The network for 'trna aminoacylation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

trna aminoacylation

The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules.

Name Description Probability Func Analog Organism
Aats-tyr Tyrosyl-tRNA synthetase 0.977
Srp68 CG5064 gene product from transcript CG5064-RA 0.641
Aats-thr Threonyl-tRNA synthetase 0.540
Aats-leu Leucyl-tRNA synthetase 0.528
CG1703 CG1703 gene product from transcript CG1703-RA 0.409
CG17259 CG17259 gene product from transcript CG17259-RA 0.372
Aats-ile Isoleucyl-tRNA synthetase 0.281
Aats-trp Tryptophanyl-tRNA synthetase 0.269
Srp54k Signal recognition particle protein 54k 0.261
Hsc70-5 Heat shock protein cognate 5 0.259
Aats-asp Aspartyl-tRNA synthetase 0.258
Drp1 Dynamin related protein 1 0.166
Aats-asn Asparaginyl-tRNA synthetase 0.143
Aats-glupro Glutamyl-prolyl-tRNA synthetase 0.134
beta'Cop beta'-coatomer protein 0.116
CG33123 CG33123 gene product from transcript CG33123-RA 0.109
Aats-ala Alanyl-tRNA synthetase 0.082
Gcn2 CG1609 gene product from transcript CG1609-RA 0.078
CG11771 CG11771 gene product from transcript CG11771-RA 0.058
l(2)k01209 lethal (2) k01209 0.056
CG8545 CG8545 gene product from transcript CG8545-RA 0.047
Aats-met Methionyl-tRNA synthetase 0.033
Aats-val Valyl-tRNA synthetase 0.032
JhI-21 CG12317 gene product from transcript CG12317-RB 0.032
T-cp1 Tcp1-like 0.031
Aats-arg Arginyl-tRNA synthetase 0.031
l(2)03709 lethal (2) 03709 0.030
SrpRbeta Signal recognition particle receptor beta 0.027
Aats-pro Prolyl-tRNA synthetase 0.027
CG8417 CG8417 gene product from transcript CG8417-RA 0.027
Hmgs HMG Coenzyme A synthase 0.025
l(2)37Cc lethal (2) 37Cc 0.021
CG7456 CG7456 gene product from transcript CG7456-RA 0.021
RFeSP Rieske iron-sulfur protein 0.019
CG4610 CG4610 gene product from transcript CG4610-RA 0.019
CG11418 CG11418 gene product from transcript CG11418-RA 0.019
eIF2B-epsilon CG3806 gene product from transcript CG3806-RB 0.018
CG7277 CG7277 gene product from transcript CG7277-RA 0.017
CG4679 CG4679 gene product from transcript CG4679-RA 0.017
CG5205 CG5205 gene product from transcript CG5205-RA 0.014
CG7556 CG7556 gene product from transcript CG7556-RA 0.014
eIF4G eukaryotic translation initiation factor 4G 0.014
Xbp1 X box binding protein-1 0.013
CG3267 CG3267 gene product from transcript CG3267-RA 0.013
CG7791 CG7791 gene product from transcript CG7791-RA 0.012
CG42630 CG42630 gene product from transcript CG42630-RA 0.012
Aats-cys Cysteinyl-tRNA synthetase 0.010
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
IARS isoleucyl-tRNA synthetase 1.000
EPRS glutamyl-prolyl-tRNA synthetase 1.000
GARS glycyl-tRNA synthetase 1.000
ASNS asparagine synthetase (glutamine-hydrolyzing) 0.991
MARS methionyl-tRNA synthetase 0.989
AARS alanyl-tRNA synthetase 0.982
AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 0.975
NARS asparaginyl-tRNA synthetase 0.932
YARS tyrosyl-tRNA synthetase 0.931
KARS lysyl-tRNA synthetase 0.842
RARS arginyl-tRNA synthetase 0.788
CARS cysteinyl-tRNA synthetase 0.696
LARS leucyl-tRNA synthetase 0.685
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial) 0.476
SARS seryl-tRNA synthetase 0.464
BCS1L BCS1-like (S. cerevisiae) 0.193
TARS threonyl-tRNA synthetase 0.162
XPOT exportin, tRNA (nuclear export receptor for tRNAs) 0.137
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 0.129
ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase 0.119
