IMP

Process View

Mus musculus

1 genes annotated in mouse

negative regulation of planar cell polarity pathway involved in pericardium morphogenesis

GO:2000166

Any process that stops, prevents, or reduces the frequency, rate or extent of planar cell polarity pathway involved in pericardium morphogenesis.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of planar cell polarity pathway involved in pericardium morphogenesis"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of planar cell polarity pathway involved in pericardium morphogenesis" (in gray)

Name	Description	Probability	Func Analog Organism
Fgfr2	fibroblast growth factor receptor 2	1.000
Fgfr1	fibroblast growth factor receptor 1	1.000
Bmp4	bone morphogenetic protein 4	1.000
Ctnnb1	catenin (cadherin associated protein), beta 1	1.000
Shh	sonic hedgehog	1.000
Gli3	GLI-Kruppel family member GLI3	1.000
Smo	smoothened homolog (Drosophila)	0.997
Foxc1	forkhead box C1	0.989
Fgfr3	fibroblast growth factor receptor 3	0.988
Vangl2	vang-like 2 (van gogh, Drosophila)	0.983
Pkd1	polycystic kidney disease 1 homolog	0.982
Tbx3	T-box 3	0.964
Foxc2	forkhead box C2	0.957
Bmp7	bone morphogenetic protein 7	0.955
Msx1	homeobox, msh-like 1	0.936
Prrx1	paired related homeobox 1	0.935
Mapk8ip1	mitogen-activated protein kinase 8 interacting protein 1	0.934
Tgfb2	transforming growth factor, beta 2	0.927
Gsk3b	glycogen synthase kinase 3 beta	0.919
Mmp14	matrix metallopeptidase 14 (membrane-inserted)	0.910
Zeb1	zinc finger E-box binding homeobox 1	0.901
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.890
Apoe	apolipoprotein E	0.876
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.870
Pax3	paired box gene 3	0.869
Pitx2	paired-like homeodomain transcription factor 2	0.860
Ndst1	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	0.847
Lrp6	low density lipoprotein receptor-related protein 6	0.840
Psen1	presenilin 1	0.826
Meox2	mesenchyme homeobox 2	0.817
Runx2	runt related transcription factor 2	0.807
Sox9	SRY-box containing gene 9	0.791
Ptch1	patched homolog 1	0.789
Otx2	orthodenticle homolog 2 (Drosophila)	0.775
Gli2	GLI-Kruppel family member GLI2	0.769
Axin1	axin 1	0.764
Rarg	retinoic acid receptor, gamma	0.735
Apc	adenomatosis polyposis coli	0.728
Hspg2	perlecan (heparan sulfate proteoglycan 2)	0.710
Fgf8	fibroblast growth factor 8	0.693
Col1a1	collagen, type I, alpha 1	0.680
Cebpa	CCAAT/enhancer binding protein (C/EBP), alpha	0.674
Dlx5	distal-less homeobox 5	0.668
Jag1	jagged 1	0.597
Npc1	Niemann Pick type C1	0.593
Eya1	eyes absent 1 homolog (Drosophila)	0.583
Tcfap2a	transcription factor AP-2, alpha	0.574
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.565
Prrx2	paired related homeobox 2	0.544
Sox11	SRY-box containing gene 11	0.535
Pbx1	pre B-cell leukemia transcription factor 1	0.527
Msx2	homeobox, msh-like 2	0.485
Chrd	chordin	0.457
Vegfa	vascular endothelial growth factor A	0.456
Nos3	nitric oxide synthase 3, endothelial cell	0.452
Egfr	epidermal growth factor receptor	0.400
Foxg1	forkhead box G1	0.397
Pdgfrb	platelet derived growth factor receptor, beta polypeptide	0.395
Rarb	retinoic acid receptor, beta	0.358
Pten	phosphatase and tensin homolog	0.329
Tbx1	T-box 1	0.326
Hand1	heart and neural crest derivatives expressed transcript 1	0.325
Bmpr1a	bone morphogenetic protein receptor, type 1A	0.324
