IMP
Process View
canonical wnt signaling pathway involved in cardiac neural crest cell differentiation involved in heart development
The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in cardiac neural crest cell differentiation.
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In addition to gene-name show these genes:
Click on a gene's description to view its network relationships with genes known to be involved in "canonical wnt signaling pathway involved in cardiac neural crest cell differentiation involved in heart development"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| Fgfr2 | fibroblast growth factor receptor 2 | 0.996 | ||
| Shh | sonic hedgehog | 0.959 | ||
| Bmp4 | bone morphogenetic protein 4 | 0.938 | ||
| Fgfr1 | fibroblast growth factor receptor 1 | 0.936 | ||
| Gli3 | GLI-Kruppel family member GLI3 | 0.931 | ||
| Ctnnb1 | catenin (cadherin associated protein), beta 1 | 0.762 | ||
| Mapk8ip1 | mitogen-activated protein kinase 8 interacting protein 1 | 0.754 | ||
| Smo | smoothened homolog (Drosophila) | 0.727 | ||
| Meox2 | mesenchyme homeobox 2 | 0.636 | ||
| Tbx3 | T-box 3 | 0.608 | ||
| Pkd1 | polycystic kidney disease 1 homolog | 0.531 | ||
| Vangl2 | vang-like 2 (van gogh, Drosophila) | 0.530 | ||
| Fgfr3 | fibroblast growth factor receptor 3 | 0.525 | ||
| Npc1 | Niemann Pick type C1 | 0.469 | ||
| Msx1 | homeobox, msh-like 1 | 0.452 | ||
| Bmp7 | bone morphogenetic protein 7 | 0.414 | ||
| Otx2 | orthodenticle homolog 2 (Drosophila) | 0.357 | ||
| Lrp6 | low density lipoprotein receptor-related protein 6 | 0.341 | ||
| Apoe | apolipoprotein E | 0.336 | ||
| Pax3 | paired box gene 3 | 0.319 | ||
| Fgf8 | fibroblast growth factor 8 | 0.306 | ||
| Gsk3b | glycogen synthase kinase 3 beta | 0.291 | ||
| Axin1 | axin 1 | 0.263 | ||
| Cebpa | CCAAT/enhancer binding protein (C/EBP), alpha | 0.256 | ||
| Ror2 | receptor tyrosine kinase-like orphan receptor 2 | 0.255 | ||
| Ndst1 | N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 | 0.249 | ||
| Foxc1 | forkhead box C1 | 0.246 | ||
| Runx2 | runt related transcription factor 2 | 0.243 | ||
| Pitx2 | paired-like homeodomain transcription factor 2 | 0.220 | ||
| Tenc1 | tensin like C1 domain-containing phosphatase | 0.214 | ||
| Mmp14 | matrix metallopeptidase 14 (membrane-inserted) | 0.214 | ||
| Foxc2 | forkhead box C2 | 0.190 | ||
| Prrx1 | paired related homeobox 1 | 0.168 | ||
| Msx2 | homeobox, msh-like 2 | 0.167 | ||
| Zeb1 | zinc finger E-box binding homeobox 1 | 0.143 | ||
| Hand1 | heart and neural crest derivatives expressed transcript 1 | 0.126 | ||
| Prrx2 | paired related homeobox 2 | 0.123 | ||
| Eya1 | eyes absent 1 homolog (Drosophila) | 0.107 | ||
| Hspg2 | perlecan (heparan sulfate proteoglycan 2) | 0.100 | ||
| Tcfap2a | transcription factor AP-2, alpha | 0.098 | ||
| Sertad2 | SERTA domain containing 2 | 0.098 | ||
| Sox11 | SRY-box containing gene 11 | 0.091 | ||
| Six1 | sine oculis-related homeobox 1 homolog (Drosophila) | 0.090 | ||
| Pick1 | protein interacting with C kinase 1 | 0.088 | ||
| Rarg | retinoic acid receptor, gamma | 0.085 | ||
