IMP

Process View

Danio rerio

4 genes annotated in zebrafish

heart valve formation

The developmental process pertaining to the initial formation of a heart valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable.

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Known genes in the process in zebrafish Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "heart valve formation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "heart valve formation" (in gray)

Name	Description	Probability	Func Analog Organism
tbx5a	T-box 5a	0.994
hand2	heart and neural crest derivatives expressed transcript 2	0.990
tal1	T-cell acute lymphocytic leukemia 1	0.968
bmp4	bone morphogenetic protein 4	0.953
tbx1	T-box 1	0.920	Zebrafish
gata6	GATA-binding protein 6	0.893
tbx20	T-box 20	0.883	Zebrafish Mouse
fgf8a	fibroblast growth factor 8 a	0.856
gata2a	GATA-binding protein 2a	0.852
has2	hyaluronan synthase 2	0.831
bmp2b	bone morphogenetic protein 2b	0.792
nkx2.5	NK2 transcription factor related 5	0.785
aldh1a2	aldehyde dehydrogenase 1 family, member A2	0.775
hhex	hematopoietically expressed homeobox	0.766
hnf1ba	HNF1 homeobox Ba	0.683
foxi1	forkhead box I1	0.667
myl7	myosin, light polypeptide 7, regulatory	0.658
gata5	GATA-binding protein 5	0.603	Zebrafish
dlx2a	distal-less homeobox gene 2a	0.589
lft2	lefty2	0.573
fli1a	friend leukemia integration 1a	0.570
cdx4	caudal type homeo box transcription factor 4	0.520
chd	chordin	0.517
flh	floating head	0.472
znfl2a	zinc finger-like gene 2a	0.457
hey2	hairy/enhancer-of-split related with YRPW motif 2	0.456	Mouse
her7	hairy and enhancer of split related-7	0.454
lmo2	LIM domain only 2 (rhombotin-like 1)	0.452
tbx6	T-box gene 6	0.444	Zebrafish
tbx16	T-box gene 16	0.378	Zebrafish
runx1	runt-related transcription factor 1	0.357
raraa	retinoic acid receptor, alpha a	0.337
mef2cb	myocyte enhancer factor 2cb	0.329
drl	draculin	0.328
gata1a	GATA binding protein 1a	0.326	Zebrafish
ttna	titin a	0.325
spaw	southpaw	0.319
ptch1	patched 1	0.316
dlc	deltaC	0.314
cyp26a1	cytochrome P450, subfamily XXVIA, polypeptide 1	0.311
pcdh8	protocadherin 8	0.305
tfap2a	transcription factor AP-2 alpha	0.303
cdh2	cadherin 2, neuronal	0.298
osr2	odd-skipped related 2 (Drosophila)	0.272
wnt11	wingless-type MMTV integration site family, member 11	0.271
ntla	no tail a	0.270	Zebrafish
notch1b	notch homolog 1b	0.264	Human
pitx2	paired-like homeodomain transcription factor 2	0.248
fn1	fibronectin 1	0.237
dld	deltaD	0.237
her1	hairy-related 1	0.234
myh6	myosin, heavy polypeptide 6, cardiac muscle, alpha	0.222
shha	sonic hedgehog a	0.221
klf4	Kruppel-like factor 4	0.218
oep	one-eyed pinhead	0.214
lft1	lefty1	0.209
bmper	BMP binding endothelial regulator	0.203
tcf21	transcription factor 21	0.197
lamb1a	laminin, beta 1a	0.174
hoxb1b	homeo box B1b	0.165
eomesa	eomesodermin homolog a	0.162	Zebrafish
mib	mind bomb	0.161
six4b	sine oculis homeobox homolog 4b	0.153
cmyb	transcription factor cmyb	0.149
