The network for 'cellular protein catabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cellular protein catabolic process

The chemical reactions and pathways resulting in the breakdown of a protein by individual cells.

Name Description Probability Func Analog Organism
tefu telomere fusion 0.928
Ras85D Ras oncogene at 85D 0.877
Rpt4 CG3455 gene product from transcript CG3455-RA 0.853
CycB Cyclin B 0.816
Prosbeta3 Proteasome beta3 subunit 0.784
Prosbeta2 Proteasome beta2 subunit 0.779
Pros29 Proteasome 29kD subunit 0.737
Rpt3 CG16916 gene product from transcript CG16916-RA 0.722
CG13349 CG13349 gene product from transcript CG13349-RA 0.701
dco discs overgrown 0.695
Pros26.4 Proteasome 26S subunit subunit 4 ATPase 0.668
Vap-33-1 CG5014 gene product from transcript CG5014-RB 0.650
UbcD2 Ubiquitin conjugating enzyme 2 0.637
Rpt1 CG1341 gene product from transcript CG1341-RA 0.602
Mov34 CG3416 gene product from transcript CG3416-RA 0.573
p53 CG33336 gene product from transcript CG33336-RB 0.519
Rpn9 CG10230 gene product from transcript CG10230-RB 0.502
Rpn11 CG18174 gene product from transcript CG18174-RA 0.490
Prosalpha7 Proteasome alpha7 subunit 0.482
skpA CG16983 gene product from transcript CG16983-RD 0.469
Ube3a Ubiquitin protein ligase E3A 0.442
Prosbeta5 Proteasome beta5 subunit 0.439
nej nejire 0.434
gwl greatwall 0.424
Rpn3 Regulatory particle non-ATPase 3 0.413
Akt1 CG4006 gene product from transcript CG4006-RA 0.405
CycD Cyclin D 0.387
CycE Cyclin E 0.386
CG12321 CG12321 gene product from transcript CG12321-RA 0.382
ncd non-claret disjunctional 0.372
eff effete 0.364
Sara Smad anchor for receptor activation 0.363
smo smoothened 0.358
Prosbeta1 Proteasome beta1 subunit 0.348
fzy fizzy 0.339
ago archipelago 0.331
Tak1 TGF-beta activated kinase 1 0.325
jub Ajuba LIM protein 0.308
Pros28.1 Proteasome 28kD subunit 1 0.307
Pomp CG9324 gene product from transcript CG9324-RA 0.306
Chmp1 CG4108 gene product from transcript CG4108-RA 0.306
CG2046 CG2046 gene product from transcript CG2046-RA 0.304
Cul-5 Cullin-5 0.297
CG11347 CG11347 gene product from transcript CG11347-RE 0.289
CG32581 CG32581 gene product from transcript CG32581-RB 0.284
Tbp-1 Tat-binding protein-1 0.283
TER94 CG2331 gene product from transcript CG2331-RA 0.279
ben bendless 0.278
barr barren 0.259
EcR Ecdysone receptor 0.255
CG5555 CG5555 gene product from transcript CG5555-RA 0.251
Prosalpha5 Proteasome alpha5 subunit 0.242
Rad23 CG1836 gene product from transcript CG1836-RB 0.237
Uch-L3 Ubiquitin C-terminal hydrolase 0.231
Prosbeta7 Proteasome beta7 subunit 0.227
Pros35 Proteasome 35kD subunit 0.227
BRWD3 CG31132 gene product from transcript CG31132-RA 0.226
gammaTub37C gamma-Tubulin at 37C 0.223
step steppke 0.214
Rpn1 CG7762 gene product from transcript CG7762-RA 0.212
Iswi Imitation SWI 0.211
Fcp1 CG12252 gene product from transcript CG12252-RA 0.207
Incenp Inner centromere protein 0.203
gish gilgamesh 0.202
CG9135 CG9135 gene product from transcript CG9135-RB 0.201
stan starry night 0.201
aPKC atypical protein kinase C 0.197
lsn larsen 0.195
rl rolled 0.193
CG9986 CG9986 gene product from transcript CG9986-RA 0.192
Rpn2 CG11888 gene product from transcript CG11888-RA 0.191
CG12162 CG12162 gene product from transcript CG12162-RA 0.185
Rpn5 CG1100 gene product from transcript CG1100-RA 0.185
wts warts 0.184
CSN5 COP9 complex homolog subunit 5 0.183
krz kurtz 0.180
