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Danio rerio

15 genes annotated in zebrafish

heterocycle catabolic process

The chemical reactions and pathways resulting in the breakdown of heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings).

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Known genes in the process in zebrafish Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "heterocycle catabolic process"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "heterocycle catabolic process" (in gray)

Name	Description	Probability	Func Analog Organism
mcm6	MCM6 minichromosome maintenance deficient 6, mitotin (S. cerevisiae)	0.227	Human
dlg1	discs, large (Drosophila) homolog 1	0.109
ef1a	elongation factor 1-alpha	0.103	Worm
atp1b3b	ATPase, Na+/K+ transporting, beta 3b polypeptide	0.095	Human
mybl2	myeloblastosis oncogene-like 2	0.088
tm9sf2	transmembrane 9 superfamily member 2	0.088
tnnc1b	troponin C type 1b (slow)	0.088
gnaia	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	0.085
bida	BH3 interacting domain death agonist	0.071
atp1a1a.4	ATPase, Na+/K+ transporting, alpha 1a.4 polypeptide	0.069	Human Zebrafish Mouse Rat Worm Fly
eomesa	eomesodermin homolog a	0.065
hspa4a	heat shock protein 4a	0.064	Yeast
flot2a	flotillin 2a	0.057
tgfb3	transforming growth factor, beta 3	0.056
atp1b1b	ATPase, Na+/K+ transporting, beta 1b polypeptide	0.049
pafah1b1b	platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit b	0.047	Mouse
plxnb2a	plexin b2a	0.047	Mouse
pcna	proliferating cell nuclear antigen	0.046	Human
sass6	spindle assembly 6 homolog (C. elegans)	0.046
zgc:73142	zgc:73142	0.045
myhz1.2	myosin, heavy polypeptide 1.2, skeletal muscle	0.042
calb2b	calbindin 2b, (calretinin)	0.040
tnnt3b	troponin T3b, skeletal, fast	0.040	Human
sf3b5	splicing factor 3b, subunit 5	0.039
atp6v0ca	ATPase, H+ transporting, lysosomal, V0 subunit c, a	0.038
mylz2	myosin, light polypeptide 2, skeletal muscle	0.038
ryr3	ryanodine receptor 3	0.038
cacnb1	calcium channel, voltage-dependent, beta 1 subunit	0.035
atf4b2	activating transcription factor 4b2	0.034
sip1	survival of motor neuron protein interacting protein 1	0.034
eif3s10	eukaryotic translation initiation factor 3, subunit 10 (theta)	0.034
bactin2	bactin2	0.033
sox11b	SRY-box containing gene 11b	0.032
ilf2	interleukin enhancer binding factor 2	0.031
sncb	synuclein, beta	0.031
snx6	sorting nexin 6	0.031
tnni2a.4	troponin I, skeletal, fast 2a.4	0.031
bcl2l1	bcl2-like 1	0.030	Worm
cx43	connexin 43	0.030
cyp2y3	cytochrome P450, family 2, subfamily Y, polypeptide 3	0.030
sumo3a	SMT3 suppressor of mif two 3 homolog 3a	0.030
ndufs4	NADH dehydrogenase (ubiquinone) Fe-S protein 4, (NADH-coenzyme Q reductase)	0.030
atp1a1a.2	ATPase, Na+/K+ transporting, alpha 1a.2 polypeptide	0.030	Human Zebrafish Mouse Rat Worm Fly
atp1a1	ATPase, Na+/K+ transporting, alpha 1 polypeptide	0.029
arf5	ADP-ribosylation factor 5	0.029
arpc5a	actin related protein 2/3 complex, subunit 5A	0.029
