IMP

Process View

Mus musculus

9 genes annotated in mouse

Multi-species View

positive regulation of osteoblast proliferation

GO:0033690

Any process that activates or increases the rate or extent of osteoblast proliferation.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of osteoblast proliferation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "positive regulation of osteoblast proliferation" (in gray)

Name	Description	Probability	Func Analog Organism
Fgfr2	fibroblast growth factor receptor 2	1.000
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.987	Mouse
Shh	sonic hedgehog	0.985
Bmp4	bone morphogenetic protein 4	0.930	Mouse
Gata4	GATA binding protein 4	0.907	Mouse
Meox2	mesenchyme homeobox 2	0.907
Ctnnb1	catenin (cadherin associated protein), beta 1	0.901
Gli3	GLI-Kruppel family member GLI3	0.882
Sox9	SRY-box containing gene 9	0.877	Mouse
Pax3	paired box gene 3	0.783
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.724
Vegfa	vascular endothelial growth factor A	0.670
Tgfb2	transforming growth factor, beta 2	0.660
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.653
Jag1	jagged 1	0.631
Fgf8	fibroblast growth factor 8	0.565
Nf1	neurofibromatosis 1	0.465
Fgfr1	fibroblast growth factor receptor 1	0.426
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.386
Nodal	nodal	0.379
Hand1	heart and neural crest derivatives expressed transcript 1	0.358
Rxra	retinoid X receptor alpha	0.348
Apc	adenomatosis polyposis coli	0.299
Pitx2	paired-like homeodomain transcription factor 2	0.265
Sox2	SRY-box containing gene 2	0.260	Mouse
Hspg2	perlecan (heparan sulfate proteoglycan 2)	0.255
Prrx1	paired related homeobox 1	0.253
Fgfr3	fibroblast growth factor receptor 3	0.249
Isl1	ISL1 transcription factor, LIM/homeodomain	0.246
Nos3	nitric oxide synthase 3, endothelial cell	0.231
Tbx3	T-box 3	0.194
Acvr1	activin A receptor, type 1	0.165
Foxc1	forkhead box C1	0.159
Egfr	epidermal growth factor receptor	0.146
Notch2	Notch gene homolog 2 (Drosophila)	0.144
Smad6	MAD homolog 6 (Drosophila)	0.135
Chd7	chromodomain helicase DNA binding protein 7	0.131
Trp63	transformation related protein 63	0.130
Efnb2	ephrin B2	0.128
Vangl2	vang-like 2 (van gogh, Drosophila)	0.127
Rb1	retinoblastoma 1	0.127
Itgb3	integrin beta 3	0.124
Ptk2	PTK2 protein tyrosine kinase 2	0.119
Hes1	hairy and enhancer of split 1 (Drosophila)	0.115
Kras	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	0.114
Ret	ret proto-oncogene	0.114
Ndst1	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	0.113
Sox4	SRY-box containing gene 4	0.111	Mouse
Eng	endoglin	0.108
Pdgfrb	platelet derived growth factor receptor, beta polypeptide	0.105
Fgf10	fibroblast growth factor 10	0.104
Kif3a	kinesin family member 3A	0.103
Gbx2	gastrulation brain homeobox 2	0.100
Hhex	hematopoietically expressed homeobox	0.099
Tcfap2a	transcription factor AP-2, alpha	0.086
Runx2	runt related transcription factor 2	0.083
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.081
Otx2	orthodenticle homolog 2 (Drosophila)	0.079
Wt1	Wilms tumor 1 homolog	0.078
Mmp14	matrix metallopeptidase 14 (membrane-inserted)	0.076
Smo	smoothened homolog (Drosophila)	0.075
Col1a1	collagen, type I, alpha 1	0.074
Trp53	transformation related protein 53	0.074
Psen1	presenilin 1	0.074
