IMP

Process View

Homo sapiens

2 genes annotated in human

chronic inflammatory response

Inflammation of prolonged duration (weeks or months) in which active inflammation, tissue destruction, and attempts at repair are proceeding simultaneously. Although it may follow acute inflammation, chronic inflammation frequently begins insidiously, as a low-grade, smoldering, often asymptomatic response.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "chronic inflammatory response"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "chronic inflammatory response" (in gray)

Name	Description	Probability	Func Analog Organism
S100A9	S100 calcium binding protein A9	0.999	Rat
TNIP1	TNFAIP3 interacting protein 1	0.972
IL8	interleukin 8	0.898
S100A8	S100 calcium binding protein A8	0.893	Rat
TNFRSF1B	tumor necrosis factor receptor superfamily, member 1B	0.674
NFKBIA	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.584
CCL2	chemokine (C-C motif) ligand 2	0.557
CCR5	chemokine (C-C motif) receptor 5	0.542
PLAUR	plasminogen activator, urokinase receptor	0.471
BCL2A1	BCL2-related protein A1	0.367
ICAM1	intercellular adhesion molecule 1	0.334
CCL20	chemokine (C-C motif) ligand 20	0.304
MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	0.287
CXCL2	chemokine (C-X-C motif) ligand 2	0.287
CCL4	chemokine (C-C motif) ligand 4	0.270
PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	0.268
TNFAIP6	tumor necrosis factor, alpha-induced protein 6	0.257
CXCL1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	0.225
SRGN	serglycin	0.178
ITGB3	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	0.176
CXCL3	chemokine (C-X-C motif) ligand 3	0.159
IL6	interleukin 6 (interferon, beta 2)	0.158
NCF2	neutrophil cytosolic factor 2	0.143
IL1RN	interleukin 1 receptor antagonist	0.140	Rat
MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	0.133	Zebrafish
TRAF1	TNF receptor-associated factor 1	0.118
TGFB1	transforming growth factor, beta 1	0.116
IL1R1	interleukin 1 receptor, type I	0.115
S100A12	S100 calcium binding protein A12	0.112
IL1R2	interleukin 1 receptor, type II	0.095
PLEK	pleckstrin	0.085
ENG	endoglin	0.081
IKZF3	IKAROS family zinc finger 3 (Aiolos)	0.068
TNFAIP2	tumor necrosis factor, alpha-induced protein 2	0.067
CCL8	chemokine (C-C motif) ligand 8	0.064
CXCL5	chemokine (C-X-C motif) ligand 5	0.056
PLAU	plasminogen activator, urokinase	0.055
VCAN	versican	0.052
CCL7	chemokine (C-C motif) ligand 7	0.051
CXCL11	chemokine (C-X-C motif) ligand 11	0.047
PI3	peptidase inhibitor 3, skin-derived	0.045
TNFRSF9	tumor necrosis factor receptor superfamily, member 9	0.042
CCL18	chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)	0.035
INHBA	inhibin, beta A	0.035
THBS1	thrombospondin 1	0.035
CXCL6	chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)	0.034
RGS1	regulator of G-protein signaling 1	0.033
CD83	CD83 molecule	0.032
TLN1	talin 1	0.032
IER3	immediate early response 3	0.032
LAPTM5	lysosomal protein transmembrane 5	0.031
NNMT	nicotinamide N-methyltransferase	0.031
IL7R	interleukin 7 receptor	0.029
CD14	CD14 molecule	0.029
FERMT3	fermitin family member 3	0.029
PDPN	podoplanin	0.028
ITGAV	integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)	0.028
GPR109B	G protein-coupled receptor 109B	0.028
C5AR1	complement component 5a receptor 1	0.027
TREM1	triggering receptor expressed on myeloid cells 1	0.026
FAP	fibroblast activation protein, alpha	0.026
CLEC7A	C-type lectin domain family 7, member A	0.025
KYNU	kynureninase	0.025
FN1	fibronectin 1	0.024
SLC11A1	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	0.024
TNIP2	TNFAIP3 interacting protein 2	0.024
OLR1	oxidized low density lipoprotein (lectin-like) receptor 1	0.024
TLR2	toll-like receptor 2	0.024
HDAC9	histone deacetylase 9	0.024
SERPINB2	serpin peptidase inhibitor, clade B (ovalbumin), member 2	0.023
