IMP

Process View

Saccharomyces cerevisiae

30 genes annotated in yeast

Multi-species View

negative regulation of signal transduction

GO:0009968

Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction.

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Known genes in the process in yeast Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of signal transduction"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of signal transduction" (in gray)

Name	Description	Probability	Func Analog Organism
KSS1	Kss1p	0.665	Yeast
PPH21	Pph21p	0.640	Yeast
SSN8	Ssn8p	0.509
ROM2	Rom2p	0.507
IRA1	Ira1p	0.462
SCH9	Sch9p	0.418	Mouse
YOL087C	hypothetical protein	0.388
GSC2	Gsc2p	0.315
CRZ1	Crz1p	0.274
REG1	Reg1p	0.258
MSG5	Msg5p	0.258
MKK1	Mkk1p	0.256
PKC1	Pkc1p	0.254	Human Mouse Rat
BOI1	Boi1p	0.227	Yeast
KSP1	Ksp1p	0.225
BCK1	Bck1p	0.220
TPK1	Tpk1p	0.216	Mouse Fly
MSN2	Msn2p	0.202
PPE1	Ppe1p	0.202
FAR1	Far1p	0.189
ICE2	Ice2p	0.188
VPS36	Vps36p	0.187
PKH2	Pkh2p	0.180	Human Mouse
CDC25	Cdc25p	0.162	Mouse
LHS1	Lhs1p	0.156	Mouse
RTS1	Rts1p	0.142
TIP41	Tip41p	0.141
BOI2	Boi2p	0.137	Yeast
FUS3	Fus3p	0.136
RHO1	Rho1p	0.128	Mouse
TPK3	Tpk3p	0.121	Mouse Fly
RTT101	Rtt101p	0.120
LSB1	Lsb1p	0.114
HSP60	Hsp60p	0.112
VPS4	Vps4p	0.111	Fly
ULA1	Ula1p	0.110
STE7	Ste7p	0.103
SCP1	Scp1p	0.103
CDC55	Cdc55p	0.097
SAC7	Sac7p	0.096
VPS5	Vps5p	0.094
CDC34	Cdc34p	0.094
SIZ1	Siz1p	0.092	Human
DID4	Did4p	0.091	Fly
TPK2	Tpk2p	0.089	Mouse Fly
PBS2	Pbs2p	0.087
RAS2	Ras2p	0.086	Fly
PEP5	Pep5p	0.083
GPR1	Gpr1p	0.083
PSP2	Psp2p	0.082
YME1	Yme1p	0.081
VAM3	Vam3p	0.080
SLG1	Slg1p	0.078
SLX5	Slx5p	0.076
KIC1	Kic1p	0.076
BEM4	Bem4p	0.076
STE11	Ste11p	0.075
VPS8	Vps8p	0.075
FPK1	Fpk1p	0.074	Mouse
HOG1	Hog1p	0.071	Mouse Fly
SLN1	Sln1p	0.070
BEM1	Bem1p	0.069	Yeast
RUB1	Rub1p	0.068
TEC1	Tec1p	0.068
TSC11	Tsc11p	0.067
CRG1	Crg1p	0.063
IRA2	Ira2p	0.063
RPN4	Rpn4p	0.062
VPS15	Vps15p	0.061
PSY4	Psy4p	0.060
BCK2	Bck2p	0.059
BEM3	Bem3p	0.059
PTC1	Ptc1p	0.058
GPB2	Gpb2p	0.058
WHI2	Whi2p	0.058
POG1	Pog1p	0.058
STE5	Ste5p	0.058
SAP4	Sap4p	0.057
PRB1	Prb1p	0.057
EBS1	Ebs1p	0.054
PMR1	Pmr1p	0.054
OSH3	Osh3p	0.054
YIL001W	hypothetical protein	0.053
RER2	Rer2p	0.053
SWI1	Swi1p	0.053
