IMP

Process View

Mus musculus

1 genes annotated in mouse

negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis

GO:2000164

Any process that stops, prevents, or reduces the frequency, rate or extent of planar cell polarity pathway involved in outflow tract morphogenesis.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis" (in gray)

Name	Description	Probability	Func Analog Organism
Fgfr2	fibroblast growth factor receptor 2	1.000
Ctnnb1	catenin (cadherin associated protein), beta 1	0.990
Fgfr1	fibroblast growth factor receptor 1	0.984
Shh	sonic hedgehog	0.977
Bmp4	bone morphogenetic protein 4	0.976
Gli3	GLI-Kruppel family member GLI3	0.945
Smo	smoothened homolog (Drosophila)	0.819
Tbx3	T-box 3	0.773
Fgfr3	fibroblast growth factor receptor 3	0.704
Mapk8ip1	mitogen-activated protein kinase 8 interacting protein 1	0.700
Vangl2	vang-like 2 (van gogh, Drosophila)	0.696
Lrp6	low density lipoprotein receptor-related protein 6	0.659
Gsk3b	glycogen synthase kinase 3 beta	0.630
Pkd1	polycystic kidney disease 1 homolog	0.615
Apoe	apolipoprotein E	0.594
Foxc1	forkhead box C1	0.541
Axin1	axin 1	0.526
Bmp7	bone morphogenetic protein 7	0.418
Ndst1	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	0.395
Cebpa	CCAAT/enhancer binding protein (C/EBP), alpha	0.393
Msx1	homeobox, msh-like 1	0.367
Zeb1	zinc finger E-box binding homeobox 1	0.342
Foxc2	forkhead box C2	0.335
Npc1	Niemann Pick type C1	0.292
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.288
Pax3	paired box gene 3	0.288
Psen1	presenilin 1	0.280
Otx2	orthodenticle homolog 2 (Drosophila)	0.279
Mmp14	matrix metallopeptidase 14 (membrane-inserted)	0.278
Runx2	runt related transcription factor 2	0.256
Fgf8	fibroblast growth factor 8	0.240
Prrx2	paired related homeobox 2	0.239
Prrx1	paired related homeobox 1	0.238
Pitx2	paired-like homeodomain transcription factor 2	0.231
Apc	adenomatosis polyposis coli	0.219
Hspg2	perlecan (heparan sulfate proteoglycan 2)	0.203
Ptch1	patched homolog 1	0.176
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.167
Jag1	jagged 1	0.158
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.148
Tgfb2	transforming growth factor, beta 2	0.147
Rarg	retinoic acid receptor, gamma	0.139
Eya1	eyes absent 1 homolog (Drosophila)	0.134
Sertad2	SERTA domain containing 2	0.131
Msx2	homeobox, msh-like 2	0.121
Plin1	perilipin 1	0.118
Lrp5	low density lipoprotein receptor-related protein 5	0.114	Mouse
App	amyloid beta (A4) precursor protein	0.114
Pbx1	pre B-cell leukemia transcription factor 1	0.106
Sox11	SRY-box containing gene 11	0.101
Sox9	SRY-box containing gene 9	0.096
Abca1	ATP-binding cassette, sub-family A (ABC1), member 1	0.094
Smad6	MAD homolog 6 (Drosophila)	0.094
Tcfap2a	transcription factor AP-2, alpha	0.093
Foxg1	forkhead box G1	0.090
Pparg	peroxisome proliferator activated receptor gamma	0.087
Gli2	GLI-Kruppel family member GLI2	0.083
Itgb5	integrin beta 5	0.083
Hand1	heart and neural crest derivatives expressed transcript 1	0.077
Egfr	epidermal growth factor receptor	0.076
Vegfa	vascular endothelial growth factor A	0.076
Lef1	lymphoid enhancer binding factor 1	0.074
Crtc3	CREB regulated transcription coactivator 3	0.072
Ldlr	low density lipoprotein receptor	0.071
Rarb	retinoic acid receptor, beta	0.068
Nos3	nitric oxide synthase 3, endothelial cell	0.066
Hes1	hairy and enhancer of split 1 (Drosophila)	0.064
Bmpr1a	bone morphogenetic protein receptor, type 1A	0.060
Chrd	chordin	0.057
Tbx1	T-box 1	0.057
Twsg1	twisted gastrulation homolog 1 (Drosophila)	0.056
Pofut1	protein O-fucosyltransferase 1	0.054
Ece1	endothelin converting enzyme 1	0.053
Apaf1	apoptotic peptidase activating factor 1	0.051
Klf15	Kruppel-like factor 15	0.051
Pdgfrb	platelet derived growth factor receptor, beta polypeptide	0.051
Bmp2	bone morphogenetic protein 2	0.050
Six4	sine oculis-related homeobox 4 homolog (Drosophila)	0.050
Rxra	retinoid X receptor alpha	0.050
Dlx5	distal-less homeobox 5	0.048
Rara	retinoic acid receptor, alpha	0.048
T	brachyury	0.047
Itga3	integrin alpha 3	0.047
Pten	phosphatase and tensin homolog	0.046
Tenc1	tensin like C1 domain-containing phosphatase	0.045
Pick1	protein interacting with C kinase 1	0.043
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.042
Foxa2	forkhead box A2	0.041
Notch2	Notch gene homolog 2 (Drosophila)	0.041
Wls	wntless homolog (Drosophila)	0.040
