IMP

Process View

Homo sapiens

19 genes annotated in human

negative regulation of stress activated mapk cascade

Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the stress-activated MAPK cascade.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of stress activated mapk cascade"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of stress activated mapk cascade" (in gray)

Name	Description	Probability	Func Analog Organism
ZNF43	zinc finger protein 43	0.979
MAP2K4	mitogen-activated protein kinase kinase 4	0.824
SMAD2	SMAD family member 2	0.787
ZNF273	zinc finger protein 273	0.758	Human
ZNF253	zinc finger protein 253	0.741
CREBBP	CREB binding protein	0.705
MAPK8	mitogen-activated protein kinase 8	0.651	Fly
PPP2CA	protein phosphatase 2, catalytic subunit, alpha isozyme	0.477
CALM1	calmodulin 1 (phosphorylase kinase, delta)	0.451
ZNF675	zinc finger protein 675	0.417
MAP3K7	mitogen-activated protein kinase kinase kinase 7	0.407
ZNF746	zinc finger protein 746	0.391
MAPK14	mitogen-activated protein kinase 14	0.384
MAPK1	mitogen-activated protein kinase 1	0.361
CHUK	conserved helix-loop-helix ubiquitous kinase	0.334
GSK3B	glycogen synthase kinase 3 beta	0.288	Fly
ILK	integrin-linked kinase	0.280
ARRB1	arrestin, beta 1	0.236
MAP2K7	mitogen-activated protein kinase kinase 7	0.234
ATF2	activating transcription factor 2	0.234
CUL1	cullin 1	0.233
NCOR1	nuclear receptor corepressor 1	0.227
ZNF85	zinc finger protein 85	0.223	Human
ZNF254	zinc finger protein 254	0.190	Human
ZNF117	zinc finger protein 117	0.183	Human
ZNF91	zinc finger protein 91	0.162
CREB1	cAMP responsive element binding protein 1	0.154
PPARA	peroxisome proliferator-activated receptor alpha	0.151
ZNF93	zinc finger protein 93	0.150
IKBKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	0.141
AR	androgen receptor	0.126
CCNE1	cyclin E1	0.112
HSP90AA1	heat shock protein 90kDa alpha (cytosolic), class A member 1	0.110
ZNF430	zinc finger protein 430	0.109	Human
ZNF708	zinc finger protein 708	0.097	Human
PPP2R5C	protein phosphatase 2, regulatory subunit B', gamma	0.093
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.092
KAT2B	K(lysine) acetyltransferase 2B	0.092
ACTR3	ARP3 actin-related protein 3 homolog (yeast)	0.086
MYST3	MYST histone acetyltransferase (monocytic leukemia) 3	0.086
ZNF107	zinc finger protein 107	0.085
PPP6C	protein phosphatase 6, catalytic subunit	0.081
HDAC3	histone deacetylase 3	0.073
SIRT1	sirtuin 1	0.064
ITCH	itchy E3 ubiquitin protein ligase homolog (mouse)	0.057	Mouse
NCOA1	nuclear receptor coactivator 1	0.053
RALBP1	ralA binding protein 1	0.053
PPP4C	protein phosphatase 4, catalytic subunit	0.052
CAPZA2	capping protein (actin filament) muscle Z-line, alpha 2	0.052	Fly
CSNK1E	casein kinase 1, epsilon	0.052
MAP3K1	mitogen-activated protein kinase kinase kinase 1	0.050
PPP1R2	protein phosphatase 1, regulatory (inhibitor) subunit 2	0.050
PPP1CC	protein phosphatase 1, catalytic subunit, gamma isozyme	0.045
RCHY1	ring finger and CHY zinc finger domain containing 1	0.044
ZNF680	zinc finger protein 680	0.044	Human
AXIN1	axin 1	0.041
ZNF92	zinc finger protein 92	0.038	Human
HSPH1	heat shock 105kDa/110kDa protein 1	0.038
MAPK3	mitogen-activated protein kinase 3	0.036
MAPK9	mitogen-activated protein kinase 9	0.036	Fly
CAV1	caveolin 1, caveolae protein, 22kDa	0.035
LIMD1	LIM domains containing 1	0.035
SGK3	serum/glucocorticoid regulated kinase family, member 3	0.034
DTX1	deltex homolog 1 (Drosophila)	0.032
NCK2	NCK adaptor protein 2	0.030
DLG1	discs, large homolog 1 (Drosophila)	0.030
ZNF682	zinc finger protein 682	0.029	Human
JUN	jun proto-oncogene	0.029
SKIL	SKI-like oncogene	0.029
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.029
RAB21	RAB21, member RAS oncogene family	0.028
ARRB2	arrestin, beta 2	0.027
TWF2	twinfilin, actin-binding protein, homolog 2 (Drosophila)	0.027
ZMYND11	zinc finger, MYND-type containing 11	0.027
CAPNS1	calpain, small subunit 1	0.026
RALB	v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein)	0.026	Fly
DUSP1	dual specificity phosphatase 1	0.026