| Tgfb2 | transforming growth factor, beta 2 | 0.085 | ||
| Gli2 | GLI-Kruppel family member GLI2 | 0.084 | ||
| Foxg1 | forkhead box G1 | 0.083 | ||
| Dlx5 | distal-less homeobox 5 | 0.080 | ||
| Chrd | chordin | 0.078 | ||
| Lrp5 | low density lipoprotein receptor-related protein 5 | 0.074 | Mouse | |
| Pdgfra | platelet derived growth factor receptor, alpha polypeptide | 0.072 | ||
| Ptch1 | patched homolog 1 | 0.069 | ||
| Smad6 | MAD homolog 6 (Drosophila) | 0.067 | ||
| T | brachyury | 0.064 | ||
| Gbx2 | gastrulation brain homeobox 2 | 0.061 | ||
| Jag1 | jagged 1 | 0.059 | ||
| Psen1 | presenilin 1 | 0.056 | ||
| Nos3 | nitric oxide synthase 3, endothelial cell | 0.054 | ||
| Pparg | peroxisome proliferator activated receptor gamma | 0.053 | ||
| Lef1 | lymphoid enhancer binding factor 1 | 0.053 | ||
| Rspo2 | R-spondin 2 homolog (Xenopus laevis) | 0.045 | ||
| Abca1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.045 | ||
| Egfr | epidermal growth factor receptor | 0.043 | ||
| Six4 | sine oculis-related homeobox 4 homolog (Drosophila) | 0.043 | ||
| Pbx1 | pre B-cell leukemia transcription factor 1 | 0.041 | ||
| Pofut1 | protein O-fucosyltransferase 1 | 0.041 | ||
| Agtr2 | angiotensin II receptor, type 2 | 0.040 | ||
| Sox9 | SRY-box containing gene 9 | 0.039 | ||
| Hes1 | hairy and enhancer of split 1 (Drosophila) | 0.039 | ||
| Col1a1 | collagen, type I, alpha 1 | 0.039 | ||
| Wnt3a | wingless-related MMTV integration site 3A | 0.039 | ||
| Phex | phosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets) | 0.039 | ||
| Klf15 | Kruppel-like factor 15 | 0.037 | ||
| Nodal | nodal | 0.036 | ||
| Bmp2 | bone morphogenetic protein 2 | 0.035 | ||
| Apc | adenomatosis polyposis coli | 0.034 | ||
| Sox13 | SRY-box containing gene 13 | 0.034 | ||
| Bmp1 | bone morphogenetic protein 1 | 0.033 | ||
| Ptpn14 | protein tyrosine phosphatase, non-receptor type 14 | 0.032 | ||
| Crtc3 | CREB regulated transcription coactivator 3 | 0.032 | ||
| Itga3 | integrin alpha 3 | 0.032 | ||
| Sox2 | SRY-box containing gene 2 | 0.030 | ||
| Pdgfrb | platelet derived growth factor receptor, beta polypeptide | 0.030 | ||
| Nog | noggin | 0.029 | ||
| Ldlr | low density lipoprotein receptor | 0.029 | ||
| Mks1 | Meckel syndrome, type 1 | 0.027 | ||
| Lrp4 | low density lipoprotein receptor-related protein 4 | 0.027 | Mouse | |
| Fgfrl1 | fibroblast growth factor receptor-like 1 | 0.027 | ||
| Ece1 | endothelin converting enzyme 1 | 0.025 | ||
| Itgb1 | integrin beta 1 (fibronectin receptor beta) | 0.025 | ||
| Col4a3 | collagen, type IV, alpha 3 | 0.024 | ||
| Tbx1 | T-box 1 | 0.024 | ||
| Vegfa | vascular endothelial growth factor A | 0.023 | ||
| Gpc3 | glypican 3 | 0.022 | ||
| Ptk7 | PTK7 protein tyrosine kinase 7 | 0.022 | ||
| Rara | retinoic acid receptor, alpha | 0.022 | ||
| Npr2 | natriuretic peptide receptor 2 | 0.022 | ||
| Twsg1 | twisted gastrulation homolog 1 (Drosophila) | 0.021 | ||
| Gas1 | growth arrest specific 1 | 0.021 | ||
| Rarb | retinoic acid receptor, beta | 0.020 | ||
| Rxra | retinoid X receptor alpha | 0.020 | ||
| Chd7 | chromodomain helicase DNA binding protein 7 | 0.020 | ||
