IMP

Process View

Mus musculus

1 genes annotated in mouse

mesodermal to mesenchymal transition involved in gastrulation

The epithelial to mesenchymal transition process in which a mesodermal cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell as part of the process of gastrulation.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "mesodermal to mesenchymal transition involved in gastrulation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "mesodermal to mesenchymal transition involved in gastrulation" (in gray)

Name	Description	Probability	Func Analog Organism
Fgfr2	fibroblast growth factor receptor 2	0.999
Shh	sonic hedgehog	0.999
Pitx2	paired-like homeodomain transcription factor 2	0.999
Tbx3	T-box 3	0.999	Mouse
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.998
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.996
Hoxa1	homeobox A1	0.995
Fgf8	fibroblast growth factor 8	0.994
Foxg1	forkhead box G1	0.994
Prrx1	paired related homeobox 1	0.986
Eya1	eyes absent 1 homolog (Drosophila)	0.985
Scn5a	sodium channel, voltage-gated, type V, alpha	0.979
Pitx1	paired-like homeodomain transcription factor 1	0.978
Dlx5	distal-less homeobox 5	0.969
Msx1	homeobox, msh-like 1	0.956
Tcfap2a	transcription factor AP-2, alpha	0.947
Hcn4	hyperpolarization-activated, cyclic nucleotide-gated K+ 4	0.944
Hand1	heart and neural crest derivatives expressed transcript 1	0.940
Jag1	jagged 1	0.939
Pax3	paired box gene 3	0.936
Gli3	GLI-Kruppel family member GLI3	0.934
Chd7	chromodomain helicase DNA binding protein 7	0.928
Foxc1	forkhead box C1	0.922
Foxc2	forkhead box C2	0.919
Hand2	heart and neural crest derivatives expressed transcript 2	0.917
Pax2	paired box gene 2	0.911
Bmp4	bone morphogenetic protein 4	0.903
Tbx5	T-box 5	0.869	Mouse
Zeb1	zinc finger E-box binding homeobox 1	0.868
Vangl2	vang-like 2 (van gogh, Drosophila)	0.857
Sox9	SRY-box containing gene 9	0.851
Otx2	orthodenticle homolog 2 (Drosophila)	0.797
Fgf10	fibroblast growth factor 10	0.781
Six4	sine oculis-related homeobox 4 homolog (Drosophila)	0.738
Sox2	SRY-box containing gene 2	0.674
Runx2	runt related transcription factor 2	0.673
Lmx1a	LIM homeobox transcription factor 1 alpha	0.571
Fgfr3	fibroblast growth factor receptor 3	0.559
Efnb2	ephrin B2	0.541
Gja5	gap junction protein, alpha 5	0.521
Tbx1	T-box 1	0.505	Mouse
Tbx4	T-box 4	0.470	Mouse
Sall4	sal-like 4 (Drosophila)	0.457
Chrd	chordin	0.436
Alx1	ALX homeobox 1	0.426
Rarg	retinoic acid receptor, gamma	0.398
Gbx2	gastrulation brain homeobox 2	0.377
Lef1	lymphoid enhancer binding factor 1	0.371
Lrp6	low density lipoprotein receptor-related protein 6	0.357
Pax9	paired box gene 9	0.333
Hmx3	H6 homeobox 3	0.329
Gsc	goosecoid homeobox	0.312
Gata3	GATA binding protein 3	0.304
Emx2	empty spiracles homolog 2 (Drosophila)	0.295
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.292
Fgfr1	fibroblast growth factor receptor 1	0.288
Ighmbp2	immunoglobulin mu binding protein 2	0.271
Zic3	zinc finger protein of the cerebellum 3	0.261
Bmp7	bone morphogenetic protein 7	0.256
Msx2	homeobox, msh-like 2	0.255
Smo	smoothened homolog (Drosophila)	0.231
Tgfb2	transforming growth factor, beta 2	0.211
Bdnf	brain derived neurotrophic factor	0.205
Dlx2	distal-less homeobox 2	0.199
Mn1	meningioma 1	0.186
Myf5	myogenic factor 5	0.177
Pou5f1	POU domain, class 5, transcription factor 1	0.165
Isl1	ISL1 transcription factor, LIM/homeodomain	0.158
Wnt3a	wingless-related MMTV integration site 3A	0.155
