IMP

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Danio rerio

1 genes annotated in zebrafish

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negative regulation of histone modification

GO:0031057

Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent alteration of a histone.

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Known genes in the process in zebrafish Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of histone modification"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of histone modification" (in gray)

Name	Description	Probability	Func Analog Organism
hells	helicase, lymphoid-specific	0.330
msh6	mutS homolog 6 (E. coli)	0.304
msxd	muscle segment homeobox D	0.175
pds5b	PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)	0.157
dnmt3	DNA (cytosine-5-)-methyltransferase 3	0.128
mpx	myeloid-specific peroxidase	0.122
cdon	cell adhesion molecule-related/down-regulated by oncogenes	0.106
coro1a	coronin, actin binding protein, 1A	0.087
foxi1	forkhead box I1	0.071
ncaph	non-SMC condensin I complex, subunit H	0.069
msxc	muscle segment homeobox C	0.069	Mouse
whsc1	Wolf-Hirschhorn syndrome candidate 1	0.069
rcor2	REST corepressor 2	0.064
cmyb	transcription factor cmyb	0.056
ahctf1	AT hook containing transcription factor 1	0.053
vsx2	visual system homeobox 2	0.052
im:7156396	im:7156396	0.052
stil	TAL1 (SCL) interrupting locus	0.049
skia	nuclear oncoprotein skia	0.049	Mouse
gdf6a	growth differentiation factor 6a	0.048
tcf7l1a	transcription factor 7-like 1a (T-cell specific, HMG-box)	0.047
ikzf1	IKAROS family zinc finger 1 (Ikaros)	0.044
snrnp48	small nuclear ribonucleoprotein 48 (U11/U12)	0.044
lyz	lysozyme	0.043
hey2	hairy/enhancer-of-split related with YRPW motif 2	0.042
smc3	structural maintenance of chromosomes 3	0.041
nova2	neuro-oncological ventral antigen 2	0.039
dnmt1	DNA (cytosine-5-)-methyltransferase 1	0.039	Human
fgfrl1b	fibroblast growth factor receptor-like 1b	0.038
wu:fc85c01	wu:fc85c01	0.037
col14a1	collagen, type XIV, alpha 1	0.036
ptpro	protein tyrosine phosphatase, receptor type, O	0.034
zbtb16a	zinc finger and BTB domain containing 16a	0.034
atad5a	ATPase family, AAA domain containing 5a	0.033
ik	IK cytokine	0.032
dmd	dystrophin	0.032
rtf1	Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)	0.032
efna3b	ephrin A3b	0.031
mab21l2	mab-21-like 2	0.031
ifnphi1	interferon phi 1	0.030
zgc:92648	zgc:92648	0.030
zic6	zic family member 6	0.029
caprin1a	cell cycle associated protein 1a	0.029
unc5b	unc-5 homolog B (C. elegans)	0.028
nr2e1	nuclear receptor subfamily 2, group E, member 1	0.028
evx1	even-skipped homeobox 1	0.027
mcm4	MCM4 minichromosome maintenance deficient 4, mitotin (S. cerevisiae)	0.027
smc2	structural maintenance of chromosomes 2	0.027
LOC100536021	spectrin beta chain, brain 1-like	0.027
mcm3	MCM3 minichromosome maintenance deficient 3 (S. cerevisiae)	0.027
esco2	establishment of cohesion 1 homolog 2	0.027
her6	hairy-related 6	0.026
si:ch211-57k11.10	si:ch211-57k11.10	0.026
plagx	pleiomorphic adenoma gene X	0.025
her2	hairy-related 2	0.025
si:ch211-198a12.6	si:ch211-198a12.6	0.025
ep300b	E1A binding protein p300 b	0.025
rag1	recombination activating gene 1	0.025
pcna	proliferating cell nuclear antigen	0.024
LOC554173	abnormal spindles	0.024
