IMP

Process View

Danio rerio

1 genes annotated in zebrafish

negative regulation of histone methylation

Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent addition of methyl groups to histones.

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Known genes in the process in zebrafish Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of histone methylation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of histone methylation" (in gray)

Name	Description	Probability	Func Analog Organism
pds5b	PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)	0.292
dnmt3	DNA (cytosine-5-)-methyltransferase 3	0.242
hells	helicase, lymphoid-specific	0.199
med12	mediator of RNA polymerase II transcription, subunit 12 homolog	0.189
smc2	structural maintenance of chromosomes 2	0.177
msh6	mutS homolog 6 (E. coli)	0.174
ahctf1	AT hook containing transcription factor 1	0.171
pold1	polymerase (DNA directed), delta 1, catalytic subunit	0.141
dnmt1	DNA (cytosine-5-)-methyltransferase 1	0.126	Human
zfp36l1a	zinc finger protein 36, C3H type-like 1a	0.094
crb2a	crumbs homolog 2a	0.085
whsc1	Wolf-Hirschhorn syndrome candidate 1	0.083
dnmt7	DNA (cytosine-5-)-methyltransferase 7	0.073	Human
pola1	polymerase (DNA directed), alpha 1	0.063
smc3	structural maintenance of chromosomes 3	0.061
sox8	SRY-box containing gene 8	0.054
dnmt8	DNA (cytosine-5-)-methyltransferase 8	0.053
mcm5	MCM5 minichromosome maintenance deficient 5 (S. cerevisiae)	0.050
chek2	CHK2 checkpoint homolog (S. pombe)	0.047
epb41l5	erythrocyte membrane protein band 4.1 like 5	0.047
col15a1b	collagen, type XV, alpha 1b	0.044
dnmt5	DNA (cytosine-5-)-methyltransferase 5	0.041	Human
chtf18	CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)	0.037
chaf1b	chromatin assembly factor 1, subunit B	0.037
notch1a	notch homolog 1a	0.034
dnmt6	DNA (cytosine-5-)-methyltransferase 6	0.033
vsx2	visual system homeobox 2	0.033
gnl2	guanine nucleotide binding protein-like 2 (nucleolar)	0.032
stil	TAL1 (SCL) interrupting locus	0.032
atad5a	ATPase family, AAA domain containing 5a	0.030
cdon	cell adhesion molecule-related/down-regulated by oncogenes	0.028
nr2e1	nuclear receptor subfamily 2, group E, member 1	0.028
cc2d2a	coiled-coil and C2 domain containing 2A	0.027
ift88	intraflagellar transport 88 homolog	0.026
rad21	RAD21 homolog (S. pombe)	0.026
pou3f3a	POU class 3 homeobox 3a	0.026
foxp2	forkhead box P2	0.025
cad	carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase	0.025
ep300b	E1A binding protein p300 b	0.025
pard6gb	par-6 partitioning defective 6 homolog gamma B (C. elegans)	0.024
hat1	histone acetyltransferase 1	0.024
axin1	axin 1	0.024
meis2.2	myeloid ecotropic viral integration site 2.2	0.024
pole2	polymerase (DNA directed), epsilon 2	0.023
mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.023
nrg2a	neuregulin 2a	0.022
ifnphi1	interferon phi 1	0.022
mitfa	microphthalmia-associated transcription factor a	0.021
apc	adenomatosis polyposis coli	0.020
vdra	vitamin D receptor a	0.020
cdc34b	cell division cycle 34 homolog (S. cerevisiae) b	0.020
usp7	ubiquitin specific peptidase 7 (herpes virus-associated)	0.020
rab11fip4a	RAB11 family interacting protein 4 (class II) a	0.020
LOC554173	abnormal spindles	0.019
wdhd1	WD repeat and HMG-box DNA binding protein 1	0.019
lbr	lamin B receptor	0.019
LOC100332448	hypothetical protein LOC100332448	0.019
mcm3	MCM3 minichromosome maintenance deficient 3 (S. cerevisiae)	0.019
pwp2h	PWP2 periodic tryptophan protein homolog (yeast)	0.018
nkx2.1a	NK2 homeobox 1a	0.018
col4a5	collagen, type IV, alpha 5 (Alport syndrome)	0.018
ezh2	enhancer of zeste homolog 2 (Drosophila)	0.018
gart	phosphoribosylglycinamide formyltransferase	0.018
smc4	structural maintenance of chromosomes 4	0.018
ssrp1a	structure specific recognition protein 1a	0.018
ncaph	non-SMC condensin I complex, subunit H	0.017
col14a1	collagen, type XIV, alpha 1	0.017
wu:fc85c01	wu:fc85c01	0.017
foxe3	forkhead box E3	0.017
dopey1	dopey family member 1	0.016
znf410	zinc finger protein 410	0.016
atoh7	atonal homolog 7	0.016
ddx26b	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B	0.016
ctnnd2b	catenin (cadherin-associated protein), delta 2b	0.015
rb1	retinoblastoma 1	0.015
map2k4a	mitogen-activated protein kinase kinase 4a	0.015
foxi1	forkhead box I1	0.015
pknox1.2	pbx/knotted 1 homeobox 1.2	0.015
brip1	BRCA1 interacting protein C-terminal helicase 1	0.015
ncapd2	non-SMC condensin I complex, subunit D2	0.014
nadl1.2	neural adhesion molecule L1.2	0.014
pax6b	paired box gene 6b	0.014
rrm1	ribonucleotide reductase M1 polypeptide	0.014
ncapg	non-SMC condensin I complex, subunit G	0.013
jag2	jagged 2	0.013
zgc:56039	zgc:56039	0.013
her8a	hairy-related 8a	0.013
supt5h	suppressor of Ty 5 homolog (S. cerevisiae)	0.013
hes6	hairy and enhancer of split 6 (Drosophila)	0.013
evx2	even-skipped homeobox 2	0.013
tert	telomerase reverse transcriptase	0.013
gdf6a	growth differentiation factor 6a	0.012
mcm4	MCM4 minichromosome maintenance deficient 4, mitotin (S. cerevisiae)	0.012
pprc1	peroxisome proliferator-activated receptor gamma, coactivator-related 1	0.012
esco2	establishment of cohesion 1 homolog 2	0.012
smc1al	structural maintenance of chromosomes 1A, like	0.012
tcf7l1a	transcription factor 7-like 1a (T-cell specific, HMG-box)	0.012
si:ch211-170d8.2	si:ch211-170d8.2	0.012
her2	hairy-related 2	0.012
tyms	thymidylate synthase	0.011
brd3b	bromodomain containing 3b	0.011
zgc:158643	zgc:158643	0.011
dtl	denticleless homolog (Drosophila)	0.011
cltca	clathrin, heavy polypeptide a (Hc)	0.011
otpa	orthopedia homolog a	0.011
ppm1g	protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform	0.011
ints9	integrator complex subunit 9	0.011
nap1l1	nucleosome assembly protein 1, like 1	0.010
wu:fi25h02	wu:fi25h02	0.010
si:dkey-236e20.6	si:dkey-236e20.6	0.010
ptch1	patched 1	0.010