Prrx2	paired related homeobox 2	0.152
Hoxa13	homeobox A13	0.136
Emx1	empty spiracles homolog 1 (Drosophila)	0.132
Trp63	transformation related protein 63	0.131
Sox11	SRY-box containing gene 11	0.128
Hoxa3	homeobox A3	0.124
Nanog	Nanog homeobox	0.123
Irx3	Iroquois related homeobox 3 (Drosophila)	0.115
Myl2	myosin, light polypeptide 2, regulatory, cardiac, slow	0.114
T	brachyury	0.113	Mouse
Gata4	GATA binding protein 4	0.107
Wt1	Wilms tumor 1 homolog	0.106
Tcf21	transcription factor 21	0.104
Bmp5	bone morphogenetic protein 5	0.102
Dll4	delta-like 4 (Drosophila)	0.100
Rarb	retinoic acid receptor, beta	0.099
Aldh1a2	aldehyde dehydrogenase family 1, subfamily A2	0.099
Hoxa2	homeobox A2	0.098
Hoxd3	homeobox D3	0.095
Gli2	GLI-Kruppel family member GLI2	0.093
Nog	noggin	0.093
Smad6	MAD homolog 6 (Drosophila)	0.088
Alx4	aristaless-like homeobox 4	0.087
Six2	sine oculis-related homeobox 2 homolog (Drosophila)	0.083
Col13a1	collagen, type XIII, alpha 1	0.083
Rnf2	ring finger protein 2	0.076
Ntf3	neurotrophin 3	0.076
Fgf3	fibroblast growth factor 3	0.075
Pcsk5	proprotein convertase subtilisin/kexin type 5	0.072
Ednra	endothelin receptor type A	0.069
Hoxa11	homeobox A11	0.067
Twist2	twist homolog 2 (Drosophila)	0.066
Foxi1	forkhead box I1	0.063
Sall1	sal-like 1 (Drosophila)	0.063
Gata6	GATA binding protein 6	0.063
Shox2	short stature homeobox 2	0.061
Hoxd1	homeobox D1	0.059
Pbx1	pre B-cell leukemia transcription factor 1	0.056
Nkx3-2	NK3 homeobox 2	0.056
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.055
Hoxa10	homeobox A10	0.053
Dlx6	distal-less homeobox 6	0.050
Noto	notochord homolog (Xenopus laevis)	0.050
Bmp2	bone morphogenetic protein 2	0.049
Lrp5	low density lipoprotein receptor-related protein 5	0.048
Vegfa	vascular endothelial growth factor A	0.048
Vstm2b	V-set and transmembrane domain containing 2B	0.047
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.044
Foxf1a	forkhead box F1a	0.042
Pou4f3	POU domain, class 4, transcription factor 3	0.042
Gata5	GATA binding protein 5	0.042
Hmx2	H6 homeobox 2	0.041
Wnt5a	wingless-related MMTV integration site 5A	0.041
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.039
Tnfrsf25	tumor necrosis factor receptor superfamily, member 25	0.038
Tbx20	T-box 20	0.037	Mouse
Pax7	paired box gene 7	0.036
Otx1	orthodenticle homolog 1 (Drosophila)	0.035
Gata2	GATA binding protein 2	0.034
Alx3	aristaless-like homeobox 3	0.034
Cox4i2	cytochrome c oxidase subunit IV isoform 2	0.033
Cxadr	coxsackie virus and adenovirus receptor	0.033
Ryr2	ryanodine receptor 2, cardiac	0.033
Tbx15	T-box 15	0.033	Mouse
Pou4f2	POU domain, class 4, transcription factor 2	0.033
Bnc1	basonuclin 1	0.032
Nodal	nodal	0.031
Hey2	hairy/enhancer-of-split related with YRPW motif 2	0.031
Xirp1	xin actin-binding repeat containing 1	0.031
Foxj1	forkhead box J1	0.030
Myo6	myosin VI	0.030
Foxf2	forkhead box F2	0.030
Hoxb1	homeobox B1	0.030
Nfatc4	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4	0.029
Kcnq1	potassium voltage-gated channel, subfamily Q, member 1	0.029
Tlx3	T-cell leukemia, homeobox 3	0.029
Ptk7	PTK7 protein tyrosine kinase 7	0.028
Hoxd11	homeobox D11	0.028
Mnx1	motor neuron and pancreas homeobox 1	0.028
Gpc3	glypican 3	0.027
Irx4	Iroquois related homeobox 4 (Drosophila)	0.027
Mtl5	metallothionein-like 5, testis-specific (tesmin)	0.027
Myl3	myosin, light polypeptide 3	0.027
Fev	FEV (ETS oncogene family)	0.027
Irx5	Iroquois related homeobox 5 (Drosophila)	0.026
Hoxd13	homeobox D13	0.026
