IMP

Process View

Mus musculus

4 genes annotated in mouse

interleukin 1 mediated signaling pathway

A series of molecular signals initiated by the binding of interleukin-1 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "interleukin 1 mediated signaling pathway"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "interleukin 1 mediated signaling pathway" (in gray)

Name	Description	Probability	Func Analog Organism
Myd88	myeloid differentiation primary response gene 88	0.994
Traf6	TNF receptor-associated factor 6	0.951
Tnfaip3	tumor necrosis factor, alpha-induced protein 3	0.893
Map3k7	mitogen-activated protein kinase kinase kinase 7	0.811
Irak4	interleukin-1 receptor-associated kinase 4	0.762
Irak3	interleukin-1 receptor-associated kinase 3	0.755
Tlr4	toll-like receptor 4	0.647
Tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a	0.394
Tifa	TRAF-interacting protein with forkhead-associated domain	0.299
Cd40	CD40 antigen	0.252
Ccl2	chemokine (C-C motif) ligand 2	0.240
Birc3	baculoviral IAP repeat-containing 3	0.209
Stat3	signal transducer and activator of transcription 3	0.182
Map3k8	mitogen-activated protein kinase kinase kinase 8	0.182
Ptgs2	prostaglandin-endoperoxide synthase 2	0.171
Ripk1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.167
Tnfrsf11a	tumor necrosis factor receptor superfamily, member 11a	0.159
Il6	interleukin 6	0.115
Bcl3	B-cell leukemia/lymphoma 3	0.084
Irak1	interleukin-1 receptor-associated kinase 1	0.080
Mavs	mitochondrial antiviral signaling protein	0.076
Trafd1	TRAF type zinc finger domain containing 1	0.075
Cd44	CD44 antigen	0.071
Fos	FBJ osteosarcoma oncogene	0.068
Cxcl2	chemokine (C-X-C motif) ligand 2	0.066
Capns1	calpain, small subunit 1	0.065
Sqstm1	sequestosome 1	0.064
Egr2	early growth response 2	0.062
Junb	Jun-B oncogene	0.060
Tnfrsf1b	tumor necrosis factor receptor superfamily, member 1b	0.056
Nab2	Ngfi-A binding protein 2	0.054
Ticam1	toll-like receptor adaptor molecule 1	0.049
Mapk1	mitogen-activated protein kinase 1	0.048
Il4ra	interleukin 4 receptor, alpha	0.047
Map3k1	mitogen-activated protein kinase kinase kinase 1	0.043
Kiss1	KiSS-1 metastasis-suppressor	0.041
Nfkb1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105	0.040
Rela	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.040
Il1rap	interleukin 1 receptor accessory protein	0.040
Cav1	caveolin 1, caveolae protein	0.039
Actn4	actinin alpha 4	0.036
Cxcl1	chemokine (C-X-C motif) ligand 1	0.036
Nfkbiz	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta	0.036
Traf3ip2	TRAF3 interacting protein 2	0.034
Tnfrsf9	tumor necrosis factor receptor superfamily, member 9	0.032
Ikbkg	inhibitor of kappaB kinase gamma	0.031
Mknk2	MAP kinase-interacting serine/threonine kinase 2	0.030
Itch	itchy, E3 ubiquitin protein ligase	0.027
Ier2	immediate early response 2	0.026
Nr4a1	nuclear receptor subfamily 4, group A, member 1	0.024
Il1b	interleukin 1 beta	0.024
Ube2n	ubiquitin-conjugating enzyme E2N	0.024
Il1r1	interleukin 1 receptor, type I	0.023	Human Rat
Ikbke	inhibitor of kappaB kinase epsilon	0.022
Ripk2	receptor (TNFRSF)-interacting serine-threonine kinase 2	0.022
Nfkbia	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.021
Csf1	colony stimulating factor 1 (macrophage)	0.021
Map3k3	mitogen-activated protein kinase kinase kinase 3	0.021
Irak2	interleukin-1 receptor-associated kinase 2	0.020	Human Mouse
Lepr	leptin receptor	0.019
Pea15a	phosphoprotein enriched in astrocytes 15A	0.019
Traf2	TNF receptor-associated factor 2	0.018	Mouse
Rnf41	ring finger protein 41	0.018
Tollip	toll interacting protein	0.017
Traf3	TNF receptor-associated factor 3	0.017	Mouse
Gnb2	guanine nucleotide binding protein (G protein), beta 2	0.016
Hspa1b	heat shock protein 1B	0.015
Peli2	pellino 2	0.015
Flii	flightless I homolog (Drosophila)	0.015
Tlr2	toll-like receptor 2	0.014
Prkcd	protein kinase C, delta	0.014
Dusp1	dual specificity phosphatase 1	0.014
Fas	Fas (TNF receptor superfamily member 6)	0.014
Clec4e	C-type lectin domain family 4, member e	0.014
Relb	avian reticuloendotheliosis viral (v-rel) oncogene related B	0.013
Pik3ap1	phosphoinositide-3-kinase adaptor protein 1	0.013
Arhgdia	Rho GDP dissociation inhibitor (GDI) alpha	0.013
Casp4	caspase 4, apoptosis-related cysteine peptidase	0.013
Flot1	flotillin 1	0.013
Il1a	interleukin 1 alpha	0.012
Anapc2	anaphase promoting complex subunit 2	0.012
Atf3	activating transcription factor 3	0.012
Ltbr	lymphotoxin B receptor	0.012
Jun	Jun oncogene	0.012
Saa3	serum amyloid A 3	0.012
Tax1bp1	Tax1 (human T-cell leukemia virus type I) binding protein 1	0.012
Socs3	suppressor of cytokine signaling 3	0.011
Ldlr	low density lipoprotein receptor	0.011
Skil	SKI-like	0.011
Cxcl5	chemokine (C-X-C motif) ligand 5	0.011
Gnai2	guanine nucleotide binding protein (G protein), alpha inhibiting 2	0.011
Clec4d	C-type lectin domain family 4, member d	0.011
Icam1	intercellular adhesion molecule 1	0.011
Csf2rb	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	0.010
Tnf	tumor necrosis factor	0.010
Adam8	a disintegrin and metallopeptidase domain 8	0.010
Prkce	protein kinase C, epsilon	0.010
Ecsit	ECSIT homolog (Drosophila)	0.010