IMP

Process View

Mus musculus

2 genes annotated in mouse

intrinsic apoptotic signaling pathway in response to osmotic stress

A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to changes in intracellular ion homeostasis, and ends when the execution phase of apoptosis is triggered.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "intrinsic apoptotic signaling pathway in response to osmotic stress"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "intrinsic apoptotic signaling pathway in response to osmotic stress" (in gray)

Name	Description	Probability	Func Analog Organism
Ren1	renin 1 structural	0.999
Ryr2	ryanodine receptor 2, cardiac	0.988
Efemp2	epidermal growth factor-containing fibulin-like extracellular matrix protein 2	0.801
Lepr	leptin receptor	0.800
Gja1	gap junction protein, alpha 1	0.792
Bdkrb2	bradykinin receptor, beta 2	0.708
Tbx5	T-box 5	0.707
Agt	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	0.620
Pcdh12	protocadherin 12	0.577
Ace	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	0.562
Nos3	nitric oxide synthase 3, endothelial cell	0.558
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.521
Agtr1a	angiotensin II receptor, type 1a	0.506	Mouse
Hcn4	hyperpolarization-activated, cyclic nucleotide-gated K+ 4	0.486
Gja5	gap junction protein, alpha 5	0.413
Agtrap	angiotensin II, type I receptor-associated protein	0.355
Nos2	nitric oxide synthase 2, inducible	0.351
Fbn1	fibrillin 1	0.326
Wt1	Wilms tumor 1 homolog	0.288
Nedd4l	neural precursor cell expressed, developmentally down-regulated gene 4-like	0.270
Slc12a1	solute carrier family 12, member 1	0.246
Myl2	myosin, light polypeptide 2, regulatory, cardiac, slow	0.245
Tgfbr2	transforming growth factor, beta receptor II	0.243
Lox	lysyl oxidase	0.216
Ptgs2	prostaglandin-endoperoxide synthase 2	0.214
Gjd3	gap junction protein, delta 3	0.184
Tjp1	tight junction protein 1	0.181
Nr3c2	nuclear receptor subfamily 3, group C, member 2	0.139
Apoe	apolipoprotein E	0.138
Ldlr	low density lipoprotein receptor	0.136
Ret	ret proto-oncogene	0.128
Cacna2d2	calcium channel, voltage-dependent, alpha 2/delta subunit 2	0.117
Crim1	cysteine rich transmembrane BMP regulator 1 (chordin like)	0.113
Mas1	MAS1 oncogene	0.110
Ppargc1a	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	0.110
Umod	uromodulin	0.110
Col4a3	collagen, type IV, alpha 3	0.106
Tbx3	T-box 3	0.090
Elavl4	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)	0.078
Tnfrsf9	tumor necrosis factor receptor superfamily, member 9	0.076
Scn1a	sodium channel, voltage-gated, type I, alpha	0.073	Mouse
Gnas	GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus	0.068
Eln	elastin	0.063
Kcnj5	potassium inwardly-rectifying channel, subfamily J, member 5	0.060
Kcna6	potassium voltage-gated channel, shaker-related, subfamily, member 6	0.054
Nos1	nitric oxide synthase 1, neuronal	0.052
Xirp1	xin actin-binding repeat containing 1	0.051
Robo2	roundabout homolog 2 (Drosophila)	0.051
Myct1	myc target 1	0.051
C77614	EST C77614	0.043
Nxph1	neurexophilin 1	0.039
Hrc	histidine rich calcium binding protein	0.036
Fgf7	fibroblast growth factor 7	0.036
Gria1	glutamate receptor, ionotropic, AMPA1 (alpha 1)	0.036
Bcl6b	B-cell CLL/lymphoma 6, member B	0.035
Hoxc8	homeobox C8	0.035
Hcn1	hyperpolarization-activated, cyclic nucleotide-gated K+ 1	0.033
Casq2	calsequestrin 2	0.032
Prg2	proteoglycan 2, bone marrow	0.031
Tnni2	troponin I, skeletal, fast 2	0.031
Gzmk	granzyme K	0.030
Col22a1	collagen, type XXII, alpha 1	0.030
Alx3	aristaless-like homeobox 3	0.028
Sstr3	somatostatin receptor 3	0.027
Tmprss5	transmembrane protease, serine 5 (spinesin)	0.026