| Bmp5 | bone morphogenetic protein 5 | 0.020 | ||
| Wnt5a | wingless-related MMTV integration site 5A | 0.020 | ||
| Hoxa1 | homeobox A1 | 0.019 | ||
| Gsc | goosecoid homeobox | 0.019 | ||
| Zic3 | zinc finger protein of the cerebellum 3 | 0.019 | ||
| Foxa2 | forkhead box A2 | 0.019 | ||
| Acvr1 | activin A receptor, type 1 | 0.019 | ||
| Dact1 | dapper homolog 1, antagonist of beta-catenin (xenopus) | 0.018 | ||
| Otx1 | orthodenticle homolog 1 (Drosophila) | 0.018 | ||
| Sall4 | sal-like 4 (Drosophila) | 0.018 | ||
| Mycn | v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) | 0.017 | ||
| Mn1 | meningioma 1 | 0.017 | ||
| Ltbr | lymphotoxin B receptor | 0.017 | ||
| Tbx2 | T-box 2 | 0.017 | ||
| Itgb5 | integrin beta 5 | 0.017 | ||
| Mapk8ip2 | mitogen-activated protein kinase 8 interacting protein 2 | 0.017 | ||
| Tcf7l1 | transcription factor 7-like 1 (T-cell specific, HMG box) | 0.017 | ||
| Gpx3 | glutathione peroxidase 3 | 0.017 | ||
| Cav1 | caveolin 1, caveolae protein | 0.017 | ||
| Pax6 | paired box gene 6 | 0.016 | ||
| Alx1 | ALX homeobox 1 | 0.016 | ||
| Apaf1 | apoptotic peptidase activating factor 1 | 0.016 | ||
| Osbpl8 | oxysterol binding protein-like 8 | 0.015 | ||
| Sntg2 | syntrophin, gamma 2 | 0.015 | ||
| Bmper | BMP-binding endothelial regulator | 0.015 | ||
| Tnks1bp1 | tankyrase 1 binding protein 1 | 0.015 | ||
| Anpep | alanyl (membrane) aminopeptidase | 0.015 | ||
| Pax2 | paired box gene 2 | 0.015 | ||
| Tbx15 | T-box 15 | 0.014 | ||
| H6pd | hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) | 0.014 | ||
| Ptpn11 | protein tyrosine phosphatase, non-receptor type 11 | 0.014 | ||
| Igfbp4 | insulin-like growth factor binding protein 4 | 0.014 | ||
| Pet2 | plasmacytoma expressed transcript 2 | 0.014 | ||
| En1 | engrailed 1 | 0.014 | ||
| Emx2 | empty spiracles homolog 2 (Drosophila) | 0.014 | ||
| Lpin1 | lipin 1 | 0.014 | ||
| Pitx1 | paired-like homeodomain transcription factor 1 | 0.014 | ||
| Fn1 | fibronectin 1 | 0.014 | ||
| Ift88 | intraflagellar transport 88 homolog (Chlamydomonas) | 0.013 | ||
| Ptprf | protein tyrosine phosphatase, receptor type, F | 0.013 | ||
| Bmpr1a | bone morphogenetic protein receptor, type 1A | 0.013 | ||
| Col4a4 | collagen, type IV, alpha 4 | 0.013 | ||
| Igf1r | insulin-like growth factor I receptor | 0.013 | ||
| Notch2 | Notch gene homolog 2 (Drosophila) | 0.013 | ||
| Trp63 | transformation related protein 63 | 0.013 | ||
| Hsd3b7 | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 | 0.013 | ||
| Wls | wntless homolog (Drosophila) | 0.012 | ||
| Dlg4 | discs, large homolog 4 (Drosophila) | 0.012 | ||
| Sorbs3 | sorbin and SH3 domain containing 3 | 0.012 | ||
| Dkk1 | dickkopf homolog 1 (Xenopus laevis) | 0.012 | ||
| Kl | klotho | 0.011 | ||
| Mertk | c-mer proto-oncogene tyrosine kinase | 0.011 | ||
| Ptms | parathymosin | 0.011 | ||
| Plin1 | perilipin 1 | 0.011 | ||
| Spry4 | sprouty homolog 4 (Drosophila) | 0.011 | ||
| Mep1a | meprin 1 alpha | 0.010 | ||
| Tgfa | transforming growth factor alpha | 0.010 | ||
| Jup | junction plakoglobin | 0.010 | ||
| Folr1 | folate receptor 1 (adult) | 0.010 |