Smad6	MAD homolog 6 (Drosophila)	0.324
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.318
Sertad2	SERTA domain containing 2	0.299
Lrp5	low density lipoprotein receptor-related protein 5	0.280	Mouse
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.276
Ece1	endothelin converting enzyme 1	0.265
Bmp2	bone morphogenetic protein 2	0.253
Itga3	integrin alpha 3	0.240
Acvr1	activin A receptor, type 1	0.234
Wnt5a	wingless-related MMTV integration site 5A	0.226
Pparg	peroxisome proliferator activated receptor gamma	0.218
Rspo2	R-spondin 2 homolog (Xenopus laevis)	0.211
Abca1	ATP-binding cassette, sub-family A (ABC1), member 1	0.207
Gas1	growth arrest specific 1	0.202
Rara	retinoic acid receptor, alpha	0.201
Hes1	hairy and enhancer of split 1 (Drosophila)	0.198
Six4	sine oculis-related homeobox 4 homolog (Drosophila)	0.193
Twsg1	twisted gastrulation homolog 1 (Drosophila)	0.186
Tenc1	tensin like C1 domain-containing phosphatase	0.185
Rxra	retinoid X receptor alpha	0.181
Gbx2	gastrulation brain homeobox 2	0.177
Lef1	lymphoid enhancer binding factor 1	0.173
Apaf1	apoptotic peptidase activating factor 1	0.162
T	brachyury	0.154
Pofut1	protein O-fucosyltransferase 1	0.153
Efnb2	ephrin B2	0.151
Chd7	chromodomain helicase DNA binding protein 7	0.134
Phex	phosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets)	0.130
Gpc3	glypican 3	0.128
Pax2	paired box gene 2	0.126
Cav1	caveolin 1, caveolae protein	0.126
Notch2	Notch gene homolog 2 (Drosophila)	0.125
Bmp5	bone morphogenetic protein 5	0.123
App	amyloid beta (A4) precursor protein	0.118
Dact1	dapper homolog 1, antagonist of beta-catenin (xenopus)	0.118
Mks1	Meckel syndrome, type 1	0.116
Sox2	SRY-box containing gene 2	0.115
Npr2	natriuretic peptide receptor 2	0.112
Wls	wntless homolog (Drosophila)	0.112
Hoxa1	homeobox A1	0.102
Ldlr	low density lipoprotein receptor	0.100
Crtc3	CREB regulated transcription coactivator 3	0.095
Tcf7l1	transcription factor 7-like 1 (T-cell specific, HMG box)	0.089
Klf15	Kruppel-like factor 15	0.087
Foxa2	forkhead box A2	0.085
Lrp4	low density lipoprotein receptor-related protein 4	0.084	Mouse
Agtr2	angiotensin II receptor, type 2	0.082
Ptk7	PTK7 protein tyrosine kinase 7	0.079
Wnt3a	wingless-related MMTV integration site 3A	0.079
Igf1r	insulin-like growth factor I receptor	0.077
Efnb1	ephrin B1	0.077
Bmper	BMP-binding endothelial regulator	0.076
Tgfbr2	transforming growth factor, beta receptor II	0.075
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.073
Aldh1a2	aldehyde dehydrogenase family 1, subfamily A2	0.067
Gja1	gap junction protein, alpha 1	0.067
Ltbr	lymphotoxin B receptor	0.066
Rdh10	retinol dehydrogenase 10 (all-trans)	0.062
Fgfrl1	fibroblast growth factor receptor-like 1	0.062
Crebbp	CREB binding protein	0.062
Tnks1bp1	tankyrase 1 binding protein 1	0.062
Twist2	twist homolog 2 (Drosophila)	0.057
Tbx2	T-box 2	0.057
Sox4	SRY-box containing gene 4	0.056
Alx1	ALX homeobox 1	0.056
Ednra	endothelin receptor type A	0.055
Bmp1	bone morphogenetic protein 1	0.054
Nodal	nodal	0.052
Hoxa5	homeobox A5	0.051
Fn1	fibronectin 1	0.050
Sorbs3	sorbin and SH3 domain containing 3	0.048
Cdkn1a	cyclin-dependent kinase inhibitor 1A (P21)	0.048
Nf1	neurofibromatosis 1	0.047
Nog	noggin	0.047
Ift88	intraflagellar transport 88 homolog (Chlamydomonas)	0.046
