IMP

Process View

Saccharomyces cerevisiae

60 genes annotated in yeast

Multi-species View

negative regulation of catalytic activity

GO:0043086

Any process that stops or reduces the activity of an enzyme.

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Known genes in the process in yeast Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of catalytic activity"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of catalytic activity" (in gray)

Name	Description	Probability	Func Analog Organism
BCK1	Bck1p	0.179
PBS2	Pbs2p	0.094
STE20	Ste20p	0.091	Human
CKB1	Ckb1p	0.059
SLA2	Sla2p	0.055
CDC55	Cdc55p	0.053
PIL1	Pil1p	0.050
BUD23	Bud23p	0.045
LHS1	Lhs1p	0.042
RAD9	Rad9p	0.040
RHO1	Rho1p	0.039
GIN4	Gin4p	0.035
MOB2	Mob2p	0.033
SLT2	Slt2p	0.033
SSA3	Ssa3p	0.033
CDC15	Cdc15p	0.033
BOI2	Boi2p	0.032	Yeast
BOI1	Boi1p	0.031	Yeast
PAM1	Pam1p	0.031
VMA13	Vma13p	0.031
UTP18	Utp18p	0.030
MCD1	Mcd1p	0.030
CKB2	Ckb2p	0.028
RFC1	Rfc1p	0.028
MSG5	Msg5p	0.026
STE7	Ste7p	0.026
MIG1	Mig1p	0.026
PTC2	Ptc2p	0.026
RAT1	Rat1p	0.025
ULA1	Ula1p	0.025
CAK1	Cak1p	0.025
PCL9	Pcl9p	0.025
TWF1	Twf1p	0.025
YPT52	Ypt52p	0.025
RRD1	Rrd1p	0.025
CDC4	Cdc4p	0.024
URA6	Ura6p	0.024
BEM1	Bem1p	0.024	Yeast
GIP4	Gip4p	0.023
STI1	Sti1p	0.023
MCM10	Mcm10p	0.023
GAL83	Gal83p	0.023
PSP2	Psp2p	0.022
RIO2	Rio2p	0.022
SIP2	Sip2p	0.022
ZPR1	Zpr1p	0.022
DPB2	Dpb2p	0.022
YJR085C	hypothetical protein	0.022
SHY1	Shy1p	0.022
BUD20	Bud20p	0.021
MDN1	Mdn1p	0.021
SAC6	Sac6p	0.021
ERV25	Erv25p	0.021
ATG14	Atg14p	0.021
YGR205W	hypothetical protein	0.021
CDC28	Cdc28p	0.020
LTV1	Ltv1p	0.020
CDC20	Cdc20p	0.020
KIN3	Kin3p	0.020
YPD1	Ypd1p	0.020
MNN2	Mnn2p	0.020
ARC18	Arc18p	0.020
PAA1	Paa1p	0.020
RPN2	Rpn2p	0.019
IMP2'	Imp2'p	0.019
YTA6	Yta6p	0.019
INP53	Inp53p	0.019
NBP2	Nbp2p	0.019
SEE1	See1p	0.018
NOP1	Nop1p	0.018
YAP7	Yap7p	0.018
DAS1	Das1p	0.018
CIN2	Cin2p	0.018
RLM1	Rlm1p	0.018
SKG6	Skg6p	0.018
YGR130C	hypothetical protein	0.018
STE11	Ste11p	0.018
CTF13	Ctf13p	0.018
ENT1	Ent1p	0.018
FAB1	Fab1p	0.017
CAD1	Cad1p	0.017
XRS2	Xrs2p	0.017
NAS2	Nas2p	0.017
NUD1	Nud1p	0.017
