IMP

Process View

Mus musculus

2 genes annotated in mouse

regulation of transcription involved in primary germ layer cell fate commitment

Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that results in cells adopting an endoderm, ectoderm or mesoderm cell fate.

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "regulation of transcription involved in primary germ layer cell fate commitment"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "regulation of transcription involved in primary germ layer cell fate commitment" (in gray)

Name	Description	Probability	Func Analog Organism
Shh	sonic hedgehog	1.000
Fgfr2	fibroblast growth factor receptor 2	1.000
Bmp4	bone morphogenetic protein 4	1.000	Zebrafish
Gli3	GLI-Kruppel family member GLI3	1.000
Foxc1	forkhead box C1	1.000
Pax3	paired box gene 3	1.000
Isl1	ISL1 transcription factor, LIM/homeodomain	1.000
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.999
Fgf8	fibroblast growth factor 8	0.999
Tcfap2a	transcription factor AP-2, alpha	0.999
Eya1	eyes absent 1 homolog (Drosophila)	0.999
Otx2	orthodenticle homolog 2 (Drosophila)	0.997
Tgfb2	transforming growth factor, beta 2	0.996
Tbx1	T-box 1	0.995
Pitx2	paired-like homeodomain transcription factor 2	0.995
Sox9	SRY-box containing gene 9	0.995	Mouse
Prrx1	paired related homeobox 1	0.993
Foxc2	forkhead box C2	0.992
Smo	smoothened homolog (Drosophila)	0.991
Fgfr1	fibroblast growth factor receptor 1	0.990
Msx1	homeobox, msh-like 1	0.989
Hand2	heart and neural crest derivatives expressed transcript 2	0.988
Meox2	mesenchyme homeobox 2	0.987
Bmp7	bone morphogenetic protein 7	0.983
Hand1	heart and neural crest derivatives expressed transcript 1	0.980
Zeb1	zinc finger E-box binding homeobox 1	0.979
Pax6	paired box gene 6	0.978
Ctnnb1	catenin (cadherin associated protein), beta 1	0.977
Ednra	endothelin receptor type A	0.971
Rarb	retinoic acid receptor, beta	0.969
Pax2	paired box gene 2	0.964
Dlx5	distal-less homeobox 5	0.956
Rarg	retinoic acid receptor, gamma	0.949
Chd7	chromodomain helicase DNA binding protein 7	0.939
Jag1	jagged 1	0.933
Vegfa	vascular endothelial growth factor A	0.915
Efnb2	ephrin B2	0.905
Foxg1	forkhead box G1	0.900
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.893
Ntf3	neurotrophin 3	0.881
Gbx2	gastrulation brain homeobox 2	0.873
Fgfr3	fibroblast growth factor receptor 3	0.856
Sox2	SRY-box containing gene 2	0.855	Mouse
Gli2	GLI-Kruppel family member GLI2	0.848
Gata4	GATA binding protein 4	0.810
Fgf10	fibroblast growth factor 10	0.773
Sox11	SRY-box containing gene 11	0.756	Mouse
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.755
Chrd	chordin	0.735
Rara	retinoic acid receptor, alpha	0.696
Hoxa1	homeobox A1	0.672
Hes1	hairy and enhancer of split 1 (Drosophila)	0.660
Nf1	neurofibromatosis 1	0.623
Aldh1a2	aldehyde dehydrogenase family 1, subfamily A2	0.615
Acvr1	activin A receptor, type 1	0.600
Sox4	SRY-box containing gene 4	0.592	Mouse
Vangl2	vang-like 2 (van gogh, Drosophila)	0.589
Pbx1	pre B-cell leukemia transcription factor 1	0.544
Nog	noggin	0.522
Alx4	aristaless-like homeobox 4	0.519
Msx2	homeobox, msh-like 2	0.511
Rspo2	R-spondin 2 homolog (Xenopus laevis)	0.497
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.478
Otx1	orthodenticle homolog 1 (Drosophila)	0.473
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.470
Six4	sine oculis-related homeobox 4 homolog (Drosophila)	0.469