spns2	spinster homolog 2 (Drosophila)	0.148
sox32	SRY-box containing gene 32	0.143
atp1a1	ATPase, Na+/K+ transporting, alpha 1 polypeptide	0.138
myod1	myogenic differentiation 1	0.135
LOC566708	FL cytokine receptor-like	0.134
cxcr4a	chemokine (C-X-C motif) receptor 4a	0.134
tbx18	T-box 18	0.133	Zebrafish
ndr2	nodal-related 2	0.128
tnni1b	troponin I, skeletal, slow b	0.127
ttnb	titin b	0.114
prdm1a	PR domain containing 1a, with ZNF domain	0.112
wnt2bb	wingless-type MMTV integration site family, member 2Bb	0.111
kdrl	kinase insert domain receptor like	0.106
etv2	ets variant gene 2	0.104
mef2ca	myocyte enhancer factor 2ca	0.102
eve1	even-skipped-like1	0.098
aplnrb	apelin receptor b	0.088
notch1a	notch homolog 1a	0.087	Human
sp5l	Sp5 transcription factor-like	0.085
mll	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)	0.085
foxh1	forkhead box H1	0.084
jag1b	jagged 1b	0.083
sgcd	sarcoglycan, delta (dystrophin-associated glycoprotein)	0.080
pax2a	paired box gene 2a	0.078
lhx1a	LIM homeobox 1a	0.078
crip2	cysteine-rich protein 2	0.076
hes6	hairy and enhancer of split 6 (Drosophila)	0.076
tmem88a	transmembrane protein 88 a	0.075
dusp5	dual specificity phosphatase 5	0.075
hoxd11a	homeo box D11a	0.074
msgn1	mesogenin 1	0.073
ndr1	nodal-related 1	0.073
bmp2a	bone morphogenetic protein 2a	0.069
szl	sizzled	0.068
isl2a	islet2a	0.067
wu:fb01h12	wu:fb01h12	0.066
cdh5	cadherin 5	0.065
unc45b	unc-45 homolog B (C. elegans)	0.065
mib2	mind bomb 2	0.064
gli2a	GLI-Kruppel family member GLI2a	0.062
erg	v-ets erythroblastosis virus E26 oncogene like (avian)	0.062
tgfb3	transforming growth factor, beta 3	0.062
meis3	myeloid ecotropic viral integration site 3	0.060
wnt11r	wingless-type MMTV integration site family, member 11, related	0.060
tbx5b	T-box 5b	0.059
vent	ventral expressed homeobox	0.059
rx3	retinal homeobox gene 3	0.057
isl1	islet1	0.056
myf5	myogenic factor 5	0.056
nfatc1	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1	0.056
itga5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.056
rbm24a	RNA binding motif protein 24a	0.055
hoxd12a	homeo box D12a	0.054
robo3	roundabout homolog 3	0.053
slc8a1a	solute carrier family 8 (sodium/calcium exchanger), member 1a	0.052
jag2	jagged 2	0.050
hspb7	heat shock protein family, alpha-crystallin-related, b7	0.050
cmlc1	cardiac myosin light chain-1	0.049
tfr1a	transferrin receptor 1a	0.049
myd88	myeloid differentiation primary response gene (88)	0.048
tbx24	T-box 24	0.047	Zebrafish
notch3	notch homolog 3	0.045
tll1	tolloid-like 1	0.045
desma	desmin a	0.044
atp2a2a	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2a	0.043
slc12a2	solute carrier family 12 (potassium/chloride transporters), member 2	0.043
hoxa9a	homeo box A9a	0.043
tp63	tumor protein p63	0.042
vsx1	visual system homeobox 1 homolog, chx10-like	0.042
hspb12	heat shock protein, alpha-crystallin-related, b12	0.042
nadka	NAD kinase a	0.040
dcc	deleted in colorectal carcinoma	0.039
