The network for 'microglial cell activation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

microglial cell activation

The change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.

Drosophila melanogaster
Name Description Probability Func Analog Organism
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
ATF3 activating transcription factor 3 0.657
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein 0.333
NLRC4 NLR family, CARD domain containing 4 0.246
FOS FBJ murine osteosarcoma viral oncogene homolog 0.152
APP amyloid beta (A4) precursor protein 0.135
LY96 lymphocyte antigen 96 0.100
MAPK8 mitogen-activated protein kinase 8 0.049
MYD88 myeloid differentiation primary response gene (88) 0.048
TICAM2 toll-like receptor adaptor molecule 2 0.045
JUNB jun B proto-oncogene 0.043
DUSP1 dual specificity phosphatase 1 0.028
DOCK7 dedicator of cytokinesis 7 0.027
JUND jun D proto-oncogene 0.025
MPO myeloperoxidase 0.025
BCL2L1 BCL2-like 1 0.024
CASP4 caspase 4, apoptosis-related cysteine peptidase 0.023
SNCAIP synuclein, alpha interacting protein 0.021
RIPK2 receptor-interacting serine-threonine kinase 2 0.020
HSPA1B heat shock 70kDa protein 1B 0.018
PYCARD PYD and CARD domain containing 0.017
ELANE elastase, neutrophil expressed 0.016
MAPT microtubule-associated protein tau 0.016
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1 0.014
TPPP tubulin polymerization promoting protein 0.014
IER2 immediate early response 2 0.012
LRRK2 leucine-rich repeat kinase 2 0.012
ATF2 activating transcription factor 2 0.011
TLR1 toll-like receptor 1 0.011
CTSG cathepsin G 0.010
APLP1 amyloid beta (A4) precursor-like protein 1 0.010
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Mus musculus
Name Description Probability Func Analog Organism
Fos FBJ osteosarcoma oncogene 0.982
Ccl2 chemokine (C-C motif) ligand 2 0.940
Ccr5 chemokine (C-C motif) receptor 5 0.882
Tlr2 toll-like receptor 2 0.631
Fcrla Fc receptor-like A 0.597
Dusp1 dual specificity phosphatase 1 0.566
Ccr2 chemokine (C-C motif) receptor 2 0.470
Zfp36 zinc finger protein 36 0.464
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.456
Il1b interleukin 1 beta 0.443
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.405
Prdm1 PR domain containing 1, with ZNF domain 0.400
Ccr1 chemokine (C-C motif) receptor 1 0.376
Egr1 early growth response 1 0.341
Xcr1 chemokine (C motif) receptor 1 0.336
Itk IL2-inducible T-cell kinase 0.300
Ccl3 chemokine (C-C motif) ligand 3 0.283
Jun Jun oncogene 0.256
Mmp9 matrix metallopeptidase 9 0.245
Atf3 activating transcription factor 3 0.241
Lyz2 lysozyme 2 0.232
Klrk1 killer cell lectin-like receptor subfamily K, member 1 0.225
Mb myoglobin 0.223
Prnp prion protein 0.222
Cd180 CD180 antigen 0.217
Klf6 Kruppel-like factor 6 0.217
Btg2 B-cell translocation gene 2, anti-proliferative 0.211
Mapk8 mitogen-activated protein kinase 8 0.208
Gbp5 guanylate binding protein 5 0.197
Fasl Fas ligand (TNF superfamily, member 6) 0.195
Selp selectin, platelet 0.189
Cd7 CD7 antigen 0.181
Cd14 CD14 antigen 0.179
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.175
Hr hairless 0.170
Klrd1 killer cell lectin-like receptor, subfamily D, member 1 0.151
Klra5 killer cell lectin-like receptor, subfamily A, member 5 0.144
Nr4a1 nuclear receptor subfamily 4, group A, member 1 0.142
Il18 interleukin 18 0.140
Gpr33 G protein-coupled receptor 33 0.131
Klrb1b killer cell lectin-like receptor subfamily B member 1B 0.125
