The network for 'signal transduction' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

signal transduction

The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

Name Description Probability Func Analog Organism
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
egl-18 Protein EGL-18 0.981
vab-3 Protein VAB-3 0.923
atn-1 Protein ATN-1 0.917
faah-1 Protein FAAH-1 0.845
plc-1 Protein PLC-1 0.767
cam-1 Protein CAM-1 0.761
pry-1 Protein PRY-1 0.752
K10D6.4 Protein K10D6.4 0.740
unc-9 Protein UNC-9 0.732
bar-1 Protein BAR-1 0.731
nhr-45 Protein NHR-45 0.731
sma-6 Protein SMA-6 0.715
par-5 Protein PAR-5 0.711
mig-2 Protein MIG-2 0.699
atg-2 Protein ATG-2 0.699
CELE_T05E11.3 Protein T05E11.3 0.693
pdfr-1 Protein PDFR-1 0.692
lag-1 Protein LAG-1 0.688
dre-1 Protein DRE-1 0.681
npp-7 Protein NPP-7 0.679
B0361.6 Protein B0361.6 0.677
unc-37 Protein UNC-37 0.661
pkg-1 Protein PKG-1 0.658
uig-1 Protein UIG-1 0.654
epi-1 Protein EPI-1 0.634
egl-30 Protein EGL-30 0.620
acs-4 Protein ACS-4 0.607
unc-62 Protein UNC-62 0.606
sas-4 Protein SAS-4 0.594
alx-1 Protein ALX-1 0.583
pqn-54 Protein PQN-54 0.580
abu-8 Protein ABU-8 0.574
lin-25 Protein LIN-25 0.572
gana-1 Protein GANA-1 0.568
hsp-16.2 Protein HSP-16.2 0.567
cki-2 Protein CKI-2 0.565
hmg-1.2 Protein HMG-1.2 0.558
skn-1 Protein SKN-1 0.547
akt-1 Protein AKT-1 0.546
egal-1 Protein EGAL-1 0.543
ceh-18 Protein CEH-18 0.543
sur-2 Protein SUR-2 0.541
pha-4 Protein PHA-4 0.540
vav-1 Protein VAV-1 0.535
drp-1 Protein DRP-1 0.525
Y47D3B.6 Protein Y47D3B.6 0.525
rhi-1 Protein RHI-1 0.522
trim-9 Protein TRIM-9 0.519
rab-5 Protein RAB-5 0.507
ceh-20 Protein CEH-20 0.503
abu-11 Protein ABU-11 0.498
csn-4 Protein CSN-4 0.495
hsp-16.1 Protein HSP-16.1 0.494
gsk-3 Protein GSK-3 0.488
unc-52 Protein UNC-52 0.482
abu-15 Protein ABU-15 0.481
dpy-22 Protein DPY-22 0.480
unc-32 Protein UNC-32 0.480
teg-1 Protein TEG-1 0.472
ztf-7 Protein ZTF-7 0.465
Y44E3A.6 Protein Y44E3A.6 0.464
osm-5 Protein OSM-5 0.462
daf-12 Protein DAF-12 0.462
CELE_F25B4.5 Protein F25B4.5 0.461
lev-1 Protein LEV-1 0.458
abts-3 Protein ABTS-3 0.457
lmn-1 Protein LMN-1 0.454
egl-8 Protein EGL-8 0.451
wrm-1 Protein WRM-1 0.449
F44E5.4 Protein F44E5.4 0.448
mpz-2 Protein MPZ-2 0.447
egl-13 Protein EGL-13 0.442
let-23 Protein LET-23 0.437
dnj-10 Protein DNJ-10 0.436
nipi-3 Protein NIPI-3 0.436
cye-1 Protein CYE-1 0.435
fln-2 Protein FLN-2 0.435
vang-1 Protein VANG-1 0.435
zyg-9 Protein ZYG-9 0.434
vab-8 Protein VAB-8 0.431
ztf-4 Protein ZTF-4 0.428
cey-1 Protein CEY-1 0.426
flp-22 Protein FLP-22 0.426
zyg-8 Protein ZYG-8 0.426
lin-11 Protein LIN-11 0.425
tam-1 Protein TAM-1 0.423
mbk-1 Protein MBK-1 0.417
arf-3 Protein ARF-3 0.415
par-3 Protein PAR-3 0.413
egg-6 Protein EGG-6 0.413
pxf-1 Protein PXF-1 0.410
hsp-16.41 Protein HSP-16.41 0.409
sur-6 Protein SUR-6 0.403
daf-4 Protein DAF-4 0.402
ubq-1 Protein UBQ-1 0.402
unc-86 Protein UNC-86 0.400
unc-79 Protein UNC-79 0.398
ida-1 Protein IDA-1 0.397
zyg-1 Protein ZYG-1 0.397
lin-5 Protein LIN-5 0.392