epb41l5	erythrocyte membrane protein band 4.1 like 5	0.024
lcp1	lymphocyte cytosolic plastin 1	0.024
mcm5	MCM5 minichromosome maintenance deficient 5 (S. cerevisiae)	0.024
ezh2	enhancer of zeste homolog 2 (Drosophila)	0.023
wrb	tryptophan rich basic protein	0.023
elf2b	E74-like factor 2b (ets domain transcription factor)	0.022
rx2	retinal homeobox gene 2	0.022
zgc:85727	zgc:85727	0.022
col4a5	collagen, type IV, alpha 5 (Alport syndrome)	0.022
gsk3b	glycogen synthase kinase 3 beta	0.022
wasb	Wiskott-Aldrich syndrome (eczema-thrombocytopenia) b	0.022
pspc1	paraspeckle component 1	0.021
hnrnpul1	heterogeneous nuclear ribonucleoprotein U-like 1	0.021
ap4b1l	adaptor-related protein complex 4, beta 1 subunit-like	0.021
tcf7	transcription factor 7 (T-cell specific, HMG-box)	0.021
hoxc1a	homeo box C1a	0.021
akt2	v-akt murine thymoma viral oncogene homolog 2	0.021
boc	brother of CDO	0.021
nrp1a	neuropilin 1a	0.021
grna	granulin a	0.021
zic2b	zic family member 2 (odd-paired homolog, Drosophila) b	0.021
ctr9	Ctr9, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)	0.021
ercc2	excision repair cross-complementing rodent repair deficiency, complementation group 2	0.021
rarga	retinoic acid receptor gamma a	0.020
upf1	upf1 regulator of nonsense transcripts homolog (yeast)	0.020
fancg	Fanconi anemia, complementation group G	0.020
atoh1a	atonal homolog 1a	0.020
cdc34b	cell division cycle 34 homolog (S. cerevisiae) b	0.020
setd5	SET domain containing 5	0.020
chtf18	CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)	0.020
nr2f6a	nuclear receptor subfamily 2, group F, member 6a	0.020
ncapg	non-SMC condensin I complex, subunit G	0.020
ptprc	protein tyrosine phosphatase, receptor type, C	0.020
bsk146	brain specific kinase 146	0.019
otx1a	orthodenticle homolog 1a	0.019
foxe3	forkhead box E3	0.019
zgc:77407	zgc:77407	0.019
smc4	structural maintenance of chromosomes 4	0.019
nosip	nitric oxide synthase interacting protein	0.019
pold1	polymerase (DNA directed), delta 1, catalytic subunit	0.019
angpt1	angiopoietin 1	0.019
crb2a	crumbs homolog 2a	0.018
ewsr1a	Ewing sarcoma breakpoint region 1a	0.018
huwe1	HECT, UBA and WWE domain containing 1	0.018
sycp3l	synaptonemal complex protein 3 like	0.018
epb4.1l4	erythrocyte protein band 4.1-like 4	0.018
olig3	oligodendrocyte transcription factor 3	0.018
vasp	vasodilator-stimulated phosphoprotein	0.018
pdgfab	platelet derived growth factor alpha b	0.018
ss18	synovial sarcoma translocation, chromosome 18 (H. sapiens)	0.018
srrm1	serine/arginine repetitive matrix 1	0.018
foxp2	forkhead box P2	0.018
tial1	TIA1 cytotoxic granule-associated RNA binding protein-like 1	0.018
macf1	microtubule-actin crosslinking factor 1	0.018
slit3	slit (Drosophila) homolog 3	0.018
brd9	bromodomain containing 9	0.018
tnc	tenascin C	0.018
zgc:103440	zgc:103440	0.017
ddx46	DEAD (Asp-Glu-Ala-Asp) box polypeptide 46	0.017
fam50a	family with sequence similarity 50, member A	0.017
nrarpb	notch-regulated ankyrin repeat protein b	0.017
rbbp6	retinoblastoma binding protein 6	0.017
her3	hairy-related 3	0.017
dopey1	dopey family member 1	0.017
cad	carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase	0.017
tiparp	TCDD-inducible poly(ADP-ribose) polymerase	0.017
alp	alkaline phosphatase	0.017
gart	phosphoribosylglycinamide formyltransferase	0.017