NOG2	Nog2p	0.052
URN1	Urn1p	0.052
VAM7	Vam7p	0.051
MDS3	Mds3p	0.051
RLM1	Rlm1p	0.051
MPT5	Mpt5p	0.051
UBA3	Uba3p	0.050
NTO1	Nto1p	0.050
CLA4	Cla4p	0.049
YCL042W	hypothetical protein	0.048
GRX5	Grx5p	0.047
PRR1	Prr1p	0.046	Human
VAC7	Vac7p	0.045
RAD23	Rad23p	0.044
HSV2	Hsv2p	0.044
DIG1	Dig1p	0.043
DCN1	Dcn1p	0.043
MKK2	Mkk2p	0.042
PPH22	Pph22p	0.042	Yeast
MTL1	Mtl1p	0.041
RSC1	Rsc1p	0.041
FYV8	Fyv8p	0.041
HRP1	Hrp1p	0.041
TIM44	Tim44p	0.040
ECM27	Ecm27p	0.040
STE12	Ste12p	0.040
SFT2	Sft2p	0.040
ULP2	Ulp2p	0.039
DID2	Did2p	0.039	Fly
CKS1	Cks1p	0.039
GIS1	Gis1p	0.039
CCZ1	Ccz1p	0.038
CWC23	Cwc23p	0.037
COX9	Cox9p	0.036
VPS41	Vps41p	0.036	Fly
SNF3	Snf3p	0.036
CDC24	Cdc24p	0.036
VPS21	Vps21p	0.036
BTN2	Btn2p	0.036
ATG11	Atg11p	0.036
RSC2	Rsc2p	0.035
GFA1	Gfa1p	0.034
MSS18	Mss18p	0.034
GCN20	Gcn20p	0.034
SKT5	Skt5p	0.034
TFB1	Tfb1p	0.033
ATG4	Atg4p	0.033
MSH3	Msh3p	0.033
VPS24	Vps24p	0.033
FAT1	Fat1p	0.033
TPS1	Tps1p	0.032
DOT6	Dot6p	0.032
NOG1	Nog1p	0.032
YGR126W	hypothetical protein	0.032
BBC1	Bbc1p	0.031
CCR4	Ccr4p	0.031
RIM15	Rim15p	0.030
END3	End3p	0.030
ATG29	Atg29p	0.029
VAM6	Vam6p	0.029
YMR295C	hypothetical protein	0.029
STE23	Ste23p	0.029	Fly
VPS75	Vps75p	0.029
YPI1	Ypi1p	0.029
SKO1	Sko1p	0.029
PCL9	Pcl9p	0.028
SPS100	Sps100p	0.028
TIM23	Tim23p	0.028
GIP2	Gip2p	0.028
SSA3	Ssa3p	0.028	Human
YEL043W	hypothetical protein	0.027
KDX1	Kdx1p	0.027	Yeast
GAL7	Gal7p	0.027
SOK1	Sok1p	0.027
PPZ1	Ppz1p	0.027	Yeast
SSE1	Sse1p	0.027
IST1	Ist1p	0.027
YDR262W	hypothetical protein	0.027
YIR014W	hypothetical protein	0.027
CPR6	Cpr6p	0.027
PTC2	Ptc2p	0.026
GNP1	Gnp1p	0.026
HST3	Hst3p	0.026
CYR1	Cyr1p	0.026
RSC6	Rsc6p	0.026
SPT8	Spt8p	0.026
CMK1	Cmk1p	0.026
DED1	Ded1p	0.026	Human
VTA1	Vta1p	0.026
VPS3	Vps3p	0.025
MSN4	Msn4p	0.025
SUI1	Sui1p	0.025
MEC1	Mec1p	0.025
NRG1	Nrg1p	0.025
PPH3	Pph3p	0.025
ESS1	Ess1p	0.025
SRO77	Sro77p	0.025
TGL4	Tgl4p	0.024
CDC4	Cdc4p	0.024	Mouse
STE18	Ste18p	0.024
REV1	Rev1p	0.024
MMS2	Mms2p	0.024
UBC4	Ubc4p	0.024
CHZ1	Chz1p	0.024
NNF2	Nnf2p	0.024
UBA1	Uba1p	0.023
SAT4	Sat4p	0.023
YIR007W	hypothetical protein	0.023
YGL036W	hypothetical protein	0.023
SRL3	Srl3p	0.023
NSR1	Nsr1p	0.022
KIN28	Kin28p	0.022