Phex	phosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets)	0.040
Chd7	chromodomain helicase DNA binding protein 7	0.040
Col1a1	collagen, type I, alpha 1	0.040
Bmp5	bone morphogenetic protein 5	0.039
Hoxa1	homeobox A1	0.039
Sorbs3	sorbin and SH3 domain containing 3	0.038
Agtr2	angiotensin II receptor, type 2	0.037
Gpc3	glypican 3	0.035
Gbx2	gastrulation brain homeobox 2	0.035
Wnt5a	wingless-related MMTV integration site 5A	0.035
Rspo2	R-spondin 2 homolog (Xenopus laevis)	0.034
Cav1	caveolin 1, caveolae protein	0.034
Gas1	growth arrest specific 1	0.034
Wdr19	WD repeat domain 19	0.032
Dact1	dapper homolog 1, antagonist of beta-catenin (xenopus)	0.031
Pax6	paired box gene 6	0.031
Wnt3a	wingless-related MMTV integration site 3A	0.030
Npr2	natriuretic peptide receptor 2	0.030
Acvr1	activin A receptor, type 1	0.029
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.029
Col4a3	collagen, type IV, alpha 3	0.028
Pax2	paired box gene 2	0.026
Mesdc2	mesoderm development candidate 2	0.026
Tnks1bp1	tankyrase 1 binding protein 1	0.026
Sox2	SRY-box containing gene 2	0.026
Efnb2	ephrin B2	0.026
Rdh10	retinol dehydrogenase 10 (all-trans)	0.025
Trp63	transformation related protein 63	0.025
Nodal	nodal	0.022
Tcf7l1	transcription factor 7-like 1 (T-cell specific, HMG box)	0.022
Fn1	fibronectin 1	0.022
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.021
Ltbr	lymphotoxin B receptor	0.021
Mks1	Meckel syndrome, type 1	0.021
Bmper	BMP-binding endothelial regulator	0.021
Mertk	c-mer proto-oncogene tyrosine kinase	0.020
Ptprf	protein tyrosine phosphatase, receptor type, F	0.020
Igf1r	insulin-like growth factor I receptor	0.020
Otx1	orthodenticle homolog 1 (Drosophila)	0.020
Lpin1	lipin 1	0.020
Slc12a1	solute carrier family 12, member 1	0.020
Ift88	intraflagellar transport 88 homolog (Chlamydomonas)	0.020
Fgfrl1	fibroblast growth factor receptor-like 1	0.019
Gpx3	glutathione peroxidase 3	0.018
Bmp1	bone morphogenetic protein 1	0.018
Gsc	goosecoid homeobox	0.018
Igfbp4	insulin-like growth factor binding protein 4	0.017
Crebbp	CREB binding protein	0.017
Ctdsp1	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1	0.017
Mmp2	matrix metallopeptidase 2	0.016
Anpep	alanyl (membrane) aminopeptidase	0.016
Efnb1	ephrin B1	0.016
Numb	numb gene homolog (Drosophila)	0.016
Hoxa5	homeobox A5	0.016
Tbx2	T-box 2	0.015
Cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.015
Ptk7	PTK7 protein tyrosine kinase 7	0.015
H6pd	hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)	0.015
Lrp4	low density lipoprotein receptor-related protein 4	0.015	Mouse
Aldh1a2	aldehyde dehydrogenase family 1, subfamily A2	0.015
Emx2	empty spiracles homolog 2 (Drosophila)	0.015
Bmpr2	bone morphogenic protein receptor, type II (serine/threonine kinase)	0.015
Alx1	ALX homeobox 1	0.015
Ski	ski sarcoma viral oncogene homolog (avian)	0.015
Lamb2	laminin, beta 2	0.015
Lepr	leptin receptor	0.014
Glg1	golgi apparatus protein 1	0.014
Irf6	interferon regulatory factor 6	0.014
Notch1	Notch gene homolog 1 (Drosophila)	0.013
Ctnnd1	catenin (cadherin associated protein), delta 1	0.013
Sox13	SRY-box containing gene 13	0.013
Col4a4	collagen, type IV, alpha 4	0.013
Sall4	sal-like 4 (Drosophila)	0.013
Cdon	cell adhesion molecule-related/down-regulated by oncogenes	0.012
Yap1	yes-associated protein 1	0.012
Grb7	growth factor receptor bound protein 7	0.012
Smagp	small cell adhesion glycoprotein	0.012
Pitx1	paired-like homeodomain transcription factor 1	0.012
Cldn6	claudin 6	0.012
Bcl2	B-cell leukemia/lymphoma 2	0.012
Hoxa2	homeobox A2	0.012
Ncoa3	nuclear receptor coactivator 3	0.011
Htt	huntingtin	0.011
Gja1	gap junction protein, alpha 1	0.011
Ptpn21	protein tyrosine phosphatase, non-receptor type 21	0.011
Ext1	exostoses (multiple) 1	0.011
Mn1	meningioma 1	0.011
Irs1	insulin receptor substrate 1	0.011
Jup	junction plakoglobin	0.011
Cdkn1a	cyclin-dependent kinase inhibitor 1A (P21)	0.011
Cdkn1c	cyclin-dependent kinase inhibitor 1C (P57)	0.011
Tmem150a	transmembrane protein 150A	0.011
Tgfbr2	transforming growth factor, beta receptor II	0.010
Ppap2b	phosphatidic acid phosphatase type 2B	0.010
Thra	thyroid hormone receptor alpha	0.010
Tbx15	T-box 15	0.010
Zfhx3	zinc finger homeobox 3	0.010
Col18a1	collagen, type XVIII, alpha 1	0.010
Kif3a	kinesin family member 3A	0.010
Ghr	growth hormone receptor	0.010