IMP

Process View

Mus musculus

14 genes annotated in mouse

positive regulation of type i interferon production

Any process that activates or increases the frequency, rate, or extent of type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of type i interferon production"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "positive regulation of type i interferon production" (in gray)

Name	Description	Probability	Func Analog Organism
Myd88	myeloid differentiation primary response gene 88	0.992
Tlr4	toll-like receptor 4	0.972
Stat1	signal transducer and activator of transcription 1	0.884
Ccr2	chemokine (C-C motif) receptor 2	0.749
Ticam1	toll-like receptor adaptor molecule 1	0.678
Ddx60	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60	0.663
Il10	interleukin 10	0.636
Ikbkg	inhibitor of kappaB kinase gamma	0.599
Unc93b1	unc-93 homolog B1 (C. elegans)	0.587
Ifit1	interferon-induced protein with tetratricopeptide repeats 1	0.472
Ddx58	DEAD (Asp-Glu-Ala-Asp) box polypeptide 58	0.462
Irf9	interferon regulatory factor 9	0.446	Mouse
Tapbp	TAP binding protein	0.433
Trim21	tripartite motif-containing 21	0.413
Tnfrsf1b	tumor necrosis factor receptor superfamily, member 1b	0.381
Irgm1	immunity-related GTPase family M member 1	0.377
Irgm2	immunity-related GTPase family M member 2	0.363
Tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a	0.361
Tax1bp1	Tax1 (human T-cell leukemia virus type I) binding protein 1	0.351
Nfkb1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105	0.349
Map3k8	mitogen-activated protein kinase kinase kinase 8	0.340
Stat2	signal transducer and activator of transcription 2	0.321
Tnf	tumor necrosis factor	0.300
Uba7	ubiquitin-like modifier activating enzyme 7	0.279
Trim25	tripartite motif-containing 25	0.251
Parp14	poly (ADP-ribose) polymerase family, member 14	0.177
Mavs	mitochondrial antiviral signaling protein	0.161
Ifi35	interferon-induced protein 35	0.157
Nfkb2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	0.146
Psmb9	proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)	0.146
Dhx58	DEXH (Asp-Glu-X-His) box polypeptide 58	0.139
Tor3a	torsin family 3, member A	0.137
Relb	avian reticuloendotheliosis viral (v-rel) oncogene related B	0.123
Ikbkb	inhibitor of kappaB kinase beta	0.118	Mouse
Birc3	baculoviral IAP repeat-containing 3	0.105
Ifi47	interferon gamma inducible protein 47	0.101
Gbp3	guanylate binding protein 3	0.100
Igtp	interferon gamma induced GTPase	0.099
Parp9	poly (ADP-ribose) polymerase family, member 9	0.096
Ifi44	interferon-induced protein 44	0.095
Sfpi1	SFFV proviral integration 1	0.093
Usp18	ubiquitin specific peptidase 18	0.093
BC006779	cDNA sequence BC006779	0.092
Rtp4	receptor transporter protein 4	0.090
Stat3	signal transducer and activator of transcription 3	0.089
Chuk	conserved helix-loop-helix ubiquitous kinase	0.088	Mouse
Nmi	N-myc (and STAT) interactor	0.086
Ifnar1	interferon (alpha and beta) receptor 1	0.084
Gbp7	guanylate binding protein 7	0.082
Oasl2	2'-5' oligoadenylate synthetase-like 2	0.072
Mx2	myxovirus (influenza virus) resistance 2	0.072
Casp4	caspase 4, apoptosis-related cysteine peptidase	0.071
Hspa9	heat shock protein 9	0.064
Irf7	interferon regulatory factor 7	0.064	Human Mouse
Ccl2	chemokine (C-C motif) ligand 2	0.062
Rnf31	ring finger protein 31	0.062
Pik3ap1	phosphoinositide-3-kinase adaptor protein 1	0.055
Parp10	poly (ADP-ribose) polymerase family, member 10	0.053
Samd9l	sterile alpha motif domain containing 9-like	0.050
Rela	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.049
Pml	promyelocytic leukemia	0.048
Rnf135	ring finger protein 135	0.047	Human
Tmem106a	transmembrane protein 106A	0.047
Irf5	interferon regulatory factor 5	0.046	Mouse
Casp1	caspase 1	0.044
Eif2ak2	eukaryotic translation initiation factor 2-alpha kinase 2	0.044
Bcl3	B-cell leukemia/lymphoma 3	0.042
Sykb	spleen tyrosine kinase	0.041
Trim30a	tripartite motif-containing 30A	0.041
Tlr2	toll-like receptor 2	0.041
Ms4a4c	membrane-spanning 4-domains, subfamily A, member 4C	0.041
Traf3	TNF receptor-associated factor 3	0.039
Lyz2	lysozyme 2	0.039
Irak4	interleukin-1 receptor-associated kinase 4	0.038
Il10ra	interleukin 10 receptor, alpha	0.037
Erap1	endoplasmic reticulum aminopeptidase 1	0.037
Gsdmd	gasdermin D	0.036
Tap1	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	0.035
Ikbke	inhibitor of kappaB kinase epsilon	0.035	Mouse
Cd19	CD19 antigen	0.035
