IMP

Process View

Homo sapiens

17 genes annotated in human

mammary gland development

The process whose specific outcome is the progression of the mammary gland over time, from its formation to the mature structure. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. Its development starts with the formation of the mammary line and ends as the mature gland cycles between nursing and weaning stages.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "mammary gland development"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "mammary gland development" (in gray)

Name	Description	Probability	Func Analog Organism
ESR1	estrogen receptor 1	0.989	Mouse
EGFR	epidermal growth factor receptor	0.986	Human
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.981
CREBBP	CREB binding protein	0.869
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.819
INSR	insulin receptor	0.783
IGF1R	insulin-like growth factor 1 receptor	0.765	Mouse
FGFR2	fibroblast growth factor receptor 2	0.700	Mouse
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.640	Human Rat
NCOA1	nuclear receptor coactivator 1	0.556
STAT3	signal transducer and activator of transcription 3 (acute-phase response factor)	0.523
JAG1	jagged 1	0.503
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.300
GRB10	growth factor receptor-bound protein 10	0.280
TAL1	T-cell acute lymphocytic leukemia 1	0.266
IRS1	insulin receptor substrate 1	0.238	Mouse
NKX2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.226
AR	androgen receptor	0.169	Mouse
EP300	E1A binding protein p300	0.161
RUNX1	runt-related transcription factor 1	0.134
PTPN11	protein tyrosine phosphatase, non-receptor type 11	0.132
STAT5A	signal transducer and activator of transcription 5A	0.125	Mouse Rat
GSK3B	glycogen synthase kinase 3 beta	0.121
FGFR1	fibroblast growth factor receptor 1	0.110
NR4A1	nuclear receptor subfamily 4, group A, member 1	0.110
RARA	retinoic acid receptor, alpha	0.107
NCOA2	nuclear receptor coactivator 2	0.103
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.103	Human Rat
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.092
FGF1	fibroblast growth factor 1 (acidic)	0.092	Human
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.091	Mouse
IL4R	interleukin 4 receptor	0.081
SP1	Sp1 transcription factor	0.075
IKBKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	0.075
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.073
GHR	growth hormone receptor	0.069
NRP1	neuropilin 1	0.069
FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.064
TRIP6	thyroid hormone receptor interactor 6	0.064
EHF	ets homologous factor	0.064
APC	adenomatous polyposis coli	0.061
ENG	endoglin	0.058
NCOA3	nuclear receptor coactivator 3	0.058	Mouse
SH2B1	SH2B adaptor protein 1	0.055
SMAD2	SMAD family member 2	0.052
FGF10	fibroblast growth factor 10	0.051
RXRA	retinoid X receptor, alpha	0.048
MEOX2	mesenchyme homeobox 2	0.045
TCF3	transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)	0.043
CAV1	caveolin 1, caveolae protein, 22kDa	0.043	Mouse
KAT2B	K(lysine) acetyltransferase 2B	0.041
STAT5B	signal transducer and activator of transcription 5B	0.040	Mouse
CCND3	cyclin D3	0.040
CDK6	cyclin-dependent kinase 6	0.040
CDKN2A	cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)	0.037
LDLR	low density lipoprotein receptor	0.035
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.035
CCND1	cyclin D1	0.033	Mouse
HIPK2	homeodomain interacting protein kinase 2	0.033
BCL9	B-cell CLL/lymphoma 9	0.033
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.031
TM4SF1	transmembrane 4 L six family member 1	0.031
EFNA1	ephrin-A1	0.030
EPOR	erythropoietin receptor	0.029
S100A4	S100 calcium binding protein A4	0.029
FOXO1	forkhead box O1	0.029
KDR	kinase insert domain receptor (a type III receptor tyrosine kinase)	0.027
BCL2	B-cell CLL/lymphoma 2	0.026
FZD1	frizzled homolog 1 (Drosophila)	0.026
CHEK2	CHK2 checkpoint homolog (S. pombe)	0.025
PPARA	peroxisome proliferator-activated receptor alpha	0.025
SOCS1	suppressor of cytokine signaling 1	0.025
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.025
