IMP

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Mus musculus

3 genes annotated in mouse

canonical wnt signaling pathway involved in heart development

The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes that contributes to the progression of the heart over time. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes.

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "canonical wnt signaling pathway involved in heart development"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "canonical wnt signaling pathway involved in heart development" (in gray)

Name	Description	Probability	Func Analog Organism
Vangl2	vang-like 2 (van gogh, Drosophila)	1.000
Vangl1	vang-like 1 (van gogh, Drosophila)	0.999
Fgfr2	fibroblast growth factor receptor 2	0.998
Shh	sonic hedgehog	0.997
Ctnnb1	catenin (cadherin associated protein), beta 1	0.996
Psen1	presenilin 1	0.993
Dvl2	dishevelled 2, dsh homolog (Drosophila)	0.993	Fly
Lrp6	low density lipoprotein receptor-related protein 6	0.988
Apc	adenomatosis polyposis coli	0.984
Fgfr1	fibroblast growth factor receptor 1	0.967
Pten	phosphatase and tensin homolog	0.957
Pax3	paired box gene 3	0.933
Axin1	axin 1	0.932
Notch2	Notch gene homolog 2 (Drosophila)	0.930
Notch1	Notch gene homolog 1 (Drosophila)	0.924
Dvl3	dishevelled 3, dsh homolog (Drosophila)	0.882	Fly
Gsk3b	glycogen synthase kinase 3 beta	0.866
Bmp4	bone morphogenetic protein 4	0.848
Gli3	GLI-Kruppel family member GLI3	0.837
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.807
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.779
Foxc1	forkhead box C1	0.753
Otx2	orthodenticle homolog 2 (Drosophila)	0.724
Trp53	transformation related protein 53	0.632
Dvl1	dishevelled, dsh homolog 1 (Drosophila)	0.612	Fly
Fgf8	fibroblast growth factor 8	0.571
Kras	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	0.514
Pitx2	paired-like homeodomain transcription factor 2	0.472
Smad4	MAD homolog 4 (Drosophila)	0.462
Tbx3	T-box 3	0.450
Itga3	integrin alpha 3	0.409
Pax1	paired box gene 1	0.407
Bmpr1a	bone morphogenetic protein receptor, type 1A	0.391
Apoe	apolipoprotein E	0.362
T	brachyury	0.354
Smad3	MAD homolog 3 (Drosophila)	0.340
Lrp5	low density lipoprotein receptor-related protein 5	0.329	Mouse
Foxc2	forkhead box C2	0.312
Ndst1	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	0.311
Dll1	delta-like 1 (Drosophila)	0.298
Apaf1	apoptotic peptidase activating factor 1	0.274
Rxra	retinoid X receptor alpha	0.268
Chd7	chromodomain helicase DNA binding protein 7	0.267
Meox2	mesenchyme homeobox 2	0.263
Smo	smoothened homolog (Drosophila)	0.255
Vegfa	vascular endothelial growth factor A	0.249
Lef1	lymphoid enhancer binding factor 1	0.247
Pkd1	polycystic kidney disease 1 homolog	0.246
Hes1	hairy and enhancer of split 1 (Drosophila)	0.232
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.231
Jag1	jagged 1	0.229
Efnb2	ephrin B2	0.212
Egfr	epidermal growth factor receptor	0.210
Fgfr3	fibroblast growth factor receptor 3	0.209