Adora3 adenosine A3 receptor 0.123
Fut7 fucosyltransferase 7 0.110
Ccr6 chemokine (C-C motif) receptor 6 0.109
Uts2r urotensin 2 receptor 0.108
Tnfrsf4 tumor necrosis factor receptor superfamily, member 4 0.105
Cxcr3 chemokine (C-X-C motif) receptor 3 0.102
Ier2 immediate early response 2 0.101
Mapk1 mitogen-activated protein kinase 1 0.100
Ticam1 toll-like receptor adaptor molecule 1 0.100
Ly96 lymphocyte antigen 96 0.098
Fgd3 FYVE, RhoGEF and PH domain containing 3 0.097
Blk B lymphoid kinase 0.096
Oxt oxytocin 0.092
Rhob ras homolog gene family, member B 0.089
Ciita class II transactivator 0.089
Ppp1r15a protein phosphatase 1, regulatory (inhibitor) subunit 15A 0.086
Ccr4 chemokine (C-C motif) receptor 4 0.085
Mapk14 mitogen-activated protein kinase 14 0.083
C3ar1 complement component 3a receptor 1 0.083
Itgax integrin alpha X 0.082
Gzmb granzyme B 0.082
Pycard PYD and CARD domain containing 0.082
Klrg1 killer cell lectin-like receptor subfamily G, member 1 0.081
Mc5r melanocortin 5 receptor 0.079
Klra9 killer cell lectin-like receptor subfamily A, member 9 0.079
Il18rap interleukin 18 receptor accessory protein 0.077
Gzmk granzyme K 0.074
Cxcr2 chemokine (C-X-C motif) receptor 2 0.073
Fosb FBJ osteosarcoma oncogene B 0.073
P2rx7 purinergic receptor P2X, ligand-gated ion channel, 7 0.071
Il18r1 interleukin 18 receptor 1 0.071
S1pr4 sphingosine-1-phosphate receptor 4 0.070
Itgam integrin alpha M 0.068
Opn1sw opsin 1 (cone pigments), short-wave-sensitive (color blindness, tritan) 0.068
Gcet2 germinal center expressed transcript 2 0.068
Slc30a3 solute carrier family 30 (zinc transporter), member 3 0.067
Pik3cg phosphoinositide-3-kinase, catalytic, gamma polypeptide 0.067
Il12rb2 interleukin 12 receptor, beta 2 0.067
H2-M9 histocompatibility 2, M region locus 9 0.067
Il1r1 interleukin 1 receptor, type I 0.066
Drd2 dopamine receptor D2 0.065
Nos2 nitric oxide synthase 2, inducible 0.065
Cd44 CD44 antigen 0.064
Olfr140 olfactory receptor 140 0.064
Csf1 colony stimulating factor 1 (macrophage) 0.064
Il10 interleukin 10 0.063
Itgal integrin alpha L 0.063
Mag myelin-associated glycoprotein 0.063
Ccr3 chemokine (C-C motif) receptor 3 0.061
Cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.060
Cd6 CD6 antigen 0.059
Gadd45b growth arrest and DNA-damage-inducible 45 beta 0.059
LOC100502924 hypothetical protein LOC100502924 0.058
Art2a-ps ADP-ribosyltransferase 2a, pseudogene 0.057
Tff1 trefoil factor 1 0.057
Cd4 CD4 antigen 0.057
Htr3a 5-hydroxytryptamine (serotonin) receptor 3A 0.056
Shbg sex hormone binding globulin 0.055
Myd88 myeloid differentiation primary response gene 88 0.055
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Rattus norvegicus
Name Description Probability Func Analog Organism
Ptprc protein tyrosine phosphatase, receptor type, C 0.310
Tlr4 toll-like receptor 4 0.282
Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.191
Adam17 ADAM metallopeptidase domain 17 0.172
Casp1 caspase 1 0.159
Igsf6 immunoglobulin superfamily, member 6 0.086
Pdcl phosducin-like 0.079
Cd38 CD38 molecule 0.069
Arl11 ADP-ribosylation factor-like 11 0.059
Cd86 CD86 molecule 0.059
Mmp12 matrix metallopeptidase 12 0.058
Cdk2 cyclin dependent kinase 2 0.049
Pla2g4a phospholipase A2, group IVA (cytosolic, calcium-dependent) 0.049
Nat1 N-acetyltransferase 1 0.048
Gucy2d guanylate cyclase 2d 0.046
St8sia4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 0.044