Ptch1	patched homolog 1	0.026
Tcfcp2l1	transcription factor CP2-like 1	0.025
Atoh8	atonal homolog 8 (Drosophila)	0.025
Hoxb2	homeobox B2	0.024
Olig3	oligodendrocyte transcription factor 3	0.024
Gimap7	GTPase, IMAP family member 7	0.023
Notch1	Notch gene homolog 1 (Drosophila)	0.023
Prdm6	PR domain containing 6	0.023
Satb2	special AT-rich sequence binding protein 2	0.023
Mecom	MDS1 and EVI1 complex locus	0.023
Zic1	zinc finger protein of the cerebellum 1	0.022
Hoxb4	homeobox B4	0.021
Rybp	RING1 and YY1 binding protein	0.021
Dnahc5	dynein, axonemal, heavy chain 5	0.021
Rxra	retinoid X receptor alpha	0.021
Sim2	single-minded homolog 2 (Drosophila)	0.021
Rdh10	retinol dehydrogenase 10 (all-trans)	0.021
Col2a1	collagen, type II, alpha 1	0.021
Erbb2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.021
Gja1	gap junction protein, alpha 1	0.021
Fgf18	fibroblast growth factor 18	0.020
Isl2	insulin related protein 2 (islet 2)	0.020
Dlx1	distal-less homeobox 1	0.020
Msc	musculin	0.020
Sp8	trans-acting transcription factor 8	0.020
Hoxd9	homeobox D9	0.020
Foxa1	forkhead box A1	0.020
Foxb1	forkhead box B1	0.020
BC020535	cDNA sequence BC020535	0.020
Ece1	endothelin converting enzyme 1	0.019
Dll1	delta-like 1 (Drosophila)	0.019
Fgfrl1	fibroblast growth factor receptor-like 1	0.019
Hoxc8	homeobox C8	0.019
Hes7	hairy and enhancer of split 7 (Drosophila)	0.019
Lhx9	LIM homeobox protein 9	0.018
Gdnf	glial cell line derived neurotrophic factor	0.018
Lhx4	LIM homeobox protein 4	0.018
Foxi3	forkhead box I3	0.018
Tcfap2c	transcription factor AP-2, gamma	0.018
Sox7	SRY-box containing gene 7	0.018
Rspo2	R-spondin 2 homolog (Xenopus laevis)	0.018
Asb10	ankyrin repeat and SOCS box-containing 10	0.018
Zfpm2	zinc finger protein, multitype 2	0.018
Ntn3	netrin 3	0.018
Bmpr1a	bone morphogenetic protein receptor, type 1A	0.018
Ncr1	natural cytotoxicity triggering receptor 1	0.017
Acvr1	activin A receptor, type 1	0.017
Il27ra	interleukin 27 receptor, alpha	0.017
Pax1	paired box gene 1	0.017
Runx3	runt related transcription factor 3	0.017
Edar	ectodysplasin-A receptor	0.017
Cdx2	caudal type homeobox 2	0.017
Hoxa4	homeobox A4	0.017
Pcdh18	protocadherin 18	0.017
Txk	TXK tyrosine kinase	0.016
Snai1	snail homolog 1 (Drosophila)	0.016
Pla2r1	phospholipase A2 receptor 1	0.016
Meox2	mesenchyme homeobox 2	0.016
Sox17	SRY-box containing gene 17	0.016
Zic2	zinc finger protein of the cerebellum 2	0.016
Tal1	T-cell acute lymphocytic leukemia 1	0.016
Myh6	myosin, heavy polypeptide 6, cardiac muscle, alpha	0.015
Eya4	eyes absent 4 homolog (Drosophila)	0.015
Hoxd8	homeobox D8	0.015
Nckap5l	NCK-associated protein 5-like	0.015
Egfr	epidermal growth factor receptor	0.015
Spn	sialophorin	0.015
Hoxb3	homeobox B3	0.015
Itga8	integrin alpha 8	0.014
Zfp503	zinc finger protein 503	0.014
Myf6	myogenic factor 6	0.014
Nkx1-2	NK1 transcription factor related, locus 2 (Drosophila)	0.014
Tead1	TEA domain family member 1	0.014
Cyp1a1	cytochrome P450, family 1, subfamily a, polypeptide 1	0.014
Hesx1	homeobox gene expressed in ES cells	0.014
Megf8	multiple EGF-like-domains 8	0.014
Neurog2	neurogenin 2	0.014
Kremen1	kringle containing transmembrane protein 1	0.014
Setdb1	SET domain, bifurcated 1	0.014
Fign	fidgetin	0.014
Dkk1	dickkopf homolog 1 (Xenopus laevis)	0.014
Styxl1	serine/threonine/tyrosine interacting-like 1	0.014
Fam89a	family with sequence similarity 89, member A	0.014
Dact1	dapper homolog 1, antagonist of beta-catenin (xenopus)	0.014
