IMP

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Danio rerio

2 genes annotated in zebrafish

Multi-species View

positive regulation of heart contraction

GO:0045823

Any process that activates or increases the frequency, rate or extent of heart contraction.

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Known genes in the process in zebrafish Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of heart contraction"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "positive regulation of heart contraction" (in gray)

Name	Description	Probability	Func Analog Organism
myog	myogenin	0.512
actc1a	actin, alpha, cardiac muscle 1a	0.380
vmhc	ventricular myosin heavy chain	0.377
cmlc1	cardiac myosin light chain-1	0.335
tnnt2a	troponin T2a, cardiac	0.251
tnnc1b	troponin C type 1b (slow)	0.242
actc1b	actin, alpha, cardiac muscle 1b	0.222
chrna1	cholinergic receptor, nicotinic, alpha polypeptide 1	0.204
aldh1a2	aldehyde dehydrogenase 1 family, member A2	0.197
unc45b	unc-45 homolog B (C. elegans)	0.170
myh6	myosin, heavy polypeptide 6, cardiac muscle, alpha	0.166
ttna	titin a	0.164
atp1b1a	ATPase, Na+/K+ transporting, beta 1a polypeptide	0.146
wnt11r	wingless-type MMTV integration site family, member 11, related	0.128
nkx2.5	NK2 transcription factor related 5	0.115
zgc:66286	zgc:66286	0.101
tnnc2	troponin C type 2 (fast)	0.093
slc8a1a	solute carrier family 8 (sodium/calcium exchanger), member 1a	0.093
acta1b	actin, alpha 1b, skeletal muscle	0.086
cdh2	cadherin 2, neuronal	0.086
tnnc1a	troponin C type 1a (slow)	0.085
atp2a2a	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2a	0.085
tbx5b	T-box 5b	0.078
nppa	natriuretic peptide precursor A	0.077
tbx1	T-box 1	0.077
atp1b1b	ATPase, Na+/K+ transporting, beta 1b polypeptide	0.073
tbx5a	T-box 5a	0.073
ckma	creatine kinase, muscle a	0.071
synpo2lb	synaptopodin 2-like b	0.067
myod1	myogenic differentiation 1	0.066
atp1a1a.2	ATPase, Na+/K+ transporting, alpha 1a.2 polypeptide	0.063	Mouse
dpf3	D4, zinc and double PHD fingers, family 3	0.063
vcana	versican a	0.062
cav3	caveolin 3	0.061
xirp1	xin actin-binding repeat containing 1	0.059
nexn	nexilin (F actin binding protein)	0.058
atp1b2b	ATPase, Na+/K+ transporting, beta 2b polypeptide	0.056
tgfb3	transforming growth factor, beta 3	0.056
agr2	anterior gradient homolog 2 (Xenopus laevis)	0.053
pvalb8	parvalbumin 8	0.052
atp1a1a.3	ATPase, Na+/K+ transporting, alpha 1a.3 polypeptide	0.051	Mouse
aldoab	aldolase a, fructose-bisphosphate, b	0.051
atp2a1	ATPase, Ca++ transporting, cardiac muscle, fast twitch 1	0.050
scn12aa	sodium channel, voltage gated, type XII, alpha a	0.050
glula	glutamate-ammonia ligase (glutamine synthase) a	0.046
myl7	myosin, light polypeptide 7, regulatory	0.046
ttnb	titin b	0.046
rbm24b	RNA binding motif protein 24b	0.045
crip2	cysteine-rich protein 2	0.045
acta1a	actin, alpha 1a, skeletal muscle	0.044
bmp10	bone morphogenetic protein 10	0.043
lrrc10	leucine rich repeat containing 10	0.040