foxc1a	forkhead box C1a	0.039
chrna2a	cholinergic receptor, nicotinic, alpha polypeptide 2a (neuronal)	0.039
foxn4	forkhead box N4	0.039
otx2	orthodenticle homolog 2	0.038
otx1b	orthodenticle homolog 1b	0.038
klf2a	Kruppel-like factor 2a	0.037
limk1	LIM domain kinase 1	0.036
hoxc8a	homeo box C8a	0.036
dact2	dapper homolog 2, antagonist of beta-catenin (xenopus)	0.036
wnt5b	wingless-type MMTV integration site family, member 5b	0.036
gsc	goosecoid	0.036
ets1a	v-ets erythroblastosis virus E26 oncogene homolog 1a	0.035
pdlim2	PDZ and LIM domain 2 (mystique)	0.035
slc25a37	solute carrier family 25, member 37	0.035
tnnc1a	troponin C type 1a (slow)	0.035
gata3	GATA-binding protein 3	0.034	Zebrafish
irx1a	iroquois homeobox protein 1, a	0.034
foxg1a	forkhead box G1a	0.034
tfeb	transcription factor EB	0.034
pomt1	protein-O-mannosyltransferase 1	0.034
zgc:136773	zgc:136773	0.033
fgf17	fibroblast growth factor 17	0.033
epb41	erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)	0.033
fgf10a	fibroblast growth factor 10a	0.033
hoxa10b	homeo box A10b	0.033
tp53	tumor protein p53	0.032
sema3h	semaphorin 3h	0.032
foxd5	forkhead box D5	0.032
arhgef7b	Rho guanine nucleotide exchange factor (GEF) 7b	0.031
med12	mediator of RNA polymerase II transcription, subunit 12 homolog	0.031
epor	erythropoietin receptor	0.031
capn9	calpain 9	0.031
fli1b	friend leukemia integration 1b	0.029
kcnh2	potassium voltage-gated channel, subfamily H (eag-related), member 2	0.029
flt4	fms-related tyrosine kinase 4	0.029
rad21	RAD21 homolog (S. pombe)	0.029
gdf6a	growth differentiation factor 6a	0.029
ikzf1	IKAROS family zinc finger 1 (Ikaros)	0.029
hoxa11a	homeo box A11a	0.029
plagx	pleiomorphic adenoma gene X	0.028
mespb	mesoderm posterior b	0.028
trim33	tripartite motif-containing 33	0.028
bmp3	bone morphogenetic protein 3	0.028
eya1	eyes absent homolog 1	0.028
dhrs3a	dehydrogenase/reductase (SDR family) member 3a	0.028
ved	ventrally expressed dharma/bozozok antagonist	0.027
wnt9a	wingless-type MMTV integration site family, member 9A	0.027
supt5h	suppressor of Ty 5 homolog (S. cerevisiae)	0.027
mbtps1	membrane-bound transcription factor protease, site 1	0.027
bcdo2l	beta-carotene 15, 15-dioxygenase 2, like	0.027
prickle1a	prickle-like 1 (Drosophila) a	0.026
irx3a	iroquois homeobox protein 3a	0.026
ek1	eph-like kinase 1	0.026
pdlim3b	PDZ and LIM domain 3b	0.026
lect1	leukocyte cell derived chemotaxin 1	0.026
rxrga	retinoid x receptor, gamma a	0.025
dspa	desmoplakin a	0.025
ascl1a	achaete-scute complex-like 1a (Drosophila)	0.025
cftr	cystic fibrosis transmembrane conductance regulator, ATP-binding cassette (sub-family C, member 7)	0.025
pcdh10b	protocadherin 10b	0.025
foxa1	forkhead box A1	0.025
tgfb2	transforming growth factor, beta 2	0.025
pdlim4	PDZ and LIM domain 4	0.025
supt6h	suppressor of Ty 6 homolog	0.024
pkd2	polycystic kidney disease 2	0.024
fzd10	frizzled homolog 10	0.024
prrx1a	paired related homeobox 1a	0.024
osr1	odd-skipped related 1 (Drosophila)	0.024
pou5f1	POU domain, class 5, transcription factor 1	0.024
vcana	versican a	0.024
bin1	bridging integrator 1	0.023
fgf24	fibroblast growth factor 24	0.023
bambia	BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a	0.023
sox10	SRY-box containing gene 10	0.023
nkx2.3	NK2 transcription factor related 3	0.023
glrx5	glutaredoxin 5 homolog (S. cerevisiae)	0.022
zeb1	zinc finger E-box binding homeobox 1	0.022
gbx2	gastrulation brain homeo box 2	0.022
col15a1a	collagen, type XV, alpha 1a	0.022
smtnl	smoothelin, like	0.021
e2f7	E2F transcription factor 7	0.021
sf3b1	splicing factor 3b, subunit 1	0.021
fezf2	FEZ family zinc finger 2	0.021
stat1b	signal transducer and activator of transcription 1b	0.021
sulf1	sulfatase 1	0.021
gja3	gap junction protein, alpha 3	0.021
fgfrl1a	fibroblast growth factor receptor-like 1a	0.021
wu:fv91b12	wu:fv91b12	0.021
rarab	retinoic acid receptor, alpha b	0.021
esr1	estrogen receptor 1	0.020
kdr	kinase insert domain receptor (a type III receptor tyrosine kinase)	0.020
lypd6	LY6/PLAUR domain containing 6	0.020
hadha	hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase, alpha subunit	0.020
sp5	Sp5 transcription factor	0.020
smyd1b	SET and MYND domain containing 1b	0.020
spi1	spleen focus forming virus (SFFV) proviral integration oncogene spi1	0.020
fhla	four and a half LIM domains a	0.019
her12	hairy-related 12	0.019
siah1	seven in absentia homolog 1 (Drosophila)	0.019
dlx1a	distal-less homeobox gene 1a	0.019
col27a1a	collagen, type XXVII, alpha 1a	0.019
clic2	chloride intracellular channel 2	0.019
auts2	autism susceptibility candidate 2	0.019
prickle1b	prickle homolog 1 (Drosophila) b	0.019
dla	deltaA	0.018
sec23a	Sec23 homolog A (S. cerevisiae)	0.018
rest	RE1-silencing transcription factor	0.018
dlx4b	distal-less homeobox gene 4b	0.018
barhl2	BarH-like 2	0.018
zgc:73311	zgc:73311	0.018
ephb3a	eph receptor B3a	0.018
ptprb	protein tyrosine phosphatase, receptor type, b	0.018
ihha	Indian hedgehog homolog a	0.018
slc8a4a	solute carrier family 8 (sodium/calcium exchanger), member 4a	0.018
cldn11b	claudin 11b	0.017
alas2	aminolevulinate, delta-, synthetase 2	0.017
barx1	BarH-like homeobox 1	0.017
sox17	SRY-box containing gene 17	0.017
hoxb10a	homeo box B10a	0.017
ctnnd2b	catenin (cadherin-associated protein), delta 2b	0.017
mtp	microsomal triglyceride transfer protein	0.017
pdlim7	PDZ and LIM domain 7	0.017
ssr2	signal sequence receptor, beta	0.017
tbx2b	T-box 2b	0.017	Zebrafish
hibadha	3-hydroxyisobutyrate dehydrogenase a	0.017
lnpa	limb and neural patterns a	0.017
cpox	coproporphyrinogen oxidase	0.016
disc1	disrupted in schizophrenia 1	0.016
zfpm1	zinc finger protein, multitype 1	0.016	Mouse
zic5	zic family member 5 (odd-paired homolog, Drosophila)	0.016
lmo4a	LIM domain only 4a	0.016
vsx2	visual system homeobox 2	0.016
pdlim3a	PDZ and LIM domain 3a	0.016
dbx1b	developing brain homeobox 1b	0.016
grhl3	grainyhead-like 3	0.016