Mapk8ip1	mitogen-activated protein kinase 8 interacting protein 1	0.205
Bmp7	bone morphogenetic protein 7	0.180
Sox9	SRY-box containing gene 9	0.177
Lmx1b	LIM homeobox transcription factor 1 beta	0.174
Esr1	estrogen receptor 1 (alpha)	0.171
Ptk7	PTK7 protein tyrosine kinase 7	0.165
Abca1	ATP-binding cassette, sub-family A (ABC1), member 1	0.164
Numb	numb gene homolog (Drosophila)	0.160
Hif1a	hypoxia inducible factor 1, alpha subunit	0.159
Htt	huntingtin	0.157
Foxa2	forkhead box A2	0.155
Twsg1	twisted gastrulation homolog 1 (Drosophila)	0.154
Smad2	MAD homolog 2 (Drosophila)	0.149
Wnt3a	wingless-related MMTV integration site 3A	0.148	Human
Mark4	MAP/microtubule affinity-regulating kinase 4	0.136
Ptch1	patched homolog 1	0.134
Rb1	retinoblastoma 1	0.133
Rarg	retinoic acid receptor, gamma	0.132
Wls	wntless homolog (Drosophila)	0.130
Pax6	paired box gene 6	0.129
Adam17	a disintegrin and metallopeptidase domain 17	0.125
Nf1	neurofibromatosis 1	0.118
Nodal	nodal	0.111
Ctnna1	catenin (cadherin associated protein), alpha 1	0.110
Lrp2	low density lipoprotein receptor-related protein 2	0.107	Mouse
Tbx1	T-box 1	0.107
Cebpa	CCAAT/enhancer binding protein (C/EBP), alpha	0.104
Tnks1bp1	tankyrase 1 binding protein 1	0.103
Sox11	SRY-box containing gene 11	0.099
Mks1	Meckel syndrome, type 1	0.094
Pparg	peroxisome proliferator activated receptor gamma	0.094
Zeb1	zinc finger E-box binding homeobox 1	0.093
Pax2	paired box gene 2	0.088
Dact1	dapper homolog 1, antagonist of beta-catenin (xenopus)	0.087
Msx1	homeobox, msh-like 1	0.087
Emx1	empty spiracles homolog 1 (Drosophila)	0.087
Col1a1	collagen, type I, alpha 1	0.086
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.083
Lama5	laminin, alpha 5	0.081
Npc1	Niemann Pick type C1	0.079
Smurf2	SMAD specific E3 ubiquitin protein ligase 2	0.078
Grin1	glutamate receptor, ionotropic, NMDA1 (zeta 1)	0.072
Acvr1	activin A receptor, type 1	0.071
Cdkn1a	cyclin-dependent kinase inhibitor 1A (P21)	0.071
Tenc1	tensin like C1 domain-containing phosphatase	0.070
Nos3	nitric oxide synthase 3, endothelial cell	0.067
Esr2	estrogen receptor 2 (beta)	0.066
Stat3	signal transducer and activator of transcription 3	0.066
Nf2	neurofibromatosis 2	0.066
Kit	kit oncogene	0.064
Rac1	RAS-related C3 botulinum substrate 1	0.064
Pofut1	protein O-fucosyltransferase 1	0.064
App	amyloid beta (A4) precursor protein	0.063
Il6st	interleukin 6 signal transducer	0.063
Otx1	orthodenticle homolog 1 (Drosophila)	0.062
Vhl	von Hippel-Lindau tumor suppressor	0.061
Ctnnd1	catenin (cadherin associated protein), delta 1	0.060
Gbx2	gastrulation brain homeobox 2	0.057
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.054
Hoxa2	homeobox A2	0.054
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.054
Wnt1	wingless-related MMTV integration site 1	0.053	Fly
Hand2	heart and neural crest derivatives expressed transcript 2	0.053
Rela	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.052
Lrrk2	leucine-rich repeat kinase 2	0.051