Gsc	goosecoid homeobox	0.459
Prrx2	paired related homeobox 2	0.453
Alx1	ALX homeobox 1	0.423
Emx2	empty spiracles homolog 2 (Drosophila)	0.399
Rxra	retinoid X receptor alpha	0.381
Lef1	lymphoid enhancer binding factor 1	0.376
Runx2	runt related transcription factor 2	0.360
Hoxa3	homeobox A3	0.306
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.288
Hesx1	homeobox gene expressed in ES cells	0.273
Ece1	endothelin converting enzyme 1	0.273
Ptch1	patched homolog 1	0.269
Ret	ret proto-oncogene	0.268
Bmper	BMP-binding endothelial regulator	0.256
Pou5f1	POU domain, class 5, transcription factor 1	0.242
Bmpr1a	bone morphogenetic protein receptor, type 1A	0.234
Bmp2	bone morphogenetic protein 2	0.232
Lmx1b	LIM homeobox transcription factor 1 beta	0.231
Fgf3	fibroblast growth factor 3	0.195
Mesp1	mesoderm posterior 1	0.189
Sall4	sal-like 4 (Drosophila)	0.182
Cdh5	cadherin 5	0.167
Col2a1	collagen, type II, alpha 1	0.163
Etv4	ets variant gene 4 (E1A enhancer binding protein, E1AF)	0.161	Mouse
Sall3	sal-like 3 (Drosophila)	0.156
Pitx1	paired-like homeodomain transcription factor 1	0.152
Rasip1	Ras interacting protein 1	0.146
Emx1	empty spiracles homolog 1 (Drosophila)	0.141
Lrp6	low density lipoprotein receptor-related protein 6	0.138
Trp53	transformation related protein 53	0.120
Lhx1	LIM homeobox protein 1	0.113
Hey1	hairy/enhancer-of-split related with YRPW motif 1	0.105
Hes5	hairy and enhancer of split 5 (Drosophila)	0.101
Hey2	hairy/enhancer-of-split related with YRPW motif 2	0.095
Foxi3	forkhead box I3	0.094
Alx3	aristaless-like homeobox 3	0.094
Tbx3	T-box 3	0.090
Zic3	zinc finger protein of the cerebellum 3	0.087
Hoxa2	homeobox A2	0.086
Nanog	Nanog homeobox	0.082
Lmx1a	LIM homeobox transcription factor 1 alpha	0.081
Dlx6	distal-less homeobox 6	0.081
Tbx10	T-box 10	0.079
Ascl1	achaete-scute complex homolog 1 (Drosophila)	0.079
Atoh7	atonal homolog 7 (Drosophila)	0.079
Lhx3	LIM homeobox protein 3	0.078
Cited2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	0.078
Esam	endothelial cell-specific adhesion molecule	0.073
Nrg1	neuregulin 1	0.073
Tbx15	T-box 15	0.073
Pax9	paired box gene 9	0.073
Smad6	MAD homolog 6 (Drosophila)	0.071
Fgf4	fibroblast growth factor 4	0.071
Gata3	GATA binding protein 3	0.070
Rdh10	retinol dehydrogenase 10 (all-trans)	0.070
Gata6	GATA binding protein 6	0.070
Rb1	retinoblastoma 1	0.066
Tcof1	Treacher Collins Franceschetti syndrome 1, homolog	0.065
Tbx2	T-box 2	0.065
Bdnf	brain derived neurotrophic factor	0.064
Insm1	insulinoma-associated 1	0.063
En1	engrailed 1	0.062
Hhex	hematopoietically expressed homeobox	0.062
Gja1	gap junction protein, alpha 1	0.060
Apc	adenomatosis polyposis coli	0.060
Ednrb	endothelin receptor type B	0.059
Dlx2	distal-less homeobox 2	0.059
Crebbp	CREB binding protein	0.057
She	src homology 2 domain-containing transforming protein E	0.057
En2	engrailed 2	0.057
Nodal	nodal	0.056
Erbb3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.055
Pou4f2	POU domain, class 4, transcription factor 2	0.054
Notch1	Notch gene homolog 1 (Drosophila)	0.054
Zic2	zinc finger protein of the cerebellum 2	0.054
Hmx3	H6 homeobox 3	0.054
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.052
Tcfap2c	transcription factor AP-2, gamma	0.052
Edar	ectodysplasin-A receptor	0.050
Neurod1	neurogenic differentiation 1	0.050
Gdnf	glial cell line derived neurotrophic factor	0.049