AIMP1 aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 0.088
GOT1 glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1) 0.078
OTUD5 OTU domain containing 5 0.053
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase 0.052
XPO5 exportin 5 0.044
DARS aspartyl-tRNA synthetase 0.041
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma 0.039
LRPPRC leucine-rich PPR-motif containing 0.036
BOP1 block of proliferation 1 0.035
WDR46 WD repeat domain 46 0.031
MRPS27 mitochondrial ribosomal protein S27 0.027
MINA MYC induced nuclear antigen 0.026
EIF3CL eukaryotic translation initiation factor 3, subunit C-like 0.023
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase 0.023
EIF2B3 eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa 0.023
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.023
BMS1 BMS1 homolog, ribosome assembly protein (yeast) 0.022
LARS2 leucyl-tRNA synthetase 2, mitochondrial 0.021
PUS1 pseudouridylate synthase 1 0.021
PSAT1 phosphoserine aminotransferase 1 0.020
OGFOD1 2-oxoglutarate and iron-dependent oxygenase domain containing 1 0.020
ECSIT ECSIT homolog (Drosophila) 0.019
CNO cappuccino homolog (mouse) 0.019
KRT8 keratin 8 0.019
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 0.018
EEF1E1 eukaryotic translation elongation factor 1 epsilon 1 0.018
METTL13 methyltransferase like 13 0.017
ARMC6 armadillo repeat containing 6 0.016
LIAS lipoic acid synthetase 0.015
FKBP4 FK506 binding protein 4, 59kDa 0.014
DAP3 death associated protein 3 0.014
TSEN2 tRNA splicing endonuclease 2 homolog (S. cerevisiae) 0.014
FARSB phenylalanyl-tRNA synthetase, beta subunit 0.013
EIF2B2 eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa 0.013
UBA5 ubiquitin-like modifier activating enzyme 5 0.013
SKIV2L2 superkiller viralicidic activity 2-like 2 (S. cerevisiae) 0.013
GEMIN5 gem (nuclear organelle) associated protein 5 0.012
VARS valyl-tRNA synthetase 0.012
THG1L tRNA-histidine guanylyltransferase 1-like (S. cerevisiae) 0.012
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) 0.012
METTL17 methyltransferase like 17 0.012
C12orf44 chromosome 12 open reading frame 44 0.012
POLR1A polymerase (RNA) I polypeptide A, 194kDa 0.011
RTN4IP1 reticulon 4 interacting protein 1 0.011
FUBP1 far upstream element (FUSE) binding protein 1 0.011
MRRF mitochondrial ribosome recycling factor 0.010
MRPS9 mitochondrial ribosomal protein S9 0.010
NAT10 N-acetyltransferase 10 (GCN5-related) 0.010
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1 0.010
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase 0.010
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Mus musculus
Name Description Probability Func Analog Organism
Gars glycyl-tRNA synthetase 0.993
Nars asparaginyl-tRNA synthetase 0.847
Tars threonyl-tRNA synthetase 0.726
Lars leucyl-tRNA synthetase 0.634
Eprs glutamyl-prolyl-tRNA synthetase 0.438
Rars arginyl-tRNA synthetase 0.379
Yars tyrosyl-tRNA synthetase 0.316
Farsb phenylalanyl-tRNA synthetase, beta subunit 0.259
Iars isoleucine-tRNA synthetase 0.256
Mars methionine-tRNA synthetase 0.151
Lrpprc leucine-rich PPR-motif containing 0.151
Eif3c eukaryotic translation initiation factor 3, subunit C 0.087
Aars alanyl-tRNA synthetase 0.073
Lonp1 lon peptidase 1, mitochondrial 0.068
Hspa9 heat shock protein 9 0.066
Ddx1 DEAD (Asp-Glu-Ala-Asp) box polypeptide 1 0.061
Asns asparagine synthetase 0.057
Immt inner membrane protein, mitochondrial 0.052
