protein	0.020
PEX14	peroxisomal biogenesis factor 14	0.019
STRN3	striatin, calmodulin binding protein 3	0.019
PBRM1	polybromo 1	0.019
ECH1	enoyl CoA hydratase 1, peroxisomal	0.019
GSK3B	glycogen synthase kinase 3 beta	0.019
FERMT2	fermitin family member 2	0.019
SKI	v-ski sarcoma viral oncogene homolog (avian)	0.019
NOG	noggin	0.019
MPDZ	multiple PDZ domain protein	0.018
CHMP2A	chromatin modifying protein 2A	0.018
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.018
BMPR2	bone morphogenetic protein receptor, type II (serine/threonine kinase)	0.018
UQCRC2	ubiquinol-cytochrome c reductase core protein II	0.018
MED1	mediator complex subunit 1	0.017
ARRB2	arrestin, beta 2	0.017
SUMO1	SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)	0.017
NFKBIA	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.017
NFIX	nuclear factor I/X (CCAAT-binding transcription factor)	0.017
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.017
SLX4	SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)	0.017
WFIKKN1	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1	0.017
NR2E3	nuclear receptor subfamily 2, group E, member 3	0.017
ATP5L	ATP synthase, H+ transporting, mitochondrial Fo complex, subunit G	0.016
COX7B	cytochrome c oxidase subunit VIIb	0.016
GSTZ1	glutathione transferase zeta 1	0.016
PARVA	parvin, alpha	0.016
MED8	mediator complex subunit 8	0.016
SMARCC2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2	0.016	Fly
PPARA	peroxisome proliferator-activated receptor alpha	0.015
PPP2R5A	protein phosphatase 2, regulatory subunit B', alpha	0.015
TST	thiosulfate sulfurtransferase (rhodanese)	0.015
AXIN2	axin 2	0.015
IGBP1	immunoglobulin (CD79A) binding protein 1	0.015
NRP1	neuropilin 1	0.015
MED14	mediator complex subunit 14	0.015
NDUFB5	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa	0.015
NFKB2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)	0.015	Fly
NFKBIB	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta	0.015
ARID1A	AT rich interactive domain 1A (SWI-like)	0.015
CYFIP1	cytoplasmic FMR1 interacting protein 1	0.015
DMAP1	DNA methyltransferase 1 associated protein 1	0.014
MAPK8	mitogen-activated protein kinase 8	0.014
COX6B1	cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous)	0.014
PEBP1	phosphatidylethanolamine binding protein 1	0.014
SMAD1	SMAD family member 1	0.014
SPINT1	serine peptidase inhibitor, Kunitz type 1	0.014
ACTN1	actinin, alpha 1	0.014
WWC1	WW and C2 domain containing 1	0.014
SUCLG1	succinate-CoA ligase, alpha subunit	0.014
DST	dystonin	0.014
GSPT1	G1 to S phase transition 1	0.014
HADHA	hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit	0.014
TIRAP	toll-interleukin 1 receptor (TIR) domain containing adaptor protein	0.013
PRDX2	peroxiredoxin 2	0.013
ARIH2	ariadne homolog 2 (Drosophila)	0.013
CACNA1A	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	0.013
BCL3	B-cell CLL/lymphoma 3	0.013
CCNC	cyclin C	0.013
MGMT	O-6-methylguanine-DNA methyltransferase	0.013
ERCC4	excision repair cross-complementing rodent repair deficiency, complementation group 4	0.013
BMPR1B	bone morphogenetic protein receptor, type IB	0.013
MAGEB18	melanoma antigen family B, 18	0.013
UQCRFS1	ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1	0.013
MED18	mediator complex subunit 18	0.013
TEAD1	TEA domain family member 1 (SV40 transcriptional enhancer factor)	0.013
BANP	BTG3 associated nuclear protein	0.013
ZMYND11	zinc finger, MYND-type containing 11	0.013
DHX30	DEAH (Asp-Glu-Ala-His) box polypeptide 30	0.013
LAMB1	laminin, beta 1	0.013
NDUFB11	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa	0.013
MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	0.012
PPP2R1A	protein phosphatase 2, regulatory subunit A, alpha	0.012
WDYHV1	WDYHV motif containing 1	0.012
SURF1	surfeit 1	0.012
PPP6R2	protein phosphatase 6, regulatory subunit 2	0.012
COX7A2L	cytochrome c oxidase subunit VIIa polypeptide 2 like	0.012
GLRX5	glutaredoxin 5	0.012
LIMCH1	LIM and calponin homology domains 1	0.012
BAG2	BCL2-associated athanogene 2	0.012
IKBKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	0.012
SMAD7	SMAD family member 7	0.012
SPAG7	sperm associated antigen 7	0.012
SNAP25	synaptosomal-associated protein, 25kDa	0.012
MED17	mediator complex subunit 17	0.012
KRT5	keratin 5	0.012
SKA1	spindle and kinetochore associated complex subunit 1	0.012
C22orf39	chromosome 22 open reading frame 39	0.012
STK24	serine/threonine kinase 24	0.012
FZD2	frizzled homolog 2 (Drosophila)	0.012
TJP1	tight junction protein 1 (zona occludens 1)	0.012
TRRAP	transformation/transcription domain-associated protein	0.011
FGF4	fibroblast growth factor 4	0.011
ITSN1	intersectin 1 (SH3 domain protein)	0.011
RPL36A	ribosomal protein L36a	0.011
JAG1	jagged 1	0.011
NR2F2	nuclear receptor subfamily 2, group F, member 2	0.011
SKP1	S-phase kinase-associated protein 1	0.011
PTK7	PTK7 protein tyrosine kinase 7	0.011
GATAD2B	GATA zinc finger domain containing 2B	0.011
CSNK1D	casein kinase 1, delta	0.011
NDUFA5	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5, 13kDa	0.011
UQCRH	ubiquinol-cytochrome c reductase hinge protein	0.011
FST	follistatin	0.011
BLVRB	biliverdin reductase B (flavin reductase (NADPH))	0.011
ZFP28	zinc finger protein 28 homolog (mouse)	0.011
MEIS1	Meis homeobox 1	0.011
AFG3L2	AFG3 ATPase family gene 3-like 2 (S. cerevisiae)	0.011
SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	0.011
HMGCL	3-hydroxymethyl-3-methylglutaryl-CoA lyase	0.011
KIAA1967	KIAA1967	0.010
C20orf94	chromosome 20 open reading frame 94	0.010
BAZ1B	bromodomain adjacent to zinc finger domain, 1B	0.010
CFTR	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	0.010
BCL2	B-cell CLL/lymphoma 2	0.010
SMURF1	SMAD specific E3 ubiquitin protein ligase 1	0.010
TGIF1	TGFB-induced factor homeobox 1	0.010
XRCC1	X-ray repair complementing defective repair in Chinese hamster cells 1	0.010
KIF1C	kinesin family member 1C	0.010
ARHGAP31	Rho GTPase activating protein 31	0.010
ZNF207	zinc finger protein 207	0.010
COX1	cytochrome c oxidase subunit I	0.010
APP	amyloid beta (A4) precursor protein	0.010
DAPK1	death-associated protein kinase 1	0.010
ACAA1	acetyl-CoA acyltransferase 1	0.010
MED11	mediator complex subunit 11	0.010
CDH3	cadherin 3, type 1, P-cadherin (placental)	0.010
MUS81	MUS81 endonuclease homolog (S. cerevisiae)	0.010
PEX5	peroxisomal biogenesis factor 5	0.010
SAP30	Sin3A-associated protein, 30kDa	0.010