The network for 'acetylcholine secretion neurotransmission' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

acetylcholine secretion neurotransmission

The regulated release of acetylcholine by a cell. The acetylcholine acts as a neurotransmitter that acts in both the peripheral nervous system (PNS) and central nervous system (CNS).

Name Description Probability Func Analog Organism
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
F32B5.7 Protein F32B5.7 0.016
itr-1 Protein ITR-1 0.013
gpb-1 Protein GPB-1 0.013
gar-2 Protein GAR-2 0.012
egl-8 Protein EGL-8 0.012
pgal-1 Protein PGAL-1 0.011
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Danio rerio
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Chrnb4 cholinergic receptor, nicotinic, beta polypeptide 4 1.000
Chrna3 cholinergic receptor, nicotinic, alpha polypeptide 3 0.996
Drd2 dopamine receptor D2 0.923
Thrb thyroid hormone receptor beta 0.893
Kcnma1 potassium large conductance calcium-activated channel, subfamily M, alpha member 1 0.868
Ache acetylcholinesterase 0.855
Thra thyroid hormone receptor alpha 0.785
Chrna9 cholinergic receptor, nicotinic, alpha polypeptide 9 0.669
Ryr1 ryanodine receptor 1, skeletal muscle 0.500
Tbpl2 TATA box binding protein like 2 0.459
Rapsn receptor-associated protein of the synapse 0.414
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.375
Has1 hyaluronan synthase1 0.372
Bsn bassoon 0.358
Chrnb2 cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal) 0.340
Rac1 RAS-related C3 botulinum substrate 1 0.339
Duox2 dual oxidase 2 0.320
Cacng1 calcium channel, voltage-dependent, gamma subunit 1 0.319
Cacnb4 calcium channel, voltage-dependent, beta 4 subunit 0.317
En2 engrailed 2 0.310
Chrna10 cholinergic receptor, nicotinic, alpha polypeptide 10 0.303
Gabrb3 gamma-aminobutyric acid (GABA) A receptor, subunit beta 3 0.302
Myog myogenin 0.294
Chrng cholinergic receptor, nicotinic, gamma polypeptide 0.271
Mybph myosin binding protein H 0.261
Tshr thyroid stimulating hormone receptor 0.253
Cacnb2 calcium channel, voltage-dependent, beta 2 subunit 0.229
Hcn3 hyperpolarization-activated, cyclic nucleotide-gated K+ 3 0.225
Kcnj11 potassium inwardly rectifying channel, subfamily J, member 11 0.224
Rho rhodopsin 0.221
Aff2 AF4/FMR2 family, member 2 0.216
Wdr1 WD repeat domain 1 0.206
Cacna2d1 calcium channel, voltage-dependent, alpha2/delta subunit 1 0.205
Pax8 paired box gene 8 0.200
Gnaq guanine nucleotide binding protein, alpha q polypeptide 0.191
Kcnk4 potassium channel, subfamily K, member 4 0.173
Lpar5 lysophosphatidic acid receptor 5 0.172
Cdk5r1 cyclin-dependent kinase 5, regulatory subunit 1 (p35) 0.167
Cdc42 cell division cycle 42 homolog (S. cerevisiae) 0.167
Smyd1 SET and MYND domain containing 1 0.166
Htr5a 5-hydroxytryptamine (serotonin) receptor 5A 0.163
Gprin1 G protein-regulated inducer of neurite outgrowth 1 0.154
Tpo thyroid peroxidase 0.152
Chrna6 cholinergic receptor, nicotinic, alpha polypeptide 6 0.150
Homer1 homer homolog 1 (Drosophila) 0.144
Myf6 myogenic factor 6 0.143
Neurod1 neurogenic differentiation 1 0.139
Fitm1 fat storage-inducing transmembrane protein 1 0.138
Cacna1b calcium channel, voltage-dependent, N type, alpha 1B subunit 0.136
Cga glycoprotein hormones, alpha subunit 0.136
Dynlt1b dynein light chain Tctex-type 1D 0.131
Psap prosaposin 0.127
Thbs2 thrombospondin 2 0.126
Mas1 MAS1 oncogene 0.125
Slc17a8 solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8 0.123
Gzmm granzyme M (lymphocyte met-ase 1) 0.122
Adcy4 adenylate cyclase 4 0.116
Psapl1 prosaposin-like 1 0.114
Avil advillin 0.109
Dcx doublecortin 0.108