arf2	ADP-ribosylation factor 2	0.028
upf2	UPF2 regulator of nonsense transcripts homolog (yeast)	0.028
gro2	groucho 2	0.028
zbtb4	zinc finger and BTB domain containing 4	0.027
ncor1	nuclear receptor co-repressor 1	0.027
lrp2	low density lipoprotein-related protein 2	0.027
usp5	ubiquitin specific protease 5	0.026
ndufb8	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8	0.026
eif4e1c	eukaryotic translation initiation factor 4E family member 1c	0.026
psmd13	proteasome (prosome, macropain) 26S subunit, non-ATPase, 13	0.026
rtcd1	RNA terminal phosphate cyclase domain 1	0.026
etf1	eukaryotic translation termination factor 1	0.025
srpr	signal recognition particle receptor (docking protein)	0.025
smg5	Smg-5 homolog, nonsense mediated mRNA decay factor (C. elegans)	0.025
lmx1b.1	LIM homeobox transcription factor 1, beta 1	0.025
aaas	achalasia, adrenocortical insufficiency, alacrimia	0.024
terfa	telomeric repeat binding factor a	0.024
sncgb	synuclein, gamma b (breast cancer-specific protein 1)	0.024
bcl2l10	BCL2-like 10 (apoptosis facilitator)	0.024
tpm1	tropomyosin 1 (alpha)	0.024
rap2ip	Rap2 interacting protein	0.023
smg1	PI-3-kinase-related kinase SMG-1	0.023	Human Worm
zgc:101661	zgc:101661	0.023
mycbp2	MYC binding protein 2	0.023
bcl2	B-cell leukemia/lymphoma 2	0.023	Worm
mif	macrophage migration inhibitory factor	0.023
nf1a	neurofibromin 1a	0.023	Mouse Rat Fly
adcyap1b	adenylate cyclase activating polypeptide 1b	0.023
foxi3a	forkhead box I3a	0.022
strap	serine/threonine kinase receptor associated protein	0.022
atp6v1h	ATPase, H+ transporting, lysosomal, V1 subunit H	0.022
msh2	mutS homolog 2 (E. coli)	0.022	Human Yeast Mouse
nedd8	neural precursor cell expressed, developmentally down-regulated 8	0.022
fhla	four and a half LIM domains a	0.022
fen1	flap structure-specific endonuclease 1	0.022	Human Yeast Mouse Worm
epb41l5	erythrocyte membrane protein band 4.1 like 5	0.021
zgc:56085	zgc:56085	0.021
odc1	ornithine decarboxylase 1	0.021
csrp1a	cysteine and glycine-rich protein 1a	0.021
sept2	septin 2	0.021
msna	moesin a	0.020
jun	jun proto-oncogene	0.020	Human
whsc1	Wolf-Hirschhorn syndrome candidate 1	0.020
bms1l	BMS1-like, ribosome assembly protein (yeast)	0.020
snap25b	synaptosome-associated protein 25b	0.020
rbm4.1	RNA binding motif protein 4.1	0.020
nanos3	nanos homolog 3	0.019
trpc1	transient receptor potential cation channel, subfamily C, member 1	0.019
wnt5a	wingless-type MMTV integration site family, member 5a	0.019
ldb3a	LIM-domain binding factor 3a	0.019
rab1a	RAB1A, member RAS oncogene family	0.019	Human
podxl	podocalyxin-like	0.019
tpm4	tropomyosin 4	0.019
psmc6	proteasome (prosome, macropain) 26S subunit, ATPase, 6	0.019
atp5a1	ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle	0.019	Human Mouse
gngt1	guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1	0.019
zgc:100994	zgc:100994	0.018
pccb	propionyl Coenzyme A carboxylase, beta polypeptide	0.018
stm	starmaker	0.018