scn3b	sodium channel, voltage-gated, type III, beta	0.040	Mouse
smyd1b	SET and MYND domain containing 1b	0.040
myl1	myosin, light chain 1, alkali; skeletal, fast	0.040
fabp2	fatty acid binding protein 2, intestinal	0.039
atp1a1	ATPase, Na+/K+ transporting, alpha 1 polypeptide	0.039	Mouse
slc6a6	solute carrier family 6 (neurotransmitter transporter, taurine), member 6	0.039
pvalb4	parvalbumin 4	0.038
slc5a5	solute carrier family 5 (sodium iodide symporter), member 5	0.037
wu:fb01h12	wu:fb01h12	0.036
pax9	paired box gene 9	0.035
edn1	endothelin 1	0.034
mylk3	myosin light chain kinase 3	0.034
cldnh	claudin h	0.033
rbfox1l	RNA binding protein, fox-1 homolog (C. elegans) 1-like	0.033
scn2b	sodium channel, voltage-gated, type II, beta	0.033
mef2cb	myocyte enhancer factor 2cb	0.032
scn12ab	sodium channel, voltage gated, type XII, alpha b	0.032
tnni2b.1	troponin I, skeletal, fast 2b.1	0.031
tmem38a	transmembrane protein 38A	0.031
plekha7	pleckstrin homology domain containing, family A member 7	0.029
bcdo2l	beta-carotene 15, 15-dioxygenase 2, like	0.029
tpm4	tropomyosin 4	0.028
copeb	core promoter element binding protein	0.028
scn4ba	sodium channel, voltage-gated, type IV, beta a	0.027
gja3	gap junction protein, alpha 3	0.027
adrb2a	adrenergic receptor, beta 2a	0.027
ldb3b	LIM domain binding 3b	0.026
csrp3	cysteine and glycine-rich protein 3 (cardiac LIM protein)	0.026
wu:fc31e07	wu:fc31e07	0.026
tnni1b	troponin I, skeletal, slow b	0.025
myca	myelocytomatosis oncogene a	0.025
gpia	glucose phosphate isomerase a	0.025
anxa11a	annexin A11a	0.024
adipoql	adiponectin, C1Q and collagen domain containing, like	0.024
txnipa	thioredoxin interacting protein a	0.024
six2a	sine oculis-related homeobox 2a	0.024
tgfbr2	transforming growth factor, beta receptor II	0.023
cdh17	cadherin 17, LI cadherin (liver-intestine)	0.023
pvalb7	parvalbumin 7	0.022
eef2l2	eukaryotic translation elongation factor 2, like 2	0.022
desma	desmin a	0.022
kbtbd10b	kelch repeat and BTB (POZ) domain containing 10b	0.022
eya4	eyes absent homolog 4 (Drosophila)	0.022
pes	pescadillo	0.021
pabpc4	poly(A) binding protein, cytoplasmic 4 (inducible form)	0.021
s100b	S100 calcium binding protein, beta (neural)	0.020
ckmb	creatine kinase, muscle b	0.020
jam2a	junctional adhesion molecule 2a	0.020
npnt	nephronectin	0.020
mhc2dcb	major histocompatibility complex class II DCB gene	0.019
slc12a2	solute carrier family 12 (potassium/chloride transporters), member 2	0.019
mef2ca	myocyte enhancer factor 2ca	0.019
kcnh2	potassium voltage-gated channel, subfamily H (eag-related), member 2	0.019
kcnq1	potassium voltage-gated channel, KQT-like subfamily, member 1	0.019
cebpa	CCAAT/enhancer binding protein (C/EBP), alpha	0.019
mybpc3	myosin binding protein C, cardiac	0.018
bcl2l1	bcl2-like 1	0.018
ogg1	8-oxoguanine DNA glycosylase	0.018
cpne3	copine III	0.018
neb	nebulin	0.017
atf3	activating transcription factor 3	0.017
gpr126	G protein-coupled receptor 126	0.017
wu:fk35f04	wu:fk35f04	0.017
aqp8a.1	aquaporin 8a, tandem duplicate 1	0.017