PTAFR	platelet-activating factor receptor	0.023
AQP9	aquaporin 9	0.023
CHI3L1	chitinase 3-like 1 (cartilage glycoprotein-39)	0.023
CSTA	cystatin A (stefin A)	0.023
COL1A1	collagen, type I, alpha 1	0.022
VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor	0.022
SPHK1	sphingosine kinase 1	0.021
CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	0.021
IL1B	interleukin 1, beta	0.020	Rat
SELE	selectin E	0.020
TNC	tenascin C	0.019
TAGLN	transgelin	0.019
SOD2	superoxide dismutase 2, mitochondrial	0.019
BIRC3	baculoviral IAP repeat containing 3	0.018
S100P	S100 calcium binding protein P	0.018
FPR1	formyl peptide receptor 1	0.018
THBS2	thrombospondin 2	0.018	Human
PTX3	pentraxin 3, long	0.018
PTPRE	protein tyrosine phosphatase, receptor type, E	0.018
CCL22	chemokine (C-C motif) ligand 22	0.017
THY1	Thy-1 cell surface antigen	0.017
MMP1	matrix metallopeptidase 1 (interstitial collagenase)	0.017
FCER1G	Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide	0.016
G0S2	G0/G1switch 2	0.016
IL32	interleukin 32	0.016
SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	0.016
MSC	musculin	0.016
CXCL9	chemokine (C-X-C motif) ligand 9	0.015
MEP1A	meprin A, alpha (PABA peptide hydrolase)	0.015
COL4A1	collagen, type IV, alpha 1	0.015
AEBP1	AE binding protein 1	0.015
HSPA6	heat shock 70kDa protein 6 (HSP70B')	0.015
GNA15	guanine nucleotide binding protein (G protein), alpha 15 (Gq class)	0.015
DPP4	dipeptidyl-peptidase 4	0.014
TRADD	TNFRSF1A-associated via death domain	0.014
COL6A3	collagen, type VI, alpha 3	0.014
MMP12	matrix metallopeptidase 12 (macrophage elastase)	0.014
UBD	ubiquitin D	0.014
BGN	biglycan	0.014
CLEC5A	C-type lectin domain family 5, member A	0.014
OASL	2'-5'-oligoadenylate synthetase-like	0.014
PCOLCE	procollagen C-endopeptidase enhancer	0.013
LIF	leukemia inhibitory factor (cholinergic differentiation factor)	0.013
IGSF21	immunoglobin superfamily, member 21	0.013
GPR84	G protein-coupled receptor 84	0.013
HBG1	hemoglobin, gamma A	0.013
CXCR2	chemokine (C-X-C motif) receptor 2	0.013
OSMR	oncostatin M receptor	0.013
THBD	thrombomodulin	0.013
CD68	CD68 molecule	0.013
SERPINA1	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1	0.012
ITGA2B	integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)	0.012
HBG2	hemoglobin, gamma G	0.012
COL16A1	collagen, type XVI, alpha 1	0.012
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.012
SPP1	secreted phosphoprotein 1	0.012
CH25H	cholesterol 25-hydroxylase	0.012
TNFRSF1A	tumor necrosis factor receptor superfamily, member 1A	0.012
PPBP	pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)	0.012
MXRA5	matrix-remodelling associated 5	0.012
RBCK1	RanBP-type and C3HC4-type zinc finger containing 1	0.012
SLPI	secretory leukocyte peptidase inhibitor	0.012
ITGA4	integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)	0.011
POSTN	periostin, osteoblast specific factor	0.011
SULF1	sulfatase 1	0.011
VNN1	vanin 1	0.011
CD48	CD48 molecule	0.011
SOCS3	suppressor of cytokine signaling 3	0.011
CXCL13	chemokine (C-X-C motif) ligand 13	0.011
SFRP4	secreted frizzled-related protein 4	0.011
EGR2	early growth response 2	0.011
FCN1	ficolin (collagen/fibrinogen domain containing) 1	0.011
RNF31	ring finger protein 31	0.011
SLC2A1	solute carrier family 2 (facilitated glucose transporter), member 1	0.011
ANGPTL2	angiopoietin-like 2	0.011
SLC2A5	solute carrier family 2 (facilitated glucose/fructose transporter), member 5	0.010
PRDM1	PR domain containing 1, with ZNF domain	0.010
ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	0.010
SERPINB8	serpin peptidase inhibitor, clade B (ovalbumin), member 8	0.010
SLC16A3	solute carrier family 16, member 3 (monocarboxylic acid transporter 4)	0.010
COL3A1	collagen, type III, alpha 1	0.010
IKBKG	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma	0.010