Itgb5	integrin beta 5	0.046
Notch1	Notch gene homolog 1 (Drosophila)	0.045
Jup	junction plakoglobin	0.044
Lep	leptin	0.043
Mesdc2	mesoderm development candidate 2	0.043
Glg1	golgi apparatus protein 1	0.043
Trp63	transformation related protein 63	0.042
Kif3a	kinesin family member 3A	0.042
Bmpr2	bone morphogenic protein receptor, type II (serine/threonine kinase)	0.042
Hand2	heart and neural crest derivatives expressed transcript 2	0.042
Col4a3	collagen, type IV, alpha 3	0.041
Gpx3	glutathione peroxidase 3	0.041
Gsc	goosecoid homeobox	0.040
Thra	thyroid hormone receptor alpha	0.039
Smad3	MAD homolog 3 (Drosophila)	0.038
Zic3	zinc finger protein of the cerebellum 3	0.037
Igfbp4	insulin-like growth factor binding protein 4	0.036
Otx1	orthodenticle homolog 1 (Drosophila)	0.036
Pkdcc	protein kinase domain containing, cytoplasmic	0.035
Lmna	lamin A	0.035
Numb	numb gene homolog (Drosophila)	0.034
Mn1	meningioma 1	0.034
Cdon	cell adhesion molecule-related/down-regulated by oncogenes	0.034
Pcsk5	proprotein convertase subtilisin/kexin type 5	0.033
Esr1	estrogen receptor 1 (alpha)	0.033
Lpin1	lipin 1	0.032
Ephb4	Eph receptor B4	0.032
Fgf9	fibroblast growth factor 9	0.030
Ptprf	protein tyrosine phosphatase, receptor type, F	0.030
Chuk	conserved helix-loop-helix ubiquitous kinase	0.030
Ext1	exostoses (multiple) 1	0.030
Yap1	yes-associated protein 1	0.030
Mertk	c-mer proto-oncogene tyrosine kinase	0.029
Anpep	alanyl (membrane) aminopeptidase	0.028
Tbx15	T-box 15	0.028
Sox13	SRY-box containing gene 13	0.027
Il6st	interleukin 6 signal transducer	0.027
Lama5	laminin, alpha 5	0.026
Lepr	leptin receptor	0.026
Ctnnd1	catenin (cadherin associated protein), delta 1	0.025
Fgf10	fibroblast growth factor 10	0.025
Pitx1	paired-like homeodomain transcription factor 1	0.025
Zfhx3	zinc finger homeobox 3	0.025
Cdkn1c	cyclin-dependent kinase inhibitor 1C (P57)	0.025
Fzd1	frizzled homolog 1 (Drosophila)	0.024
Adam17	a disintegrin and metallopeptidase domain 17	0.023
H6pd	hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)	0.023
Pthlh	parathyroid hormone-like peptide	0.023
Pax6	paired box gene 6	0.023
Hoxa2	homeobox A2	0.023
Lrp2	low density lipoprotein receptor-related protein 2	0.023	Mouse
Ptms	parathymosin	0.023
Wwc2	WW, C2 and coiled-coil domain containing 2	0.023
Emx2	empty spiracles homolog 2 (Drosophila)	0.022
Bcl2	B-cell leukemia/lymphoma 2	0.022
Leprel2	leprecan-like 2	0.022
Irf6	interferon regulatory factor 6	0.021
Fuz	fuzzy homolog (Drosophila)	0.021
Htt	huntingtin	0.021
Crim1	cysteine rich transmembrane BMP regulator 1 (chordin like)	0.021
Sall4	sal-like 4 (Drosophila)	0.020
Cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.020
Tcf21	transcription factor 21	0.020
Fzd2	frizzled homolog 2 (Drosophila)	0.020
Tmem150a	transmembrane protein 150A	0.020
Tcf7l2	transcription factor 7-like 2, T-cell specific, HMG-box	0.019
Fbn1	fibrillin 1	0.019
Plin1	perilipin 1	0.019
Dll1	delta-like 1 (Drosophila)	0.019
Ptk2	PTK2 protein tyrosine kinase 2	0.018
Dlg1	discs, large homolog 1 (Drosophila)	0.018
Lamb2	laminin, beta 2	0.017
Xrn1	5'-3' exoribonuclease 1	0.017
Wdr19	WD repeat domain 19	0.017
Ncoa3	nuclear receptor coactivator 3	0.017
Col4a4	collagen, type IV, alpha 4	0.017
Pltp	phospholipid transfer protein	0.017
Hhat	hedgehog acyltransferase	0.017
Nfia	nuclear factor I/A	0.017
