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Homo sapiens

18 genes annotated in human

negative regulation of g protein coupled receptor protein signaling pathway

Any process that stops, prevents, or reduces the frequency, rate or extent of G-protein coupled receptor protein signaling pathway activity.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of g protein coupled receptor protein signaling pathway"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of g protein coupled receptor protein signaling pathway" (in gray)

Name	Description	Probability	Func Analog Organism
IL8	interleukin 8	1.000
CXCL3	chemokine (C-X-C motif) ligand 3	0.998	Human
CXCL1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	0.983	Human
CXCL2	chemokine (C-X-C motif) ligand 2	0.982	Human
IL6	interleukin 6 (interferon, beta 2)	0.972
IL1B	interleukin 1, beta	0.944
PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	0.860
CCL2	chemokine (C-C motif) ligand 2	0.825	Human
CCL4	chemokine (C-C motif) ligand 4	0.811	Human
CCR5	chemokine (C-C motif) receptor 5	0.767
CCL20	chemokine (C-C motif) ligand 20	0.765	Human
ARRB1	arrestin, beta 1	0.703
CCL8	chemokine (C-C motif) ligand 8	0.670	Human
DPP4	dipeptidyl-peptidase 4	0.591
CXCL10	chemokine (C-X-C motif) ligand 10	0.581	Human
ZNF496	zinc finger protein 496	0.554
CXCL5	chemokine (C-X-C motif) ligand 5	0.506	Human
ICAM1	intercellular adhesion molecule 1	0.483
MAGI2	membrane associated guanylate kinase, WW and PDZ domain containing 2	0.387
MPDZ	multiple PDZ domain protein	0.376
CXCL9	chemokine (C-X-C motif) ligand 9	0.372	Human
KLK10	kallikrein-related peptidase 10	0.344	Human
CXCL6	chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)	0.301	Human
CXCL11	chemokine (C-X-C motif) ligand 11	0.286	Human
CCL18	chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)	0.270	Human
CAMK2A	calcium/calmodulin-dependent protein kinase II alpha	0.247
CCR1	chemokine (C-C motif) receptor 1	0.188
SOD2	superoxide dismutase 2, mitochondrial	0.178
GPRASP1	G protein-coupled receptor associated sorting protein 1	0.160
CCL13	chemokine (C-C motif) ligand 13	0.159	Human
CCL5	chemokine (C-C motif) ligand 5	0.130
ADORA2A	adenosine A2a receptor	0.113
ARMCX3	armadillo repeat containing, X-linked 3	0.110
UBD	ubiquitin D	0.108
TNFAIP6	tumor necrosis factor, alpha-induced protein 6	0.105
BCL2A1	BCL2-related protein A1	0.101
GPRASP2	G protein-coupled receptor associated sorting protein 2	0.097
ERCC8	excision repair cross-complementing rodent repair deficiency, complementation group 8	0.092
GIT1	G protein-coupled receptor kinase interacting ArfGAP 1	0.091
PI3	peptidase inhibitor 3, skin-derived	0.089
ATP2B2	ATPase, Ca++ transporting, plasma membrane 2	0.088	Human
CDSN	corneodesmosin	0.079
HDAC6	histone deacetylase 6	0.076
PLAUR	plasminogen activator, urokinase receptor	0.074
VCAM1	vascular cell adhesion molecule 1	0.074
IER3	immediate early response 3	0.071
GRIN2B	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	0.071
MAPT	microtubule-associated protein tau	0.070
CALCA	calcitonin-related polypeptide alpha	0.069
KLK8	kallikrein-related peptidase 8	0.066	Human
RGS1	regulator of G-protein signaling 1	0.063
MAPK10	mitogen-activated protein kinase 10	0.062
MAP3K5	mitogen-activated protein kinase kinase kinase 5	0.062
NAMPT	nicotinamide phosphoribosyltransferase	0.061
SLC6A3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	0.059
CFL1	cofilin 1 (non-muscle)	0.057
SELE	selectin E	0.057
BBS10	Bardet-Biedl syndrome 10	0.056
MMP12	matrix metallopeptidase 12 (macrophage elastase)	0.055
CXCL13	chemokine (C-X-C motif) ligand 13	0.054
IL10	interleukin 10	0.051
CCL7	chemokine (C-C motif) ligand 7	0.049	Human
GNAQ	guanine nucleotide binding protein (G protein), q polypeptide	0.048
KLK11	kallikrein-related peptidase 11	0.044	Human
MAGI3	membrane associated guanylate kinase, WW and PDZ domain containing 3	0.042
KLK7	kallikrein-related peptidase 7	0.040	Human
CCL3	chemokine (C-C motif) ligand 3	0.038	Human
GNMT	glycine N-methyltransferase	0.038
IFNG	interferon, gamma	0.037
PPP1R9B	protein phosphatase 1, regulatory (inhibitor) subunit 9B	0.037
DCTN1	dynactin 1	0.035
CCL11	chemokine (C-C motif) ligand 11	0.034	Human
TNF	tumor necrosis factor	0.034
TNFAIP3	tumor necrosis factor, alpha-induced protein 3	0.034
CH25H	cholesterol 25-hydroxylase	0.032
RELB	v-rel reticuloendotheliosis viral oncogene homolog B	0.031
MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	0.031
KLK2	kallikrein-related peptidase 2	0.030	Human
VPS29	vacuolar protein sorting 29 homolog (S. cerevisiae)	0.030
KLK3	kallikrein-related peptidase 3	0.029	Human
OR2AG1	olfactory receptor, family 2, subfamily AG, member 1	0.029
PF4	platelet factor 4	0.029
ARRDC3	arrestin domain containing 3	0.027
KLK5	kallikrein-related peptidase 5	0.025	Human
DLG2	discs, large homolog 2 (Drosophila)	0.025
REEP5	receptor accessory protein 5	0.025
ALB	albumin	0.025
CD83	CD83 molecule	0.024
CCL19	chemokine (C-C motif) ligand 19	0.024	Human
ARMCX2	armadillo repeat containing, X-linked 2	0.024	Human
INHBA	inhibin, beta A	0.024
BIRC3	baculoviral IAP repeat containing 3	0.024
IL7R	interleukin 7 receptor	0.024
AKT2	v-akt murine thymoma viral oncogene homolog 2	0.023
KYNU	kynureninase	0.023
IL1RN	interleukin 1 receptor antagonist	0.023
HIST2H2AB	histone cluster 2, H2ab	0.023
LIF	leukemia inhibitory factor (cholinergic differentiation factor)	0.023
CD163	CD163 molecule	0.022
CLEC7A	C-type lectin domain family 7, member A	0.022
CSF3	colony stimulating factor 3 (granulocyte)	0.022
TLR2	toll-like receptor 2	0.021
CCR7	chemokine (C-C motif) receptor 7	0.021
KLK12	kallikrein-related peptidase 12	0.020	Human
SOCS5	suppressor of cytokine signaling 5	0.020
F13A1	coagulation factor XIII, A1 polypeptide	0.020
TNFAIP2	tumor necrosis factor, alpha-induced protein 2	0.020
DARC	Duffy blood group, chemokine receptor	0.019
ARRB2	arrestin, beta 2	0.019
TNFRSF9	tumor necrosis factor receptor superfamily, member 9	0.018
CXCR3	chemokine (C-X-C motif) receptor 3	0.018
GTF2H1	general transcription factor IIH, polypeptide 1, 62kDa	0.018
AQP9	aquaporin 9	0.017
PHLDA1	pleckstrin homology-like domain, family A, member 1	0.017
IDO1	indoleamine 2,3-dioxygenase 1	0.017
SSTR3	somatostatin receptor 3	0.017
C3AR1	complement component 3a receptor 1	0.017
CCL22	chemokine (C-C motif) ligand 22	0.016
MAP3K8	mitogen-activated protein kinase kinase kinase 8	0.016
NFKBIZ	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta	0.016
KLK13	kallikrein-related peptidase 13	0.016	Human
G0S2	G0/G1switch 2	0.015
SLC9A3R1	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	0.015
PTX3	pentraxin 3, long	0.015
HTT	huntingtin	0.015
RHO	rhodopsin	0.015
NR4A3	nuclear receptor subfamily 4, group A, member 3	0.015
SLAMF8	SLAM family member 8	0.015
CCR4	chemokine (C-C motif) receptor 4	0.014
PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	0.014
S100A7	S100 calcium binding protein A7	0.014
IL2RG	interleukin 2 receptor, gamma	0.014
SERPINB2	serpin peptidase inhibitor, clade B (ovalbumin), member 2	0.014
SNCAIP	synuclein, alpha interacting protein	0.014
MMP1	matrix metallopeptidase 1 (interstitial collagenase)	0.014
PLEKHA1	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1	0.014
DEFB4A	defensin, beta 4A	0.014
IL1F5	interleukin 1 family, member 5 (delta)	0.014
MMP10	matrix metallopeptidase 10 (stromelysin 2)	0.014
PLAU	plasminogen activator, urokinase	0.014
GSK3B	glycogen synthase kinase 3 beta	0.014
IL1A	interleukin 1, alpha	0.014
CDK7	cyclin-dependent kinase 7	0.014
IL2RB	interleukin 2 receptor, beta	0.014
RASGRF1	Ras protein-specific guanine nucleotide-releasing factor 1	0.013
TCEAL4	transcription elongation factor A (SII)-like 4	0.013
NFKBIA	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.013
DSG3	desmoglein 3	0.013
TPPP	tubulin polymerization promoting protein	0.013
C5AR1	complement component 5a receptor 1	0.013
ARHGEF7	Rho guanine nucleotide exchange factor (GEF) 7	0.013
MAFF	v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)	0.012
IL6R	interleukin 6 receptor	0.012
DLG4	discs, large homolog 4 (Drosophila)	0.012
STAT4	signal transducer and activator of transcription 4	0.012
PPP6R1	protein phosphatase 6, regulatory subunit 1	0.012
ARMCX1	armadillo repeat containing, X-linked 1	0.012	Human
GNAO1	guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O	0.012
CCK	cholecystokinin	0.012
NIN	ninein (GSK3B interacting protein)	0.012
GPR109B	G protein-coupled receptor 109B	0.011
PRSS2	protease, serine, 2 (trypsin 2)	0.011
PRSS3	protease, serine, 3	0.011	Human
IVL	involucrin	0.011
GRIN1	glutamate receptor, ionotropic, N-methyl D-aspartate 1	0.011
FPR3	formyl peptide receptor 3	0.011
OASL	2'-5'-oligoadenylate synthetase-like	0.011
SIGLEC1	sialic acid binding Ig-like lectin 1, sialoadhesin	0.011
CCNH	cyclin H	0.011
C1orf116	chromosome 1 open reading frame 116	0.010
PLA2G7	phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)	0.010
KLK6	kallikrein-related peptidase 6	0.010	Human
OSMR	oncostatin M receptor	0.010