Sox17	SRY-box containing gene 17	0.048
Dlx1	distal-less homeobox 1	0.048
Adam17	a disintegrin and metallopeptidase domain 17	0.047
Tgfbr2	transforming growth factor, beta receptor II	0.046
Gja4	gap junction protein, alpha 4	0.044
Foxd2	forkhead box D2	0.040
Ndst1	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	0.040
Sall1	sal-like 1 (Drosophila)	0.040
Hoxd13	homeobox D13	0.040
Pou3f3	POU domain, class 3, transcription factor 3	0.038
Mn1	meningioma 1	0.037
Trp63	transformation related protein 63	0.036
Dkk1	dickkopf homolog 1 (Xenopus laevis)	0.036
Kdr	kinase insert domain protein receptor	0.036
Ngfr	nerve growth factor receptor (TNFR superfamily, member 16)	0.035
Tie1	tyrosine kinase with immunoglobulin-like and EGF-like domains 1	0.035
Bmp5	bone morphogenetic protein 5	0.035
Pou4f3	POU domain, class 4, transcription factor 3	0.034
Gas1	growth arrest specific 1	0.034
Cldn5	claudin 5	0.034
Epha4	Eph receptor A4	0.033
Pou3f1	POU domain, class 3, transcription factor 1	0.032
Wnt3a	wingless-related MMTV integration site 3A	0.031
Sult4a1	sulfotransferase family 4A, member 1	0.031
Chrna4	cholinergic receptor, nicotinic, alpha polypeptide 4	0.030
Hoxb13	homeobox B13	0.030
Cdx1	caudal type homeobox 1	0.030
Pkd1	polycystic kidney disease 1 homolog	0.029
Hoxb3	homeobox B3	0.028
Hoxa5	homeobox A5	0.028
Olig2	oligodendrocyte transcription factor 2	0.028
Pthlh	parathyroid hormone-like peptide	0.028
Hoxd11	homeobox D11	0.027
Hhat	hedgehog acyltransferase	0.027
Foxf2	forkhead box F2	0.027
Tcf15	transcription factor 15	0.026
Nkx2-2	NK2 transcription factor related, locus 2 (Drosophila)	0.026
Neurog2	neurogenin 2	0.026
Nkx6-1	NK6 homeobox 1	0.026
Fgfrl1	fibroblast growth factor receptor-like 1	0.026
Hoxa13	homeobox A13	0.025
Six3	sine oculis-related homeobox 3 homolog (Drosophila)	0.025
Tcf21	transcription factor 21	0.025
Rbpj	recombination signal binding protein for immunoglobulin kappa J region	0.024
Kif3a	kinesin family member 3A	0.024
Twsg1	twisted gastrulation homolog 1 (Drosophila)	0.024
Kcnh3	potassium voltage-gated channel, subfamily H (eag-related), member 3	0.024
Lrp2	low density lipoprotein receptor-related protein 2	0.023
Bmp6	bone morphogenetic protein 6	0.023
Flt1	FMS-like tyrosine kinase 1	0.023
Nrtn	neurturin	0.023
Prkd2	protein kinase D2	0.023
Etv1	ets variant gene 1	0.022	Mouse
Ikbkap	inhibitor of kappa light polypeptide enhancer in B-cells, kinase complex-associated protein	0.022
Phox2b	paired-like homeobox 2b	0.022
Slc25a29	solute carrier family 25 (mitochondrial carrier, palmitoylcarnitine transporter), member 29	0.022
Rhox6	reproductive homeobox 6	0.022
Adam19	a disintegrin and metallopeptidase domain 19 (meltrin beta)	0.022
Efna1	ephrin A1	0.021
Myl7	myosin, light polypeptide 7, regulatory	0.021
Ihh	Indian hedgehog	0.021
Foxe3	forkhead box E3	0.020
Emcn	endomucin	0.020
Six2	sine oculis-related homeobox 2 homolog (Drosophila)	0.020
Smad7	MAD homolog 7 (Drosophila)	0.020
Erbb2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.020
Sox18	SRY-box containing gene 18	0.020	Mouse
Nr2f1	nuclear receptor subfamily 2, group F, member 1	0.020
Wnt6	wingless-related MMTV integration site 6	0.020
Yap1	yes-associated protein 1	0.019
Tgfa	transforming growth factor alpha	0.019
Nkx2-3	NK2 transcription factor related, locus 3 (Drosophila)	0.019
Pds5b	PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)	0.019