Xpot exportin, tRNA (nuclear export receptor for tRNAs) 0.052
Adsl adenylosuccinate lyase 0.046
Fam98a family with sequence similarity 98, member A 0.039
Fastkd2 FAST kinase domains 2 0.035
Dus1l dihydrouridine synthase 1-like (S. cerevisiae) 0.033
Aifm1 apoptosis-inducing factor, mitochondrion-associated 1 0.029
1110002N22Rik RIKEN cDNA 1110002N22 gene 0.027
Rpn1 ribophorin I 0.027
Eif2b4 eukaryotic translation initiation factor 2B, subunit 4 delta 0.025
Abce1 ATP-binding cassette, sub-family E (OABP), member 1 0.023
Rrp12 ribosomal RNA processing 12 homolog (S. cerevisiae) 0.023
Mettl5 methyltransferase like 5 0.022
Orc5 origin recognition complex, subunit 5 0.022
Psmd12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 0.021
Ppp1r7 protein phosphatase 1, regulatory (inhibitor) subunit 7 0.020
Cars cysteinyl-tRNA synthetase 0.019
Arl6ip4 ADP-ribosylation factor-like 6 interacting protein 4 0.019
Mtif2 mitochondrial translational initiation factor 2 0.019
Polr2b polymerase (RNA) II (DNA directed) polypeptide B 0.017
Tcp1 t-complex protein 1 0.017
Xrcc5 X-ray repair complementing defective repair in Chinese hamster cells 5 0.016
Ndufs1 NADH dehydrogenase (ubiquinone) Fe-S protein 1 0.015
Bccip BRCA2 and CDKN1A interacting protein 0.015
Ndufaf1 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 1 0.015
Mrpl37 mitochondrial ribosomal protein L37 0.014
Srp68 signal recognition particle 68 0.014
Wdr36 WD repeat domain 36 0.014
Mthfd2 methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase 0.014
Psmc5 protease (prosome, macropain) 26S subunit, ATPase 5 0.013
Rai12 retinoic acid induced 12 0.013
Bms1 BMS1 homolog, ribosome assembly protein (yeast) 0.013
Rabggtb RAB geranylgeranyl transferase, b subunit 0.013
Sars seryl-aminoacyl-tRNA synthetase 0.013
Dnajb11 DnaJ (Hsp40) homolog, subfamily B, member 11 0.013
Lap3 leucine aminopeptidase 3 0.013
Atf4 activating transcription factor 4 0.012
Spcs3 signal peptidase complex subunit 3 homolog (S. cerevisiae) 0.012
Eif2b3 eukaryotic translation initiation factor 2B, subunit 3 0.011
Cse1l chromosome segregation 1-like (S. cerevisiae) 0.011
Las1l LAS1-like (S. cerevisiae) 0.011
Xrcc6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.011
Lias lipoic acid synthetase 0.011
Ptcd3 pentatricopeptide repeat domain 3 0.011
Gfm1 G elongation factor, mitochondrial 1 0.011
Ccnh cyclin H 0.011
Tbrg4 transforming growth factor beta regulated gene 4 0.011
Wbscr22 Williams Beuren syndrome chromosome region 22 0.011
Cct5 chaperonin containing Tcp1, subunit 5 (epsilon) 0.010
Cdc123 cell division cycle 123 homolog (S. cerevisiae) 0.010
H2-Ke2 H2-K region expressed gene 2 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism
Yars tyrosyl-tRNA synthetase 0.929
Mars methionine-tRNA synthetase 0.727
Tars threonyl-tRNA synthetase 0.661
Vcp valosin-containing protein 0.598
Eif3c eukaryotic translation initiation factor 3, subunit C 0.483
Eif3b eukaryotic translation initiation factor 3, subunit B 0.406
Cars cysteinyl-tRNA synthetase 0.403
Aars alanyl-tRNA synthetase 0.379
Gars glycyl-tRNA synthetase 0.344
Eif3d eukaryotic translation initiation factor 3, subunit D 0.270
Sars seryl-tRNA synthetase 0.245
Cpsf3 cleavage and polyadenylation specificity factor 3 0.135
Nmt1 N-myristoyltransferase 1 0.101
Ubxn4 UBX domain protein 4 0.089
Eif2d eukaryotic translation initiation factor 2D 0.069
Tcp1 t-complex 1 0.068
Psmd2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.056
