IMP

Process View

Danio rerio

9 genes annotated in zebrafish

intrinsic apoptotic signaling pathway by p53 class mediator

A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, and ends when the execution phase of apoptosis is triggered.

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Known genes in the process in zebrafish Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "intrinsic apoptotic signaling pathway by p53 class mediator"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "intrinsic apoptotic signaling pathway by p53 class mediator" (in gray)

Name	Description	Probability	Func Analog Organism
rhoab	ras homolog gene family, member Ab	0.530
krt4	keratin 4	0.102
slc2a10	solute carrier family 2 (facilitated glucose transporter), member 10	0.098
vax2	ventral anterior homeobox 2	0.096
ube2q2	ubiquitin-conjugating enzyme E2Q family member 2	0.087
sass6	spindle assembly 6 homolog (C. elegans)	0.085
ywhabb	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide b	0.084
psen1	presenilin 1	0.072
hug	HuG	0.068
ccng1	cyclin G1	0.055
cdkn1a	cyclin-dependent kinase inhibitor 1A	0.050
tp73	tumor protein p73	0.049	Human Zebrafish Mouse Worm Fly
zgc:112089	zgc:112089	0.048
gins2	GINS complex subunit 2	0.046
zgc:101724	zgc:101724	0.046
rps12	ribosomal protein S12	0.045
tiprl	TIP41, TOR signaling pathway regulator-like (S. cerevisiae)	0.044
tfap2c	transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)	0.042
si:ch211-215h6.2	si:ch211-215h6.2	0.040
bbc3	BCL2 binding component 3	0.036
prim1	primase polypeptide 1	0.034
sox4b	SRY-box containing gene 4b	0.034
surf6	surfeit 6	0.033
calm3b	calmodulin 3b (phosphorylase kinase, delta)	0.033
rpl11	ribosomal protein L11	0.033
bactin1	bactin1	0.033
zgc:77702	zgc:77702	0.032
setd6	SET domain containing 6	0.032
tbx1	T-box 1	0.031
trpm7	transient receptor potential cation channel, subfamily M, member 7	0.030
zgc:92648	zgc:92648	0.030
sox9a	SRY-box containing gene 9a	0.030
ube2g2	ubiquitin-conjugating enzyme E2G 2	0.029
ahctf1	AT hook containing transcription factor 1	0.029
vax1	ventral anterior homeobox 1	0.029
rps18	ribosomal protein S18	0.028
hdac1	histone deacetylase 1	0.028
zgc:114188	zgc:114188	0.028
msh6	mutS homolog 6 (E. coli)	0.027
nr3c1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	0.027
tmem167a	transmembrane protein 167A	0.026
rps27a	ribosomal protein S27a	0.026
rpl36a	ribosomal protein L36A	0.026
baxa	bcl2-associated X protein, a	0.024	Mouse
ccnl1	cyclin L1	0.023
rpl9	ribosomal protein L9	0.023
nkx2.3	NK2 transcription factor related 3	0.023
atp1a1	ATPase, Na+/K+ transporting, alpha 1 polypeptide	0.022
tmprss4a	transmembrane protease, serine 4a	0.022
rpl35	ribosomal protein L35	0.022
mif	macrophage migration inhibitory factor	0.022
zgc:63992	zgc:63992	0.021
smc3	structural maintenance of chromosomes 3	0.021
rps21	ribosomal protein S21	0.021
sf3b1	splicing factor 3b, subunit 1	0.021
rpl14	ribosomal protein L14	0.020
puf60a	poly-U binding splicing factor a	0.020
rab11ba	RAB11B, member RAS oncogene family, a	0.020
rnf7	ring finger protein 7	0.020
pola2	polymerase (DNA directed), alpha 2	0.020
ywhaqb	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide b	0.020
gins1	GINS complex subunit 1 (Psf1 homolog)	0.019
cldne	claudin e	0.019
rps6kal	ribosomal protein S6 kinase, like	0.019
capns1b	calpain, small subunit 1 b	0.019
nkx2.1a	NK2 homeobox 1a	0.018
mybl2	myeloblastosis oncogene-like 2	0.018
grina	glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)	0.018
nar	no arches	0.018
rps11	ribosomal protein S11	0.017
rbm39a	RNA binding motif protein 39a	0.017
foxi2	forkhead box I2	0.017
snrnp70	small nuclear ribonucleoprotein 70 (U1)	0.017