MDM32	Mdm32p	0.017
CHC1	Chc1p	0.017
UTP20	Utp20p	0.017
TEN1	Ten1p	0.017
COT1	Cot1p	0.017
PPH22	Pph22p	0.017
NAP1	Nap1p	0.017
ATM1	Atm1p	0.017
DYN3	Dyn3p	0.017
YLR162W	hypothetical protein	0.017
SNF1	Snf1p	0.017
PTP3	Ptp3p	0.017
ARF2	Arf2p	0.017
OSH7	Osh7p	0.016
CRZ1	Crz1p	0.016
GUT2	Gut2p	0.016
GAL7	Gal7p	0.016
MDH3	Mdh3p	0.016
BCD1	Bcd1p	0.016
YER039C-A	hypothetical protein	0.016
DED1	Ded1p	0.016	Human
TMA16	Tma16p	0.016
ARC15	Arc15p	0.016
AZF1	Azf1p	0.016
KNH1	Knh1p	0.016
YMR086W	hypothetical protein	0.016
SSK22	Ssk22p	0.016
SHO1	Sho1p	0.016
YLR419W	hypothetical protein	0.016
STF1	Stf1p	0.016
CHK1	Chk1p	0.016
FPK1	Fpk1p	0.016
ATX1	Atx1p	0.016
RKI1	Rki1p	0.016
KEM1	Kem1p	0.016
CRP1	Crp1p	0.016
RLP7	Rlp7p	0.015
SUI1	Sui1p	0.015
RAD53	Rad53p	0.015
YDL129W	hypothetical protein	0.015
ACC1	Acc1p	0.015
RPT6	Rpt6p	0.015
YIR035C	hypothetical protein	0.015
SIC1	Sic1p	0.015
CYM1	Cym1p	0.015
ATG4	Atg4p	0.015
DSK2	Dsk2p	0.015
KDX1	Kdx1p	0.015
KIP1	Kip1p	0.015
SNX41	Snx41p	0.015
PKH1	Pkh1p	0.015	Human
BIK1	Bik1p	0.015
TAF10	Taf10p	0.015
YGR210C	hypothetical protein	0.015
SKM1	Skm1p	0.015	Human
YBR296C-A	hypothetical protein	0.015
YHB1	Yhb1p	0.015
FES1	Fes1p	0.015
YBR235W	hypothetical protein	0.015
RAD55	Rad55p	0.015
HSL1	Hsl1p	0.014
DCS2	Dcs2p	0.014
ARE2	Are2p	0.014
ECO1	Eco1p	0.014
VPS62	Vps62p	0.014
PKP2	Pkp2p	0.014
SLD5	Sld5p	0.014
BEM3	Bem3p	0.014
SIS1	Sis1p	0.014
ARK1	Ark1p	0.014
TRM112	Trm112p	0.014
TED1	Ted1p	0.014
CTR1	Ctr1p	0.014
ARP10	Arp10p	0.014
SCH9	Sch9p	0.014
YOL038C-A	hypothetical protein	0.014
TAE1	Tae1p	0.014
GYL1	Gyl1p	0.014
PAN1	Pan1p	0.014
ATP3	Atp3p	0.014
FMP48	Fmp48p	0.014
OSH6	Osh6p	0.014
SRD1	Srd1p	0.014
VMA3	Vma3p	0.014
KTR3	Ktr3p	0.014
ORC6	Orc6p	0.014
PBP2	Pbp2p	0.014
DAT1	Dat1p	0.014
YBR085C-A	hypothetical protein	0.014
YSC83	Ysc83p	0.014
YLR264C-A	hypothetical protein	0.014
GLO2	Glo2p	0.014
RNH70	Rnh70p	0.014
PGS1	Pgs1p	0.014
CDC6	Cdc6p	0.013
IRA1	Ira1p	0.013
SEC26	Sec26p	0.013
CHA1	Cha1p	0.013
YBR138C	hypothetical protein	0.013
YCH1	Ych1p	0.013
ROM2	Rom2p	0.013
RPT1	Rpt1p	0.013
SMC4	Smc4p	0.013
DNF2	Dnf2p	0.013
