IMP

Process View

Mus musculus

14 genes annotated in mouse

response to cocaine

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cocaine stimulus. Cocaine is a crystalline alkaloid obtained from the leaves of the coca plant.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "response to cocaine"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "response to cocaine" (in gray)

Name	Description	Probability	Func Analog Organism
Grin1	glutamate receptor, ionotropic, NMDA1 (zeta 1)	1.000
Drd2	dopamine receptor D2	1.000
Slc6a3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	0.999
Mef2d	myocyte enhancer factor 2D	0.963
Nos1	nitric oxide synthase 1, neuronal	0.959	Rat
Chrnb4	cholinergic receptor, nicotinic, beta polypeptide 4	0.865	Mouse
Pparg	peroxisome proliferator activated receptor gamma	0.861
Drd1a	dopamine receptor D1A	0.852
Chrnb2	cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal)	0.728
Emx1	empty spiracles homolog 1 (Drosophila)	0.656
Grin2b	glutamate receptor, ionotropic, NMDA2B (epsilon 2)	0.639	Rat
Grm1	glutamate receptor, metabotropic 1	0.627	Mouse
Ntrk2	neurotrophic tyrosine kinase, receptor, type 2	0.610
Lhx3	LIM homeobox protein 3	0.581
Htr5a	5-hydroxytryptamine (serotonin) receptor 5A	0.538	Mouse
Homer1	homer homolog 1 (Drosophila)	0.476
Lepr	leptin receptor	0.458
Pnpla2	patatin-like phospholipase domain containing 2	0.457
Kl	klotho	0.447
Lep	leptin	0.376
Chrna3	cholinergic receptor, nicotinic, alpha polypeptide 3	0.326	Mouse
Shank2	SH3/ankyrin domain gene 2	0.317
Ar	androgen receptor	0.292
Plcg1	phospholipase C, gamma 1	0.277
Esr1	estrogen receptor 1 (alpha)	0.251
Npy2r	neuropeptide Y receptor Y2	0.250
Prkaca	protein kinase, cAMP dependent, catalytic, alpha	0.247
Dlgap1	discs, large (Drosophila) homolog-associated protein 1	0.220
Insr	insulin receptor	0.219	Fly
Slc18a2	solute carrier family 18 (vesicular monoamine), member 2	0.209	Rat
Htr1a	5-hydroxytryptamine (serotonin) receptor 1A	0.200	Mouse
Camk2a	calcium/calmodulin-dependent protein kinase II alpha	0.196
Kiss1	KiSS-1 metastasis-suppressor	0.189
Ncor2	nuclear receptor co-repressor 2	0.170
Pomc	pro-opiomelanocortin-alpha	0.150
Gnas	GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus	0.147
Npy1r	neuropeptide Y receptor Y1	0.138
Dlg2	discs, large homolog 2 (Drosophila)	0.137
Cdk5r1	cyclin-dependent kinase 5, regulatory subunit 1 (p35)	0.134
Per1	period homolog 1 (Drosophila)	0.132
Kcnq2	potassium voltage-gated channel, subfamily Q, member 2	0.128
Nf1	neurofibromatosis 1	0.122
Chrna4	cholinergic receptor, nicotinic, alpha polypeptide 4	0.118	Mouse
Rp1	retinitis pigmentosa 1 (human)	0.115
Chrna6	cholinergic receptor, nicotinic, alpha polypeptide 6	0.115	Mouse
Bsn	bassoon	0.113
Cckbr	cholecystokinin B receptor	0.111
Kcna1	potassium voltage-gated channel, shaker-related subfamily, member 1	0.108
Crhr1	corticotropin releasing hormone receptor 1	0.107	Rat
Shc3	src homology 2 domain-containing transforming protein C3	0.100
Kcnj6	potassium inwardly-rectifying channel, subfamily J, member 6	0.095
Grb10	growth factor receptor bound protein 10	0.087
Oprk1	opioid receptor, kappa 1	0.087
Ins2	insulin II	0.086
Adrb2	adrenergic receptor, beta 2	0.084	Mouse
Nr3c1	nuclear receptor subfamily 3, group C, member 1	0.082
Foxd2	forkhead box D2	0.082
Adra2b	adrenergic receptor, alpha 2b	0.081	Mouse
Grik2	glutamate receptor, ionotropic, kainate 2 (beta 2)	0.081
Kcnma1	potassium large conductance calcium-activated channel, subfamily M, alpha member 1	0.080
