IMP

Process View

Mus musculus

1 genes annotated in mouse

regulation of planar cell polarity pathway involved in neural tube closure

GO:2000167

Any process that modulates the frequency, rate or extent of planar cell polarity pathway involved in neural tube closure.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "regulation of planar cell polarity pathway involved in neural tube closure"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "regulation of planar cell polarity pathway involved in neural tube closure" (in gray)

Name	Description	Probability	Func Analog Organism
Fgfr2	fibroblast growth factor receptor 2	1.000
Shh	sonic hedgehog	0.989
Bmp4	bone morphogenetic protein 4	0.986
Fgfr1	fibroblast growth factor receptor 1	0.985
Gli3	GLI-Kruppel family member GLI3	0.983
Ctnnb1	catenin (cadherin associated protein), beta 1	0.971
Smo	smoothened homolog (Drosophila)	0.905
Foxc1	forkhead box C1	0.817
Vangl2	vang-like 2 (van gogh, Drosophila)	0.755
Fgfr3	fibroblast growth factor receptor 3	0.738
Bmp7	bone morphogenetic protein 7	0.684
Msx1	homeobox, msh-like 1	0.672
Tbx3	T-box 3	0.669
Foxc2	forkhead box C2	0.611
Mapk8ip1	mitogen-activated protein kinase 8 interacting protein 1	0.599
Apoe	apolipoprotein E	0.595
Pax3	paired box gene 3	0.583
Meox2	mesenchyme homeobox 2	0.542
Prrx1	paired related homeobox 1	0.538
Fgf8	fibroblast growth factor 8	0.467
Pkd1	polycystic kidney disease 1 homolog	0.466
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.456
Gsk3b	glycogen synthase kinase 3 beta	0.455
Pitx2	paired-like homeodomain transcription factor 2	0.447
Otx2	orthodenticle homolog 2 (Drosophila)	0.435
Axin1	axin 1	0.373
Zeb1	zinc finger E-box binding homeobox 1	0.365
Tgfb2	transforming growth factor, beta 2	0.358
Lrp6	low density lipoprotein receptor-related protein 6	0.354
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.341
Eya1	eyes absent 1 homolog (Drosophila)	0.324
Ndst1	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	0.317
Tcfap2a	transcription factor AP-2, alpha	0.300
Runx2	runt related transcription factor 2	0.291
Msx2	homeobox, msh-like 2	0.284
Mmp14	matrix metallopeptidase 14 (membrane-inserted)	0.266
Psen1	presenilin 1	0.265
Gli2	GLI-Kruppel family member GLI2	0.247
Cebpa	CCAAT/enhancer binding protein (C/EBP), alpha	0.235
Sox9	SRY-box containing gene 9	0.225
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.215
Prrx2	paired related homeobox 2	0.199
Foxg1	forkhead box G1	0.196
Jag1	jagged 1	0.187
Rarg	retinoic acid receptor, gamma	0.170
Dlx5	distal-less homeobox 5	0.168
Ptch1	patched homolog 1	0.168
Tbx1	T-box 1	0.167
Hand1	heart and neural crest derivatives expressed transcript 1	0.154
Sox11	SRY-box containing gene 11	0.147
Npc1	Niemann Pick type C1	0.135
Chrd	chordin	0.129
Pbx1	pre B-cell leukemia transcription factor 1	0.117
Lrp5	low density lipoprotein receptor-related protein 5	0.107	Mouse
Abca1	ATP-binding cassette, sub-family A (ABC1), member 1	0.094
Gbx2	gastrulation brain homeobox 2	0.092
Rarb	retinoic acid receptor, beta	0.090
Six4	sine oculis-related homeobox 4 homolog (Drosophila)	0.088
Rspo2	R-spondin 2 homolog (Xenopus laevis)	0.086
Apc	adenomatosis polyposis coli	0.084
Hoxa1	homeobox A1	0.083
Sertad2	SERTA domain containing 2	0.079
Smad6	MAD homolog 6 (Drosophila)	0.076
Bmp2	bone morphogenetic protein 2	0.074
T	brachyury	0.071
Hspg2	perlecan (heparan sulfate proteoglycan 2)	0.068
Egfr	epidermal growth factor receptor	0.060
Chd7	chromodomain helicase DNA binding protein 7	0.058
Lef1	lymphoid enhancer binding factor 1	0.053
Pick1	protein interacting with C kinase 1	0.051
Rara	retinoic acid receptor, alpha	0.049
Ece1	endothelin converting enzyme 1	0.049
Fn1	fibronectin 1	0.047
Itga3	integrin alpha 3	0.047
Phex	phosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets)	0.045
Hes1	hairy and enhancer of split 1 (Drosophila)	0.045
Vegfa	vascular endothelial growth factor A	0.044
Sox2	SRY-box containing gene 2	0.043
Pax2	paired box gene 2	0.042
Fgfrl1	fibroblast growth factor receptor-like 1	0.041
Bmpr1a	bone morphogenetic protein receptor, type 1A	0.040
Wnt3a	wingless-related MMTV integration site 3A	0.039
Acvr1	activin A receptor, type 1	0.038
Wnt5a	wingless-related MMTV integration site 5A	0.037
