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Process View

Danio rerio

3 genes annotated in zebrafish

lens fiber cell development

The process whose specific outcome is the progression of a lens fiber cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a lens fiber cell fate. A lens fiber cell is any of the elongated, tightly packed cells that make up the bulk of the mature lens in a camera-type eye.

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Known genes in the process in zebrafish Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "lens fiber cell development"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "lens fiber cell development" (in gray)

Name	Description	Probability	Func Analog Organism
crygmxl2	crystallin, gamma MX, like 2	0.947
crygm2f	crystallin, gamma M2f	0.858
crygm2d8	crystallin, gamma M2d8	0.820	Mouse
crygm3	crystallin, gamma M3	0.749
crygm1	crystallin, gamma M1	0.616	Mouse
crygm2a	crystallin, gamma M2a	0.599	Mouse
crygmx	crystallin, gamma MX	0.589
crygm7	crystallin, gamma M7	0.565	Mouse
zgc:153846	zgc:153846	0.558	Mouse
crygn2	crystallin, gamma N2	0.543
crygm2d2	crystallin, gamma M2d2	0.526
crygn1	crystallin, gamma N1	0.524
crygm2d15	crystallin, gamma M2d15	0.522	Mouse
crygmxl1	crystallin, gamma MX, like 1	0.495	Mouse
crygm2d16	crystallin, gamma M2d16	0.473
crygm2d10	crystallin, gamma M2d10	0.459
crygm2d11	crystallin, gamma M2d11	0.403	Mouse
crygm6	crystallin, gamma M6	0.385	Mouse
crygm2b	crystallin, gamma M2b	0.371
crygm2d13	crystallin, gamma M2d13	0.357	Mouse
her1	hairy-related 1	0.357
LOC799807	novel protein similar to crystallin, gamma family	0.354
zgc:171792	zgc:171792	0.351
crygm2d6	crystallin, gamma M2d6	0.342
crygs4	crystallin, gamma S4	0.322
crygm2d7	crystallin, gamma M2d7	0.247
zgc:101859	zgc:101859	0.222
crygm2d12	crystallin, gamma M2d12	0.206	Mouse
ikzf1	IKAROS family zinc finger 1 (Ikaros)	0.177
crygm2c	crystallin, gamma M2c	0.171	Mouse
dlc	deltaC	0.166
cryba2a	crystallin, beta A2a	0.143
wif1	wnt inhibitory factor 1	0.115
crygm5	crystallin, gamma M5	0.114	Mouse
crygm4	crystallin, gamma M4	0.113	Mouse
cryba1b	crystallin, beta A1b	0.108
cryba2b	crystallin, beta A2b	0.103
lgsn	lengsin, lens protein with glutamine synthetase domain	0.101
lama5	laminin, alpha 5	0.098
msxd	muscle segment homeobox D	0.097
cryba1l	crystallin, beta A1, like	0.080
cdh23	cadherin-like 23	0.080
pxn	paxillin	0.074
crybb1	crystallin, beta B1	0.072
fshb	follicle stimulating hormone, beta polypeptide	0.070
cryba4	crystallin, beta A4	0.069
grifin	galectin related inter-fiber protein	0.067
cntn1b	contactin 1b	0.062
mpz	myelin protein zero	0.062
si:ch211-212m21.5	si:ch211-212m21.5	0.060
ccbe1	collagen and calcium binding EGF domains 1	0.059
ctgf	connective tissue growth factor	0.059
crybb1l2	crystallin, beta B1, like 2	0.058
crybb2	crystallin, beta B2	0.056
dag1	dystroglycan 1	0.056
zgc:112285	zgc:112285	0.055
crygs1	crystallin, gamma S1	0.051
csf1ra	colony stimulating factor 1 receptor, a	0.051