Zfhx4	zinc finger homeodomain 4	0.025
Vegfa	vascular endothelial growth factor A	0.025
Gabra1	gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1	0.025
Mtap1b	microtubule-associated protein 1B	0.025
U46068	cDNA sequence U46068	0.024
Vdr	vitamin D receptor	0.024
Arap3	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3	0.024
Ky	kyphoscoliosis peptidase	0.023
Myh6	myosin, heavy polypeptide 6, cardiac muscle, alpha	0.023
Ednrb	endothelin receptor type B	0.023
Clvs1	clavesin 1	0.023
Gdap1	ganglioside-induced differentiation-associated-protein 1	0.022
Nrsn1	neurensin 1	0.022
Aff2	AF4/FMR2 family, member 2	0.022
Tgfb1	transforming growth factor, beta 1	0.022
Abcc8	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	0.022
Npy2r	neuropeptide Y receptor Y2	0.022
Prmt1	protein arginine N-methyltransferase 1	0.021
Kcnd2	potassium voltage-gated channel, Shal-related family, member 2	0.021
Add2	adducin 2 (beta)	0.021
Grik1	glutamate receptor, ionotropic, kainate 1	0.021
Rbfox1	RNA binding protein, fox-1 homolog (C. elegans) 1	0.021
Scn7a	sodium channel, voltage-gated, type VII, alpha	0.020	Mouse
Il12b	interleukin 12b	0.020
Gsbs	G substrate	0.020
Ebf2	early B-cell factor 2	0.020
Art5	ADP-ribosyltransferase 5	0.020
Upk3a	uroplakin 3A	0.020
Htr2c	5-hydroxytryptamine (serotonin) receptor 2C	0.019
Fam184b	family with sequence similarity 184, member B	0.019
Syt4	synaptotagmin IV	0.019
Ptgs1	prostaglandin-endoperoxide synthase 1	0.019
Dmd	dystrophin, muscular dystrophy	0.019
Hdgf	hepatoma-derived growth factor	0.018
Il12rb1	interleukin 12 receptor, beta 1	0.018
Gad2	glutamic acid decarboxylase 2	0.018
Snap25	synaptosomal-associated protein 25	0.018
Lrp1b	low density lipoprotein-related protein 1B (deleted in tumors)	0.018
Cacna1b	calcium channel, voltage-dependent, N type, alpha 1B subunit	0.018
Myt1l	myelin transcription factor 1-like	0.018
Aqp2	aquaporin 2	0.018
Krt25	keratin 25	0.017
Rhox6	reproductive homeobox 6	0.017
Glrx3	glutaredoxin 3	0.017
C78859	expressed sequence C78859	0.017
Rai2	retinoic acid induced 2	0.017
Fgf23	fibroblast growth factor 23	0.017
Zfp28	zinc finger protein 28	0.017
Klra8	killer cell lectin-like receptor, subfamily A, member 8	0.017
Il6	interleukin 6	0.016
Obp1a	odorant binding protein Ia	0.016
Pdx1	pancreatic and duodenal homeobox 1	0.016
Tnfsf11	tumor necrosis factor (ligand) superfamily, member 11	0.016
Cntn4	contactin 4	0.016
Mmp3	matrix metallopeptidase 3	0.016
Agtr2	angiotensin II receptor, type 2	0.016	Mouse
Adamts1	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1	0.016
Camk2a	calcium/calmodulin-dependent protein kinase II alpha	0.016
Rem1	rad and gem related GTP binding protein 1	0.016
Ttn	titin	0.016
Fgf12	fibroblast growth factor 12	0.016
Szt2	seizure threshold 2	0.015
Gjd2	gap junction protein, delta 2	0.015
Odz1	odd Oz/ten-m homolog 1 (Drosophila)	0.015
Ccl11	chemokine (C-C motif) ligand 11	0.015
Tcf15	transcription factor 15	0.015
Fgf2	fibroblast growth factor 2	0.015
Rit2	Ras-like without CAAX 2	0.015
Itgb3	integrin beta 3	0.015
She	src homology 2 domain-containing transforming protein E	0.015
Mmel1	membrane metallo-endopeptidase-like 1	0.015
Prss22	protease, serine, 22	0.014
Runx1t1	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	0.014
Abca8a	ATP-binding cassette, sub-family A (ABC1), member 8a	0.014
Dpt	dermatopontin	0.014
Mmp9	matrix metallopeptidase 9	0.014
Scn5a	sodium channel, voltage-gated, type V, alpha	0.014	Mouse
Scg3	secretogranin III	0.014
Cacna1s	calcium channel, voltage-dependent, L type, alpha 1S subunit	0.014
Snhg11	small nucleolar RNA host gene 11	0.014
Cdh15	cadherin 15	0.014
Trpc3	transient receptor potential cation channel, subfamily C, member 3	0.014