Apoe	apolipoprotein E	0.072
Bmp7	bone morphogenetic protein 7	0.070
Lef1	lymphoid enhancer binding factor 1	0.069
Lrp2	low density lipoprotein receptor-related protein 2	0.068	Mouse
Gata6	GATA binding protein 6	0.068	Mouse
Tgfbr2	transforming growth factor, beta receptor II	0.067
Gja1	gap junction protein, alpha 1	0.066
Chrd	chordin	0.065
Adam17	a disintegrin and metallopeptidase domain 17	0.065
Bmpr1a	bone morphogenetic protein receptor, type 1A	0.065
Selp	selectin, platelet	0.064
Hif1a	hypoxia inducible factor 1, alpha subunit	0.062
Notch1	Notch gene homolog 1 (Drosophila)	0.059
Pax2	paired box gene 2	0.056
Ptch1	patched homolog 1	0.055
Wls	wntless homolog (Drosophila)	0.054
Zic3	zinc finger protein of the cerebellum 3	0.053
Cdon	cell adhesion molecule-related/down-regulated by oncogenes	0.052
Itgal	integrin alpha L	0.051	Mouse
Emx1	empty spiracles homolog 1 (Drosophila)	0.050
Tbx1	T-box 1	0.049
Msx2	homeobox, msh-like 2	0.047
Alx4	aristaless-like homeobox 4	0.046
Ece1	endothelin converting enzyme 1	0.045
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.045
Pax6	paired box gene 6	0.044
She	src homology 2 domain-containing transforming protein E	0.044
Zeb1	zinc finger E-box binding homeobox 1	0.043
Pkd1	polycystic kidney disease 1 homolog	0.043
Lrp6	low density lipoprotein receptor-related protein 6	0.041	Mouse
Alx1	ALX homeobox 1	0.041
Nog	noggin	0.041
Smad3	MAD homolog 3 (Drosophila)	0.041
P2rx1	purinergic receptor P2X, ligand-gated ion channel, 1	0.038
Hand2	heart and neural crest derivatives expressed transcript 2	0.038
Gata3	GATA binding protein 3	0.037	Mouse
Erbb3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.036
Mapk8ip1	mitogen-activated protein kinase 8 interacting protein 1	0.036
Twsg1	twisted gastrulation homolog 1 (Drosophila)	0.035
Epas1	endothelial PAS domain protein 1	0.035
Acvrl1	activin A receptor, type II-like 1	0.035
Apaf1	apoptotic peptidase activating factor 1	0.035
Axin1	axin 1	0.034
Pdgfb	platelet derived growth factor, B polypeptide	0.034
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.032
Msx1	homeobox, msh-like 1	0.032
Prrx2	paired related homeobox 2	0.032
Itga5	integrin alpha 5 (fibronectin receptor alpha)	0.031	Mouse
Bmp5	bone morphogenetic protein 5	0.031
Smad4	MAD homolog 4 (Drosophila)	0.031
Lmna	lamin A	0.031
Sfn	stratifin	0.030
Bmper	BMP-binding endothelial regulator	0.030
Foxa2	forkhead box A2	0.029
Eya1	eyes absent 1 homolog (Drosophila)	0.028
Foxg1	forkhead box G1	0.028
Kit	kit oncogene	0.028
Dll1	delta-like 1 (Drosophila)	0.026
Tcf21	transcription factor 21	0.026
Spn	sialophorin	0.025
Pick1	protein interacting with C kinase 1	0.025
Foxf1a	forkhead box F1a	0.025
Runx1	runt related transcription factor 1	0.024
Pten	phosphatase and tensin homolog	0.024
Cdkn1a	cyclin-dependent kinase inhibitor 1A (P21)	0.023
Thbs1	thrombospondin 1	0.022
Inpp5d	inositol polyphosphate-5-phosphatase D	0.022
Ric8	resistance to inhibitors of cholinesterase 8 homolog (C. elegans)	0.022
Gp9	glycoprotein 9 (platelet)	0.021
Fgf3	fibroblast growth factor 3	0.020
Col4a2	collagen, type IV, alpha 2	0.020
Lama5	laminin, alpha 5	0.020
Gli2	GLI-Kruppel family member GLI2	0.019
Cfc1	cripto, FRL-1, cryptic family 1	0.019
Nkx2-1	NK2 homeobox 1	0.019
Gsk3b	glycogen synthase kinase 3 beta	0.019
