IMP

Process View

Mus musculus

11 genes annotated in mouse

enteric nervous system development

The process whose specific outcome is the progression of the enteric nervous system over time, from its formation to the mature structure. The enteric nervous system is composed of two ganglionated neural plexuses in the gut wall which form one of the three major divisions of the autonomic nervous system. The enteric nervous system innervates the gastrointestinal tract, the pancreas, and the gall bladder. It contains sensory neurons, interneurons, and motor neurons. Thus the circuitry can autonomously sense the tension and the chemical environment in the gut and regulate blood vessel tone, motility, secretions, and fluid transport. The system is itself governed by the central nervous system and receives both parasympathetic and sympathetic innervation.

Loading network...

In addition to gene-name show these genes:

Known genes in the process in mouse Include functional analogs

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network

Save Options

Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "enteric nervous system development"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "enteric nervous system development" (in gray)

Name	Description	Probability	Func Analog Organism
Ret	ret proto-oncogene	0.999
Isl1	ISL1 transcription factor, LIM/homeodomain	0.971
Erbb3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.966
Gfra1	glial cell line derived neurotrophic factor family receptor alpha 1	0.914	Zebrafish
Phox2a	paired-like homeobox 2a	0.896	Mouse
Ntf3	neurotrophin 3	0.882
Sox10	SRY-box containing gene 10	0.878
Phox2b	paired-like homeobox 2b	0.847
Pax3	paired box gene 3	0.780	Zebrafish
Ntrk2	neurotrophic tyrosine kinase, receptor, type 2	0.712
Gli3	GLI-Kruppel family member GLI3	0.608
Bdnf	brain derived neurotrophic factor	0.576	Mouse
Shh	sonic hedgehog	0.546
Fgf8	fibroblast growth factor 8	0.535
Alx4	aristaless-like homeobox 4	0.530
Nrg1	neuregulin 1	0.449
Tcfap2a	transcription factor AP-2, alpha	0.418
Hand2	heart and neural crest derivatives expressed transcript 2	0.331
Fgfr1	fibroblast growth factor receptor 1	0.313
Tbx1	T-box 1	0.301
Gdnf	glial cell line derived neurotrophic factor	0.299
Chrd	chordin	0.279
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.224
Fgfr2	fibroblast growth factor receptor 2	0.204
Meox2	mesenchyme homeobox 2	0.198
Foxc1	forkhead box C1	0.187
Prrx2	paired related homeobox 2	0.186	Mouse
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.174
Bmp4	bone morphogenetic protein 4	0.171
Otx2	orthodenticle homolog 2 (Drosophila)	0.157
Hand1	heart and neural crest derivatives expressed transcript 1	0.156
Prrx1	paired related homeobox 1	0.153	Mouse
Pax6	paired box gene 6	0.143
Eya1	eyes absent 1 homolog (Drosophila)	0.140
Erbb2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.135
Ngfr	nerve growth factor receptor (TNFR superfamily, member 16)	0.131
Msx1	homeobox, msh-like 1	0.122
Nrtn	neurturin	0.093	Mouse
Gfra3	glial cell line derived neurotrophic factor family receptor alpha 3	0.084
Ascl1	achaete-scute complex homolog 1 (Drosophila)	0.081
Rara	retinoic acid receptor, alpha	0.076
Rspo2	R-spondin 2 homolog (Xenopus laevis)	0.067
Gbx2	gastrulation brain homeobox 2	0.065
Sox11	SRY-box containing gene 11	0.057	Mouse
Pou5f1	POU domain, class 5, transcription factor 1	0.057
Sox2	SRY-box containing gene 2	0.053	Mouse
Hoxa3	homeobox A3	0.049
Foxc2	forkhead box C2	0.048
Nog	noggin	0.048
Aplnr	apelin receptor	0.047
Nf1	neurofibromatosis 1	0.046
Tgfb2	transforming growth factor, beta 2	0.046
Ednrb	endothelin receptor type B	0.044