Cd80	CD80 antigen	0.014
Htr1f	5-hydroxytryptamine (serotonin) receptor 1F	0.014
Meox1	mesenchyme homeobox 1	0.013
Il11	interleukin 11	0.013
Tm4sf1	transmembrane 4 superfamily member 1	0.013
Ighmbp2	immunoglobulin mu binding protein 2	0.013
Usp13	ubiquitin specific peptidase 13 (isopeptidase T-3)	0.013
Crxos1	Crx opposite strand transcript 1	0.013
Phox2a	paired-like homeobox 2a	0.013
Ankrd2	ankyrin repeat domain 2 (stretch responsive muscle)	0.013
Tal1	T-cell acute lymphocytic leukemia 1	0.013
Neto1	neuropilin (NRP) and tolloid (TLL)-like 1	0.013
Sgcd	sarcoglycan, delta (dystrophin-associated glycoprotein)	0.013
Fbxo41	F-box protein 41	0.013
Myl3	myosin, light polypeptide 3	0.013
Lbx1	ladybird homeobox homolog 1 (Drosophila)	0.013
Omg	oligodendrocyte myelin glycoprotein	0.013
Diras1	DIRAS family, GTP-binding RAS-like 1	0.013
Cdh4	cadherin 4	0.013
Agtr1b	angiotensin II receptor, type 1b	0.012	Mouse
Tgfbr1	transforming growth factor, beta receptor I	0.012
Lypd1	Ly6/Plaur domain containing 1	0.012
Slc26a8	solute carrier family 26, member 8	0.012
Grem1	gremlin 1	0.012
Prkg1	protein kinase, cGMP-dependent, type I	0.012
Pip	prolactin induced protein	0.012
Crhr2	corticotropin releasing hormone receptor 2	0.012
Cdh13	cadherin 13	0.012
S1pr4	sphingosine-1-phosphate receptor 4	0.012
Chodl	chondrolectin	0.012
Cdh9	cadherin 9	0.012
Vsx1	visual system homeobox 1 homolog (zebrafish)	0.012
Cyp19a1	cytochrome P450, family 19, subfamily a, polypeptide 1	0.012
Adipoq	adiponectin, C1Q and collagen domain containing	0.012
Lrrtm2	leucine rich repeat transmembrane neuronal 2	0.012
Fgf14	fibroblast growth factor 14	0.012
Mog	myelin oligodendrocyte glycoprotein	0.012
Ccbp2	chemokine binding protein 2	0.012
Cntn1	contactin 1	0.012
Aprt	adenine phosphoribosyl transferase	0.012
Cst11	cystatin 11	0.012
Slco5a1	solute carrier organic anion transporter family, member 5A1	0.012
Pdcd1	programmed cell death 1	0.011
Tlr2	toll-like receptor 2	0.011
Snai2	snail homolog 2 (Drosophila)	0.011
Kcns1	K+ voltage-gated channel, subfamily S, 1	0.011
Zg16	zymogen granule protein 16	0.011
Epha5	Eph receptor A5	0.011
Gfra3	glial cell line derived neurotrophic factor family receptor alpha 3	0.011
Calcb	calcitonin-related polypeptide, beta	0.011
Ebf1	early B-cell factor 1	0.011
Cryba4	crystallin, beta A4	0.011
Mfsd4	major facilitator superfamily domain containing 4	0.011
Runx3	runt related transcription factor 3	0.011
Wnt8a	wingless-related MMTV integration site 8A	0.011
Prop1	paired like homeodomain factor 1	0.011
Pcdh10	protocadherin 10	0.011
Angpt1	angiopoietin 1	0.011
Ywhab	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.011
Lnx1	ligand of numb-protein X 1	0.011
Mpz	myelin protein zero	0.011
Foxf2	forkhead box F2	0.011
Tdrd1	tudor domain containing 1	0.011
Col5a3	collagen, type V, alpha 3	0.011
Sntb1	syntrophin, basic 1	0.011
Pcsk2	proprotein convertase subtilisin/kexin type 2	0.011
Csf2	colony stimulating factor 2 (granulocyte-macrophage)	0.011
Hcrt	hypocretin	0.011
Akr1b3	aldo-keto reductase family 1, member B3 (aldose reductase)	0.011
Tmod2	tropomodulin 2	0.010
Hoxb3	homeobox B3	0.010
Spna1	spectrin alpha 1	0.010
Astn1	astrotactin 1	0.010
Kcna5	potassium voltage-gated channel, shaker-related subfamily, member 5	0.010
Mucl1	mucin-like 1	0.010
6330527O06Rik	RIKEN cDNA 6330527O06 gene	0.010
Rnf112	ring finger protein 112	0.010
Calcrl	calcitonin receptor-like	0.010
Dbc1	deleted in bladder cancer 1 (human)	0.010
Pdyn	prodynorphin	0.010
Cacna1c	calcium channel, voltage-dependent, L type, alpha 1C subunit	0.010
Ins2	insulin II	0.010
4833422F24Rik	RIKEN cDNA 4833422F24 gene	0.010