adrb2a	adrenergic receptor, beta 2a	0.018
mcm5	MCM5 minichromosome maintenance deficient 5 (S. cerevisiae)	0.018	Yeast
aldh7a1	aldehyde dehydrogenase 7 family, member A1	0.017
rpl3	ribosomal protein L3	0.017
hprt1	hypoxanthine phosphoribosyltransferase 1	0.017	Human
ddx42	DEAD (Asp-Glu-Ala-Asp) box polypeptide 42	0.017
hsp90a.2	heat shock protein 90-alpha 2	0.017	Human Worm
flot1	flotillin 1	0.017
atp1a1a.5	ATPase, Na+/K+ transporting, alpha 1a.5 polypeptide	0.017	Human Zebrafish Mouse Rat Worm Fly
ckbb	creatine kinase, brain b	0.017
bon	bonnie and clyde	0.017
piwil2	piwi-like 2 (Drosophila)	0.017	Fly
ap2a1	adaptor-related protein complex 2, alpha 1 subunit	0.017
huwe1	HECT, UBA and WWE domain containing 1	0.016
gnat2	guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2	0.016	Mouse
si:dkey-189i22.1	si:dkey-189i22.1	0.016
ptprk	protein tyrosine phosphatase, receptor type, K	0.016
zgc:92139	zgc:92139	0.016
zgc:86903	zgc:86903	0.016
bmp7a	bone morphogenetic protein 7a	0.015
zgc:65894	zgc:65894	0.015
zgc:136346	zgc:136346	0.015
lrrn1	leucine rich repeat neuronal 1	0.015
h3f3c	H3 histone, family 3C	0.015
ddx19	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 19 (DBP5 homolog, yeast)	0.015	Yeast
eme1	essential meiotic endonuclease 1 homolog 1 (S. pombe)	0.015
pak2a	p21 (CDKN1A)-activated kinase 2a	0.015
esco2	establishment of cohesion 1 homolog 2	0.015
s100t	S100 calcium binding protein T	0.015
emx2	empty spiracles homeobox 2	0.015
pold1	polymerase (DNA directed), delta 1, catalytic subunit	0.015	Yeast
hspa8	heat shock protein 8	0.015	Human Worm
wu:fb71f10	wu:fb71f10	0.015
im:7150454	im:7150454	0.015
prp19	PRP19/PSO4 homolog (S. cerevisiae)	0.015
psmd6	proteasome (prosome, macropain) 26S subunit, non-ATPase, 6	0.015
copeb	core promoter element binding protein	0.014
rbl1	retinoblastoma-like 1 (p107)	0.014
gna14	guanine nucleotide binding protein (G protein), alpha 14	0.014
uap1l1	UDP-N-acteylglucosamine pyrophosphorylase 1, like 1	0.014
hspg2	heparan sulfate proteoglycan 2	0.014
tmem59l	transmembrane protein 59-like and transmembrane protein 59-like	0.014
zgc:55461	zgc:55461	0.014
sept9b	septin 9b	0.014
tnnt3a	troponin T3a, skeletal, fast	0.014	Human
rc3	rabconnectin 3	0.014
nme2b.2	non-metastatic cells 2b.2, protein (NM23B) expressed in	0.014
baxb	bcl2-associated X protein, b	0.014	Worm
pknox1.2	pbx/knotted 1 homeobox 1.2	0.014
paxip1	PAX interacting (with transcription-activation domain) protein 1	0.014
prim1	primase polypeptide 1	0.014
pvalb8	parvalbumin 8	0.014
kif20bb	kinesin family member 20Bb	0.014
cct5	chaperonin containing TCP1, subunit 5 (epsilon)	0.014
ran	ras-related nuclear protein	0.013
hnrnpab	heterogeneous nuclear ribonucleoprotein A/B	0.013
api5	apoptosis inhibitor 5	0.013
cand1	cullin-associated and neddylation-dissociated 1	0.013
macf1	microtubule-actin crosslinking factor 1	0.013
zgc:112254	zgc:112254	0.013
rorb	RAR-related orphan receptor B	0.013
ndufs5	NADH dehydrogenase (ubiquinone) Fe-S protein 5	0.013