Sox17	SRY-box containing gene 17	0.018	Mouse
Muc13	mucin 13, epithelial transmembrane	0.018
Fgr	Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog	0.018
Hprt	hypoxanthine guanine phosphoribosyl transferase	0.018
Foxc2	forkhead box C2	0.017
Sall4	sal-like 4 (Drosophila)	0.017
Tbx2	T-box 2	0.017
Cdkn1b	cyclin-dependent kinase inhibitor 1B	0.017
Fgfrl1	fibroblast growth factor receptor-like 1	0.017
Gp5	glycoprotein 5 (platelet)	0.017
Ikzf1	IKAROS family zinc finger 1	0.017
Myo1f	myosin IF	0.017
Wnt3a	wingless-related MMTV integration site 3A	0.016
Pitx1	paired-like homeodomain transcription factor 1	0.016
Snai1	snail homolog 1 (Drosophila)	0.016
Rdh10	retinol dehydrogenase 10 (all-trans)	0.016
Hoxa1	homeobox A1	0.016
Lrp5	low density lipoprotein receptor-related protein 5	0.016
Smad7	MAD homolog 7 (Drosophila)	0.016
Cdh5	cadherin 5	0.016
Six4	sine oculis-related homeobox 4 homolog (Drosophila)	0.016
Hhat	hedgehog acyltransferase	0.015
Phex	phosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets)	0.015
Elf4	E74-like factor 4 (ets domain transcription factor)	0.014
Csf3r	colony stimulating factor 3 receptor (granulocyte)	0.014
Sox11	SRY-box containing gene 11	0.014	Mouse
Bmp1	bone morphogenetic protein 1	0.014
Tal1	T-cell acute lymphocytic leukemia 1	0.014
Hey2	hairy/enhancer-of-split related with YRPW motif 2	0.014
Mmp9	matrix metallopeptidase 9	0.014
Gna15	guanine nucleotide binding protein, alpha 15	0.014
Alx3	aristaless-like homeobox 3	0.014
Tgfa	transforming growth factor alpha	0.014
Adcy4	adenylate cyclase 4	0.014
Dok2	docking protein 2	0.013
Gas1	growth arrest specific 1	0.013
Tdgf1	teratocarcinoma-derived growth factor 1	0.013
Rarb	retinoic acid receptor, beta	0.013
Ptprb	protein tyrosine phosphatase, receptor type, B	0.013
Yap1	yes-associated protein 1	0.013
Ext1	exostoses (multiple) 1	0.013
Col4a3	collagen, type IV, alpha 3	0.013
Ptgs2	prostaglandin-endoperoxide synthase 2	0.013
Klf3	Kruppel-like factor 3 (basic)	0.013
Emx2	empty spiracles homolog 2 (Drosophila)	0.012
Pofut1	protein O-fucosyltransferase 1	0.012
Dact1	dapper homolog 1, antagonist of beta-catenin (xenopus)	0.012
Erbb2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.012
Gpr132	G protein-coupled receptor 132	0.012
Vhl	von Hippel-Lindau tumor suppressor	0.012
Bmp2	bone morphogenetic protein 2	0.012
Fn1	fibronectin 1	0.012
Fuz	fuzzy homolog (Drosophila)	0.012
Rarg	retinoic acid receptor, gamma	0.012
Zfpm2	zinc finger protein, multitype 2	0.011
Braf	Braf transforming gene	0.011
Bmpr2	bone morphogenic protein receptor, type II (serine/threonine kinase)	0.011
Ednrb	endothelin receptor type B	0.011
Mitf	microphthalmia-associated transcription factor	0.011
Pthlh	parathyroid hormone-like peptide	0.011
Il27ra	interleukin 27 receptor, alpha	0.011
Crebbp	CREB binding protein	0.011
Abl1	c-abl oncogene 1, non-receptor tyrosine kinase	0.011
Fgf4	fibroblast growth factor 4	0.011
Nrg1	neuregulin 1	0.010
Kdr	kinase insert domain protein receptor	0.010
Abl2	v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)	0.010	Mouse
Cd6	CD6 antigen	0.010
Tspo2	translocator protein 2	0.010
Jun	Jun oncogene	0.010
Cxcr3	chemokine (C-X-C motif) receptor 3	0.010
Ciita	class II transactivator	0.010
Tead4	TEA domain family member 4	0.010