fzd7a	frizzled homolog 7a	0.050
foxa1	forkhead box A1	0.049
zbtb16a	zinc finger and BTB domain containing 16a	0.049
notch3	notch homolog 3	0.049
LOC559976	similar to glutamate receptor, ionotropic, NMDA2B (epsilon 2)	0.049
tgfb1a	transforming growth factor, beta 1a	0.048
plp1b	proteolipid protein 1b	0.047
fgfr3	fibroblast growth factor receptor 3	0.046	Mouse
col4a5	collagen, type IV, alpha 5 (Alport syndrome)	0.046
tie2	endothelium-specific receptor tyrosine kinase 2	0.046
fras1	Fraser syndrome 1	0.045
ighz	immunoglobulin heavy constant zeta	0.045
mipa	major intrinsic protein of lens fiber a	0.044
fgfr4	fibroblast growth factor receptor 4	0.043
lamc1	laminin, gamma 1	0.042
lctla	lactase-like a	0.042
ntrk2b	neurotrophic tyrosine kinase, receptor, type 2b	0.040
optc	opticin	0.040
pea3	ETS-domain transcription factor pea3	0.039
col17a1b	collagen, type XVII, alpha 1b	0.038
ralgapa1	Ral GTPase activating protein, alpha subunit 1 (catalytic)	0.037
aox3	aldehyde oxidase 3	0.036
mpx	myeloid-specific peroxidase	0.035
col4a2	collagen, type IV, alpha 2	0.035
pdgfaa	platelet-derived growth factor alpha a	0.034
col4a6	collagen, type IV, alpha 6	0.034
nr2f2	nuclear receptor subfamily 2, group F, member 2	0.032
sema3aa	semaphorin 3aa	0.032
fgfrl1a	fibroblast growth factor receptor-like 1a	0.032
anxa2a	annexin A2a	0.032
six2a	sine oculis-related homeobox 2a	0.031
zgc:103750	zgc:103750	0.031	Mouse
zgc:56116	zgc:56116	0.030
ntd5	ntl-dependent gene 5	0.030
alpi	alkaline phosphatase, intestinal	0.029
mipb	major intrinsic protein of lens fiber b	0.029
spon1b	spondin 1b	0.029
cxcl12a	chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1)	0.029
olig1	oligodendrocyte lineage transcription factor 1	0.028
hhip	hedgehog interacting protein	0.027
pabpc1b	poly A binding protein, cytoplasmic 1 b	0.027
foxf1	forkhead box F1	0.026
rag1	recombination activating gene 1	0.026
cdc42ep1	CDC42 effector protein (Rho GTPase binding) 1	0.026
guk1	guanylate kinase 1	0.026
LOC567405	novel protein similar to vertebrate megakaryocyte-associated tyrosine kinase (MATK)	0.025
LOC100148845	neurogenin-1-like	0.025
igf2b	insulin-like growth factor 2b	0.025
tnfsf10l	tumor necrosis factor (ligand) superfamily, member 10 like	0.025
col12a1	collagen, type XII, alpha 1	0.025
dlx5a	distal-less homeobox gene 5a	0.025
mef2a	myocyte enhancer factor 2a	0.025
fbn2b	fibrillin 2b	0.024
igfbp5a	insulin-like growth factor binding protein 5a	0.024
rspo1	R-spondin homolog (Xenopus laevis)	0.024
her9	hairy-related 9	0.024
ptf1a	pancreas specific transcription factor, 1a	0.024
hmcn2	hemicentin 2	0.024
her2	hairy-related 2	0.023
irx5a	iroquois homeobox protein 5a	0.023
rbp4	retinol binding protein 4, plasma	0.023
or125-8	odorant receptor, family E, subfamily 125, member 8	0.023
ptgs1	prostaglandin-endoperoxide synthase 1	0.023
itga5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.023
neu4	sialidase 4	0.022
cast	calpastatin	0.022
sb:cb166	sb:cb166	0.021
zdhhc8b	zinc finger, DHHC-type containing 8b	0.021