Cnr1	cannabinoid receptor 1 (brain)	0.074	Rat
Nab2	Ngfi-A binding protein 2	0.072
Htr4	5 hydroxytryptamine (serotonin) receptor 4	0.072	Mouse
Grin2a	glutamate receptor, ionotropic, NMDA2A (epsilon 1)	0.071	Rat
Pitx3	paired-like homeodomain transcription factor 3	0.068
Hrh1	histamine receptor H1	0.067
Chrna10	cholinergic receptor, nicotinic, alpha polypeptide 10	0.067	Mouse
Esr2	estrogen receptor 2 (beta)	0.066
Gjd2	gap junction protein, delta 2	0.060
Stk32b	serine/threonine kinase 32B	0.059
Gpr26	G protein-coupled receptor 26	0.058
Pgr	progesterone receptor	0.057	Rat
Cyp19a1	cytochrome P450, family 19, subfamily a, polypeptide 1	0.054
Ptgs2	prostaglandin-endoperoxide synthase 2	0.053
Gpr12	G-protein coupled receptor 12	0.050
Epha6	Eph receptor A6	0.048
Npy5r	neuropeptide Y receptor Y5	0.048
Igf2r	insulin-like growth factor 2 receptor	0.047
Kcnv1	potassium channel, subfamily V, member 1	0.044
Mef2c	myocyte enhancer factor 2C	0.044
Irs2	insulin receptor substrate 2	0.044
Wwox	WW domain-containing oxidoreductase	0.043
Atp4a	ATPase, H+/K+ exchanging, gastric, alpha polypeptide	0.043
Zp1	zona pellucida glycoprotein 1	0.042
Mc3r	melanocortin 3 receptor	0.041
Adcyap1	adenylate cyclase activating polypeptide 1	0.041
Dlg4	discs, large homolog 4 (Drosophila)	0.041
Sstr1	somatostatin receptor 1	0.040
Chrm1	cholinergic receptor, muscarinic 1, CNS	0.040
Nxph1	neurexophilin 1	0.039
B3gat1	beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)	0.038
Trpc5	transient receptor potential cation channel, subfamily C, member 5	0.038
Sstr4	somatostatin receptor 4	0.037
Opn1sw	opsin 1 (cone pigments), short-wave-sensitive (color blindness, tritan)	0.037
Cacng2	calcium channel, voltage-dependent, gamma subunit 2	0.035
Glra1	glycine receptor, alpha 1 subunit	0.034
Rs1	retinoschisis (X-linked, juvenile) 1 (human)	0.034
Myod1	myogenic differentiation 1	0.033
Cyp11a1	cytochrome P450, family 11, subfamily a, polypeptide 1	0.033
Adra1a	adrenergic receptor, alpha 1a	0.033	Mouse
Nsf	N-ethylmaleimide sensitive fusion protein	0.032
Gpr45	G protein-coupled receptor 45	0.032
Asap1	ArfGAP with SH# domain, ankyrin repeat and PH domain1	0.031
Fezf2	Fez family zinc finger 2	0.031
Gsx1	GS homeobox 1	0.031
Pde6a	phosphodiesterase 6A, cGMP-specific, rod, alpha	0.031
Drd4	dopamine receptor D4	0.030
Grid1	glutamate receptor, ionotropic, delta 1	0.030
Olfr155	olfactory receptor 155	0.030
Kcns2	K+ voltage-gated channel, subfamily S, 2	0.030
Adcy1	adenylate cyclase 1	0.029
Adora2a	adenosine A2a receptor	0.029
ND6	NADH dehydrogenase subunit 6	0.029
Syt10	synaptotagmin X	0.028
Psg17	pregnancy specific glycoprotein 17	0.027
Oprm1	opioid receptor, mu 1	0.027	Rat
Pde6b	phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide	0.027
Nrg3	neuregulin 3	0.027
Ppargc1a	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	0.027
Tectb	tectorin beta	0.026
Gabrg3	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 3	0.026
Prkce	protein kinase C, epsilon	0.025
Cga	glycoprotein hormones, alpha subunit	0.025
Cacna1b	calcium channel, voltage-dependent, N type, alpha 1B subunit	0.025
Dnm1	dynamin 1	0.024
Htr7	5-hydroxytryptamine (serotonin) receptor 7	0.024	Mouse
Neurod2	neurogenic differentiation 2	0.023
Cntn4	contactin 4	0.023
Nxph2	neurexophilin 2	0.023
Pcsk5	proprotein convertase subtilisin/kexin type 5	0.023
Onecut1	one cut domain, family member 1	0.022
Gria1	glutamate receptor, ionotropic, AMPA1 (alpha 1)	0.022
Snca	synuclein, alpha	0.022	Rat
Ptgfrn	prostaglandin F2 receptor negative regulator	0.022