Sox13	SRY-box containing gene 13	0.051
Smad6	MAD homolog 6 (Drosophila)	0.050
Gja1	gap junction protein, alpha 1	0.049
Pax9	paired box gene 9	0.046
Braf	Braf transforming gene	0.046
Hand1	heart and neural crest derivatives expressed transcript 1	0.045
Tgfbr2	transforming growth factor, beta receptor II	0.045
Gata4	GATA binding protein 4	0.044
Trp63	transformation related protein 63	0.043
Gsc	goosecoid homeobox	0.041
Tgfa	transforming growth factor alpha	0.041
Chrd	chordin	0.040
Rara	retinoic acid receptor, alpha	0.039
Hspg2	perlecan (heparan sulfate proteoglycan 2)	0.038
Cdc42	cell division cycle 42 homolog (S. cerevisiae)	0.037
En1	engrailed 1	0.037
Dicer1	Dicer1, Dcr-1 homolog (Drosophila)	0.037
Kl	klotho	0.037
Hrc	histidine rich calcium binding protein	0.036
Ccnd1	cyclin D1	0.036
Foxk1	forkhead box K1	0.035
Ptk2	PTK2 protein tyrosine kinase 2	0.034
Fgf15	fibroblast growth factor 15	0.033
Dlg1	discs, large homolog 1 (Drosophila)	0.033
Cxadr	coxsackie virus and adenovirus receptor	0.033
Mmp14	matrix metallopeptidase 14 (membrane-inserted)	0.033
Pcdh12	protocadherin 12	0.032
Smad1	MAD homolog 1 (Drosophila)	0.032
Tgfb2	transforming growth factor, beta 2	0.032
Hoxa13	homeobox A13	0.032
Cav1	caveolin 1, caveolae protein	0.031
Kif3a	kinesin family member 3A	0.031
Cldn6	claudin 6	0.031
Rdh10	retinol dehydrogenase 10 (all-trans)	0.031
Tcfap2c	transcription factor AP-2, gamma	0.030
Tax1bp3	Tax1 (human T-cell leukemia virus type I) binding protein 3	0.029
Dll4	delta-like 4 (Drosophila)	0.028
Sertad2	SERTA domain containing 2	0.028
Tcf7l2	transcription factor 7-like 2, T-cell specific, HMG-box	0.027
Bmp2	bone morphogenetic protein 2	0.027
Smad7	MAD homolog 7 (Drosophila)	0.027
Ldlr	low density lipoprotein receptor	0.027
Dab1	disabled homolog 1 (Drosophila)	0.026
Runx2	runt related transcription factor 2	0.026
Fgf10	fibroblast growth factor 10	0.025
Bcl2	B-cell leukemia/lymphoma 2	0.025
Agrn	agrin	0.025
Nog	noggin	0.024
Pax8	paired box gene 8	0.024
Kitl	kit ligand	0.024
Pou5f1	POU domain, class 5, transcription factor 1	0.024
Rbpj	recombination signal binding protein for immunoglobulin kappa J region	0.023
Slc9a3r2	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2	0.023
Trp73	transformation related protein 73	0.023
Foxg1	forkhead box G1	0.023
Msx2	homeobox, msh-like 2	0.023
Llgl2	lethal giant larvae homolog 2 (Drosophila)	0.022
Pitx1	paired-like homeodomain transcription factor 1	0.022
Rnf111	ring finger 111	0.022
Sgpl1	sphingosine phosphate lyase 1	0.022
Ybx2	Y box protein 2	0.022
Lhx1	LIM homeobox protein 1	0.022
Ptf1a	pancreas specific transcription factor, 1a	0.022
Jag2	jagged 2	0.021
Igdcc3	immunoglobulin superfamily, DCC subclass, member 3	0.021
Six3	sine oculis-related homeobox 3 homolog (Drosophila)	0.021
Pbx1	pre B-cell leukemia transcription factor 1	0.021
Hoxd11	homeobox D11	0.021
Cdkn2a	cyclin-dependent kinase inhibitor 2A	0.020
Sox2	SRY-box containing gene 2	0.020
Efnb1	ephrin B1	0.020
a	nonagouti	0.020