lsm7	LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)	0.013	Yeast
zgc:55891	zgc:55891	0.013
arf1	ADP-ribosylation factor 1	0.013
fech	ferrochelatase	0.013
eif3b	eukaryotic translation initiation factor 3, subunit B	0.013
nptna	neuroplastin a	0.013
eif2d	eukaryotic translation initiation factor 2D	0.013
rab32a	RAB32a, member RAS oncogene family	0.013	Human
psmd10	proteasome (prosome, macropain) 26S subunit, non-ATPase, 10	0.013
stam	signal transducing adaptor molecule (SH3 domain and ITAM motif) 1	0.013
ddx39b	DEAD (Asp-Glu-Ala-Asp) box polypeptide 39b	0.013	Yeast
mdh1a	malate dehydrogenase 1a, NAD (soluble)	0.013
arpc5b	actin related protein 2/3 complex, subunit 5B	0.013
adssl	adenylosuccinate synthase, like	0.013
rbm19	RNA binding motif protein 19	0.013
flr	fleer	0.013
tm9sf4	transmembrane 9 superfamily protein member 4	0.012
snrpc	small nuclear ribonucleoprotein polypeptide C	0.012
tia1l	cytotoxic granule-associated RNA binding protein 1, like	0.012	Yeast
eif3d	eukaryotic translation initiation factor 3, subunit D	0.012
zgc:101724	zgc:101724	0.012
ndel1a	nudE nuclear distribution gene E homolog like 1 (A. nidulans) A	0.012	Mouse
calb2a	calbindin 2a	0.012
ivns1abpa	influenza virus NS1A binding protein a	0.012
srm	spermidine synthase	0.012
ccna2	cyclin A2	0.012
gna11	guanine nucleotide binding protein (G protein), alpha 11 (Gq class)	0.012
rpa2	replication protein A2	0.012
sox1a	SRY-box containing gene 1a	0.012
ddx56	DEAD (Asp-Glu-Ala-Asp) box polypeptide 56	0.012	Yeast
wnt2bb	wingless-type MMTV integration site family, member 2Bb	0.012
bactin1	bactin1	0.012
zgc:110682	zgc:110682	0.012
prkcbp1l	protein kinase C binding protein 1, like	0.012
polr2d	polymerase (RNA) II (DNA directed) polypeptide D	0.012
org	oogenesis-related gene	0.012
atp2a1l	ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 like	0.012	Worm Fly
wu:fa27a01	wu:fa27a01	0.012
neurod6b	neurogenic differentiation 6b	0.012
csnk1g2a	casein kinase 1, gamma 2a	0.012
tie1	endothelium-specific receptor tyrosine kinase 1	0.012
ccdc47	coiled-coil domain containing 47	0.012
gna12	guanine nucleotide binding protein (G protein) alpha 12	0.012
rac1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	0.012
rqcd1	RCD1 required for cell differentiation1 homolog (S. pombe)	0.012
arpp19b	cAMP-regulated phosphoprotein 19b	0.012
gnai1	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	0.012	Yeast
aldh18a1	aldehyde dehydrogenase 18 family, member A1	0.012
rbm4.2	RNA binding motif protein 4.2	0.012
si:ch211-243g18.2	si:ch211-243g18.2	0.012
ndufs2	NADH dehydrogenase (ubiquinone) Fe-S protein 2	0.012
upf1	upf1 regulator of nonsense transcripts homolog (yeast)	0.012
zgc:112425	zgc:112425	0.011
evx1	even-skipped homeobox 1	0.011
psmc4	proteasome (prosome, macropain) 26S subunit, ATPase, 4	0.011
spry4	sprouty (Drosophila) homolog 4	0.011
pgam2	phosphoglycerate mutase 2 (muscle)	0.011
rfc4	replication factor C (activator 1) 4	0.011
setd8a	SET domain containing (lysine methyltransferase) 8a	0.011