ints9	integrator complex subunit 9	0.016
notch3	notch homolog 3	0.016
atp2b4	ATPase, Ca++ transporting, plasma membrane 4	0.016
prkcbp1l	protein kinase C binding protein 1, like	0.016
znf410	zinc finger protein 410	0.016
ppm1g	protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform	0.016
dync1h1	dynein, cytoplasmic 1, heavy chain 1	0.016
prdm2b	PR domain containing 2, with ZNF domain b	0.016
cdc16	cell division cycle 16 homolog (S. cerevisiae)	0.016
dedd1	death effector domain-containing 1	0.016
gtf2f2a	general transcription factor IIF, polypeptide 2a	0.016
klhl18	kelch-like 18 (Drosophila)	0.016
wwp2	WW domain containing E3 ubiquitin protein ligase 2	0.016
pola1	polymerase (DNA directed), alpha 1	0.016
supt5h	suppressor of Ty 5 homolog (S. cerevisiae)	0.016
arntl1b	aryl hydrocarbon receptor nuclear translocator-like 1b	0.016
med24	mediator complex subunit 24	0.016
illr3	immune-related, lectin-like receptor 3	0.016
kdm1a	lysine (K)-specific demethylase 1a	0.016
med12	mediator of RNA polymerase II transcription, subunit 12 homolog	0.016
si:ch211-59d15.5	si:ch211-59d15.5	0.016
phf8	PHD finger protein 8	0.016
zgc:153061	zgc:153061	0.016
ncor2	nuclear receptor co-repressor 2	0.016
crb1	crumbs homolog 1 (Drosophila)	0.016
tubg1	tubulin, gamma 1	0.016
rb1	retinoblastoma 1	0.015
ube2q2	ubiquitin-conjugating enzyme E2Q family member 2	0.015
skiv2l2	superkiller viralicidic activity 2-like 2	0.015
zgc:154068	zgc:154068	0.015
insra	insulin receptor a	0.015
msh2	mutS homolog 2 (E. coli)	0.015
sec31a	sec31 homolog A (S. cerevisiae)	0.015
cand1	cullin-associated and neddylation-dissociated 1	0.015
trpv6	transient receptor potential cation channel, subfamily V, member 6	0.015
asb2b	ankyrin repeat and SOCS box-containing 2b	0.015
otx1b	orthodenticle homolog 1b	0.015
kdm6al	lysine (K)-specific demethylase 6A, like	0.015
ankrd13c	ankyrin repeat domain 13C	0.015
lbr	lamin B receptor	0.015
zgc:158345	zgc:158345	0.015
mical3	flavoprotein oxidoreductase MICAL3	0.015
ptbp2	polypyrimidine tract binding protein 2	0.015
cabin1	calcineurin binding protein 1	0.015
si:dkey-9k8.1	si:dkey-9k8.1	0.014
zgc:66385	zgc:66385	0.014
si:dkey-42i9.10	si:dkey-42i9.10	0.014
smad7	MAD, mothers against decapentaplegic homolog 7 (Drosophila)	0.014
arpp19a	cAMP-regulated phosphoprotein 19a	0.014
zgc:113518	zgc:113518	0.014
npm4	nucleophosmin/nucleoplasmin, 4	0.014
zgc:92217	zgc:92217	0.014
si:dkeyp-27b10.2	si:dkeyp-27b10.2	0.014
axin2	axin 2 (conductin, axil)	0.014
stk25b	serine/threonine kinase 25b	0.014
si:ch73-9j13.1	si:ch73-9j13.1	0.014
sox9b	SRY-box containing gene 9b	0.014
puf60a	poly-U binding splicing factor a	0.014
tcf3	transcription factor 3	0.014
lin7c	lin-7 homolog C (C. elegans)	0.014
chd7	chromodomain helicase DNA binding protein 7	0.014
pnn	pinin, desmosome associated protein	0.014
cwc25	CWC25 spliceosome-associated protein homolog (S. cerevisiae)	0.014
ets1a	v-ets erythroblastosis virus E26 oncogene homolog 1a	0.014
ehmt2	euchromatic histone-lysine N-methyltransferase 2	0.014
si:dkeyp-113d7.1	si:dkeyp-113d7.1	0.014
cryaba	crystallin, alpha B, a	0.014
stk11	serine/threonine kinase 11	0.014
ubl7	ubiquitin-like 7	0.013
zgc:136878	zgc:136878	0.013
slu7	SLU7 splicing factor homolog (S. cerevisiae)	0.013
mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.013