Lmx1a	LIM homeobox transcription factor 1 alpha	0.020
Csnk1e	casein kinase 1, epsilon	0.020
Axin2	axin2	0.019
Sox4	SRY-box containing gene 4	0.019
Zic3	zinc finger protein of the cerebellum 3	0.019
Dact3	dapper homolog 3, antagonist of beta-catenin (xenopus)	0.019
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.019
Prm2	protamine 2	0.019
Ncoa3	nuclear receptor coactivator 3	0.019
Ihh	Indian hedgehog	0.019
Crebbp	CREB binding protein	0.019
Eya1	eyes absent 1 homolog (Drosophila)	0.018
Epha2	Eph receptor A2	0.018
Dact2	dapper homolog 2, antagonist of beta-catenin (xenopus)	0.018
Ptprf	protein tyrosine phosphatase, receptor type, F	0.018
Prop1	paired like homeodomain factor 1	0.018
Lepr	leptin receptor	0.018
Nfib	nuclear factor I/B	0.018
Cbfb	core binding factor beta	0.018
Prkar1a	protein kinase, cAMP dependent regulatory, type I, alpha	0.017
Rhox6	reproductive homeobox 6	0.017
Crtc3	CREB regulated transcription coactivator 3	0.017
Fut7	fucosyltransferase 7	0.017
Fzd8	frizzled homolog 8 (Drosophila)	0.017
Prox1	prospero-related homeobox 1	0.017
Pick1	protein interacting with C kinase 1	0.017
Slc5a11	solute carrier family 5 (sodium/glucose cotransporter), member 11	0.017
Col4a3	collagen, type IV, alpha 3	0.017
Mapk8ip3	mitogen-activated protein kinase 8 interacting protein 3	0.017
Pcdh1	protocadherin 1	0.017
Onecut1	one cut domain, family member 1	0.017
Vdr	vitamin D receptor	0.017
Wnt3	wingless-related MMTV integration site 3	0.017
Dkk1	dickkopf homolog 1 (Xenopus laevis)	0.017	Human
Gata3	GATA binding protein 3	0.017
Hpd	4-hydroxyphenylpyruvic acid dioxygenase	0.017
Ctnnbip1	catenin beta interacting protein 1	0.016
Klf15	Kruppel-like factor 15	0.016
Cdh1	cadherin 1	0.016
Dlx6	distal-less homeobox 6	0.016
Chuk	conserved helix-loop-helix ubiquitous kinase	0.016
Tcfap2a	transcription factor AP-2, alpha	0.016
Hnf1a	HNF1 homeobox A	0.016
Tead3	TEA domain family member 3	0.015
Slc34a2	solute carrier family 34 (sodium phosphate), member 2	0.015
Clic3	chloride intracellular channel 3	0.015
Sema6a	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A	0.015
Hprt	hypoxanthine guanine phosphoribosyl transferase	0.015
Acr	acrosin prepropeptide	0.015
Ptpn14	protein tyrosine phosphatase, non-receptor type 14	0.015
Smagp	small cell adhesion glycoprotein	0.015
Drd2	dopamine receptor D2	0.015
Eda	ectodysplasin-A	0.015
Cdx2	caudal type homeobox 2	0.015
Bmp10	bone morphogenetic protein 10	0.015
Six4	sine oculis-related homeobox 4 homolog (Drosophila)	0.015
Pcgf2	polycomb group ring finger 2	0.015
Dyrk1b	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1b	0.015
Ets2	E26 avian leukemia oncogene 2, 3' domain	0.015
Nkd1	naked cuticle 1 homolog (Drosophila)	0.015
Sall4	sal-like 4 (Drosophila)	0.015
Foxo1	forkhead box O1	0.015
C80256	expressed sequence C80256	0.015
Ggt1	gamma-glutamyltransferase 1	0.015
Tert	telomerase reverse transcriptase	0.014
Ephb4	Eph receptor B4	0.014
Jup	junction plakoglobin	0.014	Mouse Fly
Cdk18	cyclin-dependent kinase 18	0.014