gdf11	growth differentiation factor 11	0.017
rpl22l1	ribosomal protein L22-like 1	0.017
rpl34	ribosomal protein L34	0.016
ppia	peptidylprolyl isomerase A (cyclophilin A)	0.016
wu:fk48d07	wu:fk48d07	0.016
srsf1a	serine/arginine-rich splicing factor 1a	0.016
max	myc-associated factor X	0.016
eif4e1c	eukaryotic translation initiation factor 4E family member 1c	0.016
rbm4.2	RNA binding motif protein 4.2	0.016
eif4a1a	eukaryotic translation initiation factor 4A, isoform 1A	0.016
eif1b	eukaryotic translation initiation factor 1B	0.015
krt5	keratin 5	0.015
chmp4b	chromatin modifying protein 4B	0.015
sox9b	SRY-box containing gene 9b	0.015
zgc:73230	zgc:73230	0.015
zgc:77235	zgc:77235	0.015
tbeta-a	beta thymosin-like protein 2	0.015
rap1a	RAP1A, member of RAS oncogene family	0.015
sumo3a	SMT3 suppressor of mif two 3 homolog 3a	0.015
rab1a	RAB1A, member RAS oncogene family	0.015
bmpr1aa	bone morphogenetic protein receptor, type 1aa	0.014
mbd3a	methyl-CpG binding domain protein 3a	0.014
dnmt5	DNA (cytosine-5-)-methyltransferase 5	0.014
raf1a	v-raf-1 murine leukemia viral oncogene homolog 1a	0.014
lamc1	laminin, gamma 1	0.014
faua	Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed a	0.014
smad7	MAD, mothers against decapentaplegic homolog 7 (Drosophila)	0.013
rpl23a	ribosomal protein L23a	0.013
crkl	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.013
ptges3a	prostaglandin E synthase 3a (cytosolic)	0.013
rp2	retinitis pigmentosa 2 (X-linked recessive)	0.013
rer1	RER1 retention in endoplasmic reticulum 1 homolog (S. cerevisiae)	0.013
rplp2	ribosomal protein, large P2	0.013
ef1a	elongation factor 1-alpha	0.013
card9	caspase recruitment domain family, member 9	0.013
six3b	sine oculis homeobox homolog 3b	0.013
atp6v0ca	ATPase, H+ transporting, lysosomal, V0 subunit c, a	0.013
anxa1a	annexin A1a	0.013
chuk	conserved helix-loop-helix ubiquitous kinase	0.013
ppp6c	protein phosphatase 6, catalytic subunit	0.012
bcl2l1	bcl2-like 1	0.012
bmp5	bone morphogenetic protein 5	0.012
aida	axin interaction partner and dorsalization antagonist	0.012
efnb3b	ephrin B3b	0.012
otx5	orthodenticle homolog 5	0.012
maea	macrophage erythroblast attacher	0.012
nos2b	nitric oxide synthase 2b, inducible	0.012
tfeb	transcription factor EB	0.012
thraa	thyroid hormone receptor alpha a	0.012
ruvbl2	RuvB-like 2 (E. coli)	0.012
chek1	CHK1 checkpoint homolog (S. pombe)	0.012
palb2	partner and localizer of BRCA2	0.012
adra2da	adrenergic, alpha-2D-, receptor a	0.012
pds5b	PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)	0.012
caprin1a	cell cycle associated protein 1a	0.011
s100a10b	S100 calcium binding protein A10b	0.011
nup107	nucleoporin 107	0.011
cand1	cullin-associated and neddylation-dissociated 1	0.011
odc1	ornithine decarboxylase 1	0.011
si:dkeyp-50f5.1	si:dkeyp-50f5.1	0.011
rps15	ribosomal protein S15	0.011
rbm19	RNA binding motif protein 19	0.011
zgc:55671	zgc:55671	0.011
bat1	HLA-B associated transcript 1	0.011
znf703	zinc finger protein 703	0.011
tceb1a	transcription elongation factor B (SIII), polypeptide 1a	0.011
tk2	thymidine kinase 2, mitochondrial	0.011
cnih	cornichon homolog (Drosophila)	0.011
nolc1	nucleolar and coiled-body phosphoprotein 1	0.011
atpif1	ATPase inhibitory factor 1	0.011
dlx3b	distal-less homeobox gene 3b	0.011
srsf5a	serine/arginine-rich splicing factor 5a	0.010
trmt2a	trm2 tRNA methyltransferase 2 homolog A (S. cerevisiae)	0.010
myst2	MYST histone acetyltransferase 2	0.010
yes1	v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1	0.010
fkbp5	FK506 binding protein 5	0.010
src	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	0.010
si:ch1073-351m12.1	si:ch1073-351m12.1	0.010