smad6a	SMAD family member 6a	0.016
klf2b	Kruppel-like factor 2b	0.016
LOC100151531	zinc finger protein Gfi-1b-like	0.016
ung	uracil-DNA glycosylase	0.016
dlx6a	distal-less homeobox gene 6a	0.016
tcf7l2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.015
brca2	breast cancer 2, early onset	0.015
prrx1b	paired related homeobox 1b	0.015
pdcd2	programmed cell death 2	0.015
vmhc	ventricular myosin heavy chain	0.015
rp42-pen	rp42 homolog (pending) and rp42 homolog	0.015
tp73	tumor protein p73	0.015
wnt8a	wingless-type MMTV integration site family, member 8a	0.015
zic6	zic family member 6	0.015
krcp	kelch repeat-containing protein	0.015
tjp1	tight junction protein 1 (zona occludens 1)	0.015
jph2	junctophilin 2	0.015
prmt5	protein arginine methyltransferase 5	0.015
fgfr4	fibroblast growth factor receptor 4	0.015
gli1	GLI-Kruppel family member 1	0.015
mespa	mesoderm posterior a	0.015
im:7150469	im:7150469	0.015
wt1a	wilms tumor 1a	0.014
ldlrap1a	low density lipoprotein receptor adaptor protein 1a	0.014
gpia	glucose phosphate isomerase a	0.014
plag1	pleiomorphic adenoma gene 1	0.014
itga2b	integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41B)	0.014
si:ch211-285f17.1	si:ch211-285f17.1	0.014
col8a1a	collagen, type VIII, alpha 1a	0.014
smo	smoothened homolog (Drosophila)	0.014
tpm4	tropomyosin 4	0.014
lhx5	LIM homeobox 5	0.014
rbm24b	RNA binding motif protein 24b	0.014
bmp7a	bone morphogenetic protein 7a	0.014
ech1	enoyl CoA hydratase 1, peroxisomal	0.014
zgc:63938	zgc:63938	0.014
gfi1.1	growth factor independent 1.1	0.013
runx2b	runt-related transcription factor 2b	0.013
ctrb1	chymotrypsinogen B1	0.013
tmem86b	transmembrane protein 86B	0.013
nipblb	novel protein similar to vertebrate Nipped-B homolog and nipped-b homolog b (Drosophila)	0.013
sesn1	sestrin 1	0.013
pi4kb	phosphatidylinositol 4-kinase, catalytic, beta	0.013
loxl3b	lysyl oxidase-like 3b	0.013
hoxd9a	homeo box D9a	0.013
xirp1	xin actin-binding repeat containing 1	0.013
rag1	recombination activating gene 1	0.013
crfa31.2	IL-4RA-like protein 2	0.013
LOC572344	hypothetical protein LOC572344	0.013
elovl7a	ELOVL family member 7, elongation of long chain fatty acids (yeast) a	0.013
pcdh10a	protocadherin 10a	0.013
zgc:92061	zgc:92061	0.013
zgc:163008	zgc:163008	0.013
foxa3	forkhead box A3	0.013
pdlim5	PDZ and LIM domain 5	0.013
mllt3	myeloid/lymphoid or mixed lineage-leukemia translocation to 3 homolog (Drosophila)	0.013
aqp3a	aquaporin 3a	0.012
slc11a2	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	0.012
kdelr2l	KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2, like	0.012
fkbp10	FK506 binding protein 10	0.012
hdr	hematopoietic death receptor	0.012
eif3hb	eukaryotic translation initiation factor 3, subunit H, b	0.012
gdf6b	growth differentiation factor 6b	0.012
foxm1	forkhead box M1	0.012
col2a1a	collagen type II, alpha-1a	0.012
mylk3	myosin light chain kinase 3	0.012
uck2b	uridine-cytidine kinase 2b	0.012
fzd8a	frizzled homolog 8a	0.012
