IMP

Process View

Homo sapiens

23 genes annotated in human

positive regulation of cell cycle arrest

Any process that increases the rate, frequency, or extent of cell cycle arrest, the process in which the cell cycle is halted during one of the normal phases.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of cell cycle arrest"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "positive regulation of cell cycle arrest" (in gray)

Name	Description	Probability	Func Analog Organism
CASP3	caspase 3, apoptosis-related cysteine peptidase	0.999	Human
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.995
RB1	retinoblastoma 1	0.993
XIAP	X-linked inhibitor of apoptosis	0.956
TAL1	T-cell acute lymphocytic leukemia 1	0.909
CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	0.825
CASP8	caspase 8, apoptosis-related cysteine peptidase	0.824	Human
PPP2R5C	protein phosphatase 2, regulatory subunit B', gamma	0.705
TCF3	transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)	0.617
POU3F2	POU class 3 homeobox 2	0.558
MDM4	Mdm4 p53 binding protein homolog (mouse)	0.460	Human
FAS	Fas (TNF receptor superfamily, member 6)	0.447
APAF1	apoptotic peptidase activating factor 1	0.436
CHEK2	CHK2 checkpoint homolog (S. pombe)	0.406
PPP2R1B	protein phosphatase 2, regulatory subunit A, beta	0.391
CCND1	cyclin D1	0.373
CDK6	cyclin-dependent kinase 6	0.371
TP53	tumor protein p53	0.338
CASP4	caspase 4, apoptosis-related cysteine peptidase	0.318	Human
BCL2	B-cell CLL/lymphoma 2	0.299
RBL1	retinoblastoma-like 1 (p107)	0.283
LRDD	leucine-rich repeats and death domain containing	0.283
SMAD7	SMAD family member 7	0.280
AKT1	v-akt murine thymoma viral oncogene homolog 1	0.270
PPP2CA	protein phosphatase 2, catalytic subunit, alpha isozyme	0.242
PKD1	polycystic kidney disease 1 (autosomal dominant)	0.221
PPP2R2A	protein phosphatase 2, regulatory subunit B, alpha	0.190
RARA	retinoic acid receptor, alpha	0.182
RXRA	retinoid X receptor, alpha	0.178
CASP9	caspase 9, apoptosis-related cysteine peptidase	0.177	Human
NLRC4	NLR family, CARD domain containing 4	0.174
CASP10	caspase 10, apoptosis-related cysteine peptidase	0.164	Human
CDK2	cyclin-dependent kinase 2	0.163
E2F1	E2F transcription factor 1	0.159
CASP2	caspase 2, apoptosis-related cysteine peptidase	0.153
CFLAR	CASP8 and FADD-like apoptosis regulator	0.151
UHRF2	ubiquitin-like with PHD and ring finger domains 2	0.150
FASLG	Fas ligand (TNF superfamily, member 6)	0.147
TNFRSF10A	tumor necrosis factor receptor superfamily, member 10a	0.145
CRADD	CASP2 and RIPK1 domain containing adaptor with death domain	0.141
PPP2R5A	protein phosphatase 2, regulatory subunit B', alpha	0.133	Human
WWOX	WW domain containing oxidoreductase	0.131
RIPK2	receptor-interacting serine-threonine kinase 2	0.124
CCNE1	cyclin E1	0.121
AXIN1	axin 1	0.118
DNMT3A	DNA (cytosine-5-)-methyltransferase 3 alpha	0.110
MED1	mediator complex subunit 1	0.099
DNMT3B	DNA (cytosine-5-)-methyltransferase 3 beta	0.091
DAXX	death-domain associated protein	0.091
RBL2	retinoblastoma-like 2 (p130)	0.090
BIRC2	baculoviral IAP repeat containing 2	0.088
RUNX1	runt-related transcription factor 1	0.080
HDAC1	histone deacetylase 1	0.079
SETD7	SET domain containing (lysine methyltransferase) 7	0.074
UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.072
IER3	immediate early response 3	0.070
USP7	ubiquitin specific peptidase 7 (herpes virus-associated)	0.070
CASP7	caspase 7, apoptosis-related cysteine peptidase	0.066	Human
NMI	N-myc (and STAT) interactor	0.062
RAF1	v-raf-1 murine leukemia viral oncogene homolog 1	0.062
SP1	Sp1 transcription factor	0.061
CABLES1	Cdk5 and Abl enzyme substrate 1	0.060
CCND3	cyclin D3	0.058
MYCN	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.058
IFI16	interferon, gamma-inducible protein 16	0.054
ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	0.049
SATB2	SATB homeobox 2	0.046
CASP1	caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)	0.045	Human
MEOX2	mesenchyme homeobox 2	0.043
KRT5	keratin 5	0.043
PAX3	paired box 3	0.042
CSNK1A1	casein kinase 1, alpha 1	0.042
NEDD9	neural precursor cell expressed, developmentally down-regulated 9	0.038
ITCH	itchy E3 ubiquitin protein ligase homolog (mouse)	0.038
FADD	Fas (TNFRSF6)-associated via death domain	0.036
CDKN1B	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	0.035	Human
GSK3B	glycogen synthase kinase 3 beta	0.034
TNFRSF1A	tumor necrosis factor receptor superfamily, member 1A	0.034
POLD1	polymerase (DNA directed), delta 1, catalytic subunit 125kDa	0.033
ZNF420	zinc finger protein 420	0.031
SMPD1	sphingomyelin phosphodiesterase 1, acid lysosomal	0.031
CDC25A	cell division cycle 25 homolog A (S. pombe)	0.030
PPP2R5D	protein phosphatase 2, regulatory subunit B', delta	0.028	Human