Chrm4	cholinergic receptor, muscarinic 4	0.014
Fzd7	frizzled homolog 7 (Drosophila)	0.014
Tacr2	tachykinin receptor 2	0.014
Fgfr4	fibroblast growth factor receptor 4	0.014
Cyp27b1	cytochrome P450, family 27, subfamily b, polypeptide 1	0.014
Eif4ebp2	eukaryotic translation initiation factor 4E binding protein 2	0.014
Phex	phosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets)	0.014
Cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.014
Plcg1	phospholipase C, gamma 1	0.014
Ext1	exostoses (multiple) 1	0.013
Lep	leptin	0.013
Dlx5	distal-less homeobox 5	0.013
Etv2	ets variant gene 2	0.013
Mesp1	mesoderm posterior 1	0.013
Evx1	even skipped homeotic gene 1 homolog	0.013
Fgf4	fibroblast growth factor 4	0.013
Fuz	fuzzy homolog (Drosophila)	0.013
Chrna6	cholinergic receptor, nicotinic, alpha polypeptide 6	0.013
Bmp5	bone morphogenetic protein 5	0.013
Tigd5	tigger transposable element derived 5	0.013
Hoxb7	homeobox B7	0.013
Foxf1a	forkhead box F1a	0.013
Alx3	aristaless-like homeobox 3	0.013
Pax4	paired box gene 4	0.013
Adra2b	adrenergic receptor, alpha 2b	0.012
Ctf1	cardiotrophin 1	0.012
Edar	ectodysplasin-A receptor	0.012
Hoxc9	homeobox C9	0.012
Stk40	serine/threonine kinase 40	0.012
Tbx5	T-box 5	0.012
Sfrp2	secreted frizzled-related protein 2	0.012
Ltbr	lymphotoxin B receptor	0.012
Rarb	retinoic acid receptor, beta	0.012
Nedd4	neural precursor cell expressed, developmentally down-regulated 4	0.012
Lfng	LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase	0.012
Cited2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	0.012
Epha1	Eph receptor A1	0.012
Celsr1	cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)	0.012
Foxh1	forkhead box H1	0.012
Hhat	hedgehog acyltransferase	0.012
Cer1	cerberus 1 homolog (Xenopus laevis)	0.012
Nkx1-2	NK1 transcription factor related, locus 2 (Drosophila)	0.012
Ptms	parathymosin	0.011
Arl10	ADP-ribosylation factor-like 10	0.011
Fam83h	family with sequence similarity 83, member H	0.011
Adss	adenylosuccinate synthetase, non muscle	0.011
Anpep	alanyl (membrane) aminopeptidase	0.011
3110079O15Rik	RIKEN cDNA 3110079O15 gene	0.011
Yap1	yes-associated protein 1	0.011
Tmprss2	transmembrane protease, serine 2	0.011
Ece1	endothelin converting enzyme 1	0.011
Smad5	MAD homolog 5 (Drosophila)	0.011
Hoxa11	homeobox A11	0.011
Lyz2	lysozyme 2	0.011
Wnt7a	wingless-related MMTV integration site 7A	0.011
Alx4	aristaless-like homeobox 4	0.011
Epas1	endothelial PAS domain protein 1	0.011
Hes3	hairy and enhancer of split 3 (Drosophila)	0.011
Peg10	paternally expressed 10	0.011
Hnf1b	HNF1 homeobox B	0.011
Tcfcp2l1	transcription factor CP2-like 1	0.011
Ppl	periplakin	0.010
Syt10	synaptotagmin X	0.010
Hes2	hairy and enhancer of split 2 (Drosophila)	0.010
Cldn3	claudin 3	0.010
Cdh16	cadherin 16	0.010
Akap3	A kinase (PRKA) anchor protein 3	0.010
Fgf3	fibroblast growth factor 3	0.010
Ceacam9	carcinoembryonic antigen-related cell adhesion molecule 9	0.010
Rab25	RAB25, member RAS oncogene family	0.010