flt4	fms-related tyrosine kinase 4	0.021
acaa1	acetyl-Coenzyme A acyltransferase 1	0.021
cx43.4	connexin 43.4	0.021
pou4f3	POU domain, class 4, transcription factor 3	0.020
snai2	snail homolog 2 (Drosophila)	0.020
slc39a3	solute carrier family 39 (zinc transporter), member 3	0.020
llgl2	lethal giant larvae homolog 2 (Drosophila)	0.020
col1a1a	collagen, type I, alpha 1a	0.020
abp1	amiloride binding protein 1 (amine oxidase (copper-containing))	0.020
snai3	snail homolog 3	0.020
or103-1	odorant receptor, family C, subfamily 103, member 1	0.020
crybb1l3	crystallin, beta B1, like 3	0.020
cx55.5	connexin 55.5	0.020
sparcl1	SPARC-like 1	0.020
itgb4	integrin, beta 4	0.019
pard6gb	par-6 partitioning defective 6 homolog gamma B (C. elegans)	0.019
pax7b	paired box gene 7b	0.019
clic4	chloride intracellular channel 4	0.019
junb	jun B proto-oncogene	0.019
itga6b	integrin, alpha 6b	0.019
cyp26b1	cytochrome P450, family 26, subfamily b, polypeptide 1	0.019
abl1	c-abl oncogene 1, non-receptor tyrosine kinase	0.018
si:ch211-195h23.3	si:ch211-195h23.3	0.018
epb4.1l4	erythrocyte protein band 4.1-like 4	0.018
mst1rb	macrophage stimulating 1 receptor (c-met-related tyrosine kinase), b	0.018
tecpr2	tectonin beta-propeller repeat containing 2	0.018
LOC100537975	thyroid receptor-interacting protein 11-like	0.018
lhcgr	luteinizing hormone/choriogonadotropin receptor	0.018
lim2.1	lens intrinsic membrane protein 2.1	0.018
fbln4	fibulin 4	0.018
mpll	myeloproliferative leukemia virus oncogene, like	0.018
fmnl2a	formin-like 2a	0.017
zgc:85975	zgc:85975	0.017
zgc:136220	zgc:136220	0.017
vcana	versican a	0.017
itgb3b	integrin beta 3b	0.017
sec24d	SEC24 family, member D (S. cerevisiae)	0.017
foxn1	forkhead box N1	0.017
bbs2	Bardet-Biedl syndrome 2	0.017
eda	ectodysplasin A	0.017
metrnl	meteorin, glial cell differentiation regulator-like	0.017
xirp1	xin actin-binding repeat containing 1	0.017
nr2f5	nuclear receptor subfamily 2, group F, member 5	0.017
hmcn1	hemicentin 1	0.017
LOC566040	protein notum homolog	0.016
gh1	growth hormone 1	0.016
dmd	dystrophin	0.016
hspb2	heat shock protein, alpha-crystallin-related, b2	0.016
utrn	utrophin	0.016
pax4	paired box 4	0.016
zgc:171531	zgc:171531	0.016
mesp2	mesoderm posterior 2 homolog (mouse)	0.016
c8a	complement component 8, alpha polypeptide	0.016
col7a1l	collagen type VII alpha 1-like	0.016
dntt	deoxynucleotidyltransferase, terminal	0.016
spi1	spleen focus forming virus (SFFV) proviral integration oncogene spi1	0.016
crygm2d3	crystallin, gamma M2d3	0.016
dhrs3a	dehydrogenase/reductase (SDR family) member 3a	0.016
foxc1b	forkhead box C1b	0.015
foxi3b	forkhead box I3b	0.015
htr1aa	5-hydroxytryptamine (serotonin) receptor 1A a	0.015
spon2b	spondin 2b, extracellular matrix protein	0.015
irg1l	immunoresponsive gene 1, like	0.015
plg	plasminogen	0.015
nrp2b	neuropilin 2b	0.015
col6a2	collagen, type VI, alpha 2	0.015
zgc:66426	zgc:66426	0.015
lysmd3	LysM, putative peptidoglycan-binding, domain containing 3	0.015