Psmc3 proteasome (prosome, macropain) 26S subunit, ATPase 3 0.036
Lars leucyl-tRNA synthetase 0.031
Farsb phenylalanyl-tRNA synthetase, beta subunit 0.030
Aatf apoptosis antagonizing transcription factor 0.029
LOC100362155 cysteine and histidine rich 1 0.028
Mrps18b mitochondrial ribosomal protein S18B 0.028
Abce1 ATP-binding cassette, subfamily E (OABP), member 1 0.025
Kars lysyl-tRNA synthetase 0.022
LOC362855 P55 0.022
Psmc1 proteasome (prosome, macropain) 26S subunit, ATPase, 1 0.022
Abcf1 ATP-binding cassette, subfamily F (GCN20), member 1 0.020
Nsfl1c NSFL1 (p97) cofactor (p47) 0.020
Iars isoleucyl-tRNA synthetase 0.019
LOC100360406 rCG34104-like 0.018
Cct3 chaperonin containing Tcp1, subunit 3 (gamma) 0.017
Ddx1 DEAD (Asp-Glu-Ala-Asp) box polypeptide 1 0.015
Asns asparagine synthetase 0.015
Rpl28 ribosomal protein L28 0.015
Utp3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae) 0.015
Taldo1 transaldolase 1 0.014
Faf1 Fas (TNFRSF6) associated factor 1 0.013
Trap1 TNF receptor-associated protein 1 0.013
Tmem69 transmembrane protein 69 0.013
Strap serine/threonine kinase receptor associated protein 0.012
Wars tryptophanyl-tRNA synthetase 0.012
Cct7 chaperonin containing Tcp1, subunit 7 (eta) 0.012
Psmd12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 0.011
Dusp19 dual specificity phosphatase 19 0.011
Eprs glutamyl-prolyl-tRNA synthetase 0.010
Pno1 partner of NOB1 homolog (S. cerevisiae) 0.010
Cirh1a cirrhosis, autosomal recessive 1A (cirhin) 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
GUS1 Gus1p 0.999
VAS1 Vas1p 0.965
CDC60 Cdc60p 0.961
ILS1 Ils1p 0.960
SES1 Ses1p 0.951
DYS1 Dys1p 0.949
SLM5 Slm5p 0.940
THS1 Ths1p 0.938
FRS2 Frs2p 0.915
DED81 Ded81p 0.882
MSE1 Mse1p 0.858
YHR020W hypothetical protein 0.843
KRS1 Krs1p 0.811
GRS1 Grs1p 0.803
MES1 Mes1p 0.730
TYS1 Tys1p 0.669
HTS1 Hts1p 0.654
IFM1 Ifm1p 0.617
MSD1 Msd1p 0.582
ASN2 Asn2p 0.512
ALA1 Ala1p 0.504
MSF1 Msf1p 0.501
GLN4 Gln4p 0.417
MRF1 Mrf1p 0.336
MSY1 Msy1p 0.300
KAP104 Kap104p 0.294
ISM1 Ism1p 0.270
PET112 Pet112p 0.244
YNL247W hypothetical protein 0.240
YDR341C hypothetical protein 0.234
GUA1 Gua1p 0.225
AIM10 Aim10p 0.223
RRF1 Rrf1p 0.216
MST1 Mst1p 0.203
FRS1 Frs1p 0.180
SUP35 Sup35p 0.164
GYL1 Gyl1p 0.163
TCM62 Tcm62p 0.138
CYM1 Cym1p 0.137
ISA2 Isa2p 0.133
IMD2 Imd2p 0.131
IBA57 Iba57p 0.127
ART10 Art10p 0.126
COQ1 Coq1p 0.122
DPS1 Dps1p 0.121
YFH7 Yfh7p 0.117
GCN20 Gcn20p 0.105
ADE6 Ade6p 0.101
GUF1 Guf1p 0.095
KEL3 Kel3p 0.093
DBP5 Dbp5p 0.086
NAM2 Nam2p 0.083
SUB2 Sub2p 0.077
OLA1 Ola1p 0.073
PRO2 Pro2p 0.072
AIM32 Aim32p 0.070
CTM1 Ctm1p 0.067
FMP30 Fmp30p 0.061
AGC1 Agc1p 0.051
LYS21 Lys21p 0.050
YLR264C-A hypothetical protein 0.050
URA4 Ura4p 0.050
CYT2 Cyt2p 0.049
RPS20 Rps20p 0.048
DIA4 Dia4p 0.048
MDM34 Mdm34p 0.048
SRD1 Srd1p 0.047
MSR1 Msr1p 0.047
YNR040W hypothetical protein 0.046
MRP20 Mrp20p 0.046
YOL038C-A hypothetical protein 0.044
MEF2 Mef2p 0.044
ARP10 Arp10p 0.043
MDN1 Mdn1p 0.040
YLR162W hypothetical protein 0.040
LEU2 Leu2p 0.039
PET494 Pet494p 0.037
YRB1 Yrb1p 0.037
MAP2 Map2p 0.036
GCN1 Gcn1p 0.036
MER1 Mer1p 0.035
CUP1-1 Cup1-1p 0.034
AAP1 Aap1p 0.032
ATP6 Atp6p 0.032
DPH5 Dph5p 0.032
ILV3 Ilv3p 0.032
ATP25 Atp25p 0.032
OPT2 Opt2p 0.032
YAR068W hypothetical protein 0.031
AEP3 Aep3p 0.031
YPR157W hypothetical protein 0.030
ASN1 Asn1p 0.030
SHM1 Shm1p 0.030
AIM33 Aim33p 0.030
ICP55 Icp55p 0.029
PRS2 Prs2p 0.029
ABP140 Abp140p 0.028
ZPS1 Zps1p 0.028
CPD1 Cpd1p 0.028
URA3 Ura3p 0.028