hoxa11b	homeo box A11b	0.013
ube4b	ubiquitination factor E4B, UFD2 homolog (S. cerevisiae)	0.013
hat1	histone acetyltransferase 1	0.013
adipoql	adiponectin, C1Q and collagen domain containing, like	0.013
cebp1	CCAAT/enhancer binding protein (C/EBP) 1	0.013
thrb	thyroid hormone receptor beta	0.013
LOC100333215	dystonin-like	0.013
angptl2	angiopoietin-like 2	0.013
gata1a	GATA binding protein 1a	0.013
zgc:92683	zgc:92683	0.013
epha2	eph receptor A2	0.013
dlx3b	distal-less homeobox gene 3b	0.013
zgc:101598	zgc:101598	0.013
wu:fb25b09	wu:fb25b09	0.013
rbbp5	retinoblastoma binding protein 5	0.013
dlx2a	distal-less homeobox gene 2a	0.013
nitr9	novel immune-type receptor 9	0.013
sema3aa	semaphorin 3aa	0.013
gli3	GLI-Kruppel family member GLI3	0.013
pou3f2	POU class 3 homeobox 2	0.013
kiaa0907	KIAA0907 protein	0.013
vwf	von Willebrand factor	0.013
snx12	sorting nexin 12	0.013
fem1c	fem-1 homolog c (C.elegans)	0.013
wisp1b	WNT1 inducible signaling pathway protein 1b	0.013
nktr	natural killer-tumor recognition sequence	0.013
pwp2h	PWP2 periodic tryptophan protein homolog (yeast)	0.013
LOC100534970	hypothetical protein LOC100534970	0.013
skp1	S-phase kinase-associated protein 1	0.013
mcm7	MCM7 minichromosome maintenance deficient 7 (S. cerevisiae)	0.013
ssrp1a	structure specific recognition protein 1a	0.013
cobra1	cofactor of BRCA1	0.012
adam23a	a disintegrin and metallopeptidase domain 23a	0.012
fcer1gl	Fc receptor, IgE, high affinity I, gamma polypeptide like	0.012
tfam	transcription factor A, mitochondrial	0.012
urod	uroporphyrinogen decarboxylase	0.012
tp53bp2	tumor protein p53 binding protein, 2	0.012
pknox1.2	pbx/knotted 1 homeobox 1.2	0.012
sim2	single-minded homolog 2 (Drosophila)	0.012
fzd9b	frizzled homolog 9b	0.012
dnmt6	DNA (cytosine-5-)-methyltransferase 6	0.012
rxrga	retinoid x receptor, gamma a	0.012
usp7	ubiquitin specific peptidase 7 (herpes virus-associated)	0.012
nle1	notchless homolog 1 (Drosophila)	0.012
zgc:73100	zgc:73100	0.012
zdhhc8b	zinc finger, DHHC-type containing 8b	0.012
prom1a	prominin 1a	0.012
btbd2	BTB (POZ) domain containing 2	0.012
slka	STE20-like kinase a	0.012
rab11fip4a	RAB11 family interacting protein 4 (class II) a	0.012
zgc:101761	zgc:101761	0.012
zgc:91844	zgc:91844	0.012
cd40lg	CD40 ligand	0.012
evx2	even-skipped homeobox 2	0.012
mxa	myxovirus (influenza) resistance A	0.012
snai1b	snail homolog 1b (Drosophila)	0.012
lck	lymphocyte-specific protein tyrosine kinase	0.012
zgc:56039	zgc:56039	0.012
LOC100151049	lysosomal-associated protein transmembrane 5	0.012
six1a	sine oculis homeobox homolog 1a	0.012
lta4h	leukotriene A4 hydrolase	0.012
ndufa6	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6	0.012
brap	BRCA1 associated protein	0.012
ddx26b	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B	0.012
lin54	lin-54 homolog	0.012
si:ch211-279m15.1	si:ch211-279m15.1	0.012
taf11	TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor	0.012
mfap1	microfibrillar-associated protein 1	0.011
ubtd2	ubiquitin domain containing 2	0.011
dnmt7	DNA (cytosine-5-)-methyltransferase 7	0.011	Human
zgc:154063	zgc:154063	0.011
hnrnph1	heterogeneous nuclear ribonucleoprotein H1	0.011
eif4g2b	eukaryotic translation initiation factor 4, gamma 2b	0.011
rif1	RAP1 interacting factor homolog (yeast)	0.011