NCOR2	nuclear receptor corepressor 2	0.024	Rat
CDK4	cyclin-dependent kinase 4	0.023
CUEDC2	CUE domain containing 2	0.022
LAT	linker for activation of T cells	0.022
MCL1	myeloid cell leukemia sequence 1 (BCL2-related)	0.021
EPAS1	endothelial PAS domain protein 1	0.021
PDZD11	PDZ domain containing 11	0.021
MSX1	msh homeobox 1	0.021	Mouse
FGF8	fibroblast growth factor 8 (androgen-induced)	0.020
PLCG1	phospholipase C, gamma 1	0.020
BBS10	Bardet-Biedl syndrome 10	0.020
MED25	mediator complex subunit 25	0.020
JDP2	Jun dimerization protein 2	0.020
RBPJ	recombination signal binding protein for immunoglobulin kappa J region	0.019
ITGB3	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	0.018
CTNND1	catenin (cadherin-associated protein), delta 1	0.018
CALCA	calcitonin-related polypeptide alpha	0.018
MEIS1	Meis homeobox 1	0.018
WNT1	wingless-type MMTV integration site family, member 1	0.018	Human
KLF13	Kruppel-like factor 13	0.018
FGF18	fibroblast growth factor 18	0.018
SFRP1	secreted frizzled-related protein 1	0.017
CDK8	cyclin-dependent kinase 8	0.017
HR	hairless homolog (mouse)	0.017
PGF	placental growth factor	0.017
LRP6	low density lipoprotein receptor-related protein 6	0.017	Mouse
APEX1	APEX nuclease (multifunctional DNA repair enzyme) 1	0.017
MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	0.017
SKI	v-ski sarcoma viral oncogene homolog (avian)	0.017
MUC1	mucin 1, cell surface associated	0.017
STAT1	signal transducer and activator of transcription 1, 91kDa	0.016
NCOA6	nuclear receptor coactivator 6	0.016
TGFB3	transforming growth factor, beta 3	0.016	Mouse
FOXO3	forkhead box O3	0.016
PTPRJ	protein tyrosine phosphatase, receptor type, J	0.016
WNT3A	wingless-type MMTV integration site family, member 3A	0.015	Mouse
POU3F2	POU class 3 homeobox 2	0.015
S100A2	S100 calcium binding protein A2	0.015
PPP5C	protein phosphatase 5, catalytic subunit	0.015
UBQLN4	ubiquilin 4	0.015
FGF7	fibroblast growth factor 7	0.015	Human
SMAD3	SMAD family member 3	0.015
PGR	progesterone receptor	0.015	Mouse
NOTCH2NL	notch 2 N-terminal like	0.015
GATA2	GATA binding protein 2	0.015	Human
MET	met proto-oncogene (hepatocyte growth factor receptor)	0.015	Rat
AKT1	v-akt murine thymoma viral oncogene homolog 1	0.014
CITED2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	0.014
NR3C1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	0.014	Mouse
RPS6KA5	ribosomal protein S6 kinase, 90kDa, polypeptide 5	0.014
DLL1	delta-like 1 (Drosophila)	0.014
NCOR1	nuclear receptor corepressor 1	0.013
BARX1	BARX homeobox 1	0.013
PTGIS	prostaglandin I2 (prostacyclin) synthase	0.013
FHL2	four and a half LIM domains 2	0.013
SFRP5	secreted frizzled-related protein 5	0.013
CEBPD	CCAAT/enhancer binding protein (C/EBP), delta	0.013
PHLPP1	PH domain and leucine rich repeat protein phosphatase 1	0.013
EPT1	ethanolaminephosphotransferase 1 (CDP-ethanolamine-specific)	0.013
JAG2	jagged 2	0.012
THRA	thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)	0.012
FRZB	frizzled-related protein	0.012
PML	promyelocytic leukemia	0.012
USF1	upstream transcription factor 1	0.012
TBX2	T-box 2	0.012
APBB2	amyloid beta (A4) precursor protein-binding, family B, member 2	0.012
DLG2	discs, large homolog 2 (Drosophila)	0.012
FZD7	frizzled homolog 7 (Drosophila)	0.012
BRCA1	breast cancer 1, early onset	0.012
PMAIP1	phorbol-12-myristate-13-acetate-induced protein 1	0.011
MTA1	metastasis associated 1	0.011
TGFB2	transforming growth factor, beta 2	0.011
FBLN1	fibulin 1	0.011
CPE	carboxypeptidase E	0.011
DKK1	dickkopf homolog 1 (Xenopus laevis)	0.011
MSX2	msh homeobox 2	0.011	Mouse
TLE1	transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)	0.011
SHC3	SHC (Src homology 2 domain containing) transforming protein 3	0.011
FGF3	fibroblast growth factor 3	0.011	Human
ANKS1B	ankyrin repeat and sterile alpha motif domain containing 1B	0.011
RUNX1T1	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	0.010
ZFPM1	zinc finger protein, multitype 1	0.010
DDX17	DEAD (Asp-Glu-Ala-Asp) box polypeptide 17	0.010
FSTL1	follistatin-like 1	0.010
RNF144B	ring finger protein 144B	0.010