Ebf3	early B-cell factor 3	0.019
Elk3	ELK3, member of ETS oncogene family	0.019
Kcnc4	potassium voltage gated channel, Shaw-related subfamily, member 4	0.019
Sfn	stratifin	0.018
Ski	ski sarcoma viral oncogene homolog (avian)	0.018
Myo6	myosin VI	0.018
Foxh1	forkhead box H1	0.018
Zfp42	zinc finger protein 42	0.018
Dlg1	discs, large homolog 1 (Drosophila)	0.018
Irx5	Iroquois related homeobox 5 (Drosophila)	0.018
Zfp503	zinc finger protein 503	0.018
Notch3	Notch gene homolog 3 (Drosophila)	0.018
Fuz	fuzzy homolog (Drosophila)	0.018
Dll1	delta-like 1 (Drosophila)	0.018
Nkx2-4	NK2 transcription factor related, locus 4 (Drosophila)	0.017
Gfra1	glial cell line derived neurotrophic factor family receptor alpha 1	0.017
Mks1	Meckel syndrome, type 1	0.017
Onecut1	one cut domain, family member 1	0.017
Hoxa4	homeobox A4	0.017
Wnt1	wingless-related MMTV integration site 1	0.017
Id4	inhibitor of DNA binding 4	0.017
Zic1	zinc finger protein of the cerebellum 1	0.017
Lefty1	left right determination factor 1	0.016
Hspg2	perlecan (heparan sulfate proteoglycan 2)	0.016
Kcnk2	potassium channel, subfamily K, member 2	0.016
Id1	inhibitor of DNA binding 1	0.016
Fli1	Friend leukemia integration 1	0.016
Bcl2	B-cell leukemia/lymphoma 2	0.016
Icam2	intercellular adhesion molecule 2	0.016
Klk8	kallikrein related-peptidase 8	0.016
Ptpn14	protein tyrosine phosphatase, non-receptor type 14	0.016
Nkx2-1	NK2 homeobox 1	0.016
Apaf1	apoptotic peptidase activating factor 1	0.016
Tshz1	teashirt zinc finger family member 1	0.016
Mitf	microphthalmia-associated transcription factor	0.015
Uncx	UNC homeobox	0.015
Tgif2	TGFB-induced factor homeobox 2	0.015
Gh	growth hormone	0.015
Lbx1	ladybird homeobox homolog 1 (Drosophila)	0.015
Jun	Jun oncogene	0.015
Sema5b	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B	0.015
Ptk7	PTK7 protein tyrosine kinase 7	0.015
Cxcr4	chemokine (C-X-C motif) receptor 4	0.015
Hoxd3	homeobox D3	0.015
Egfr	epidermal growth factor receptor	0.015
Zfpm2	zinc finger protein, multitype 2	0.015
Psen1	presenilin 1	0.015
Bcan	brevican	0.015
Btbd17	BTB (POZ) domain containing 17	0.015
Tnfrsf19	tumor necrosis factor receptor superfamily, member 19	0.015
Irx1	Iroquois related homeobox 1 (Drosophila)	0.014
Lgr4	leucine-rich repeat-containing G protein-coupled receptor 4	0.014
Efnb3	ephrin B3	0.014
Epas1	endothelial PAS domain protein 1	0.014
Ptprb	protein tyrosine phosphatase, receptor type, B	0.014
Chrm4	cholinergic receptor, muscarinic 4	0.014
Hoxb6	homeobox B6	0.014
Foxd1	forkhead box D1	0.014
Npr3	natriuretic peptide receptor 3	0.014
Fhl3	four and a half LIM domains 3	0.014
Cdon	cell adhesion molecule-related/down-regulated by oncogenes	0.014
Ntrk2	neurotrophic tyrosine kinase, receptor, type 2	0.014
Nrp1	neuropilin 1	0.014
Ikzf1	IKAROS family zinc finger 1	0.014
Gimap4	GTPase, IMAP family member 4	0.014
Phex	phosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets)	0.014
Plxnd1	plexin D1	0.014
Wnt5a	wingless-related MMTV integration site 5A	0.014
Aplnr	apelin receptor	0.014
Pyy	peptide YY	0.014
Pax7	paired box gene 7	0.014
Lhx5	LIM homeobox protein 5	0.014
Cux1	cut-like homeobox 1	0.013
Wnt4	wingless-related MMTV integration site 4	0.013
Cxcl12	chemokine (C-X-C motif) ligand 12	0.013
Foxl2	forkhead box L2	0.013
Mapk12	mitogen-activated protein kinase 12	0.013
Xpo4	exportin 4	0.013
Tek	endothelial-specific receptor tyrosine kinase	0.013
