IMP

Process View

Mus musculus

3 genes annotated in mouse

ascending aorta development

The progression of the ascending aorta over time, from its initial formation to the mature structure. The ascending aorta is the portion of the aorta in a two-pass circulatory system that lies between the heart and the arch of aorta. In a two-pass circulatory system blood passes twice through the heart to supply the body once.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "ascending aorta development"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "ascending aorta development" (in gray)

Name	Description	Probability	Func Analog Organism
Fgfr2	fibroblast growth factor receptor 2	0.998
Gata4	GATA binding protein 4	0.995
Efnb2	ephrin B2	0.977
Gli3	GLI-Kruppel family member GLI3	0.959
Fgf8	fibroblast growth factor 8	0.955
Pax3	paired box gene 3	0.916
Shh	sonic hedgehog	0.911
Hey1	hairy/enhancer-of-split related with YRPW motif 1	0.872	Mouse
Jag1	jagged 1	0.865
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.857
Foxc1	forkhead box C1	0.805
Meox2	mesenchyme homeobox 2	0.788
Sox17	SRY-box containing gene 17	0.766	Mouse
Tgfb2	transforming growth factor, beta 2	0.757
Foxc2	forkhead box C2	0.741
Otx2	orthodenticle homolog 2 (Drosophila)	0.711
Sox4	SRY-box containing gene 4	0.679
Hand2	heart and neural crest derivatives expressed transcript 2	0.673
Isl1	ISL1 transcription factor, LIM/homeodomain	0.660
Eya1	eyes absent 1 homolog (Drosophila)	0.573
Ntf3	neurotrophin 3	0.557
Nog	noggin	0.515
Sox18	SRY-box containing gene 18	0.509	Mouse
Tcfap2a	transcription factor AP-2, alpha	0.443
Pax6	paired box gene 6	0.405
Chd7	chromodomain helicase DNA binding protein 7	0.387
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.384
Cldn5	claudin 5	0.383
Hesx1	homeobox gene expressed in ES cells	0.373
Hey2	hairy/enhancer-of-split related with YRPW motif 2	0.369
Sox11	SRY-box containing gene 11	0.365	Mouse
Emx2	empty spiracles homolog 2 (Drosophila)	0.364
Hes1	hairy and enhancer of split 1 (Drosophila)	0.362
She	src homology 2 domain-containing transforming protein E	0.354
Adam19	a disintegrin and metallopeptidase domain 19 (meltrin beta)	0.350
Gbx2	gastrulation brain homeobox 2	0.331
Msx1	homeobox, msh-like 1	0.329
Hand1	heart and neural crest derivatives expressed transcript 1	0.319
Fgfr3	fibroblast growth factor receptor 3	0.311
Hes5	hairy and enhancer of split 5 (Drosophila)	0.305	Mouse
Foxg1	forkhead box G1	0.270
Bmp4	bone morphogenetic protein 4	0.265
Rb1	retinoblastoma 1	0.254
Pitx2	paired-like homeodomain transcription factor 2	0.246
Lhx3	LIM homeobox protein 3	0.227
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.211
Tie1	tyrosine kinase with immunoglobulin-like and EGF-like domains 1	0.189
Smad6	MAD homolog 6 (Drosophila)	0.183
Nos3	nitric oxide synthase 3, endothelial cell	0.177
Zeb1	zinc finger E-box binding homeobox 1	0.168
Pax2	paired box gene 2	0.156
Kdr	kinase insert domain protein receptor	0.155
Smo	smoothened homolog (Drosophila)	0.150
Otx1	orthodenticle homolog 1 (Drosophila)	0.146
Ascl1	achaete-scute complex homolog 1 (Drosophila)	0.145
Ptprb	protein tyrosine phosphatase, receptor type, B	0.144
Gli2	GLI-Kruppel family member GLI2	0.144
Cdh5	cadherin 5	0.136
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.136
Efna1	ephrin A1	0.120
Emcn	endomucin	0.116
Eng	endoglin	0.109
Aplnr	apelin receptor	0.108
Pou5f1	POU domain, class 5, transcription factor 1	0.106
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.106
Fgf10	fibroblast growth factor 10	0.105
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.102
Rarb	retinoic acid receptor, beta	0.099
Meox1	mesenchyme homeobox 1	0.095
Tbx2	T-box 2	0.093
Hspg2	perlecan (heparan sulfate proteoglycan 2)	0.090
Fgfr1	fibroblast growth factor receptor 1	0.089
Kcnk2	potassium channel, subfamily K, member 2	0.078
Nkx2-3	NK2 transcription factor related, locus 3 (Drosophila)	0.075
Vangl2	vang-like 2 (van gogh, Drosophila)	0.074
Sox2	SRY-box containing gene 2	0.074	Mouse
Notch3	Notch gene homolog 3 (Drosophila)	0.072
Alx4	aristaless-like homeobox 4	0.071
Gja4	gap junction protein, alpha 4	0.070
Esam	endothelial cell-specific adhesion molecule	0.066
Nf1	neurofibromatosis 1	0.061
Prrx1	paired related homeobox 1	0.060
Hhex	hematopoietically expressed homeobox	0.060
Emx1	empty spiracles homolog 1 (Drosophila)	0.057
Bcl6b	B-cell CLL/lymphoma 6, member B	0.056
Eda	ectodysplasin-A	0.055
Ctnnb1	catenin (cadherin associated protein), beta 1	0.053
Lmx1b	LIM homeobox transcription factor 1 beta	0.051
Nkx6-1	NK6 homeobox 1	0.050
Egfr	epidermal growth factor receptor	0.049
Rarg	retinoic acid receptor, gamma	0.047
Sox7	SRY-box containing gene 7	0.045	Mouse
Adcy4	adenylate cyclase 4	0.045
Rasip1	Ras interacting protein 1	0.045
Tcf15	transcription factor 15	0.045
Vegfa	vascular endothelial growth factor A	0.043
Tek	endothelial-specific receptor tyrosine kinase	0.042
Ednrb	endothelin receptor type B	0.041
Sall3	sal-like 3 (Drosophila)	0.039
Col2a1	collagen, type II, alpha 1	0.038
Alx1	ALX homeobox 1	0.037
Aldh1a2	aldehyde dehydrogenase family 1, subfamily A2	0.036
Col1a1	collagen, type I, alpha 1	0.036
Flt1	FMS-like tyrosine kinase 1	0.034
Hes3	hairy and enhancer of split 3 (Drosophila)	0.034	Mouse
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.034
Mesp1	mesoderm posterior 1	0.033
Hif1a	hypoxia inducible factor 1, alpha subunit	0.033
Foxi3	forkhead box I3	0.033
Gas1	growth arrest specific 1	0.033
Atoh7	atonal homolog 7 (Drosophila)	0.032
Flt4	FMS-like tyrosine kinase 4	0.032
Vax1	ventral anterior homeobox containing gene 1	0.031
Dmrtb1	DMRT-like family B with proline-rich C-terminal, 1	0.031
Insm1	insulinoma-associated 1	0.031
Slc9a3r2	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2	0.031
Gsc	goosecoid homeobox	0.031
Ret	ret proto-oncogene	0.030
Robo4	roundabout homolog 4 (Drosophila)	0.030
Dock1	dedicator of cytokinesis 1	0.029
Bmp7	bone morphogenetic protein 7	0.029
Ldb2	LIM domain binding 2	0.028
Ushbp1	Usher syndrome 1C binding protein 1	0.027
Dll4	delta-like 4 (Drosophila)	0.027
Bmpr1a	bone morphogenetic protein receptor, type 1A	0.026
Fzd2	frizzled homolog 2 (Drosophila)	0.026
Fgd5	FYVE, RhoGEF and PH domain containing 5	0.026
Tbx1	T-box 1	0.026
Tcfap2c	transcription factor AP-2, gamma	0.026
Clec14a	C-type lectin domain family 14, member a	0.025
Alx3	aristaless-like homeobox 3	0.025
Rara	retinoic acid receptor, alpha	0.025
Mmrn2	multimerin 2	0.025
Acvrl1	activin A receptor, type II-like 1	0.025
Erbb2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.025
Ptch1	patched homolog 1	0.024
Tbx10	T-box 10	0.024
BC020535	cDNA sequence BC020535	0.024
Tbx3	T-box 3	0.024
Wnt5a	wingless-related MMTV integration site 5A	0.024
Hoxa5	homeobox A5	0.023
Egfl7	EGF-like domain 7	0.023
Pou4f3	POU domain, class 4, transcription factor 3	0.023
Cdkn1b	cyclin-dependent kinase inhibitor 1B	0.023
En2	engrailed 2	0.022
Cxcr7	chemokine (C-X-C motif) receptor 7	0.022
Hoxa3	homeobox A3	0.022
Icam2	intercellular adhesion molecule 2	0.022
Clec3b	C-type lectin domain family 3, member b	0.021
Dlx1	distal-less homeobox 1	0.021
Kitl	kit ligand	0.021
Pitx1	paired-like homeodomain transcription factor 1	0.021
Dmrt1	doublesex and mab-3 related transcription factor 1	0.021
Pcdh12	protocadherin 12	0.020
Ikbkap	inhibitor of kappa light polypeptide enhancer in B-cells, kinase complex-associated protein	0.020
Mcam	melanoma cell adhesion molecule	0.020
Kit	kit oncogene	0.020
Ramp2	receptor (calcitonin) activity modifying protein 2	0.020
Epha4	Eph receptor A4	0.020
Nr2f6	nuclear receptor subfamily 2, group F, member 6	0.019
Arap3	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3	0.019
Bmp6	bone morphogenetic protein 6	0.019
Hoxb13	homeobox B13	0.019
Npr3	natriuretic peptide receptor 3	0.019
Pkd1	polycystic kidney disease 1 homolog	0.019
Pou3f3	POU domain, class 3, transcription factor 3	0.018
Col13a1	collagen, type XIII, alpha 1	0.018
Gja1	gap junction protein, alpha 1	0.017
Twist2	twist homolog 2 (Drosophila)	0.017
Efna2	ephrin A2	0.017
Myl2	myosin, light polypeptide 2, regulatory, cardiac, slow	0.017
Gata3	GATA binding protein 3	0.017
Cela3b	chymotrypsin-like elastase family, member 3B	0.017
Ddah2	dimethylarginine dimethylaminohydrolase 2	0.017
Rspo2	R-spondin 2 homolog (Xenopus laevis)	0.016
Fbn1	fibrillin 1	0.016
Edar	ectodysplasin-A receptor	0.016
Sox9	SRY-box containing gene 9	0.016	Mouse
Kcnj8	potassium inwardly-rectifying channel, subfamily J, member 8	0.016
Trp63	transformation related protein 63	0.016
Six4	sine oculis-related homeobox 4 homolog (Drosophila)	0.016
Kif26a	kinesin family member 26A	0.016
Trp53	transformation related protein 53	0.016
Cxcl12	chemokine (C-X-C motif) ligand 12	0.016
Hcrt	hypocretin	0.016
Fhl3	four and a half LIM domains 3	0.015
Nkx2-2	NK2 transcription factor related, locus 2 (Drosophila)	0.015
Cxcr4	chemokine (C-X-C motif) receptor 4	0.015
Lhx5	LIM homeobox protein 5	0.015
Krt17	keratin 17	0.015
Lef1	lymphoid enhancer binding factor 1	0.015
Btbd17	BTB (POZ) domain containing 17	0.015
Fgf3	fibroblast growth factor 3	0.015
Foxd2	forkhead box D2	0.015
Id1	inhibitor of DNA binding 1	0.015
Mest	mesoderm specific transcript	0.015
Olig2	oligodendrocyte transcription factor 2	0.015
Rprm	reprimo, TP53 dependent G2 arrest mediator candidate	0.015
Ergic3	ERGIC and golgi 3	0.014
Zfpm2	zinc finger protein, multitype 2	0.014
Efnb1	ephrin B1	0.014
Ltbp4	latent transforming growth factor beta binding protein 4	0.014