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Danio rerio
Name Description Probability Func Analog Organism
chd chordin 1.000
ntla no tail a 0.997
shha sonic hedgehog a 0.996
tbx1 T-box 1 0.996
notch1a notch homolog 1a 0.991
med12 mediator of RNA polymerase II transcription, subunit 12 homolog 0.986
bmp2b bone morphogenetic protein 2b 0.986
sox9b SRY-box containing gene 9b 0.986
crabp2a cellular retinoic acid binding protein 2, a 0.984
dusp6 dual specificity phosphatase 6 0.981
tbx16 T-box gene 16 0.978
dzip1 DAZ interacting protein 1 0.976
fn1 fibronectin 1 0.972
fgf3 fibroblast growth factor 3 0.970
gsc goosecoid 0.965
flt4 fms-related tyrosine kinase 4 0.961
alcamb activated leukocyte cell adhesion molecule b 0.960
pax8 paired box gene 8 0.957
hey1 hairy/enhancer-of-split related with YRPW motif 1 0.951
ndr2 nodal-related 2 0.950
cdh5 cadherin 5 0.947
otpa orthopedia homolog a 0.945
gdf6a growth differentiation factor 6a 0.944
tshb thyroid stimulating hormone, beta subunit 0.943
lef1 lymphocyte enhancer binding factor 1 0.943
fras1 Fraser syndrome 1 0.942
cyp26c1 cytochrome P450, family 26, subfamily C, polypeptide 1 0.940
spry4 sprouty (Drosophila) homolog 4 0.940
wnt8b wingless-type MMTV integration site family, member 8b 0.936
isl1 islet1 0.934
dharma dharma 0.930
sox9a SRY-box containing gene 9a 0.926
irf6 interferon regulatory factor 6 0.926
lhx1a LIM homeobox 1a 0.922
pcdh18b protocadherin 18b 0.922
otx1a orthodenticle homolog 1a 0.919
snai1b snail homolog 1b (Drosophila) 0.915
evx1 even-skipped homeobox 1 0.913
jun jun proto-oncogene 0.909
dact1 dapper homolog 1, antagonist of beta-catenin (xenopus) 0.907
mafba v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian) 0.900
fzd10 frizzled homolog 10 0.899
apoeb apolipoprotein Eb 0.895
pitx3 paired-like homeodomain transcription factor 3 0.892
rarab retinoic acid receptor, alpha b 0.886
sall1a sal-like 1a (Drosophila) 0.885
arl13b ADP-ribosylation factor-like 13b 0.875
notch3 notch homolog 3 0.874
cdh1 cadherin 1, epithelial 0.866
zeb1 zinc finger E-box binding homeobox 1 0.860
frem3 Fras1 related extracellular matrix 3 0.860
lmo4a LIM domain only 4a 0.859
gng3 guanine nucleotide binding protein (G protein), gamma 3 0.855
runx2b runt-related transcription factor 2b 0.854
adra2a adrenergic, alpha-2A-, receptor 0.850
vox ventral homeobox 0.849
fzd8a frizzled homolog 8a 0.846
sox19a SRY-box containing gene 19a 0.845
gli2a GLI-Kruppel family member GLI2a 0.844
lft1 lefty1 0.844
wnt2 wingless-type MMTV integration site family member 2 0.843
brd4 bromodomain containing 4 0.840
rasl11b RAS-like, family 11, member B 0.840
pkd2 polycystic kidney disease 2 0.839
cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.835
ptgs2a prostaglandin-endoperoxide synthase 2a 0.830
gro1 groucho 1 0.829
ephb4b eph receptor B4b 0.825
rag1 recombination activating gene 1 0.825
tbx6 T-box gene 6 0.824
nog3 noggin 3 0.819
mc2r melanocortin 2 receptor 0.818
myhz2 myosin, heavy polypeptide 2, fast muscle specific 0.812