Nfkbia	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.034
Ikzf1	IKAROS family zinc finger 1	0.034
Atr	ataxia telangiectasia and Rad3 related	0.033
Psmb8	proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)	0.032
Isg15	ISG15 ubiquitin-like modifier	0.032
Samhd1	SAM domain and HD domain, 1	0.030
Tgfb1	transforming growth factor, beta 1	0.029
Cd14	CD14 antigen	0.029
Il1r1	interleukin 1 receptor, type I	0.028
Cd180	CD180 antigen	0.027	Mouse
Tap2	transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)	0.027
Ccl4	chemokine (C-C motif) ligand 4	0.027
Gbp2	guanylate binding protein 2	0.027
Ly96	lymphocyte antigen 96	0.024
Cd40	CD40 antigen	0.024
1810019J16Rik	RIKEN cDNA 1810019J16 gene	0.024
Ankfy1	ankyrin repeat and FYVE domain containing 1	0.024
Ciita	class II transactivator	0.024
Apobec1	apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1	0.023
Adar	adenosine deaminase, RNA-specific	0.023
Tcirg1	T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3	0.023
Tnfaip3	tumor necrosis factor, alpha-induced protein 3	0.023
Inpp5d	inositol polyphosphate-5-phosphatase D	0.022
Ncoa3	nuclear receptor coactivator 3	0.022
Itgal	integrin alpha L	0.022
Igh	immunoglobulin heavy chain complex	0.022
Lrpprc	leucine-rich PPR-motif containing	0.021
Ptpn6	protein tyrosine phosphatase, non-receptor type 6	0.021
Irf1	interferon regulatory factor 1	0.021
Nlrc5	NLR family, CARD domain containing 5	0.021
Stat6	signal transducer and activator of transcription 6	0.021
Nfkbie	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon	0.020
Oasl1	2'-5' oligoadenylate synthetase-like 1	0.020
Runx1	runt related transcription factor 1	0.020
Trp53	transformation related protein 53	0.019
Sfn	stratifin	0.019
Herc6	hect domain and RLD 6	0.018
Cblb	Casitas B-lineage lymphoma b	0.018
Map3k14	mitogen-activated protein kinase kinase kinase 14	0.018
Cmpk2	cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial	0.018
Vav1	vav 1 oncogene	0.018
Safb	scaffold attachment factor B	0.018
Cd79b	CD79B antigen	0.018
Ifit3	interferon-induced protein with tetratricopeptide repeats 3	0.017
Dtx3l	deltex 3-like (Drosophila)	0.017
Tlr6	toll-like receptor 6	0.017	Mouse
Map3k7	mitogen-activated protein kinase kinase kinase 7	0.017
Sp100	nuclear antigen Sp100	0.016
Batf	basic leucine zipper transcription factor, ATF-like	0.016
C1ra	complement component 1, r subcomponent A	0.016
Tlr9	toll-like receptor 9	0.016
Oas2	2'-5' oligoadenylate synthetase 2	0.015
Pik3cd	phosphatidylinositol 3-kinase catalytic delta polypeptide	0.015
Rasal3	RAS protein activator like 3	0.014
Mvp	major vault protein	0.014
Mx1	myxovirus (influenza virus) resistance 1	0.014
Rel	reticuloendotheliosis oncogene	0.014
Mcoln2	mucolipin 2	0.014
Il4ra	interleukin 4 receptor, alpha	0.014
Rsad2	radical S-adenosyl methionine domain containing 2	0.013
Ube2l6	ubiquitin-conjugating enzyme E2L 6	0.013
Fas	Fas (TNF receptor superfamily member 6)	0.013
Icam1	intercellular adhesion molecule 1	0.013
Spib	Spi-B transcription factor (Spi-1/PU.1 related)	0.013
Spp1	secreted phosphoprotein 1	0.013
Gja1	gap junction protein, alpha 1	0.013
Icos	inducible T-cell co-stimulator	0.013
Azi2	5-azacytidine induced gene 2	0.013
Nfkbiz	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta	0.013
Btk	Bruton agammaglobulinemia tyrosine kinase	0.013
Fcgr1	Fc receptor, IgG, high affinity I	0.012
Cd33	CD33 antigen	0.012
Lgals9	lectin, galactose binding, soluble 9	0.012
Psme2	proteasome (prosome, macropain) 28 subunit, beta	0.012
Tlr5	toll-like receptor 5	0.012	Mouse
Csprs	component of Sp100-rs	0.012
Fadd	Fas (TNFRSF6)-associated via death domain	0.012
Ripk1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.012
Casp8	caspase 8	0.011
Siglece	sialic acid binding Ig-like lectin E	0.011
Lilrb3	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3	0.011
Tlr7	toll-like receptor 7	0.011
Pou2f2	POU domain, class 2, transcription factor 2	0.011
Aim2	absent in melanoma 2	0.011
Casp7	caspase 7	0.011
Cd300ld	CD300 molecule-like family member d	0.011
Jak3	Janus kinase 3	0.011
Ifnar2	interferon (alpha and beta) receptor 2	0.011
H2-D1	histocompatibility 2, D region locus 1	0.010
Prkdc	protein kinase, DNA activated, catalytic polypeptide	0.010
Cd4	CD4 antigen	0.010
Sh3bp2	SH3-domain binding protein 2	0.010
Mov10	Moloney leukemia virus 10	0.010
Cxcl10	chemokine (C-X-C motif) ligand 10	0.010
Trim14	tripartite motif-containing 14	0.010
Fgr	Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog	0.010