zgc:152982	zgc:152982	0.015
coe2	coe2	0.015
zgc:77409	zgc:77409	0.015
col19a1	collagen, type XIX, alpha 1	0.015
tec	tec protein tyrosine kinase	0.015
cebpd	CCAAT/enhancer binding protein (C/EBP), delta	0.015
emx2	empty spiracles homeobox 2	0.015
chrm5b	cholinergic receptor, muscarinic 5b	0.015
p4ha2	procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide 2	0.014
nkx2.9	NK2 transcription factor related, locus 9 (Drosophila)	0.014
dacha	dachshund a	0.014
col17a1a	collagen, type XVII, alpha 1a	0.014
vsx2	visual system homeobox 2	0.014
grhl2a	grainyhead-like 2a (Drosophila)	0.014
lamb1a	laminin, beta 1a	0.014
helt	hey-like transcription factor	0.014
si:ch73-73d17.3	si:ch73-73d17.3	0.014
chrm3a	cholinergic receptor, muscarinic 3a	0.014
ctbp2l	C-terminal binding protein 2, like	0.014
twist2	twist2	0.014
si:dkey-72l14.3	si:dkey-72l14.3	0.014
si:dkey-245p14.4	si:dkey-245p14.4	0.014
vwf	von Willebrand factor	0.014
fstl5	follistatin-like 5 and follistatin-like 5	0.014
igfbp2a	insulin-like growth factor binding protein 2a	0.014
zgc:85727	zgc:85727	0.014
mapk12	mitogen-activated protein kinase 12	0.014
znf703	zinc finger protein 703	0.014
cadps2	Ca2+-dependent activator protein for secretion 2	0.014
adcy8	adenylate cyclase 8 (brain)	0.014
s1pr1	sphingosine-1-phosphate receptor 1	0.014
zgc:112294	zgc:112294	0.014
frem2a	Fras1 related extracellular matrix protein 2a	0.014
boc	brother of CDO	0.014
tlx1	T-cell leukemia, homeobox 1	0.014
ntn1b	netrin 1b	0.013
zgc:136614	zgc:136614	0.013
atp1a1b	ATPase, Na+/K+ transporting, alpha 1b polypeptide	0.013
dmrt2a	doublesex and mab-3 related transcription factor 2a	0.013
sb:cb118	sb:cb118	0.013
exoc7	exocyst complex component 7	0.013
atp1a1a.2	ATPase, Na+/K+ transporting, alpha 1a.2 polypeptide	0.013
nrl	neural retina leucine zipper	0.013
zgc:92432	zgc:92432	0.013
tert	telomerase reverse transcriptase	0.013
hgfa	hepatocyte growth factor a	0.013
guca1c	guanylate cyclase activator 1C	0.013
kcnj11l	potassium inwardly-rectifying channel, subfamily J, member 11, like	0.013
dnm1l	dynamin 1-like	0.013
kdrl	kinase insert domain receptor like	0.013
ccdc80	coiled-coil domain containing 80	0.013
foxe3	forkhead box E3	0.013
hlxb9la	homeo box HB9 like a	0.013
ora5	olfactory receptor class A related 5	0.013
atoh1a	atonal homolog 1a	0.013
rbfox1	RNA binding protein, fox-1 homolog (C. elegans) 1	0.013
bbs4	Bardet-Biedl syndrome 4	0.013
ptprfb	protein tyrosine phosphatase, receptor type, f, b	0.013
taf3	TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated facto	0.013
cx32.3	connexin 32.3	0.013
ndor1	NADPH dependent diflavin oxidoreductase 1	0.013
LOC100149148	novel protein similar to myosin heavy chain 4 (myhc4)	0.013
flncb	filamin C, gamma b (actin binding protein 280)	0.013
bmp1a	bone morphogenetic protein 1a	0.013
zgc:55420	zgc:55420	0.013
guca1a	guanylate cyclase activator 1A	0.013
stmn4	stathmin-like 4	0.013
baiap2a	BAI1-associated protein 2a	0.012