Kl	klotho	0.017
Dkk1	dickkopf homolog 1 (Xenopus laevis)	0.017
Ppap2b	phosphatidic acid phosphatase type 2B	0.016
Fbln1	fibulin 1	0.016
Cdc42ep1	CDC42 effector protein (Rho GTPase binding) 1	0.016
Chd4	chromodomain helicase DNA binding protein 4	0.016
Tshz1	teashirt zinc finger family member 1	0.016
Slc9a3r2	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2	0.016
Smagp	small cell adhesion glycoprotein	0.016
Itga8	integrin alpha 8	0.016
Zbtb20	zinc finger and BTB domain containing 20	0.015
Mmp2	matrix metallopeptidase 2	0.015
Smad2	MAD homolog 2 (Drosophila)	0.015
Ghr	growth hormone receptor	0.015
Dag1	dystroglycan 1	0.015
Smtn	smoothelin	0.015
Pkd2	polycystic kidney disease 2	0.015
Ptpn14	protein tyrosine phosphatase, non-receptor type 14	0.014
Grb7	growth factor receptor bound protein 7	0.014
Amotl2	angiomotin-like 2	0.014
Ptpn21	protein tyrosine phosphatase, non-receptor type 21	0.014
Ncor2	nuclear receptor co-repressor 2	0.014
Epas1	endothelial PAS domain protein 1	0.014
Dab1	disabled homolog 1 (Drosophila)	0.014
Col18a1	collagen, type XVIII, alpha 1	0.014
Jag2	jagged 2	0.013
Gtf2ird1	general transcription factor II I repeat domain-containing 1	0.013
Pax9	paired box gene 9	0.013
Vdr	vitamin D receptor	0.013
Dlg4	discs, large homolog 4 (Drosophila)	0.013
Sema3f	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F	0.013
Fzd8	frizzled homolog 8 (Drosophila)	0.013
Trp53	transformation related protein 53	0.013
Notch3	Notch gene homolog 3 (Drosophila)	0.013
Ltbp4	latent transforming growth factor beta binding protein 4	0.013
Kif7	kinesin family member 7	0.013
Nfic	nuclear factor I/C	0.013
Smpd3	sphingomyelin phosphodiesterase 3, neutral	0.012
Marveld1	MARVEL (membrane-associating) domain containing 1	0.012
Rest	RE1-silencing transcription factor	0.012
Lima1	LIM domain and actin binding 1	0.012
Nfib	nuclear factor I/B	0.012
Ctnna1	catenin (cadherin associated protein), alpha 1	0.012
Frem1	Fras1 related extracellular matrix protein 1	0.012
En1	engrailed 1	0.012
Folr1	folate receptor 1 (adult)	0.011
Smad4	MAD homolog 4 (Drosophila)	0.011
Ski	ski sarcoma viral oncogene homolog (avian)	0.011
Stab1	stabilin 1	0.011
Six5	sine oculis-related homeobox 5 homolog (Drosophila)	0.011
Braf	Braf transforming gene	0.011
Arap3	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3	0.011
Ihh	Indian hedgehog	0.011
Nbl1	neuroblastoma, suppression of tumorigenicity 1	0.011
Ppargc1a	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	0.011
Sulf2	sulfatase 2	0.011
Zc3h11a	zinc finger CCCH type containing 11A	0.011
Flt1	FMS-like tyrosine kinase 1	0.011
Nr2f2	nuclear receptor subfamily 2, group F, member 2	0.011
Pcdh1	protocadherin 1	0.011
Nrbp2	nuclear receptor binding protein 2	0.010
Cdh1	cadherin 1	0.010
Hsd3b7	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7	0.010
Hoxa3	homeobox A3	0.010
Pdgfb	platelet derived growth factor, B polypeptide	0.010
Rtkn	rhotekin	0.010
Smad7	MAD homolog 7 (Drosophila)	0.010
Inppl1	inositol polyphosphate phosphatase-like 1	0.010
Fzd7	frizzled homolog 7 (Drosophila)	0.010
Akap9	A kinase (PRKA) anchor protein (yotiao) 9	0.010
Adcy6	adenylate cyclase 6	0.010
Cxadr	coxsackie virus and adenovirus receptor	0.010
Acvr2b	activin receptor IIB	0.010
Nab2	Ngfi-A binding protein 2	0.010
Idua	iduronidase, alpha-L-	0.010