IMP
Process View
positive thymic t cell selection
The process of sparing immature T cells in the thymus which react with self-MHC protein complexes with low affinity levels from apoptotic death.
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In addition to gene-name show these genes:
Click on a gene's description to view its network relationships with genes known to be involved in "positive thymic t cell selection"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| LCK | lymphocyte-specific protein tyrosine kinase | 0.999 | ||
| CD247 | CD247 molecule | 0.994 | ||
| CD3E | CD3e molecule, epsilon (CD3-TCR complex) | 0.973 | ||
| LAT | linker for activation of T cells | 0.876 | ||
| HLA-DMB | major histocompatibility complex, class II, DM beta | 0.822 | ||
| HLA-DRA | major histocompatibility complex, class II, DR alpha | 0.734 | ||
| PTPN22 | protein tyrosine phosphatase, non-receptor type 22 (lymphoid) | 0.668 | ||
| HLA-DPA1 | major histocompatibility complex, class II, DP alpha 1 | 0.489 | ||
| HLA-DRB1 | major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 1 | 0.484 | ||
| VAV1 | vav 1 guanine nucleotide exchange factor | 0.359 | ||
| SH2D1A | SH2 domain containing 1A | 0.301 | ||
| STRADA | STE20-related kinase adaptor alpha | 0.239 | ||
| HLA-DQA1 | major histocompatibility complex, class II, DQ alpha 1 | 0.180 | ||
| CD74 | CD74 molecule, major histocompatibility complex, class II invariant chain | 0.178 | Mouse | |
| MKL1 | megakaryoblastic leukemia (translocation) 1 | 0.148 | ||
| SH2D2A | SH2 domain containing 2A | 0.144 | ||
| CXCR4 | chemokine (C-X-C motif) receptor 4 | 0.114 | ||
| GHR | growth hormone receptor | 0.113 | ||
| HLA-DPB1 | major histocompatibility complex, class II, DP beta 1 | 0.112 | ||
| SYK | spleen tyrosine kinase | 0.102 | Human | |
| STRADB | STE20-related kinase adaptor beta | 0.095 | ||
| LCP2 | lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) | 0.081 | ||
| PTPN6 | protein tyrosine phosphatase, non-receptor type 6 | 0.055 | ||
| HLA-DRB5 | major histocompatibility complex, class II, DR beta 5 | 0.049 | ||
| WAS | Wiskott-Aldrich syndrome (eczema-thrombocytopenia) | 0.049 | ||
| CD2 | CD2 molecule | 0.049 | ||
| ITGAL | integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) | 0.048 | ||
| PRKCQ | protein kinase C, theta | 0.043 | ||
| CD8A | CD8a molecule | 0.042 | ||
| CD52 | CD52 molecule | 0.041 | ||
| SH3BP2 | SH3-domain binding protein 2 | 0.034 | ||
| SEMA4D | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D | 0.028 | ||
| MYOCD | myocardin | 0.028 | ||
| MKL2 | MKL/myocardin-like 2 | 0.025 | ||
| ITGB2 | integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) | 0.024 | ||
| PIK3R1 | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | 0.024 | ||
| HCLS1 | hematopoietic cell-specific Lyn substrate 1 | 0.021 | ||
| CBL | Cas-Br-M (murine) ecotropic retroviral transforming sequence | 0.019 | ||
| CD3D | CD3d molecule, delta (CD3-TCR complex) | 0.018 | Mouse | |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.018 | ||
| PTPRB | protein tyrosine phosphatase, receptor type, B | 0.014 | ||
| ITGA1 | integrin, alpha 1 | 0.013 | ||
| HLA-DQB1 | major histocompatibility complex, class II, DQ beta 1 | 0.013 | ||
| FCGR2A | Fc fragment of IgG, low affinity IIa, receptor (CD32) | 0.012 | ||
| BTK | Bruton agammaglobulinemia tyrosine kinase | 0.012 | ||
| CD7 | CD7 molecule | 0.012 | ||
| TYROBP | TYRO protein tyrosine kinase binding protein | 0.012 | ||
| HLA-DRB4 | major histocompatibility complex, class II, DR beta 4 | 0.012 | ||
| LRMP | lymphoid-restricted membrane protein | 0.011 | ||
| TRAT1 | T cell receptor associated transmembrane adaptor 1 | 0.011 | ||
| CD3G | CD3g molecule, gamma (CD3-TCR complex) | 0.010 |