flnca	filamin C, gamma a (actin binding protein 280)	0.012
si:dkey-24h22.4	si:dkey-24h22.4	0.012
crtap	cartilage associated protein	0.012
cpne2	copine II	0.012
slc2a9l1	solute carrier family 2 (facilitated glucose transporter), member 9-like 1	0.012
ca10a	carbonic anhydrase Xa	0.012
zgc:172101	zgc:172101	0.012
frem1a	Fras1 related extracellular matrix 1a	0.012
ift81	intraflagellar transport 81 homolog	0.012
kiss1ra	KISS1 receptor a	0.012
crtac1a	cartilage acidic protein 1a	0.012
nrarpa	notch-regulated ankyrin repeat protein a	0.012
rpl23a	ribosomal protein L23a	0.012
gpib	glucose phosphate isomerase b	0.012
col4a1	collagen, type IV, alpha 1	0.012
grk1b	G protein-coupled receptor kinase 1 b	0.012
ren	renin	0.012
lrrtm4l1	leucine rich repeat transmembrane neuronal 4 like 1	0.012
im:7137555	im:7137555	0.012
zgc:85722	zgc:85722	0.012
piga	phosphatidylinositol glycan anchor biosynthesis, class A	0.012
bmpr1ab	bone morphogenetic protein receptor, type 1ab	0.012
stau2	staufen, RNA binding protein, homolog 2 (Drosophila)	0.012
pla2g12b	phospholipase A2, group XIIB	0.012
entpd1	ectonucleoside triphosphate diphosphohydrolase 1	0.012
herpud2	HERPUD family member 2	0.012
egfl6	EGF-like-domain, multiple 6	0.012
ptprsa	protein tyrosine phosphatase, receptor type, s, a	0.012
thap7	THAP domain containing 7	0.012
skib	nuclear oncoprotein skib	0.012
her6	hairy-related 6	0.012
zgc:86759	zgc:86759	0.012
atp1a1a.5	ATPase, Na+/K+ transporting, alpha 1a.5 polypeptide	0.012
hoxc9a	homeo box C9a	0.012
s1pr2	sphingosine-1-phosphate receptor 2	0.012
brap	BRCA1 associated protein	0.012
peli1b	pellino homolog 1b (Drosophila)	0.012
pcsk9	proprotein convertase subtilisin/kexin type 9	0.012
grk7a	G-protein-coupled receptor kinase 7a	0.012
bbs1	Bardet-Biedl syndrome 1	0.011
zgc:158327	zgc:158327	0.011
synj1	synaptojanin 1	0.011
st3gal5l	ST3 beta-galactoside alpha-2,3-sialyltransferase 5, like	0.011
ets2	v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)	0.011
zgc:136903	zgc:136903	0.011
trpn1	transient receptor potential cation channel, subfamily N, member 1	0.011
socs3a	suppressor of cytokine signaling 3a	0.011
wu:fc67d01	wu:fc67d01	0.011
cps1	carbamoyl-phosphate synthase 1, mitochondrial	0.011
odf3l2	outer dense fiber of sperm tails 3-like 2	0.011
hsf4	heat shock transcription factor 4	0.011
LOC100002342	carboxypeptidase A6-like	0.011
slc18a2	solute carrier family 18 (vesicular monoamine), member 2	0.011
arfgef1	ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited)	0.011
dopey1	dopey family member 1	0.011
tmem178	transmembrane protein 178	0.011
heyl	hairy/enhancer-of-split related with YRPW motif-like	0.011
pdhx	pyruvate dehydrogenase complex, component X	0.011
rpz	rapunzel	0.011
tas1r1	taste receptor, type 1, member 1	0.011
sdprb	serum deprivation response b	0.011
LOC555739	serine/threonine-protein kinase LMTK1-like	0.011
gadd45bb	growth arrest and DNA-damage-inducible, beta b	0.011
inhbab	inhibin, beta Ab	0.011
arrb2a	arrestin, beta 2a	0.011