MSB3	Msb3p	0.013
ESF1	Esf1p	0.013
ARB1	Arb1p	0.013
TPO4	Tpo4p	0.013
SGN1	Sgn1p	0.013
ATP4	Atp4p	0.013
ADR1	Adr1p	0.013
FTH1	Fth1p	0.013
CKA2	Cka2p	0.013	Human
ICS2	Ics2p	0.013
TYW1	Tyw1p	0.013
YGP1	Ygp1p	0.013
YGL082W	hypothetical protein	0.013
CHS1	Chs1p	0.013
STB2	Stb2p	0.013
STU1	Stu1p	0.013
UFO1	Ufo1p	0.013
URA3	Ura3p	0.013
COA4	Coa4p	0.013
SLK19	Slk19p	0.013
SSK1	Ssk1p	0.013
DAP1	Dap1p	0.013
ABD1	Abd1p	0.013
LEU2	Leu2p	0.013
LOT5	Lot5p	0.013
ELP4	Elp4p	0.013
NNK1	Nnk1p	0.013
NVJ1	Nvj1p	0.013
RSN1	Rsn1p	0.013
VPS5	Vps5p	0.013
CUP1-1	Cup1-1p	0.013
BMH1	Bmh1p	0.013
VPS13	Vps13p	0.013
TOR1	Tor1p	0.013
YHR127W	hypothetical protein	0.012
HSP12	Hsp12p	0.012
CRG1	Crg1p	0.012
VPS38	Vps38p	0.012
SFK1	Sfk1p	0.012
HBT1	Hbt1p	0.012
TRS65	Trs65p	0.012
CIN8	Cin8p	0.012
HYM1	Hym1p	0.012
WSC4	Wsc4p	0.012
CTS1	Cts1p	0.012
SRO77	Sro77p	0.012
ENP1	Enp1p	0.012
YLR132C	hypothetical protein	0.012
YGL036W	hypothetical protein	0.012
SPL2	Spl2p	0.012
SOK1	Sok1p	0.012
CPR8	Cpr8p	0.012
SPC110	Spc110p	0.012
JHD1	Jhd1p	0.012
REE1	Ree1p	0.012
YMR144W	hypothetical protein	0.012
FRE1	Fre1p	0.012
YAR068W	hypothetical protein	0.012
OPT2	Opt2p	0.012
ATP6	Atp6p	0.012
UPS3	Ups3p	0.012
YDR514C	hypothetical protein	0.012
YLR042C	hypothetical protein	0.012
ABP1	Abp1p	0.012	Yeast
MSH6	Msh6p	0.012
PCL1	Pcl1p	0.012
ATP16	Atp16p	0.012
ACE2	Ace2p	0.012
YIL151C	hypothetical protein	0.012
SWI1	Swi1p	0.012
YDR306C	hypothetical protein	0.012
RPT2	Rpt2p	0.012
HPF1	Hpf1p	0.012
ASK10	Ask10p	0.012
YBR013C	hypothetical protein	0.012
DUR1,2	Dur1,2p	0.012
HRK1	Hrk1p	0.012
PDS1	Pds1p	0.012
MPD2	Mpd2p	0.012
SPE2	Spe2p	0.012
YIM1	Yim1p	0.012
YVH1	Yvh1p	0.012
ECM27	Ecm27p	0.012
SOG2	Sog2p	0.012
BNS1	Bns1p	0.012
MKK1	Mkk1p	0.012
OPI10	Opi10p	0.012
SFA1	Sfa1p	0.012
YRA2	Yra2p	0.012
TAF8	Taf8p	0.012
STT3	Stt3p	0.012
PXA1	Pxa1p	0.012
PHO87	Pho87p	0.012
IPI1	Ipi1p	0.012
AIR2	Air2p	0.012
GLC8	Glc8p	0.012
AUA1	Aua1p	0.012
DDI1	Ddi1p	0.012
MER1	Mer1p	0.012
COX9	Cox9p	0.012
YNL024C	hypothetical protein	0.012
YJL144W	hypothetical protein	0.012
VPS15	Vps15p	0.012
TIS11	Tis11p	0.012