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.042
Robo3	roundabout homolog 3 (Drosophila)	0.039
Pou3f3	POU domain, class 3, transcription factor 3	0.039
Hoxa1	homeobox A1	0.039
Mitf	microphthalmia-associated transcription factor	0.038
Sox18	SRY-box containing gene 18	0.038	Mouse
Ntrk3	neurotrophic tyrosine kinase, receptor, type 3	0.037
Dlx5	distal-less homeobox 5	0.034
Ebf3	early B-cell factor 3	0.033
Zeb1	zinc finger E-box binding homeobox 1	0.033
Nkx2-3	NK2 transcription factor related, locus 3 (Drosophila)	0.033
Pax2	paired box gene 2	0.033
Pitx2	paired-like homeodomain transcription factor 2	0.030
She	src homology 2 domain-containing transforming protein E	0.027
Vti1a	vesicle transport through interaction with t-SNAREs homolog 1A (yeast)	0.027
Rarb	retinoic acid receptor, beta	0.024
Bmp7	bone morphogenetic protein 7	0.024
Nos3	nitric oxide synthase 3, endothelial cell	0.023
Bcl6b	B-cell CLL/lymphoma 6, member B	0.023
Hhex	hematopoietically expressed homeobox	0.023
Ntf5	neurotrophin 5	0.022	Mouse
Hcrt	hypocretin	0.022
Hif3a	hypoxia inducible factor 3, alpha subunit	0.022
Igdcc3	immunoglobulin superfamily, DCC subclass, member 3	0.021
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.021
Atoh7	atonal homolog 7 (Drosophila)	0.021
Gfra2	glial cell line derived neurotrophic factor family receptor alpha 2	0.020	Zebrafish
Sall4	sal-like 4 (Drosophila)	0.020
Kdr	kinase insert domain protein receptor	0.020
Foxd2	forkhead box D2	0.020
Pbx1	pre B-cell leukemia transcription factor 1	0.020
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.019
Gsc	goosecoid homeobox	0.019
Tcf15	transcription factor 15	0.019
Sox7	SRY-box containing gene 7	0.018	Mouse
Mn1	meningioma 1	0.018
Fgf10	fibroblast growth factor 10	0.018
Six4	sine oculis-related homeobox 4 homolog (Drosophila)	0.018
Sox17	SRY-box containing gene 17	0.017	Mouse
Ikbkap	inhibitor of kappa light polypeptide enhancer in B-cells, kinase complex-associated protein	0.017
Lmx1b	LIM homeobox transcription factor 1 beta	0.017
Acvr1	activin A receptor, type 1	0.017
Vegfa	vascular endothelial growth factor A	0.017
Dlx6	distal-less homeobox 6	0.016
Cldn5	claudin 5	0.015
Msx2	homeobox, msh-like 2	0.015
Wnt6	wingless-related MMTV integration site 6	0.015
Nkx3-2	NK3 homeobox 2	0.015
Sall3	sal-like 3 (Drosophila)	0.014
Pou3f1	POU domain, class 3, transcription factor 1	0.014
Fhl3	four and a half LIM domains 3	0.014
Foxg1	forkhead box G1	0.014
Flt4	FMS-like tyrosine kinase 4	0.014
Wnt7b	wingless-related MMTV integration site 7B	0.014
Hoxb1	homeobox B1	0.013
Sox4	SRY-box containing gene 4	0.013	Mouse
Nanog	Nanog homeobox	0.013
Lhx5	LIM homeobox protein 5	0.013
Hes1	hairy and enhancer of split 1 (Drosophila)	0.013
Emcn	endomucin	0.013
Chrnb2	cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal)	0.012
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.012
Mesp1	mesoderm posterior 1	0.012
Meox1	mesenchyme homeobox 1	0.012
Neurog2	neurogenin 2	0.012
Npas1	neuronal PAS domain protein 1	0.012
Esrrb	estrogen related receptor, beta	0.012
Msx3	homeobox, msh-like 3	0.011
Plac1	placental specific protein 1	0.011
Htr4	5 hydroxytryptamine (serotonin) receptor 4	0.011
Emx1	empty spiracles homolog 1 (Drosophila)	0.011
Tbx10	T-box 10	0.011
Kit	kit oncogene	0.011
Tcfap2c	transcription factor AP-2, gamma	0.011
Cckbr	cholecystokinin B receptor	0.011
Edar	ectodysplasin-A receptor	0.011
Prph	peripherin	0.011
Shbg	sex hormone binding globulin	0.011
Snai1	snail homolog 1 (Drosophila)	0.010
Gli2	GLI-Kruppel family member GLI2	0.010
En2	engrailed 2	0.010
Gja4	gap junction protein, alpha 4	0.010
a	nonagouti	0.010