Calcrl calcitonin receptor-like 0.041
Ccr5 chemokine (C-C motif) receptor 5 0.040
Clec4a3 C-type lectin domain family 4, member a3 0.039
Casp8 caspase 8 0.037
Casp12 caspase 12 0.037
Drd3 dopamine receptor D3 0.037
RT1-N3 RT1 class Ib, locus N3 0.034
Klrc2 killer cell lectin-like receptor subfamily C, member 2 0.032
Tas2r126 taste receptor, type 2, member 126 0.030
Itpr2 inositol 1,4,5-triphosphate receptor, type 2 0.028
Olr1496 olfactory receptor 1496 0.028
Casp2 caspase 2 0.027
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.027
Ets1 v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) 0.022
Ocln occludin 0.022
Cybb cytochrome b-245, beta polypeptide 0.021
Tas2r118 taste receptor, type 2, member 118 0.020
Ifi204 interferon activated gene 204 0.019
Junb jun B proto-oncogene 0.018
Dock8 dedicator of cytokinesis 8 0.017
Nmi N-myc (and STAT) interactor 0.017
Tgfbr2 transforming growth factor, beta receptor II 0.017
Casp3 caspase 3 0.017
Klf6 Kruppel-like factor 6 0.016
Trpm8 transient receptor potential cation channel, subfamily M, member 8 0.016
Vom1r102 vomeronasal 1 receptor 102 0.016
Cd44 Cd44 molecule 0.016
Cd48 Cd48 molecule 0.016
Slco2b1 solute carrier organic anion transporter family, member 2b1 0.016
Top2a topoisomerase (DNA) II alpha 0.015
Ctsc cathepsin C 0.015
Elk3 ELK3, ETS-domain protein 0.015
Adam2 ADAM metallopeptidase domain 2 0.015
Ccl22 chemokine (C-C motif) ligand 22 0.014
Plod2 procollagen lysine, 2-oxoglutarate 5-dioxygenase 2 0.014
Myl7 myosin, light chain 7, regulatory 0.014
Vegp1 von Ebners gland protein 1 0.014
Ppp1r15a protein phosphatase 1, regulatory (inhibitor) subunit 15A 0.013
Fcgr3a Fc fragment of IgG, low affinity IIIa, receptor 0.013
Plau plasminogen activator, urokinase 0.013
Serpinb3 serine protease inhibitor B3 0.013
P2ry6 pyrimidinergic receptor P2Y, G-protein coupled, 6 0.013
Kcna2 potassium voltage-gated channel, shaker-related subfamily, member 2 0.013
Msn moesin 0.013
Il2rg interleukin 2 receptor, gamma 0.012
Glipr1 GLI pathogenesis-related 1 0.012
Parp14 poly (ADP-ribose) polymerase family, member 14 0.012
Rasgrp4 RAS guanyl releasing protein 4 0.012
Fam38b family with sequence similarity 38, member B 0.012
Ptger2 prostaglandin E receptor 2 (subtype EP2) 0.012
Clecsf6 C-type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 6 0.012
Smad1 SMAD family member 1 0.012
Hhipl1 HHIP-like 1 0.012
Prkcg protein kinase C, gamma 0.012
Klhl6 kelch-like 6 (Drosophila) 0.012
LOC685834 similar to zinc finger protein 740 0.012
Apaf1 apoptotic peptidase activating factor 1 0.012
Edn1 endothelin 1 0.011
Mapk8 mitogen-activated protein kinase 8 0.011
Tlr7 toll-like receptor 7 0.011
RT1-A3 RT1 class I, locus A3 0.011
Cd8a CD8a molecule 0.011
Skap2 src kinase associated phosphoprotein 2 0.011
Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 0.011
Mlana melan-A 0.011
LOC687856 similar to Myeloid cell surface antigen CD33 precursor (Siglec-3) 0.011
Fas Fas (TNF receptor superfamily, member 6) 0.011
Cdk11b cyclin-dependent kinase 11B 0.011
Olr1082 olfactory receptor 1082 0.011
Akr1c14 aldo-keto reductase family 1, member C14 0.011
Cyp27b1 cytochrome P450, family 27, subfamily b, polypeptide 1 0.011
Map3k8 mitogen-activated protein kinase kinase kinase 8 0.010
Cd247 Cd247 molecule 0.010
Htr1f 5-hydroxytryptamine (serotonin) receptor 1F 0.010
Svs1 seminal vesicle secretory protein 1 0.010
Esr1 estrogen receptor 1 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism