IMP

Process View

Danio rerio

8 genes annotated in zebrafish

limb development

The process whose specific outcome is the progression of a limb over time, from its formation to the mature structure. A limb is an appendage of an animal used for locomotion or grasping. Examples include legs, arms or some types of fin.

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Known genes in the process in zebrafish Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "limb development"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "limb development" (in gray)

Name	Description	Probability	Func Analog Organism
bmp2b	bone morphogenetic protein 2b	0.975
wnt5b	wingless-type MMTV integration site family, member 5b	0.602	Mouse
dlx2a	distal-less homeobox gene 2a	0.583
dlx5a	distal-less homeobox gene 5a	0.523	Mouse
fgf24	fibroblast growth factor 24	0.483
shha	sonic hedgehog a	0.429	Mouse
hoxa9b	homeo box A9b	0.419	Mouse
hoxd13a	homeo box D13a	0.313	Mouse
hoxa11b	homeo box A11b	0.300	Mouse
osr2	odd-skipped related 2 (Drosophila)	0.257	Mouse
hand2	heart and neural crest derivatives expressed transcript 2	0.253	Mouse
hoxa13b	homeo box A13b	0.238	Mouse
gli2a	GLI-Kruppel family member GLI2a	0.221	Mouse
hoxd11a	homeo box D11a	0.203	Mouse
hoxa11a	homeo box A11a	0.203
msxd	muscle segment homeobox D	0.193
sox9a	SRY-box containing gene 9a	0.186	Mouse
gbx2	gastrulation brain homeo box 2	0.173
chd	chordin	0.162
tbx18	T-box 18	0.134	Zebrafish
bmp4	bone morphogenetic protein 4	0.124	Mouse
msxc	muscle segment homeobox C	0.119
fgf10a	fibroblast growth factor 10a	0.118	Mouse
gsc	goosecoid	0.117
neo1	neogenin 1	0.110
aldh1a2	aldehyde dehydrogenase 1 family, member A2	0.107	Mouse
prrx1a	paired related homeobox 1a	0.105	Mouse
hoxa9a	homeo box A9a	0.092	Mouse
hoxa10b	homeo box A10b	0.092	Mouse
robo3	roundabout homolog 3	0.085
fgf8a	fibroblast growth factor 8 a	0.081	Zebrafish Mouse
pax9	paired box gene 9	0.072
bmp2a	bone morphogenetic protein 2a	0.071
hoxd10a	homeo box D10a	0.066	Mouse
hoxd12a	homeo box D12a	0.065	Mouse
msxb	muscle segment homeobox B	0.063
mib	mind bomb	0.062
msxe	muscle segment homeobox E	0.062	Human Mouse
hoxd9a	homeo box D9a	0.053	Mouse
fgf3	fibroblast growth factor 3	0.051
cyp26b1	cytochrome P450, family 26, subfamily b, polypeptide 1	0.050
dlx3b	distal-less homeobox gene 3b	0.050
hoxa13a	homeo box A13a	0.047	Mouse
col2a1a	collagen type II, alpha-1a	0.047	Mouse
dusp6	dual specificity phosphatase 6	0.047
hoxc6a	homeo box C6a	0.045
pcdh8	protocadherin 8	0.041
dact2	dapper homolog 2, antagonist of beta-catenin (xenopus)	0.039
snai1a	snail homolog 1a (Drosophila)	0.039
dlx4b	distal-less homeobox gene 4b	0.038
tfap2a	transcription factor AP-2 alpha	0.038	Mouse
vcanb	versican b	0.038
tbx2b	T-box 2b	0.037	Zebrafish
tbx2a	T-box gene 2a	0.035	Zebrafish Mouse
wnt11	wingless-type MMTV integration site family, member 11	0.034
spry4	sprouty (Drosophila) homolog 4	0.032
lef1	lymphocyte enhancer binding factor 1	0.032	Mouse
notch1a	notch homolog 1a	0.031	Mouse
vcana	versican a	0.031
osr1	odd-skipped related 1 (Drosophila)	0.031	Mouse
prdm16	PR domain containing 16	0.030
hey1	hairy/enhancer-of-split related with YRPW motif 1	0.030
col1a1a	collagen, type I, alpha 1a	0.030
dact1	dapper homolog 1, antagonist of beta-catenin (xenopus)	0.029
twist3	twist3	0.029
dkk1b	dickkopf 1b	0.028	Mouse
barx2	BarH-like homeobox 2	0.028
meis3	myeloid ecotropic viral integration site 3	0.027
tbx16	T-box gene 16	0.027	Zebrafish
pea3	ETS-domain transcription factor pea3	0.026
eya1	eyes absent homolog 1	0.025
tcf7	transcription factor 7 (T-cell specific, HMG-box)	0.024
sox9b	SRY-box containing gene 9b	0.024
gli3	GLI-Kruppel family member GLI3	0.024
aldh1a3	aldehyde dehydrogenase 1 family, member A3	0.023
bmpr2a	bone morphogenetic protein receptor, type II a (serine/threonine kinase)	0.023
pitx3	paired-like homeodomain transcription factor 3	0.022
tbx5a	T-box 5a	0.022
sparc	secreted acidic cysteine rich glycoprotein	0.022
ihha	Indian hedgehog homolog a	0.021
and1	actinodin1	0.021
si:ch211-173o4.2	si:ch211-173o4.2	0.021
notch3	notch homolog 3	0.021
smad9	MAD homolog 9 (Drosophila)	0.021
runx2b	runt-related transcription factor 2b	0.020	Mouse
ascl1a	achaete-scute complex-like 1a (Drosophila)	0.020
fgf17	fibroblast growth factor 17	0.020	Zebrafish
crabp2b	cellular retinoic acid binding protein 2, b	0.020	Mouse
rxraa	retinoid X receptor, alpha a	0.020
hoxb1b	homeo box B1b	0.019
znf503	zinc finger protein 503	0.019
smo	smoothened homolog (Drosophila)	0.019
etv5b	ets variant 5b	0.019
eve1	even-skipped-like1	0.019
tbx15	T-box 15	0.019	Zebrafish
tcf12	transcription factor 12	0.018
prrx1b	paired related homeobox 1b	0.018	Mouse
nkx2.5	NK2 transcription factor related 5	0.018
dcc	deleted in colorectal carcinoma	0.018
pcsk5b	proprotein convertase subtilisin/kexin type 5b	0.018
sall1a	sal-like 1a (Drosophila)	0.018
fn1	fibronectin 1	0.018
fgfr2	fibroblast growth factor receptor 2	0.017	Mouse
lbx1a	ladybird homeobox 1a	0.017
zic3	zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila)	0.017
ahr2	aryl hydrocarbon receptor 2	0.017
pax2a	paired box gene 2a	0.016
bmp1a	bone morphogenetic protein 1a	0.016
gyltl1b	glycosyltransferase-like 1b	0.016
nr2f1a	nuclear receptor subfamily 2, group F, member 1a	0.015
slc12a2	solute carrier family 12 (potassium/chloride transporters), member 2	0.015
frem2a	Fras1 related extracellular matrix protein 2a	0.015
dlx1a	distal-less homeobox gene 1a	0.015
wnt9a	wingless-type MMTV integration site family, member 9A	0.015	Mouse
il17rd	interleukin 17 receptor D	0.014
nog2	noggin 2	0.014
sulf2l	sulfatase 2, like	0.014
myod1	myogenic differentiation 1	0.014
tmem2	transmembrane protein 2	0.014
foxg1a	forkhead box G1a	0.014
gli1	GLI-Kruppel family member 1	0.014
hoxc8a	homeo box C8a	0.013
cdh2	cadherin 2, neuronal	0.013
sall4	sal-like 4 (Drosophila)	0.013	Mouse
sema3h	semaphorin 3h	0.013
prkci	protein kinase C, iota	0.013
jag1b	jagged 1b	0.013
hmx4	H6 family homeobox 4	0.013
dacha	dachshund a	0.013
dhrs3a	dehydrogenase/reductase (SDR family) member 3a	0.013
foxn4	forkhead box N4	0.012
eng1a	engrailed 1a	0.012	Mouse
axin2	axin 2 (conductin, axil)	0.012
mib2	mind bomb 2	0.012
barx1	BarH-like homeobox 1	0.012
sp9	sp9 transcription factor	0.012
rarab	retinoic acid receptor, alpha b	0.012	Mouse
LOC100002342	carboxypeptidase A6-like	0.012
wnt2bb	wingless-type MMTV integration site family, member 2Bb	0.012
wnt3a	wingless-type MMTV integration site family, member 3A	0.012
mapk4	mitogen-activated protein kinase 4	0.012
ntla	no tail a	0.012	Zebrafish
frem1a	Fras1 related extracellular matrix 1a	0.011
zic2a	zic family member 2 (odd-paired homolog, Drosophila), a	0.011
tgfbi	transforming growth factor, beta-induced	0.011
flh	floating head	0.011
slit3	slit (Drosophila) homolog 3	0.011
sulf1	sulfatase 1	0.011
twist1a	twist1a	0.011
col7a1l	collagen type VII alpha 1-like	0.011
rag1	recombination activating gene 1	0.011
ets1a	v-ets erythroblastosis virus E26 oncogene homolog 1a	0.011
atp1a1	ATPase, Na+/K+ transporting, alpha 1 polypeptide	0.010
kcnj13	potassium inwardly-rectifying channel, subfamily J, member 13	0.010
gata3	GATA-binding protein 3	0.010
tfap2c	transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)	0.010