smyd3	SET and MYND domain containing 3	0.012
fmnl2a	formin-like 2a	0.012
numbl	numb homolog (Drosophila)-like	0.012
nadl1.1	neural adhesion molecule L1.1	0.012
urod	uroporphyrinogen decarboxylase	0.012
epcam	epithelial cell adhesion molecule	0.012
vox	ventral homeobox	0.012
nbl1	neuroblastoma, suppression of tumorigenicity 1	0.012
apc	adenomatosis polyposis coli	0.012
neurod6b	neurogenic differentiation 6b	0.012
pax9	paired box gene 9	0.012
sema3e	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E	0.012
pdcd4b	programmed cell death 4b	0.012
si:ch73-60e21.1	si:ch73-60e21.1	0.012
msxe	muscle segment homeobox E	0.012
ppox	protoporphyrinogen oxidase	0.012
stab2	stabilin 2	0.012
tie1	endothelium-specific receptor tyrosine kinase 1	0.011
id:ibd2050	id:ibd2050	0.011
LOC100332039	ectonucleotide pyrophosphatase/phosphodiesterase family member 2-like	0.011
hapln1b	hyaluronan and proteoglycan link protein 1b	0.011
zgc:92467	zgc:92467	0.011
lhx1b	LIM homeobox 1b	0.011
zgc:85975	zgc:85975	0.011
senp6a	SUMO1/sentrin specific peptidase 6a	0.011
gng2	guanine nucleotide binding protein (G protein), gamma 2	0.011
acsf2	acyl-CoA synthetase family member 2	0.011
hoxa9b	homeo box A9b	0.011
metap2	methionyl aminopeptidase 2	0.011
dlx3b	distal-less homeobox gene 3b	0.011
rbpms2	RNA binding protein with multiple splicing 2	0.011
pigq	phosphatidylinositol glycan, class Q	0.011
rnasel1	ribonuclease like 1	0.011
alcama	activated leukocyte cell adhesion molecule a	0.011
csnk1a1	casein kinase 1, alpha 1	0.011
arpp19b	cAMP-regulated phosphoprotein 19b	0.011
asf1bb	ASF1 anti-silencing function 1 homolog Bb	0.011
and1	actinodin1	0.011
hoxa11b	homeo box A11b	0.011
hoxd10a	homeo box D10a	0.011
ippk	inositol 1,3,4,5,6-pentakisphosphate 2-kinase	0.011
ptgs1	prostaglandin-endoperoxide synthase 1	0.011
zgc:76872	zgc:76872	0.011
gsna	gelsolin a	0.011
limk2	LIM domain kinase 2	0.011
slc2a10	solute carrier family 2 (facilitated glucose transporter), member 10	0.010
si:ch73-9j13.1	si:ch73-9j13.1	0.010
id:ibd5051	id:ibd5051	0.010
edn1	endothelin 1	0.010
ankrd10a	ankyrin repeat domain 10a	0.010
tfap2c	transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)	0.010
rpl23a	ribosomal protein L23a	0.010
vcanb	versican b	0.010
or102-3	odorant receptor, family C, subfamily 102, member 3	0.010
vmhcl	ventricular myosin heavy chain-like	0.010
etv5b	ets variant 5b	0.010
kdm5bb	lysine (K)-specific demethylase 5Bb	0.010
foxd3	forkhead box D3	0.010
sbno1	strawberry notch homolog 1 (Drosophila)	0.010
LOC558520	melanin-concentrating hormone receptor 2-like	0.010
pitrm1	pitrilysin metalloproteinase 1	0.010
tie2	endothelium-specific receptor tyrosine kinase 2	0.010
sox9a	SRY-box containing gene 9a	0.010	Mouse
zic4	zic family member 4	0.010
cd8a	CD8 antigen, alpha polypeptide	0.010
cd9a	CD9 antigen (p24) a	0.010
tmem135	transmembrane protein 135	0.010
ublcp1	ubiquitin-like domain containing CTD phosphatase 1	0.010
apln	apelin	0.010