YNR014W	hypothetical protein	0.022
SAP190	Sap190p	0.022
VPS33	Vps33p	0.022
FYV10	Fyv10p	0.022
FAR11	Far11p	0.022
KIN82	Kin82p	0.022	Mouse
ZDS1	Zds1p	0.021
FAB1	Fab1p	0.021
ASK10	Ask10p	0.021
CAK1	Cak1p	0.021
YGK3	Ygk3p	0.021
ARE2	Are2p	0.021
REB1	Reb1p	0.021
CDC6	Cdc6p	0.021
CAP1	Cap1p	0.021
AST2	Ast2p	0.021
MON1	Mon1p	0.021
CRS5	Crs5p	0.021
MDM32	Mdm32p	0.021
LAP4	Lap4p	0.020
RMD5	Rmd5p	0.020
YBR056W	hypothetical protein	0.020
AHP1	Ahp1p	0.020
YCF1	Ycf1p	0.020
YEL1	Yel1p	0.020
SKN7	Skn7p	0.020	Yeast
ATG21	Atg21p	0.020
HUR1	Hur1p	0.020
BRR2	Brr2p	0.020
MMS21	Mms21p	0.019
STE4	Ste4p	0.019
RRM3	Rrm3p	0.019
ACK1	Ack1p	0.019
RAD16	Rad16p	0.019
DIA2	Dia2p	0.019
SAP155	Sap155p	0.019
PHM7	Phm7p	0.019
MHT1	Mht1p	0.019
GLN3	Gln3p	0.019
SKG3	Skg3p	0.019
YPT7	Ypt7p	0.019	Human
AZF1	Azf1p	0.018
CUP2	Cup2p	0.018
GLR1	Glr1p	0.018
PMA2	Pma2p	0.018
SET1	Set1p	0.018
MSB3	Msb3p	0.018
SNG1	Sng1p	0.018
FRA1	Fra1p	0.018
TOM1	Tom1p	0.018
VPS53	Vps53p	0.018
NAT1	Nat1p	0.018
UBP9	Ubp9p	0.018	Fly
HSH49	Hsh49p	0.018
FSH3	Fsh3p	0.018
NYV1	Nyv1p	0.018
AKL1	Akl1p	0.018
COQ6	Coq6p	0.017
YHR033W	hypothetical protein	0.017
CHS1	Chs1p	0.017
ERG28	Erg28p	0.017
YLR419W	hypothetical protein	0.017
ENO1	Eno1p	0.017
SKG6	Skg6p	0.017
TGL2	Tgl2p	0.017
LRO1	Lro1p	0.017
PBA1	Pba1p	0.017
TOS4	Tos4p	0.017
APM2	Apm2p	0.017
TPM1	Tpm1p	0.017
DAL82	Dal82p	0.017
RIF1	Rif1p	0.016
MBR1	Mbr1p	0.016
YBL081W	hypothetical protein	0.016
RIM101	Rim101p	0.016
MCA1	Mca1p	0.016
SCT1	Sct1p	0.016
STE2	Ste2p	0.016
DBP2	Dbp2p	0.016
HOS4	Hos4p	0.016
AAC3	Aac3p	0.016	Human
CRT10	Crt10p	0.016
YDR186C	hypothetical protein	0.016
OPY2	Opy2p	0.016
PTR3	Ptr3p	0.016
BEM2	Bem2p	0.016
TUB3	Tub3p	0.016
YER039C-A	hypothetical protein	0.016
SOG2	Sog2p	0.016
NIS1	Nis1p	0.016
FOB1	Fob1p	0.016
MGS1	Mgs1p	0.016
RHB1	Rhb1p	0.016
SIA1	Sia1p	0.016
TRX2	Trx2p	0.016
MKT1	Mkt1p	0.016
TWF1	Twf1p	0.015
BRE5	Bre5p	0.015
HSL7	Hsl7p	0.015
VPS29	Vps29p	0.015
YBR235W	hypothetical protein	0.015
NFI1	Nfi1p	0.015	Human
PIB2	Pib2p	0.015
CKB1	Ckb1p	0.015
NOP10	Nop10p	0.015
PPQ1	Ppq1p	0.015
RHO5	Rho5p	0.015
SNF5	Snf5p	0.015
NBP2	Nbp2p	0.015
KRE2	Kre2p	0.015
PAN3	Pan3p	0.015
CHC1	Chc1p	0.015
GPA1	Gpa1p	0.015
STP2	Stp2p	0.015