msxb	muscle segment homeobox B	0.011	Mouse
gja3	gap junction protein, alpha 3	0.011
zgc:112355	zgc:112355	0.011
wdr45l	wdr45 like	0.011
si:ch211-191d7.6	si:ch211-191d7.6	0.011
fxr2	fragile X mental retardation, autosomal homolog 2	0.011
dlx1a	distal-less homeobox gene 1a	0.011
tkt	transketolase	0.011
gnsb	glucosamine (N-acetyl)-6-sulfatase (Sanfilippo disease IIID), b	0.011
lman2la	lectin, mannose-binding 2-like a	0.011
im:7163548	im:7163548	0.011
med18	mediator of RNA polymerase II transcription, subunit 18 homolog (yeast)	0.011
mmp13a	matrix metalloproteinase 13a	0.011
LOC793458	peptide Y-like	0.011
prim1	primase polypeptide 1	0.011
crygm2d11	crystallin, gamma M2d11	0.011
sass6	spindle assembly 6 homolog (C. elegans)	0.011
znf148	zinc finger protein 148	0.011
npepps	aminopeptidase puromycin sensitive	0.011
cd99l2	CD99 antigen-like 2	0.011
si:ch211-207m11.1	si:ch211-207m11.1	0.011
hdac8	histone deacetylase 8	0.011
sumo1	SMT3 suppressor of mif two 3 homolog 1 (yeast)	0.011
wasa	Wiskott-Aldrich syndrome (eczema-thrombocytopenia) a	0.011
abi1a	abl-interactor 1a	0.011
mll4b	myeloid/lymphoid or mixed-lineage leukemia 4b	0.011
slit2	slit (Drosophila) homolog 2	0.011
hoxa5a	homeo box A5a	0.011
smo	smoothened homolog (Drosophila)	0.011
cryba1b	crystallin, beta A1b	0.011
furinb	furin (paired basic amino acid cleaving enzyme) b	0.011
samsn1a	SAM domain, SH3 domain and nuclear localisation signals, 1a	0.011
tcf7l2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.011
tprb	translocated promoter region b (to activated MET oncogene)	0.011
si:dkey-97o5.1	si:dkey-97o5.1	0.011
ncoa2	nuclear receptor coactivator 2	0.011
veph	ventricular zone expressed PH domain protein	0.011
plxnb2a	plexin b2a	0.011
phf20b	PHD finger protein 20, b	0.011
mdka	midkine-related growth factor	0.010
egr2a	early growth response 2a	0.010
tuba7l	tubulin, alpha 7 like	0.010
csf3r	colony stimulating factor 3 receptor (granulocyte)	0.010
zgc:110298	zgc:110298	0.010
ift88	intraflagellar transport 88 homolog	0.010
fam192a	family with sequence similarity 192, member A	0.010
nitr5	novel immune-type receptor 5 and immune-type receptor 5-like	0.010
efcab7	EF-hand calcium binding domain 7	0.010
crygmxl1	crystallin, gamma MX, like 1	0.010
drl	draculin	0.010
pggt1b	protein geranylgeranyltransferase type I, beta subunit	0.010
rmi1	RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae)	0.010
lrrc33	leucine rich repeat containing 33	0.010
hp1bp3	heterochromatin protein 1, binding protein 3	0.010
pou2f1a	POU class 2 homeobox 1a	0.010
LOC567504	interferon-induced protein with tetratricopeptide repeats 5-like	0.010
hoxc10a	homeo box C10a and homeobox protein Hox-C10a-like	0.010
zgc:123282	zgc:123282	0.010
epor	erythropoietin receptor	0.010
dlat	dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)	0.010
LOC566708	FL cytokine receptor-like	0.010
gab1	GRB2-associated binding protein 1	0.010
hoxa10b	homeo box A10b	0.010
ptpn13	protein tyrosine phosphatase, non-receptor type 13	0.010
zbtb4	zinc finger and BTB domain containing 4	0.010
slc2a10	solute carrier family 2 (facilitated glucose transporter), member 10	0.010
mycl1a	v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian) a	0.010
wu:fi04c06	wu:fi04c06	0.010
arglu1b	arginine and glutamate rich 1b	0.010