Musk muscle, skeletal, receptor tyrosine kinase 0.105
Kcnj3 potassium inwardly-rectifying channel, subfamily J, member 3 0.105
Art5 ADP-ribosyltransferase 5 0.102
Myod1 myogenic differentiation 1 0.102
Kcna2 potassium voltage-gated channel, shaker-related subfamily, member 2 0.102
Cbl Casitas B-lineage lymphoma 0.101
St8sia3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 0.101
Isl2 insulin related protein 2 (islet 2) 0.101
Grem1 gremlin 1 0.100
Vip vasoactive intestinal polypeptide 0.098
Tnnt3 troponin T3, skeletal, fast 0.093
Ankrd1 ankyrin repeat domain 1 (cardiac muscle) 0.090
Ryr2 ryanodine receptor 2, cardiac 0.090
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.089
Cav1 caveolin 1, caveolae protein 0.089
Myh8 myosin, heavy polypeptide 8, skeletal muscle, perinatal 0.089
Adarb2 adenosine deaminase, RNA-specific, B2 0.085
Prodh2 proline dehydrogenase (oxidase) 2 0.085
Prph2 peripherin 2 0.084
Gnb3 guanine nucleotide binding protein (G protein), beta 3 0.082
Itpr1 inositol 1,4,5-trisphosphate receptor 1 0.080
Htr1d 5-hydroxytryptamine (serotonin) receptor 1D 0.080
Scn8a sodium channel, voltage-gated, type VIII, alpha 0.079
Ebf3 early B-cell factor 3 0.079
Dcc deleted in colorectal carcinoma 0.078
Serpina10 serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 0.077
Kcnc3 potassium voltage gated channel, Shaw-related subfamily, member 3 0.077
Kif5a kinesin family member 5A 0.076
Aipl1 aryl hydrocarbon receptor-interacting protein-like 1 0.075
Alox12e arachidonate lipoxygenase, epidermal 0.075
Nell2 NEL-like 2 (chicken) 0.075
Neurog2 neurogenin 2 0.074
Pramel7 preferentially expressed antigen in melanoma like 7 0.073
Dnajb5 DnaJ (Hsp40) homolog, subfamily B, member 5 0.072
Lcn8 lipocalin 8 0.071
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.070
Clcn1 chloride channel 1 0.069
Pde6c phosphodiesterase 6C, cGMP specific, cone, alpha prime 0.069
Sfrp4 secreted frizzled-related protein 4 0.069
Sag retinal S-antigen 0.069
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Rattus norvegicus
Name Description Probability Func Analog Organism
Nfasc neurofascin 0.037
Kcnq3 potassium voltage-gated channel, KQT-like subfamily, member 3 0.036
Syt7 synaptotagmin VII 0.034
Hpcal4 hippocalcin-like 4 0.028
Adora1 adenosine A1 receptor 0.028
Strn striatin, calmodulin binding protein 0.024
Slc1a2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 0.024
Grin2b glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.022
Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 0.021
Begain brain-enriched guanylate kinase-associated 0.019
Fgfr2 fibroblast growth factor receptor 2 0.018
Itgam integrin, alpha M 0.017
Calcrl calcitonin receptor-like 0.017
Cx3cr1 chemokine (C-X3-C motif) receptor 1 0.016
Slc6a11 solute carrier family 6 (neurotransmitter transporter, GABA), member 11 0.016
Orm1 orosomucoid 1 0.015
Bcan brevican 0.014
Drd2 dopamine receptor D2 0.014
Adcyap1r1 adenylate cyclase activating polypeptide 1 receptor 1 0.014
Tacr1 tachykinin receptor 1 0.014
Hand1 heart and neural crest derivatives expressed 1 0.013
Unc5a unc-5 homolog A (C. elegans) 0.013
Ptafr platelet-activating factor receptor 0.013
Tnr tenascin R 0.012
Pfkfb2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 0.012
Gck glucokinase 0.012
Uhmk1 U2AF homology motif (UHM) kinase 1 0.012
B3gat1 beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P) 0.012
St8sia1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 0.011
Spink3 serine peptidase inhibitor, Kazal type 3 0.011
Grm6 glutamate receptor, metabotropic 6 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism