IMP

Process View

Homo sapiens

12 genes annotated in human

morphogenesis of an epithelial sheet

GO:0002011

The process in which the anatomical structures of an epithelial sheet are generated and organized. An epithelial sheet is a flat surface consisting of closely packed epithelial cells.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "morphogenesis of an epithelial sheet"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "morphogenesis of an epithelial sheet" (in gray)

Name	Description	Probability	Func Analog Organism
ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	1.000	Fly
FN1	fibronectin 1	0.994
FHL2	four and a half LIM domains 2	0.989
ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.967
JAG1	jagged 1	0.909	Mouse
ITGAV	integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)	0.748	Human
DDR2	discoidin domain receptor tyrosine kinase 2	0.719	Human
CASK	calcium/calmodulin-dependent serine protein kinase (MAGUK family)	0.681	Human
ENG	endoglin	0.644
COL1A1	collagen, type I, alpha 1	0.633	Human
ITGB3	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	0.553
KCNJ4	potassium inwardly-rectifying channel, subfamily J, member 4	0.553
PDGFB	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	0.543
NOTCH3	notch 3	0.511
ITGA3	integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)	0.495	Human
ITGA6	integrin, alpha 6	0.481	Human
BMPR2	bone morphogenetic protein receptor, type II (serine/threonine kinase)	0.457	Human
COL1A2	collagen, type I, alpha 2	0.383	Human
DLG1	discs, large homolog 1 (Drosophila)	0.374
ABI2	abl-interactor 2	0.367
CTGF	connective tissue growth factor	0.362	Human
PXN	paxillin	0.327
FKBP1A	FK506 binding protein 1A, 12kDa	0.318
NKX2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.307
EPS8	epidermal growth factor receptor pathway substrate 8	0.290
FLNA	filamin A, alpha	0.246
PTPRC	protein tyrosine phosphatase, receptor type, C	0.223
LATS2	LATS, large tumor suppressor, homolog 2 (Drosophila)	0.202
COL3A1	collagen, type III, alpha 1	0.191	Human
THBS1	thrombospondin 1	0.190
DVL3	dishevelled, dsh homolog 3 (Drosophila)	0.190
SFN	stratifin	0.188
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.185
TGFB3	transforming growth factor, beta 3	0.179
BMP2	bone morphogenetic protein 2	0.171
COL5A2	collagen, type V, alpha 2	0.149	Human
HSF1	heat shock transcription factor 1	0.145
NOTCH1	notch 1	0.145	Mouse
TP63	tumor protein p63	0.134
SPARC	secreted protein, acidic, cysteine-rich (osteonectin)	0.126
CTNNA1	catenin (cadherin-associated protein), alpha 1, 102kDa	0.120
AMOTL2	angiomotin like 2	0.119
LRRK2	leucine-rich repeat kinase 2	0.117
ITGA2	integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)	0.111	Human Fly
F11R	F11 receptor	0.108
COL4A1	collagen, type IV, alpha 1	0.096
LAMC1	laminin, gamma 1 (formerly LAMB2)	0.096
SDC2	syndecan 2	0.095
MAP2K4	mitogen-activated protein kinase kinase 4	0.092
TM4SF1	transmembrane 4 L six family member 1	0.088
INADL	InaD-like (Drosophila)	0.087
RANBP9	RAN binding protein 9	0.080
BMPR1A	bone morphogenetic protein receptor, type IA	0.077	Human
IGFBP3	insulin-like growth factor binding protein 3	0.074
LAMB1	laminin, beta 1	0.074
TLN1	talin 1	0.069
DAB2	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)	0.068
JAG2	jagged 2	0.068
CYR61	cysteine-rich, angiogenic inducer, 61	0.067
DSG2	desmoglein 2	0.058
ACVR1	activin A receptor, type I	0.057	Human
ITGB5	integrin, beta 5	0.057	Fly
GDF5	growth differentiation factor 5	0.056
PLEC	plectin	0.054
CTNND1	catenin (cadherin-associated protein), delta 1	0.054
DMD	dystrophin	0.052
ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	0.051
CD63	CD63 molecule	0.047
PDIA3	protein disulfide isomerase family A, member 3	0.045
SH3D19	SH3 domain containing 19	0.043
CYTH1	cytohesin 1	0.043
FBLN1	fibulin 1	0.041
JUN	jun proto-oncogene	0.040
COL6A1	collagen, type VI, alpha 1	0.040
MKL1	megakaryoblastic leukemia (translocation) 1	0.040
RBPJ	recombination signal binding protein for immunoglobulin kappa J region	0.039
MAPK14	mitogen-activated protein kinase 14	0.039
ITGB4	integrin, beta 4	0.038	Fly
CD9	CD9 molecule	0.036
SNX33	sorting nexin 33	0.035
CDH3	cadherin 3, type 1, P-cadherin (placental)	0.034	Zebrafish
FHL3	four and a half LIM domains 3	0.033
CDH11	cadherin 11, type 2, OB-cadherin (osteoblast)	0.033
ADAM12	ADAM metallopeptidase domain 12	0.031	Human
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.031	Zebrafish
ATF2	activating transcription factor 2	0.031
DLL1	delta-like 1 (Drosophila)	0.031
MAD2L2	MAD2 mitotic arrest deficient-like 2 (yeast)	0.030
DKK1	dickkopf homolog 1 (Xenopus laevis)	0.030
JUP	junction plakoglobin	0.030
HAP1	huntingtin-associated protein 1	0.029
VCAM1	vascular cell adhesion molecule 1	0.029
CDH5	cadherin 5, type 2 (vascular endothelium)	0.028
PDGFC	platelet derived growth factor C	0.028
SELPLG	selectin P ligand	0.027
PRKG1	protein kinase, cGMP-dependent, type I	0.027
YAP1	Yes-associated protein 1	0.026	Fly
VCL	vinculin	0.025
CSNK1E	casein kinase 1, epsilon	0.025
ELN	elastin	0.025
COL11A2	collagen, type XI, alpha 2	0.025	Human
COL11A1	collagen, type XI, alpha 1	0.024	Human
COL10A1	collagen, type X, alpha 1	0.024
COL5A3	collagen, type V, alpha 3	0.023	Human
FZD1	frizzled homolog 1 (Drosophila)	0.022
NRP1	neuropilin 1	0.022
COL4A2	collagen, type IV, alpha 2	0.022
PDGFA	platelet-derived growth factor alpha polypeptide	0.022
ATF3	activating transcription factor 3	0.021
MYO10	myosin X	0.021
APC	adenomatous polyposis coli	0.021
AXIN1	axin 1	0.020
TJP1	tight junction protein 1 (zona occludens 1)	0.020
SNAI1	snail homolog 1 (Drosophila)	0.020
AR	androgen receptor	0.020
DSP	desmoplakin	0.019
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.019
EFNB2	ephrin-B2	0.019
PKP3	plakophilin 3	0.019
WISP1	WNT1 inducible signaling pathway protein 1	0.018	Human
NCK2	NCK adaptor protein 2	0.018
FLNB	filamin B, beta	0.018
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.018
SH3PXD2A	SH3 and PX domains 2A	0.018
TNC	tenascin C	0.017
COL5A1	collagen, type V, alpha 1	0.017
IKBKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	0.017
PLXDC1	plexin domain containing 1	0.017
MMP11	matrix metallopeptidase 11 (stromelysin 3)	0.017
SMAD2	SMAD family member 2	0.017
ADAMTS2	ADAM metallopeptidase with thrombospondin type 1 motif, 2	0.017
LOX	lysyl oxidase	0.017
LIN7A	lin-7 homolog A (C. elegans)	0.017	Human
PRKCI	protein kinase C, iota	0.017
MAP4K4	mitogen-activated protein kinase kinase kinase kinase 4	0.017
SOX9	SRY (sex determining region Y)-box 9	0.017
POSTN	periostin, osteoblast specific factor	0.016
SMAD7	SMAD family member 7	0.016
GATA4	GATA binding protein 4	0.015
SOCS5	suppressor of cytokine signaling 5	0.015
MSX1	msh homeobox 1	0.015
PACSIN3	protein kinase C and casein kinase substrate in neurons 3	0.015
LYN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	0.015
ADAM10	ADAM metallopeptidase domain 10	0.015
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.015
CALD1	caldesmon 1	0.015
ADAM9	ADAM metallopeptidase domain 9	0.014	Human
TJP2	tight junction protein 2 (zona occludens 2)	0.014
NEDD4L	neural precursor cell expressed, developmentally down-regulated 4-like	0.014
FOXF2	forkhead box F2	0.014
MXRA5	matrix-remodelling associated 5	0.014
FBN1	fibrillin 1	0.014
MAP4K3	mitogen-activated protein kinase kinase kinase kinase 3	0.014
IQGAP1	IQ motif containing GTPase activating protein 1	0.014
NOTCH2NL	notch 2 N-terminal like	0.014
PHC2	polyhomeotic homolog 2 (Drosophila)	0.013
FGF18	fibroblast growth factor 18	0.013
ZCCHC17	zinc finger, CCHC domain containing 17	0.013
COL6A3	collagen, type VI, alpha 3	0.013
CD248	CD248 molecule, endosialin	0.013
NEDD4	neural precursor cell expressed, developmentally down-regulated 4	0.013
STC2	stanniocalcin 2	0.013
DACT1	dapper, antagonist of beta-catenin, homolog 1 (Xenopus laevis)	0.013
GLIS2	GLIS family zinc finger 2	0.012
NRP2	neuropilin 2	0.012
DUSP1	dual specificity phosphatase 1	0.012
BMP4	bone morphogenetic protein 4	0.012
THY1	Thy-1 cell surface antigen	0.011
SPRR2A	small proline-rich protein 2A	0.011
LIMK1	LIM domain kinase 1	0.011
COL6A2	collagen, type VI, alpha 2	0.011
TEAD1	TEA domain family member 1 (SV40 transcriptional enhancer factor)	0.011
ITGB1BP1	integrin beta 1 binding protein 1	0.011
PTPN14	protein tyrosine phosphatase, non-receptor type 14	0.011
IGFBP5	insulin-like growth factor binding protein 5	0.010
GJA1	gap junction protein, alpha 1, 43kDa	0.010
AMOT	angiomotin	0.010
FNDC1	fibronectin type III domain containing 1	0.010
PAFAH1B2	platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)	0.010