thbs4b	thrombospondin 4b	0.016
cyc1	cytochrome c-1	0.016
fxr1	fragile X mental retardation, autosomal homolog 1	0.016
s1pr1	sphingosine-1-phosphate receptor 1	0.016
flncb	filamin C, gamma b (actin binding protein 280)	0.016
zgc:194131	zgc:194131	0.016
jam3b	junctional adhesion molecule 3b	0.016
clu	clusterin (complement lysis inhibitor, SP-40,40, sulfated glycoprotein 2, testosterone-repressed prostate message 2, apolipoprotein J)	0.015
gamt	guanidinoacetate N-methyltransferase	0.015
dub	duboraya	0.015
scn4ab	sodium channel, voltage-gated, type IV, alpha, b	0.015
dlx4a	distal-less homeobox gene 4a	0.015
phlda2	pleckstrin homology-like domain, family A, member 2	0.015
igfbp1a	insulin-like growth factor binding protein 1a	0.015
hey2	hairy/enhancer-of-split related with YRPW motif 2	0.015	Mouse
gdf6b	growth differentiation factor 6b	0.015
tbx22	T-box 22	0.015
cldn1	claudin 1	0.015
fhl	four and a half LIM domains	0.015
wars	tryptophanyl-tRNA synthetase	0.015
im:7149055	im:7149055	0.015
hk1	hexokinase 1	0.014
fgf18b	fibroblast growth factor 18b	0.014
im:6903943	im:6903943	0.014
dnaja	DnaJ (Hsp40) homolog, subfamily A member	0.014
mylz3	myosin, light polypeptide 3, skeletal muscle	0.014
jun	jun proto-oncogene	0.014	Fly
magt1	magnesium transporter 1	0.014
cfdl	complement factor D (adipsin) like	0.014
zfpm1	zinc finger protein, multitype 1	0.014
hspb7	heat shock protein family, alpha-crystallin-related, b7	0.014
ahcyl2	S-adenosylhomocysteine hydrolase-like 2	0.014
hopx	HOP homeobox	0.014
pi4kb	phosphatidylinositol 4-kinase, catalytic, beta	0.014
gatm	glycine amidinotransferase (L-arginine:glycine amidinotransferase)	0.014
popdc2	popeye domain containing 2	0.014
atp1a1a.4	ATPase, Na+/K+ transporting, alpha 1a.4 polypeptide	0.013	Mouse
jag1b	jagged 1b	0.013
farsb	phenylalanyl-tRNA synthetase, beta subunit	0.013
heyl	hairy/enhancer-of-split related with YRPW motif-like	0.013
eif3jb	eukaryotic translation initiation factor 3, subunit Jb	0.013
cabp1	calcium binding protein 1	0.013
zgc:63938	zgc:63938	0.013
ggct	gamma-glutamyl cyclotransferase	0.013
snapc1b	small nuclear RNA activating complex, polypeptide 1b	0.013
hsp70l	heat shock cognate 70-kd protein, like	0.013
esrrd	estrogen-related receptor delta	0.013
c21orf59l	c21orf59 homolog (H. sapiens), like	0.013
hint2	histidine triad nucleotide binding protein 2	0.013
sars	seryl-tRNA synthetase	0.013
ahcyl1	S-adenosylhomocysteine hydrolase-like 1	0.013
cx36.7	connexin 36.7	0.012
ildr2	immunoglobulin-like domain containing receptor 2	0.012
hspb1	heat shock protein, alpha-crystallin-related, 1	0.012
tpm3	tropomyosin 3	0.012
tal1	T-cell acute lymphocytic leukemia 1	0.012
aqp7	aquaporin 7	0.012
rorab	RAR-related orphan receptor A, paralog b	0.012
vmhcl	ventricular myosin heavy chain-like	0.012
fhla	four and a half LIM domains a	0.012
mapk12	mitogen-activated protein kinase 12	0.012
col9a2	procollagen, type IX, alpha 2	0.012
scn1ba	sodium channel, voltage-gated, type I, beta a	0.012
tdh	L-threonine dehydrogenase	0.012