hspb11	heat shock protein, alpha-crystallin-related, b11	0.011
por	P450 (cytochrome) oxidoreductase	0.011
edar	ectodysplasin A receptor	0.011
zgc:136874	zgc:136874	0.011
stab2	stabilin 2	0.011
col4a3	collagen, type IV, alpha 3	0.011
notch2	notch homolog 2	0.011
hoxa4a	homeo box A4a	0.011
fzd2	frizzled homolog 2	0.011
sfrp1b	secreted frizzled-related protein 1b	0.011
gadd45ab	growth arrest and DNA-damage-inducible, alpha, b	0.011
wu:fc07e08	wu:fc07e08	0.011
cryba1a	crystallin, beta A1a	0.011
cpn1	carboxypeptidase N, polypeptide 1	0.011
aanat1	arylalkylamine N-acetyltransferase 1	0.011
ptk2.1	protein tyrosine kinase 2a	0.011
her4.2	hairy-related 4.2	0.011
sp4	sp4 transcription factor	0.011
si:dkeyp-27b10.2	si:dkeyp-27b10.2	0.011
slc1a3a	solute carrier family 1 (glial high affinity glutamate transporter), member 3a	0.011
atf3	activating transcription factor 3	0.011
mfsd4b	major facilitator superfamily domain containing 4b	0.011
olfm1b	olfactomedin 1b	0.011
si:dkey-108d22.4	si:dkey-108d22.4	0.011
sly1	suppressor of ypt1	0.011
crygm2d1	crystallin, gamma M2d1	0.011
neu3.3	sialidase 3.3	0.011
si:dkeyp-68f6.1	si:dkeyp-68f6.1	0.011
calua	calumenin a	0.011
ascl1a	achaete-scute complex-like 1a (Drosophila)	0.011
wwox	WW domain containing oxidoreductase	0.011
fam43b	family with sequence similarity 43, member B	0.010
kcnc3b	potassium voltage-gated channel, Shaw-related subfamily, member 3b	0.010
ms4a17a.4	membrane-spanning 4-domains, subfamily A, member 17A.4	0.010
scospondin	subcommissural organ spondin	0.010
dlx1a	distal-less homeobox gene 1a	0.010
LOC100000685	similar to OCTN2 protein	0.010
synpr	synaptoporin	0.010
nitr3a	novel immune-type receptor 3a	0.010
ctssa	cathepsin S, a	0.010
si:dkeyp-118a3.2	si:dkeyp-118a3.2	0.010
slc22a4	solute carrier family 22 (organic cation/ergothioneine transporter), member 4	0.010
slc47a1	solute carrier family 47, member 1	0.010
aspn	asporin (LRR class 1)	0.010
ptpra	protein tyrosine phosphatase, receptor type, A	0.010
sv2b	synaptic vesicle glycoprotein 2 b	0.010
erbb4a	v-erb-a erythroblastic leukemia viral oncogene homolog 4a (avian)	0.010
itk	IL2-inducible T-cell kinase	0.010
slc1a1	solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1	0.010
pnp4a	purine nucleoside phosphorylase 4a	0.010
wu:fb15e04	wu:fb15e04	0.010
hcn4	hyperpolarization activated cyclic nucleotide-gated potassium channel 4	0.010
cradd	CASP2 and RIPK1 domain containing adaptor with death domain	0.010
grma	glutamate receptor, metabotropic a	0.010
pbx1a	pre-B-cell leukemia transcription factor 1a	0.010
ero1l	ERO1-like (S. cerevisiae)	0.010
zgc:162213	zgc:162213	0.010
scinla	scinderin like a	0.010
dip2ba	DIP2 disco-interacting protein 2 homolog Ba (Drosophila)	0.010
cited2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	0.010
ntn2	netrin 2	0.010
gadd45ba	growth arrest and DNA-damage-inducible, beta a	0.010
c1galt1a	core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1a	0.010
im:7137597	im:7137597	0.010
rad1	RAD1 homolog (S. pombe)	0.010