zgc:91910	zgc:91910	0.011
rbbp6	retinoblastoma binding protein 6	0.011
wu:fb58e05	wu:fb58e05	0.011
pax6b	paired box gene 6b	0.011
tnni1b	troponin I, skeletal, slow b	0.011
cdc42	cell division cycle 42	0.011	Yeast Mouse Worm Fly
nudt9	nudix (nucleoside diphosphate linked moiety X)-type motif 9	0.011
slc25a25a	solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25a	0.011
celf1	cugbp, Elav-like family member 1	0.011
zgc:77052	zgc:77052	0.011
tnnt2a	troponin T2a, cardiac	0.011
epb4.1l4	erythrocyte protein band 4.1-like 4	0.011
zgc:73107	zgc:73107	0.011
s100z	S100 calcium binding protein Z	0.011
six1b	sine oculis homeobox homolog 1b	0.011
hsp70l	heat shock cognate 70-kd protein, like	0.011
tmem2	transmembrane protein 2	0.011
sbf1	SET binding factor 1	0.011	Human
zgc:77517	zgc:77517	0.011
zgc:92392	zgc:92392	0.011
acox1	acyl-Coenzyme A oxidase 1, palmitoyl	0.011
gnai2l	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2, like	0.011
hspa5	heat shock protein 5	0.011	Yeast
zgc:158138	zgc:158138	0.011
pola2	polymerase (DNA directed), alpha 2	0.011
stau2	staufen, RNA binding protein, homolog 2 (Drosophila)	0.011
hmgcs1	3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble)	0.011
zgc:63599	zgc:63599	0.011
pvalb4	parvalbumin 4	0.011
acta1b	actin, alpha 1b, skeletal muscle	0.011
acvr2a	activin receptor IIa	0.011
dnaja2	DnaJ (Hsp40) homolog, subfamily A, member 2	0.011	Yeast
uchl1	ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)	0.011
zgc:154089	zgc:154089	0.011
edar	ectodysplasin A receptor	0.011
LOC100149148	novel protein similar to myosin heavy chain 4 (myhc4)	0.011
cnn2	calponin 2	0.011
rab7	RAB7, member RAS oncogene family	0.011	Human Yeast Worm
zgc:111961	zgc:111961	0.011
zgc:65979	zgc:65979	0.011
tnni1al	troponin I, skeletal, slow like	0.011
slc38a2	solute carrier family 38, member 2	0.010
acy3.2	aspartoacylase (aminocyclase) 3.2	0.010
nrarpb	notch-regulated ankyrin repeat protein b	0.010
rfc5	replication factor C (activator 1) 5	0.010
si:dkeyp-113d7.4	si:dkeyp-113d7.4	0.010
im:7137453	im:7137453	0.010
eif4a3	eukaryotic translation initiation factor 4A, isoform 3	0.010	Human
dlst	dihydrolipoamide S-succinyltransferase	0.010
dkk1b	dickkopf 1b	0.010
atp1b2a	ATPase, Na+/K+ transporting, beta 2a polypeptide	0.010
tubb2c	tubulin, beta 2c	0.010
atp1a3b	ATPase, Na+/K+ transporting, alpha 3b polypeptide	0.010	Zebrafish Worm Fly
arnt2	aryl hydrocarbon receptor nuclear translocator 2	0.010
mga	MAX gene associated	0.010
mtp	microsomal triglyceride transfer protein	0.010
tacc2	transforming, acidic coiled-coil containing protein 2	0.010
rab25	RAB25, member RAS oncogene family	0.010	Yeast Fly
tfec	transcription factor EC	0.010
nrg1	neuregulin 1	0.010
dut	dUTP pyrophosphatase	0.010
ntrk2b	neurotrophic tyrosine kinase, receptor, type 2b	0.010	Mouse
rae1	RAE1 RNA export 1 homolog (S. pombe)	0.010
cldn12	claudin 12	0.010
LOC325449	kinesin family member 20A	0.010
pfn2l	profilin 2 like	0.010