RYR2	ryanodine receptor 2 (cardiac)	0.028
POU5F1	POU class 5 homeobox 1	0.028
TP53BP2	tumor protein p53 binding protein, 2	0.027
SPRR2A	small proline-rich protein 2A	0.027
PML	promyelocytic leukemia	0.027	Mouse
TRPC1	transient receptor potential cation channel, subfamily C, member 1	0.027
SMAD4	SMAD family member 4	0.026
CDT1	chromatin licensing and DNA replication factor 1	0.026
SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	0.025
YAP1	Yes-associated protein 1	0.025
MARCKSL1	MARCKS-like 1	0.025
PPFIA1	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1	0.025
TGFBR1	transforming growth factor, beta receptor 1	0.024
NUCB2	nucleobindin 2	0.024
PPP2R5B	protein phosphatase 2, regulatory subunit B', beta	0.023	Human Rat
PRMT6	protein arginine methyltransferase 6	0.023
SORBS3	sorbin and SH3 domain containing 3	0.023
SLC9A3R2	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2	0.022
VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor	0.022
SIRT1	sirtuin 1	0.022
IGF2BP1	insulin-like growth factor 2 mRNA binding protein 1	0.022
PRKACB	protein kinase, cAMP-dependent, catalytic, beta	0.021
TRIM43	tripartite motif containing 43	0.020
ANXA7	annexin A7	0.020
NOTCH1	notch 1	0.019
ZFPM1	zinc finger protein, multitype 1	0.019
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.019
ENG	endoglin	0.019
SMAD3	SMAD family member 3	0.019
ITGA2B	integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)	0.019
SALL2	sal-like 2 (Drosophila)	0.019
PPP5C	protein phosphatase 5, catalytic subunit	0.018
DOCK8	dedicator of cytokinesis 8	0.018
CDKN2A	cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)	0.018
SGK3	serum/glucocorticoid regulated kinase family, member 3	0.017
FSTL1	follistatin-like 1	0.017
TIAM1	T-cell lymphoma invasion and metastasis 1	0.017
CTSS	cathepsin S	0.016
ABI2	abl-interactor 2	0.016
CDK5	cyclin-dependent kinase 5	0.015
KIF1C	kinesin family member 1C	0.015
CAP2	CAP, adenylate cyclase-associated protein, 2 (yeast)	0.015
E2F4	E2F transcription factor 4, p107/p130-binding	0.015
ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.015
ID3	inhibitor of DNA binding 3, dominant negative helix-loop-helix protein	0.014
SKP2	S-phase kinase-associated protein 2 (p45)	0.014
ELF4	E74-like factor 4 (ets domain transcription factor)	0.014
KRT6C	keratin 6C	0.014
SOCS1	suppressor of cytokine signaling 1	0.014
BTN3A2	butyrophilin, subfamily 3, member A2	0.014
SMAD5	SMAD family member 5	0.014
E2F2	E2F transcription factor 2	0.014
ATM	ataxia telangiectasia mutated	0.014
ATF3	activating transcription factor 3	0.013
CBFA2T3	core-binding factor, runt domain, alpha subunit 2; translocated to, 3	0.013
MSH5	mutS homolog 5 (E. coli)	0.013
DIP2A	DIP2 disco-interacting protein 2 homolog A (Drosophila)	0.013
PPAN	peter pan homolog (Drosophila)	0.013
SMAD2	SMAD family member 2	0.013
DZIP1	DAZ interacting protein 1	0.012
CDK9	cyclin-dependent kinase 9	0.012
WT1	Wilms tumor 1	0.012
CASP8AP2	caspase 8 associated protein 2	0.012
DYRK1A	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A	0.012
CARD16	caspase recruitment domain family, member 16	0.012
TCF12	transcription factor 12	0.012
CDKN2C	cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)	0.012
HELLS	helicase, lymphoid-specific	0.012
MTHFD1L	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like	0.012
CCND2	cyclin D2	0.012
WASF1	WAS protein family, member 1	0.011
PPME1	protein phosphatase methylesterase 1	0.011
CUX1	cut-like homeobox 1	0.011
SLC4A1	solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group)	0.011
ID2	inhibitor of DNA binding 2, dominant negative helix-loop-helix protein	0.011	Mouse
IL18	interleukin 18 (interferon-gamma-inducing factor)	0.011
ZBTB16	zinc finger and BTB domain containing 16	0.011
SUV39H1	suppressor of variegation 3-9 homolog 1 (Drosophila)	0.011
BCL11B	B-cell CLL/lymphoma 11B (zinc finger protein)	0.011
SMC1A	structural maintenance of chromosomes 1A	0.011
MAPK7	mitogen-activated protein kinase 7	0.011
STK38L	serine/threonine kinase 38 like	0.011
MDFI	MyoD family inhibitor	0.011
E2F3	E2F transcription factor 3	0.011
SAMD4A	sterile alpha motif domain containing 4A	0.011
GBP2	guanylate binding protein 2, interferon-inducible	0.011
RAI1	retinoic acid induced 1	0.011
MAGED1	melanoma antigen family D, 1	0.011
DTX1	deltex homolog 1 (Drosophila)	0.010
CAMK2A	calcium/calmodulin-dependent protein kinase II alpha	0.010
COL2A1	collagen, type II, alpha 1	0.010
EFNB3	ephrin-B3	0.010
SOX9	SRY (sex determining region Y)-box 9	0.010	Human
PRKAR1B	protein kinase, cAMP-dependent, regulatory, type I, beta	0.010
BCL11A	B-cell CLL/lymphoma 11A (zinc finger protein)	0.010
DYRK1B	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B	0.010
GORAB	golgin, RAB6-interacting	0.010