C1D	C1D nuclear receptor corepressor	0.025
NCOA2	nuclear receptor coactivator 2	0.025
UHRF2	ubiquitin-like with PHD and ring finger domains 2	0.024
MDFI	MyoD family inhibitor	0.023
PPP2R2A	protein phosphatase 2, regulatory subunit B, alpha	0.022
EP300	E1A binding protein p300	0.021
ZNF506	zinc finger protein 506	0.019	Human
RANBP3	RAN binding protein 3	0.019
NCOA6	nuclear receptor coactivator 6	0.018
CACNA1C	calcium channel, voltage-dependent, L type, alpha 1C subunit	0.018
CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	0.018
GPS2	G protein pathway suppressor 2	0.018
PEA15	phosphoprotein enriched in astrocytes 15	0.018
MAPK8IP1	mitogen-activated protein kinase 8 interacting protein 1	0.018	Rat
LPXN	leupaxin	0.017
TBL1XR1	transducin (beta)-like 1 X-linked receptor 1	0.017
MAP2K1	mitogen-activated protein kinase kinase 1	0.017
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.017
RAB10	RAB10, member RAS oncogene family	0.017
MAGEA2	melanoma antigen family A, 2	0.017
NEDD9	neural precursor cell expressed, developmentally down-regulated 9	0.016
MAPK8IP3	mitogen-activated protein kinase 8 interacting protein 3	0.016
RPS6KA3	ribosomal protein S6 kinase, 90kDa, polypeptide 3	0.016
FOXO3	forkhead box O3	0.016	Human
CD2AP	CD2-associated protein	0.016
L3MBTL2	l(3)mbt-like 2 (Drosophila)	0.016
TRAF5	TNF receptor-associated factor 5	0.015
ZNF260	zinc finger protein 260	0.015
NCOA3	nuclear receptor coactivator 3	0.015
MTMR4	myotubularin related protein 4	0.015
ZCCHC17	zinc finger, CCHC domain containing 17	0.015
PINK1	PTEN induced putative kinase 1	0.015
MSH5	mutS homolog 5 (E. coli)	0.015
SNX18	sorting nexin 18	0.015
FOXO1	forkhead box O1	0.015
CDKN1B	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	0.014
FBXW7	F-box and WD repeat domain containing 7	0.014
CHD3	chromodomain helicase DNA binding protein 3	0.014
CBLC	Cas-Br-M (murine) ecotropic retroviral transforming sequence c	0.014
TRIM28	tripartite motif containing 28	0.013
CCT8	chaperonin containing TCP1, subunit 8 (theta)	0.013
DNAJA2	DnaJ (Hsp40) homolog, subfamily A, member 2	0.013	Human
GTF3C1	general transcription factor IIIC, polypeptide 1, alpha 220kDa	0.013
BRD4	bromodomain containing 4	0.013
PGR	progesterone receptor	0.013
PPP1CB	protein phosphatase 1, catalytic subunit, beta isozyme	0.013	Fly
SMAD3	SMAD family member 3	0.013
PPP2R5A	protein phosphatase 2, regulatory subunit B', alpha	0.013
SIAH1	seven in absentia homolog 1 (Drosophila)	0.012
ANXA7	annexin A7	0.012
PPP2R1A	protein phosphatase 2, regulatory subunit A, alpha	0.012
SNX9	sorting nexin 9	0.012
RECQL5	RecQ protein-like 5	0.012
TAB2	TGF-beta activated kinase 1/MAP3K7 binding protein 2	0.012
TRIM33	tripartite motif containing 33	0.012
ZNF320	zinc finger protein 320	0.012
SUGT1	SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae)	0.012
BCL2	B-cell CLL/lymphoma 2	0.012
UBE2G1	ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast)	0.012
PRKAR1A	protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)	0.011
SETD7	SET domain containing (lysine methyltransferase) 7	0.011
PPP1CA	protein phosphatase 1, catalytic subunit, alpha isozyme	0.011
AKT1	v-akt murine thymoma viral oncogene homolog 1	0.011	Rat
PRKACA	protein kinase, cAMP-dependent, catalytic, alpha	0.011
CAV2	caveolin 2	0.011
RALA	v-ral simian leukemia viral oncogene homolog A (ras related)	0.011	Fly
MAP2K3	mitogen-activated protein kinase kinase 3	0.011
REL	v-rel reticuloendotheliosis viral oncogene homolog (avian)	0.011
MBD1	methyl-CpG binding domain protein 1	0.011
FLNA	filamin A, alpha	0.011
CMTM6	CKLF-like MARVEL transmembrane domain containing 6	0.011
PARVA	parvin, alpha	0.011
PAPOLA	poly(A) polymerase alpha	0.011
HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	0.011
U2AF1	U2 small nuclear RNA auxiliary factor 1	0.010
CXXC1	CXXC finger protein 1	0.010
LIMK2	LIM domain kinase 2	0.010
PPP3R1	protein phosphatase 3, regulatory subunit B, alpha	0.010
MLL	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)	0.010
PKM2	pyruvate kinase, muscle	0.010
ZNF100	zinc finger protein 100	0.010	Human