MIG1	Mig1p	0.015
BMH1	Bmh1p	0.015
LEU5	Leu5p	0.015
APS1	Aps1p	0.015
PDE2	Pde2p	0.015
NET1	Net1p	0.015
CAM1	Cam1p	0.015
ESP1	Esp1p	0.015
HSF1	Hsf1p	0.015
RRD1	Rrd1p	0.015
NGL3	Ngl3p	0.015
COX13	Cox13p	0.015
MDM20	Mdm20p	0.015
ICS2	Ics2p	0.015
BRO1	Bro1p	0.014
VID28	Vid28p	0.014
ABP1	Abp1p	0.014	Yeast
YMR210W	hypothetical protein	0.014
RAD51	Rad51p	0.014
ECM2	Ecm2p	0.014
ATG20	Atg20p	0.014
DSK2	Dsk2p	0.014
EKI1	Eki1p	0.014
RUP1	Rup1p	0.014
RPT3	Rpt3p	0.014
YLR264C-A	hypothetical protein	0.014
ERG1	Erg1p	0.014
MOT2	Mot2p	0.014
ARG8	Arg8p	0.014
YJL144W	hypothetical protein	0.014
KIN2	Kin2p	0.014
SML1	Sml1p	0.014
BNI1	Bni1p	0.014
YBR225W	hypothetical protein	0.014
TIP1	Tip1p	0.014
SSN3	Ssn3p	0.014
GLO4	Glo4p	0.014
FMN1	Fmn1p	0.014
VPS16	Vps16p	0.014
YPD1	Ypd1p	0.014
DOG2	Dog2p	0.014
CCC1	Ccc1p	0.014
PCL2	Pcl2p	0.014
MSC1	Msc1p	0.013
RPH1	Rph1p	0.013
CSR2	Csr2p	0.013
DIB1	Dib1p	0.013
CEG1	Ceg1p	0.013
GAT2	Gat2p	0.013
ARP10	Arp10p	0.013
RAX1	Rax1p	0.013
DBR1	Dbr1p	0.013
FRT1	Frt1p	0.013
YOL038C-A	hypothetical protein	0.013
YAR068W	hypothetical protein	0.013
LEU2	Leu2p	0.013
APL4	Apl4p	0.013
DUR1,2	Dur1,2p	0.013
HEM3	Hem3p	0.013
SSP1	Ssp1p	0.013
SSU72	Ssu72p	0.013
PGS1	Pgs1p	0.013
SHO1	Sho1p	0.013
AGE1	Age1p	0.013
HSP78	Hsp78p	0.013
SRD1	Srd1p	0.013
SAM35	Sam35p	0.013
BRE4	Bre4p	0.013
YIL077C	hypothetical protein	0.013
HAP1	Hap1p	0.013
ASH1	Ash1p	0.013
CUE2	Cue2p	0.013
SAS3	Sas3p	0.013
CNB1	Cnb1p	0.013
CDC50	Cdc50p	0.013
GIC2	Gic2p	0.013
UPS3	Ups3p	0.013
RHO4	Rho4p	0.013
CHS5	Chs5p	0.013
TFB4	Tfb4p	0.013
BST1	Bst1p	0.012
MGR1	Mgr1p	0.012
DIF1	Dif1p	0.012
RAM1	Ram1p	0.012
GLC3	Glc3p	0.012
IRC21	Irc21p	0.012
RPL5	Rpl5p	0.012
YCR102C	hypothetical protein	0.012
ZEO1	Zeo1p	0.012
RAD30	Rad30p	0.012
DOP1	Dop1p	0.012
TAX4	Tax4p	0.012
GDH3	Gdh3p	0.012
YPK1	Ypk1p	0.012	Mouse
UBR1	Ubr1p	0.012
OCH1	Och1p	0.012
DAS2	Das2p	0.012
URA3	Ura3p	0.012
MIA40	Mia40p	0.012
CAF120	Caf120p	0.012
INP52	Inp52p	0.012
DOA4	Doa4p	0.012
PHO85	Pho85p	0.012
SCM4	Scm4p	0.012
CLU1	Clu1p	0.012
NRD1	Nrd1p	0.012
YJL107C	hypothetical protein	0.012
SVF1	Svf1p	0.012
SSK22	Ssk22p	0.012
SKP2	Skp2p	0.012
RTT106	Rtt106p	0.012
SSA4	Ssa4p	0.012	Human
RED1	Red1p	0.012