Pofut1	protein O-fucosyltransferase 1	0.036
Bmp5	bone morphogenetic protein 5	0.035
Gas1	growth arrest specific 1	0.035
Twsg1	twisted gastrulation homolog 1 (Drosophila)	0.035
App	amyloid beta (A4) precursor protein	0.032
Pdgfrb	platelet derived growth factor receptor, beta polypeptide	0.032
Apaf1	apoptotic peptidase activating factor 1	0.032
Kif3a	kinesin family member 3A	0.031
Gsc	goosecoid homeobox	0.030
Mks1	Meckel syndrome, type 1	0.030
Foxa2	forkhead box A2	0.030
Efnb2	ephrin B2	0.030
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.029
Agtr2	angiotensin II receptor, type 2	0.029
Klf15	Kruppel-like factor 15	0.028
Gpc3	glypican 3	0.028
Lrp2	low density lipoprotein receptor-related protein 2	0.028	Mouse
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.027
Crtc3	CREB regulated transcription coactivator 3	0.027
Wls	wntless homolog (Drosophila)	0.027
Nodal	nodal	0.027
Rxra	retinoid X receptor alpha	0.027
Pparg	peroxisome proliferator activated receptor gamma	0.026
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.026
Tenc1	tensin like C1 domain-containing phosphatase	0.025
Aldh1a2	aldehyde dehydrogenase family 1, subfamily A2	0.025
Bmper	BMP-binding endothelial regulator	0.025
Tcf7l1	transcription factor 7-like 1 (T-cell specific, HMG box)	0.024
Dact1	dapper homolog 1, antagonist of beta-catenin (xenopus)	0.024
Smpd3	sphingomyelin phosphodiesterase 3, neutral	0.023
Otx1	orthodenticle homolog 1 (Drosophila)	0.023
Ptk7	PTK7 protein tyrosine kinase 7	0.023
Tnks1bp1	tankyrase 1 binding protein 1	0.023
Alx1	ALX homeobox 1	0.023
Sall4	sal-like 4 (Drosophila)	0.023
Col4a3	collagen, type IV, alpha 3	0.023
Notch2	Notch gene homolog 2 (Drosophila)	0.023
Npy2r	neuropeptide Y receptor Y2	0.022
Rdh10	retinol dehydrogenase 10 (all-trans)	0.022
Hoxa2	homeobox A2	0.022
Trp63	transformation related protein 63	0.021
Zic3	zinc finger protein of the cerebellum 3	0.021
Nos3	nitric oxide synthase 3, endothelial cell	0.021
Hand2	heart and neural crest derivatives expressed transcript 2	0.020
Ldlr	low density lipoprotein receptor	0.020
Npr2	natriuretic peptide receptor 2	0.020
Tbx15	T-box 15	0.018
Mesdc2	mesoderm development candidate 2	0.018
Bmp1	bone morphogenetic protein 1	0.018
Ednra	endothelin receptor type A	0.018
Fgf10	fibroblast growth factor 10	0.018
Efnb1	ephrin B1	0.017
Nog	noggin	0.017
Pitx1	paired-like homeodomain transcription factor 1	0.017
Ncor2	nuclear receptor co-repressor 2	0.017
H6pd	hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)	0.017
Twist2	twist homolog 2 (Drosophila)	0.016
Ncoa3	nuclear receptor coactivator 3	0.016
Dkk1	dickkopf homolog 1 (Xenopus laevis)	0.016
Tbx2	T-box 2	0.016
Lrp4	low density lipoprotein receptor-related protein 4	0.016	Mouse
Ptprf	protein tyrosine phosphatase, receptor type, F	0.016
Hoxa5	homeobox A5	0.016
Pax9	paired box gene 9	0.016
Ift88	intraflagellar transport 88 homolog (Chlamydomonas)	0.015
Irf6	interferon regulatory factor 6	0.014
Gja1	gap junction protein, alpha 1	0.014
Mn1	meningioma 1	0.014
Plin1	perilipin 1	0.014
Igf1r	insulin-like growth factor I receptor	0.014
En1	engrailed 1	0.014
Gpx3	glutathione peroxidase 3	0.014
Col4a4	collagen, type IV, alpha 4	0.014
Sox4	SRY-box containing gene 4	0.013
Ltbr	lymphotoxin B receptor	0.013
Glg1	golgi apparatus protein 1	0.013
Itgb5	integrin beta 5	0.013
Pax6	paired box gene 6	0.012
Fgf9	fibroblast growth factor 9	0.012
Anpep	alanyl (membrane) aminopeptidase	0.012
Emx2	empty spiracles homolog 2 (Drosophila)	0.012
Grb7	growth factor receptor bound protein 7	0.012
Pcsk5	proprotein convertase subtilisin/kexin type 5	0.012
Numb	numb gene homolog (Drosophila)	0.012
Sox13	SRY-box containing gene 13	0.012
Col1a1	collagen, type I, alpha 1	0.011
Hoxd11	homeobox D11	0.011
Cav1	caveolin 1, caveolae protein	0.011
Ctnnd1	catenin (cadherin associated protein), delta 1	0.011
Crebbp	CREB binding protein	0.011
Jup	junction plakoglobin	0.011
Mertk	c-mer proto-oncogene tyrosine kinase	0.011
Lpin1	lipin 1	0.011
Igfbp4	insulin-like growth factor binding protein 4	0.010
Pkdcc	protein kinase domain containing, cytoplasmic	0.010
Cdon	cell adhesion molecule-related/down-regulated by oncogenes	0.010
Lama5	laminin, alpha 5	0.010
Tgfbr2	transforming growth factor, beta receptor II	0.010