Satb2	special AT-rich sequence binding protein 2	0.013
Foxa2	forkhead box A2	0.013
BC024139	cDNA sequence BC024139	0.013
Fzd4	frizzled homolog 4 (Drosophila)	0.013
Nfib	nuclear factor I/B	0.013
Meis2	Meis homeobox 2	0.013
Axin2	axin2	0.013
Dazl	deleted in azoospermia-like	0.013
Fam43a	family with sequence similarity 43, member A	0.013
Dusp9	dual specificity phosphatase 9	0.013
Kank3	KN motif and ankyrin repeat domains 3	0.013
Tpbg	trophoblast glycoprotein	0.013
Efna2	ephrin A2	0.012
Wnt9b	wingless-type MMTV integration site 9B	0.012
Dusp6	dual specificity phosphatase 6	0.012
Col13a1	collagen, type XIII, alpha 1	0.012
Dll3	delta-like 3 (Drosophila)	0.012
Hes3	hairy and enhancer of split 3 (Drosophila)	0.012
Lhx2	LIM homeobox protein 2	0.012
Psg17	pregnancy specific glycoprotein 17	0.012
Efna4	ephrin A4	0.012
Adam3	a disintegrin and metallopeptidase domain 3 (cyritestin)	0.012
Tcte2	t-complex-associated testis expressed 2	0.012
Spry2	sprouty homolog 2 (Drosophila)	0.012
Tcerg1l	transcription elongation regulator 1-like	0.012
Hmga2	high mobility group AT-hook 2	0.012
Slc12a2	solute carrier family 12, member 2	0.012
Krt17	keratin 17	0.012
Efs	embryonal Fyn-associated substrate	0.012
Lhx6	LIM homeobox protein 6	0.012
Pofut1	protein O-fucosyltransferase 1	0.012
Stmn2	stathmin-like 2	0.012
Eda	ectodysplasin-A	0.012
Ccnd1	cyclin D1	0.012
Foxf1a	forkhead box F1a	0.012
Trp73	transformation related protein 73	0.012
Fzd8	frizzled homolog 8 (Drosophila)	0.012
Lrp4	low density lipoprotein receptor-related protein 4	0.012
Pou3f4	POU domain, class 3, transcription factor 4	0.012
Dusp7	dual specificity phosphatase 7	0.012
Sox21	SRY-box containing gene 21	0.012
Itga8	integrin alpha 8	0.011
Plac1	placental specific protein 1	0.011
Tcf7l1	transcription factor 7-like 1 (T-cell specific, HMG box)	0.011
Dock1	dedicator of cytokinesis 1	0.011
Rcor2	REST corepressor 2	0.011
Cabp7	calcium binding protein 7	0.011
Sox1	SRY-box containing gene 1	0.011
Eltd1	EGF, latrophilin seven transmembrane domain containing 1	0.011
Foxj1	forkhead box J1	0.011
Phlda2	pleckstrin homology-like domain, family A, member 2	0.011
Hoxa9	homeobox A9	0.011
Hdac1	histone deacetylase 1	0.011
Ripply3	ripply3 homolog (zebrafish)	0.011
Prdm16	PR domain containing 16	0.011
Tlx2	T-cell leukemia, homeobox 2	0.011
Ptch2	patched homolog 2	0.011
Tulp2	tubby-like protein 2	0.011
Vstm2b	V-set and transmembrane domain containing 2B	0.011
Ext1	exostoses (multiple) 1	0.011
Arx	aristaless related homeobox	0.011
Irx4	Iroquois related homeobox 4 (Drosophila)	0.011
Nkx3-2	NK3 homeobox 2	0.011
Prdm1	PR domain containing 1, with ZNF domain	0.011
Npas1	neuronal PAS domain protein 1	0.011
Ldb2	LIM domain binding 2	0.010
Gcom1	GRINL1A complex locus	0.010
Nr0b1	nuclear receptor subfamily 0, group B, member 1	0.010
Apln	apelin	0.010
Dll4	delta-like 4 (Drosophila)	0.010
Cbln1	cerebellin 1 precursor protein	0.010
Fgf15	fibroblast growth factor 15	0.010
Pten	phosphatase and tensin homolog	0.010
Isl2	insulin related protein 2 (islet 2)	0.010
Tlx3	T-cell leukemia, homeobox 3	0.010
Nr2e1	nuclear receptor subfamily 2, group E, member 1	0.010
Id3	inhibitor of DNA binding 3	0.010
Hif1a	hypoxia inducible factor 1, alpha subunit	0.010
Cdc42ep1	CDC42 effector protein (Rho GTPase binding) 1	0.010
Cbx2	chromobox homolog 2 (Drosophila Pc class)	0.010
Gpc3	glypican 3	0.010
Mkl2	MKL/myocardin-like 2	0.010