NCE103	Nce103p	0.012
DCN1	Dcn1p	0.012
SSP120	Ssp120p	0.012
YLR346C	hypothetical protein	0.011
TBS1	Tbs1p	0.011
FAA2	Faa2p	0.011
CTR2	Ctr2p	0.011
HLR1	Hlr1p	0.011
YDL233W	hypothetical protein	0.011
SAP155	Sap155p	0.011
YPR098C	hypothetical protein	0.011
KSS1	Kss1p	0.011
INP52	Inp52p	0.011
SIS2	Sis2p	0.011
FUI1	Fui1p	0.011
HSP78	Hsp78p	0.011
MYO5	Myo5p	0.011
URA8	Ura8p	0.011
COX4	Cox4p	0.011
GAL4	Gal4p	0.011
YMR295C	hypothetical protein	0.011
NRM1	Nrm1p	0.011
CMK2	Cmk2p	0.011
ICY1	Icy1p	0.011
PEX22	Pex22p	0.011
FMP33	Fmp33p	0.011
LDB7	Ldb7p	0.011
NOP6	Nop6p	0.011
PTC4	Ptc4p	0.011
RIO1	Rio1p	0.011
CPR6	Cpr6p	0.011
HXT3	Hxt3p	0.011
CAM1	Cam1p	0.011
ARO9	Aro9p	0.011
FLC1	Flc1p	0.011
UGA4	Uga4p	0.011
ARG8	Arg8p	0.011
ZPS1	Zps1p	0.011
AIM20	Aim20p	0.011
YJR012C	hypothetical protein	0.011
MF(ALPHA)2	Mf(alpha)2p	0.011
YIL152W	hypothetical protein	0.011
ARR2	Arr2p	0.011
YER134C	hypothetical protein	0.011
RDH54	Rdh54p	0.011
RNY1	Rny1p	0.011
QCR6	Qcr6p	0.011
HSP104	Hsp104p	0.011
IPL1	Ipl1p	0.011
MTM1	Mtm1p	0.011
MKS1	Mks1p	0.011
AQR1	Aqr1p	0.011
FUS3	Fus3p	0.011
PBI2	Pbi2p	0.011
RSC9	Rsc9p	0.011
YPT11	Ypt11p	0.011
YLR108C	hypothetical protein	0.011
YLR281C	hypothetical protein	0.011
CWP1	Cwp1p	0.011
UBC1	Ubc1p	0.011
YOL013W-A	hypothetical protein	0.011
CIN1	Cin1p	0.011
HAL5	Hal5p	0.011
GPX2	Gpx2p	0.011
MCM6	Mcm6p	0.011
TYE7	Tye7p	0.011
ZIM17	Zim17p	0.011
YBL029C-A	hypothetical protein	0.011
SDS22	Sds22p	0.011
CIR2	Cir2p	0.011
ZDS2	Zds2p	0.011
TPM1	Tpm1p	0.011
TAD2	Tad2p	0.011
SHP1	Shp1p	0.011
KOG1	Kog1p	0.011
TIM44	Tim44p	0.011
PPX1	Ppx1p	0.011
FAA4	Faa4p	0.011
FTR1	Ftr1p	0.011
LRO1	Lro1p	0.011
PDS5	Pds5p	0.011
HSP26	Hsp26p	0.011
YDR034W-B	hypothetical protein	0.011
CCS1	Ccs1p	0.011
TEC1	Tec1p	0.011
OCH1	Och1p	0.011
SRX1	Srx1p	0.011
NOP15	Nop15p	0.011
SKI8	Ski8p	0.011
AIF1	Aif1p	0.011
PDA1	Pda1p	0.011
MTC5	Mtc5p	0.011
TRM5	Trm5p	0.011
CPD1	Cpd1p	0.011
GLG2	Glg2p	0.011
SPG3	Spg3p	0.011
BST1	Bst1p	0.011
YLR063W	hypothetical protein	0.011
HSM3	Hsm3p	0.011
HOR7	Hor7p	0.011
YGR237C	hypothetical protein	0.011
CIS3	Cis3p	0.011
YDL144C	hypothetical protein	0.011
PHM6	Phm6p	0.011
RTR1	Rtr1p	0.011
MSB1	Msb1p	0.011
PAR32	Par32p	0.011
LEU5	Leu5p	0.011
SPS4	Sps4p	0.010
ATP15	Atp15p	0.010
ALT2	Alt2p	0.010
YAR066W	hypothetical protein	0.010
YGR169C-A	hypothetical protein	0.010
YKR045C	hypothetical protein	0.010
SCC4	Scc4p	0.010
YBL044W	hypothetical protein	0.010
ZRG8	Zrg8p	0.010
CTK3	Ctk3p	0.010
ACT1	Act1p	0.010
YOL014W	hypothetical protein	0.010
RTN2	Rtn2p	0.010
YMR244W	hypothetical protein	0.010
CDC53	Cdc53p	0.010
ERO1	Ero1p	0.010
SPT16	Spt16p	0.010
NEM1	Nem1p	0.010
CLB3	Clb3p	0.010
NUP157	Nup157p	0.010
FET4	Fet4p	0.010
RTT105	Rtt105p	0.010
ROM1	Rom1p	0.010
YJL055W	hypothetical protein	0.010
CKS1	Cks1p	0.010
YPR157W	hypothetical protein	0.010
OYE2	Oye2p	0.010
CUE2	Cue2p	0.010
YPR096C	hypothetical protein	0.010
SDS23	Sds23p	0.010
PCL2	Pcl2p	0.010
RNP1	Rnp1p	0.010
SPO12	Spo12p	0.010
HDA2	Hda2p	0.010
UBP5	Ubp5p	0.010
YIR042C	hypothetical protein	0.010
FMT1	Fmt1p	0.010
GIS3	Gis3p	0.010
RTK1	Rtk1p	0.010
YPR027C	hypothetical protein	0.010
BAT2	Bat2p	0.010
YDR282C	hypothetical protein	0.010
BNA4	Bna4p	0.010
QDR2	Qdr2p	0.010
NAS6	Nas6p	0.010
CAB3	Cab3p	0.010	Yeast
YAL037C-A	hypothetical protein	0.010
EXO84	Exo84p	0.010
TIP1	Tip1p	0.010
TOM1	Tom1p	0.010
YGL235W	hypothetical protein	0.010
RAD59	Rad59p	0.010
PDC5	Pdc5p	0.010
DOG1	Dog1p	0.010
FPS1	Fps1p	0.010
YLL007C	hypothetical protein	0.010
TRM10	Trm10p	0.010
NOG1	Nog1p	0.010
DAS2	Das2p	0.010
YJL160C	hypothetical protein	0.010
PIM1	Pim1p	0.010
PGK1	Pgk1p	0.010
ESC8	Esc8p	0.010
UBC8	Ubc8p	0.010
SUT1	Sut1p	0.010
YNL033W	hypothetical protein	0.010
YBR016W	hypothetical protein	0.010
CLA4	Cla4p	0.010	Human
YCR102C	hypothetical protein	0.010
HUA2	Hua2p	0.010
RIM2	Rim2p	0.010
YMR210W	hypothetical protein	0.010
GLC3	Glc3p	0.010
YDL186W	hypothetical protein	0.010
CCW12	Ccw12p	0.010
TSC3	Tsc3p	0.010
CDC34	Cdc34p	0.010
YJL181W	hypothetical protein	0.010
YGL006W-A	hypothetical protein	0.010
YDL119C	hypothetical protein	0.010
RRP9	Rrp9p	0.010
YIR014W	hypothetical protein	0.010
ACH1	Ach1p	0.010
ICP55	Icp55p	0.010
BCK2	Bck2p	0.010
HOS4	Hos4p	0.010	Yeast