Tbx2	T-box 2	0.014	Mouse
Vsx2	visual system homeobox 2	0.014
Foxd3	forkhead box D3	0.014
Efna1	ephrin A1	0.013
Sox21	SRY-box containing gene 21	0.013
Bcor	BCL6 interacting corepressor	0.013
Nkx2-1	NK2 homeobox 1	0.013
Phex	phosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets)	0.013
Pcdh1	protocadherin 1	0.013
Capn6	calpain 6	0.013
Hmga2	high mobility group AT-hook 2	0.013
Ebf3	early B-cell factor 3	0.013
Efna2	ephrin A2	0.013
Olfr49	olfactory receptor 49	0.013
Lbx1	ladybird homeobox homolog 1 (Drosophila)	0.013
Defb10	defensin beta 10	0.013
Pla2g4d	phospholipase A2, group IVD	0.013
AY074887	cDNA sequence AY074887	0.013
Hapln1	hyaluronan and proteoglycan link protein 1	0.012
Olfr154	olfactory receptor 154	0.012
Cyp26a1	cytochrome P450, family 26, subfamily a, polypeptide 1	0.012
Psors1c2	psoriasis susceptibility 1 candidate 2 (human)	0.012
Nr2f1	nuclear receptor subfamily 2, group F, member 1	0.012
Osr1	odd-skipped related 1 (Drosophila)	0.012
Nfia	nuclear factor I/A	0.012
Lck	lymphocyte protein tyrosine kinase	0.012
Bmper	BMP-binding endothelial regulator	0.012
Prtg	protogenin homolog (Gallus gallus)	0.012
Zbtb46	zinc finger and BTB domain containing 46	0.012
She	src homology 2 domain-containing transforming protein E	0.012
Nkx3-1	NK-3 transcription factor, locus 1 (Drosophila)	0.012
Hs3st3b1	heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1	0.012
Gsx1	GS homeobox 1	0.012
Wnt11	wingless-related MMTV integration site 11	0.012
Tnnt3	troponin T3, skeletal, fast	0.012
Npr2	natriuretic peptide receptor 2	0.012
Eomes	eomesodermin homolog (Xenopus laevis)	0.012
Sost	sclerostin	0.012
Lrrc56	leucine rich repeat containing 56	0.012
Emilin3	elastin microfibril interfacer 3	0.011
Irx1	Iroquois related homeobox 1 (Drosophila)	0.011
Insm1	insulinoma-associated 1	0.011
Fgf16	fibroblast growth factor 16	0.011
Cbln3	cerebellin 3 precursor protein	0.011
Nkd2	naked cuticle 2 homolog (Drosophila)	0.011
Atp1b4	ATPase, (Na+)/K+ transporting, beta 4 polypeptide	0.011
Gdf3	growth differentiation factor 3	0.011
Slc26a4	solute carrier family 26, member 4	0.011
Myl7	myosin, light polypeptide 7, regulatory	0.011
Hoxa9	homeobox A9	0.011
Smpd3	sphingomyelin phosphodiesterase 3, neutral	0.011
Mll3	myeloid/lymphoid or mixed-lineage leukemia 3	0.011
Hes5	hairy and enhancer of split 5 (Drosophila)	0.011
Myoz2	myozenin 2	0.011
Wnt8b	wingless related MMTV integration site 8b	0.011
Gpr20	G protein-coupled receptor 20	0.011
Lao1	L-amino acid oxidase 1	0.011
Sp7	Sp7 transcription factor 7	0.011
Klf14	Kruppel-like factor 14	0.011
4930544G11Rik	RIKEN cDNA 4930544G11 gene	0.011
Rem1	rad and gem related GTP binding protein 1	0.011
Sftpa1	surfactant associated protein A1	0.011
Npr3	natriuretic peptide receptor 3	0.010
Hspb7	heat shock protein family, member 7 (cardiovascular)	0.010
Hoxb6	homeobox B6	0.010
Ptf1a	pancreas specific transcription factor, 1a	0.010
Ebf2	early B-cell factor 2	0.010
Ankrd1	ankyrin repeat domain 1 (cardiac muscle)	0.010
Mt4	metallothionein 4	0.010
Adrb1	adrenergic receptor, beta 1	0.010
Pax6	paired box gene 6	0.010
Ppp1r3a	protein phosphatase 1, regulatory (inhibitor) subunit 3A	0.010
Ptcra	pre T-cell antigen receptor alpha	0.010
Hs3st6	heparan sulfate (glucosamine) 3-O-sulfotransferase 6	0.010
Wnt1	wingless-related MMTV integration site 1	0.010
En1	engrailed 1	0.010
Fzd10	frizzled homolog 10 (Drosophila)	0.010
Hoxc13	homeobox C13	0.010
Gsx2	GS homeobox 2	0.010
Padi3	peptidyl arginine deiminase, type III	0.010