ANB1	Anb1p	0.012
RGD2	Rgd2p	0.012
RRT13	Rrt13p	0.012
PBP1	Pbp1p	0.012
AIR1	Air1p	0.012
FAR10	Far10p	0.012
NVJ1	Nvj1p	0.012
RRS1	Rrs1p	0.012
SFB3	Sfb3p	0.012
PSY2	Psy2p	0.012
YFR006W	hypothetical protein	0.012
CYK3	Cyk3p	0.012
YBR013C	hypothetical protein	0.012
GAL4	Gal4p	0.011
RGD1	Rgd1p	0.011	Yeast
CDS1	Cds1p	0.011
HHF1	Hhf1p	0.011
APM4	Apm4p	0.011
SGE1	Sge1p	0.011
RTT105	Rtt105p	0.011
YNL058C	hypothetical protein	0.011
YIL152W	hypothetical protein	0.011
MF(ALPHA)2	Mf(alpha)2p	0.011
AUA1	Aua1p	0.011
CYC8	Cyc8p	0.011
MF(ALPHA)1	Mf(alpha)1p	0.011
MMS1	Mms1p	0.011
YML082W	hypothetical protein	0.011
NPR3	Npr3p	0.011
FTH1	Fth1p	0.011
YKR041W	hypothetical protein	0.011
ADR1	Adr1p	0.011
YER071C	hypothetical protein	0.011
RPL19A	Rpl19ap	0.011
YNL190W	hypothetical protein	0.011
HMT1	Hmt1p	0.011
AAD6	Aad6p	0.011
ABZ1	Abz1p	0.011
COX2	Cox2p	0.011
DUG3	Dug3p	0.011
CUP1-1	Cup1-1p	0.011
STE20	Ste20p	0.011
YEL057C	hypothetical protein	0.011
MER1	Mer1p	0.011
YGR079W	hypothetical protein	0.011
YER128W	hypothetical protein	0.011
RAD24	Rad24p	0.011
STE50	Ste50p	0.011
HPF1	Hpf1p	0.011
DBP3	Dbp3p	0.011
CNE1	Cne1p	0.011
LCL1	Lcl1p	0.011
NOP15	Nop15p	0.011
HAL5	Hal5p	0.011
RAD52	Rad52p	0.011
ROM1	Rom1p	0.011	Yeast
CBP1	Cbp1p	0.011
ZPS1	Zps1p	0.011
YIR016W	hypothetical protein	0.011
PKP1	Pkp1p	0.011
GRR1	Grr1p	0.011
GLE1	Gle1p	0.011
HXT3	Hxt3p	0.010
AFR1	Afr1p	0.010
HIR1	Hir1p	0.010
DMA2	Dma2p	0.010
SAS5	Sas5p	0.010
ATP6	Atp6p	0.010
CTS1	Cts1p	0.010
NHX1	Nhx1p	0.010
YIL151C	hypothetical protein	0.010
TDH2	Tdh2p	0.010
YOL073C	hypothetical protein	0.010
FMP52	Fmp52p	0.010
YJR115W	hypothetical protein	0.010
NRG2	Nrg2p	0.010
RLF2	Rlf2p	0.010
RER1	Rer1p	0.010
CPD1	Cpd1p	0.010
AVT3	Avt3p	0.010
AAD15	Aad15p	0.010
TYE7	Tye7p	0.010
YER140W	hypothetical protein	0.010
SPT5	Spt5p	0.010
YDR348C	hypothetical protein	0.010
LDB7	Ldb7p	0.010
RFM1	Rfm1p	0.010
MSN1	Msn1p	0.010
PAA1	Paa1p	0.010
AQR1	Aqr1p	0.010
YLR162W	hypothetical protein	0.010
KCS1	Kcs1p	0.010
TKL2	Tkl2p	0.010
ARR2	Arr2p	0.010
AYT1	Ayt1p	0.010
PTR2	Ptr2p	0.010
PPZ2	Ppz2p	0.010	Yeast
YOL014W	hypothetical protein	0.010
SDP1	Sdp1p	0.010
FUN19	Fun19p	0.010
PIN3	Pin3p	0.010
TMA108	Tma108p	0.010