ccdc80	coiled-coil domain containing 80	0.012
nap1l4a	nucleosome assembly protein 1-like 4a	0.012
zgc:55574	zgc:55574	0.012
nbl1	neuroblastoma, suppression of tumorigenicity 1	0.012
erg	v-ets erythroblastosis virus E26 oncogene like (avian)	0.012
zgc:92806	zgc:92806	0.012
epb41	erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)	0.012
fabp3	fatty acid binding protein 3, muscle and heart	0.012
zgc:112024	zgc:112024	0.012
pvalb9	parvalbumin 9	0.012
tshr	thyroid stimulating hormone receptor	0.012
wu:fk57d06	wu:fk57d06	0.012
fkbp10	FK506 binding protein 10	0.012
mfi2	antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5	0.012
zgc:85866	zgc:85866	0.012
dhrs3a	dehydrogenase/reductase (SDR family) member 3a	0.012
sst3	somatostatin 3	0.011
atp6v1b2	ATPase, H+ transporting, lysosomal V1 subunit B2	0.011
ugdh	UDP-glucose dehydrogenase	0.011
cx41.8	connexin 41.8	0.011
ctsba	cathepsin B, a	0.011
ddt	D-dopachrome tautomerase	0.011
pnocb	prepronociceptin b	0.011
tppp3	tubulin polymerization-promoting protein family member 3	0.011
zgc:77938	zgc:77938	0.011
crb2a	crumbs homolog 2a	0.011
tnnt1	troponin T1, skeletal, slow	0.011
cryaba	crystallin, alpha B, a	0.011
junb	jun B proto-oncogene	0.011
hnf1bb	HNF1 homeobox Bb	0.011
tcf21	transcription factor 21	0.011
pvalb2	parvalbumin 2	0.011
ldlr	low density lipoprotein receptor	0.011
crygmxl2	crystallin, gamma MX, like 2	0.011
rbfox1	RNA binding protein, fox-1 homolog (C. elegans) 1	0.011
duox	dual oxidase	0.011
tsc22d1	TSC22 domain family, member 1	0.011
zgc:123327	zgc:123327	0.011
LOC568107	Iodotyrosine dehalogenase 1-like	0.011
slc15a2	solute carrier family 15 (H+/peptide transporter), member 2	0.011
pdk3a	pyruvate dehydrogenase kinase, isozyme 3a	0.011
hspb12	heat shock protein, alpha-crystallin-related, b12	0.011
zgc:100994	zgc:100994	0.011
myo3a	myosin IIIA	0.011
trpc1	transient receptor potential cation channel, subfamily C, member 1	0.011
hspb8	heat shock protein, alpha-crystallin-related, b8	0.011
hsd11b2	hydroxysteroid 11-beta dehydrogenase 2	0.011
tnnt3b	troponin T3b, skeletal, fast	0.010
rbm24a	RNA binding motif protein 24a	0.010
ptgs2a	prostaglandin-endoperoxide synthase 2a	0.010
dusp2	dual specificity phosphatase 2	0.010
adrb2b	adrenergic receptor, beta 2b	0.010
zgc:63734	zgc:63734	0.010
hbbe2	hemoglobin beta embryonic-2	0.010
rhcgb	Rhesus blood group, C glycoprotein b	0.010
LOC100001008	prepro-urotensin II-related peptide	0.010
hapln3	hyaluronan and proteoglycan link protein 3	0.010
myl2	myosin, light polypeptide 2, regulatory, cardiac, slow	0.010	Zebrafish
id2b	inhibitor of DNA binding 2, dominant negative helix-loop-helix protein, b	0.010
tg	thyroglobulin	0.010
rfng	radical fringe homolog (Drosophila)	0.010
si:ch211-287b5.2	si:ch211-287b5.2	0.010
elna	elastin a	0.010
myl10	myosin, light chain 10, regulatory	0.010	Zebrafish
zgc:153096	zgc:153096	0.010
LOC100000433	hypothetical LOC100000433	0.010
si:dkey-204f11.66	si:dkey-204f11.66	0.010
crygm1	crystallin, gamma M1	0.010