Gad2	glutamic acid decarboxylase 2	0.022
AF529169	cDNA sequence AF529169	0.022
Prkcc	protein kinase C, gamma	0.021
Pspn	persephin	0.021
Arr3	arrestin 3, retinal	0.021
Gast	gastrin	0.021
Cnih3	cornichon homolog 3 (Drosophila)	0.021
Mas1	MAS1 oncogene	0.021
Kcnh1	potassium voltage-gated channel, subfamily H (eag-related), member 1	0.021
Lhx6	LIM homeobox protein 6	0.020
Cacna1e	calcium channel, voltage-dependent, R type, alpha 1E subunit	0.020
Colq	collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase	0.020
Hmx1	H6 homeobox 1	0.020
Col4a4	collagen, type IV, alpha 4	0.020
Tac2	tachykinin 2	0.019
Htr3b	5-hydroxytryptamine (serotonin) receptor 3B	0.019
Tnfrsf8	tumor necrosis factor receptor superfamily, member 8	0.019
Src	Rous sarcoma oncogene	0.019
Agxt	alanine-glyoxylate aminotransferase	0.019
Nr5a1	nuclear receptor subfamily 5, group A, member 1	0.019
Plcb1	phospholipase C, beta 1	0.019
Mef2a	myocyte enhancer factor 2A	0.019
Syt6	synaptotagmin VI	0.019
Baalc	brain and acute leukemia, cytoplasmic	0.019
Ids	iduronate 2-sulfatase	0.019
Sorcs3	sortilin-related VPS10 domain containing receptor 3	0.018
Cav1	caveolin 1, caveolae protein	0.018
Krtap5-1	keratin associated protein 5-1	0.018
Adcyap1r1	adenylate cyclase activating polypeptide 1 receptor 1	0.018
Kcnk4	potassium channel, subfamily K, member 4	0.018
Gabra2	gamma-aminobutyric acid (GABA) A receptor, subunit alpha 2	0.017
Gcgr	glucagon receptor	0.017
Cntn2	contactin 2	0.017
Psap	prosaposin	0.017
Stat5b	signal transducer and activator of transcription 5B	0.017
Hcrt	hypocretin	0.017
Sebox	SEBOX homeobox	0.017
Vipr2	vasoactive intestinal peptide receptor 2	0.017
Pick1	protein interacting with C kinase 1	0.017
B3galt1	UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1	0.016
Prnp	prion protein	0.016
Cit	citron	0.016
Ldb1	LIM domain binding 1	0.016
Upp2	uridine phosphorylase 2	0.016
Atp2b1	ATPase, Ca++ transporting, plasma membrane 1	0.016
Rit2	Ras-like without CAAX 2	0.016
Gzmm	granzyme M (lymphocyte met-ase 1)	0.016
Crygs	crystallin, gamma S	0.016
Fshb	follicle stimulating hormone beta	0.016
Kcna2	potassium voltage-gated channel, shaker-related subfamily, member 2	0.016
Sema5b	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B	0.016
Opn1mw	opsin 1 (cone pigments), medium-wave-sensitive (color blindness, deutan)	0.016
Lhx9	LIM homeobox protein 9	0.016
Trpm5	transient receptor potential cation channel, subfamily M, member 5	0.016
Six3	sine oculis-related homeobox 3 homolog (Drosophila)	0.016
Adra1b	adrenergic receptor, alpha 1b	0.016
Slc1a6	solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6	0.015
Gfra2	glial cell line derived neurotrophic factor family receptor alpha 2	0.015
Trfr2	transferrin receptor 2	0.015
Hdac4	histone deacetylase 4	0.015	Mouse
Plxna1	plexin A1	0.015
Agap3	ArfGAP with GTPase domain, ankyrin repeat and PH domain 3	0.015
Gria4	glutamate receptor, ionotropic, AMPA4 (alpha 4)	0.015
Cldn26	claudin 26	0.014
3110047P20Rik	RIKEN cDNA 3110047P20 gene	0.014
Cacng5	calcium channel, voltage-dependent, gamma subunit 5	0.014
Ntsr2	neurotensin receptor 2	0.014
Thrb	thyroid hormone receptor beta	0.014
Htr1b	5-hydroxytryptamine (serotonin) receptor 1B	0.014	Mouse Rat
Gpr83	G protein-coupled receptor 83	0.014
Prox1	prospero-related homeobox 1	0.014
Odz1	odd Oz/ten-m homolog 1 (Drosophila)	0.014
Kcnj9	potassium inwardly-rectifying channel, subfamily J, member 9	0.014
Atp2b2	ATPase, Ca++ transporting, plasma membrane 2	0.014