ldb1a LIM-domain binding factor 1a 0.812
pdgfaa platelet-derived growth factor alpha a 0.812
tll1 tolloid-like 1 0.810
ptpra protein tyrosine phosphatase, receptor type, A 0.804
psen1 presenilin 1 0.803
her6 hairy-related 6 0.803
robo3 roundabout homolog 3 0.799
cluap1 clusterin associated protein 1 0.799
dact2 dapper homolog 2, antagonist of beta-catenin (xenopus) 0.797
bbc3 BCL2 binding component 3 0.797
gpc4 glypican 4 0.795
oep one-eyed pinhead 0.795
ift88 intraflagellar transport 88 homolog 0.793
wnt10b wingless-type MMTV integration site family, member 10b 0.792
tagln2 transgelin 2 0.787
sox2 SRY-box containing gene 2 0.787
foxa2 forkhead box A2 0.783
itga5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.782
per3 period homolog 3 (Drosophila) 0.780
lmx1b.1 LIM homeobox transcription factor 1, beta 1 0.779
tgfb3 transforming growth factor, beta 3 0.775
pard6gb par-6 partitioning defective 6 homolog gamma B (C. elegans) 0.773
met met proto-oncogene (hepatocyte growth factor receptor) 0.771
nrp2b neuropilin 2b 0.770
fzd7b frizzled homolog 7b 0.769
gro2 groucho 2 0.766
mecom MDS1 and EVI1 complex locus 0.763
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Homo sapiens
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
STE4 Ste4p 0.985
TOR1 Tor1p 0.964
STE20 Ste20p 0.949
CLA4 Cla4p 0.946
PBS2 Pbs2p 0.945
BCK1 Bck1p 0.944
GPA1 Gpa1p 0.914
HOG1 Hog1p 0.911
PPH21 Pph21p 0.908
SNF1 Snf1p 0.906
FUS3 Fus3p 0.897
SLT2 Slt2p 0.881
CKA1 Cka1p 0.872
GPA2 Gpa2p 0.868
STE5 Ste5p 0.847
TPK2 Tpk2p 0.845
SHO1 Sho1p 0.837
FAR1 Far1p 0.824
RHO1 Rho1p 0.815
BMH2 Bmh2p 0.808
VPS64 Vps64p 0.799
MKS1 Mks1p 0.788
CRZ1 Crz1p 0.782
FAR11 Far11p 0.755
MSN2 Msn2p 0.727
ERP4 Erp4p 0.715
RTG3 Rtg3p 0.714
TPK1 Tpk1p 0.696
IRE1 Ire1p 0.687
BEM2 Bem2p 0.685
STE12 Ste12p 0.684
STE2 Ste2p 0.684
VPS71 Vps71p 0.683
GLN3 Gln3p 0.674
ROM2 Rom2p 0.657
RPT3 Rpt3p 0.655
STE11 Ste11p 0.646
SSK2 Ssk2p 0.639
PDE2 Pde2p 0.637
YPT1 Ypt1p 0.634
CDC34 Cdc34p 0.633
TPS1 Tps1p 0.622
CMP2 Cmp2p 0.621
AKL1 Akl1p 0.604
KSP1 Ksp1p 0.598
STE50 Ste50p 0.588
RUD3 Rud3p 0.586
RRI1 Rri1p 0.580
SKP1 Skp1p 0.571
PTK2 Ptk2p 0.570
PRB1 Prb1p 0.569
KOG1 Kog1p 0.557
MKT1 Mkt1p 0.553
SLG1 Slg1p 0.547
ERP2 Erp2p 0.545
END3 End3p 0.540
FPK1 Fpk1p 0.536
GIS4 Gis4p 0.523
MKK1 Mkk1p 0.499
TFB1 Tfb1p 0.493
LHS1 Lhs1p 0.489
BEM1 Bem1p 0.489
RLM1 Rlm1p 0.477
SLA2 Sla2p 0.476
LAS17 Las17p 0.473
BEM3 Bem3p 0.470
CDC55 Cdc55p 0.460
CDC24 Cdc24p 0.457
NBP2 Nbp2p 0.456
PLC1 Plc1p 0.450
PTC1 Ptc1p 0.443
RIM101 Rim101p 0.441
KSS1 Kss1p 0.438
BMH1 Bmh1p 0.426
BBC1 Bbc1p 0.423
SCH9 Sch9p 0.421
MEC1 Mec1p 0.410
MSH3 Msh3p 0.410
IRA1 Ira1p 0.408
PFK26 Pfk26p 0.406
RDI1 Rdi1p 0.404
SKN7 Skn7p 0.399
PMT2 Pmt2p 0.393
STE18 Ste18p 0.391
PPH3 Pph3p 0.389
HSP60 Hsp60p 0.386
BEM4 Bem4p 0.382
SSK1 Ssk1p 0.381
REG1 Reg1p 0.378
RAS2 Ras2p 0.378
STE7 Ste7p 0.372
SEC7 Sec7p 0.368
AVO1 Avo1p 0.366
PIL1 Pil1p 0.361
PIK1 Pik1p 0.359
RPN4 Rpn4p 0.358
YPT10 Ypt10p 0.354
PAF1 Paf1p 0.345
PRK1 Prk1p 0.344
PKH2 Pkh2p 0.339