Fzd8	frizzled homolog 8 (Drosophila)	0.014
Rxra	retinoid X receptor alpha	0.014
Prrx2	paired related homeobox 2	0.014
Myct1	myc target 1	0.014
Apaf1	apoptotic peptidase activating factor 1	0.014
Id3	inhibitor of DNA binding 3	0.014
Bdnf	brain derived neurotrophic factor	0.013
Tshz3	teashirt zinc finger family member 3	0.013
Xpo4	exportin 4	0.013
Fgf4	fibroblast growth factor 4	0.013
Wnt3a	wingless-related MMTV integration site 3A	0.013
Zic1	zinc finger protein of the cerebellum 1	0.013
Igdcc3	immunoglobulin superfamily, DCC subclass, member 3	0.013
Tgfb1i1	transforming growth factor beta 1 induced transcript 1	0.013
Arhgef15	Rho guanine nucleotide exchange factor (GEF) 15	0.013
Ebf3	early B-cell factor 3	0.013
Pax5	paired box gene 5	0.013
Bhlhe23	basic helix-loop-helix family, member e23	0.013
Hoxd13	homeobox D13	0.013
Hspa12b	heat shock protein 12B	0.013
Tcf7l1	transcription factor 7-like 1 (T-cell specific, HMG box)	0.013
Gata6	GATA binding protein 6	0.013
Tead4	TEA domain family member 4	0.013
Cby1	chibby homolog 1 (Drosophila)	0.012
Pklr	pyruvate kinase liver and red blood cell	0.012
Nes	nestin	0.012
Nrtn	neurturin	0.012
Hist1h1t	histone cluster 1, H1t	0.012
Neurog2	neurogenin 2	0.012
Six3	sine oculis-related homeobox 3 homolog (Drosophila)	0.012
Erbb3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.012
Ephb2	Eph receptor B2	0.012
Bmper	BMP-binding endothelial regulator	0.012
Kcnq1	potassium voltage-gated channel, subfamily Q, member 1	0.012
Eln	elastin	0.011
Mapk12	mitogen-activated protein kinase 12	0.011
Epha3	Eph receptor A3	0.011
Foxf1a	forkhead box F1a	0.011
Nanog	Nanog homeobox	0.011
Nr4a3	nuclear receptor subfamily 4, group A, member 3	0.011
Pdgfb	platelet derived growth factor, B polypeptide	0.011
Apcdd1	adenomatosis polyposis coli down-regulated 1	0.011
Notch4	Notch gene homolog 4 (Drosophila)	0.011
Matn4	matrilin 4	0.011
Efs	embryonal Fyn-associated substrate	0.011
Mog	myelin oligodendrocyte glycoprotein	0.011
Lbx1	ladybird homeobox homolog 1 (Drosophila)	0.011
Tmeff2	transmembrane protein with EGF-like and two follistatin-like domains 2	0.011
Zfp503	zinc finger protein 503	0.011
Adamts20	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 20	0.011
Pofut1	protein O-fucosyltransferase 1	0.011
Col15a1	collagen, type XV, alpha 1	0.011
Podxl	podocalyxin-like	0.011
Gdnf	glial cell line derived neurotrophic factor	0.011
Ifna5	interferon alpha 5	0.011
Sema3g	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G	0.010
Fam171a1	family with sequence similarity 171, member A1	0.010
Klk8	kallikrein related-peptidase 8	0.010
Fgf18	fibroblast growth factor 18	0.010
Tnp1	transition protein 1	0.010
Myl7	myosin, light polypeptide 7, regulatory	0.010
Myl3	myosin, light polypeptide 3	0.010
Twist1	twist homolog 1 (Drosophila)	0.010
Sfn	stratifin	0.010
Crhr2	corticotropin releasing hormone receptor 2	0.010
Nkx2-1	NK2 homeobox 1	0.010
Gast	gastrin	0.010
Sall4	sal-like 4 (Drosophila)	0.010
Pou3f1	POU domain, class 3, transcription factor 1	0.010
H1foo	H1 histone family, member O, oocyte-specific	0.010
Bmp5	bone morphogenetic protein 5	0.010
Myh6	myosin, heavy polypeptide 6, cardiac muscle, alpha	0.010