Il1rapl1	interleukin 1 receptor accessory protein-like 1	0.014
Tgfbr3	transforming growth factor, beta receptor III	0.014
Grm5	glutamate receptor, metabotropic 5	0.014	Mouse
Fut1	fucosyltransferase 1	0.014
Nmbr	neuromedin B receptor	0.014
Sult4a1	sulfotransferase family 4A, member 1	0.014
Igf2	insulin-like growth factor 2	0.014
Tacr3	tachykinin receptor 3	0.013	Rat
Fndc7	fibronectin type III domain containing 7	0.013
Kcnab3	potassium voltage-gated channel, shaker-related subfamily, beta member 3	0.013
Otog	otogelin	0.013
Foxn1	forkhead box N1	0.013
Snta1	syntrophin, acidic 1	0.013
Slc32a1	solute carrier family 32 (GABA vesicular transporter), member 1	0.013
Musk	muscle, skeletal, receptor tyrosine kinase	0.013
Npc1	Niemann Pick type C1	0.013
Dhh	desert hedgehog	0.013
Mc2r	melanocortin 2 receptor	0.013
Cer1	cerberus 1 homolog (Xenopus laevis)	0.013
Dlx4	distal-less homeobox 4	0.013
Nrip3	nuclear receptor interacting protein 3	0.013
Kcnd3	potassium voltage-gated channel, Shal-related family, member 3	0.012
Sst	somatostatin	0.012
Lipe	lipase, hormone sensitive	0.012
Olfr71	olfactory receptor 71	0.012
Ppyr1	pancreatic polypeptide receptor 1	0.012
Csmd1	CUB and Sushi multiple domains 1	0.012
Arntl	aryl hydrocarbon receptor nuclear translocator-like	0.012
Hdac5	histone deacetylase 5	0.012
En1	engrailed 1	0.012
Alk	anaplastic lymphoma kinase	0.012
Gp5	glycoprotein 5 (platelet)	0.012
Per3	period homolog 3 (Drosophila)	0.012
Wnt7b	wingless-related MMTV integration site 7B	0.012
Prlr	prolactin receptor	0.012
Syt1	synaptotagmin I	0.012
Dab2ip	disabled homolog 2 (Drosophila) interacting protein	0.012
Slurp1	secreted Ly6/Plaur domain containing 1	0.012
Pura	purine rich element binding protein A	0.012
St3gal2	ST3 beta-galactoside alpha-2,3-sialyltransferase 2	0.012
Neurod6	neurogenic differentiation 6	0.012
L1cam	L1 cell adhesion molecule	0.011
Per2	period homolog 2 (Drosophila)	0.011
Aff2	AF4/FMR2 family, member 2	0.011
Mog	myelin oligodendrocyte glycoprotein	0.011
Slc12a1	solute carrier family 12, member 1	0.011
Nr1h4	nuclear receptor subfamily 1, group H, member 4	0.011
Lpar5	lysophosphatidic acid receptor 5	0.011
Ms4a2	membrane-spanning 4-domains, subfamily A, member 2	0.011
Neto1	neuropilin (NRP) and tolloid (TLL)-like 1	0.011
Pde8b	phosphodiesterase 8B	0.011
Atxn1	ataxin 1	0.011
Htr1f	5-hydroxytryptamine (serotonin) receptor 1F	0.011	Mouse
Nxnl2	nucleoredoxin-like 2	0.011
Col4a3	collagen, type IV, alpha 3	0.011
Prph2	peripherin 2	0.011
Slc1a2	solute carrier family 1 (glial high affinity glutamate transporter), member 2	0.011
Apoa5	apolipoprotein A-V	0.011
Htr1d	5-hydroxytryptamine (serotonin) receptor 1D	0.011	Mouse
Serpina10	serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10	0.011
Bfsp1	beaded filament structural protein 1, in lens-CP94	0.011
Pcsk2	proprotein convertase subtilisin/kexin type 2	0.011
Rtbdn	retbindin	0.011
Grm2	glutamate receptor, metabotropic 2	0.011
Akt1	thymoma viral proto-oncogene 1	0.011
Vsx1	visual system homeobox 1 homolog (zebrafish)	0.011
Dio2	deiodinase, iodothyronine, type II	0.011
Trh	thyrotropin releasing hormone	0.011
Csnk1e	casein kinase 1, epsilon	0.011	Fly
Sln	sarcolipin	0.010
Bsnd	Bartter syndrome, infantile, with sensorineural deafness (Barttin)	0.010
Ski	ski sarcoma viral oncogene homolog (avian)	0.010
Fgf5	fibroblast growth factor 5	0.010
Klf7	Kruppel-like factor 7 (ubiquitous)	0.010
Prss30	protease, serine, 30	0.010
Akap9	A kinase (PRKA) anchor protein (yotiao) 9	0.010
Nhedc2	Na+/H+ exchanger domain containing 2	0.010