fz2 frizzled 2 0.179
RagA CG11968 gene product from transcript CG11968-RA 0.176
swa swallow 0.169
egh egghead 0.167
RYBP Ring and YY1 Binding Protein 0.167
lqf liquid facets 0.163
bam bag of marbles 0.162
RhoGEF2 CG9635 gene product from transcript CG9635-RF 0.162
cal1 chromosome alignment defect 1 0.160
Pp1-87B Protein phosphatase 1 at 87B 0.160
ctp cut up 0.160
lin19 lin-19-like 0.157
Vps28 Vacuolar protein sorting 28 0.157
slmb supernumerary limbs 0.155
CG8979 CG8979 gene product from transcript CG8979-RC 0.154
dos daughter of sevenless 0.154
Smox Smad on X 0.153
bsk basket 0.152
Egfr Epidermal growth factor receptor 0.151
CG4603 CG4603 gene product from transcript CG4603-RA 0.148
Pros25 Proteasome 25kD subunit 0.144
Cul-2 Cullin-2 0.144
CG9772 CG9772 gene product from transcript CG9772-RB 0.142
Dhod Dihydroorotate dehydrogenase 0.141
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
rpn-7 Protein RPN-7 0.854
rpt-3 Protein RPT-3 0.743
rpt-2 Protein RPT-2 0.738
rpn-3 Protein RPN-3 0.676
rpn-12 Protein RPN-12 0.645
pas-4 Protein PAS-4 0.620
pas-1 Protein PAS-1 0.597
imb-2 Protein IMB-2 0.594
pas-2 Protein PAS-2 0.498
daf-21 Protein DAF-21 0.483
tba-2 Protein TBA-2 0.471
par-5 Protein PAR-5 0.449
cul-1 Protein CUL-1 0.446
pbs-3 Protein PBS-3 0.435
pbs-5 Protein PBS-5 0.428
rpn-6.1 Protein RPN-6.1 0.342
rpn-2 Protein RPN-2 0.327
rpn-1 Protein RPN-1 0.315
atx-3 Protein ATX-3 0.298
ztf-7 Protein ZTF-7 0.286
pbs-2 Protein PBS-2 0.280
rpn-10 Protein RPN-10 0.248
hgrs-1 Protein HGRS-1 0.241
pbs-6 Protein PBS-6 0.241
pbs-1 Protein PBS-1 0.237
T20B12.7 Protein T20B12.7 0.230
rnr-1 Protein RNR-1 0.226
stam-1 Protein STAM-1 0.221
mel-26 Protein MEL-26 0.218
T22F3.2 Protein T22F3.2 0.212
E04D5.1 Protein E04D5.1 0.211
F46F11.6 Protein F46F11.6 0.207
taf-5 Protein TAF-5 0.183
cdc-48.2 Protein CDC-48.2 0.182
mdf-2 Protein MDF-2 0.180
app-1 Protein APP-1 0.172
zen-4 Protein ZEN-4 0.165
rpn-5 Protein RPN-5 0.160
egl-18 Protein EGL-18 0.151
npl-4.2 Protein NPL-4.2 0.150
ubc-25 Protein UBC-25 0.148
rpl-11.1 Protein RPL-11.1 0.146
pbs-7 Protein PBS-7 0.133
rpt-5 Protein RPT-5 0.132
K08E3.5 Protein K08E3.5 0.131
pas-6 Protein PAS-6 0.128
ubc-3 Protein UBC-3 0.126
ect-2 Protein ECT-2 0.125
rpn-11 Protein RPN-11 0.123
pkc-3 Protein PKC-3 0.123
bub-1 Protein BUB-1 0.122
syx-17 Protein SYX-17 0.121
rsa-1 Protein RSA-1 0.121
K07H8.2 Protein K07H8.2 0.121
rad-26 Protein RAD-26 0.121
uev-3 Protein UEV-3 0.119
dnj-19 Protein DNJ-19 0.115
rpa-2 Protein RPA-2 0.114
csn-3 Protein CSN-3 0.112
zyg-1 Protein ZYG-1 0.110
R11A8.7 Protein R11A8.7 0.108
F08B4.7 Protein F08B4.7 0.107
klp-16 Protein KLP-16 0.106
tbb-1 Protein TBB-1 0.105
pas-5 Protein PAS-5 0.103
dpy-30 Protein DPY-30 0.103
flap-1 Protein FLAP-1 0.094
cdl-1 Protein CDL-1 0.092
gpr-2 Protein GPR-2 0.092
pbs-4 Protein PBS-4 0.088
pup-2 Protein PUP-2 0.087
his-6 Protein HIS-6 0.085
skr-1 Protein SKR-1 0.084
mat-3 Protein MAT-3 0.080
bir-1 Protein BIR-1 0.080
zyg-9 Protein ZYG-9 0.079
mom-2 Protein MOM-2 0.079
npl-4.1 Protein NPL-4.1 0.079
ubq-1 Protein UBQ-1 0.077
tba-1 Protein TBA-1 0.077
atg-18 Protein ATG-18 0.076
cul-2 Protein CUL-2 0.074
mig-15 Protein MIG-15 0.073
rod-1 Protein ROD-1 0.072
atg-13 Protein ATG-13 0.068
sbds-1 Protein SBDS-1 0.068
dsh-2 Protein DSH-2 0.067
spas-1 Protein SPAS-1 0.067
Y54E5A.7 Protein Y54E5A.7 0.064
CELE_T10C6.6 Protein T10C6.6 0.063
CELE_Y106G6H.6 Protein Y106G6H.6 0.062
htz-1 Protein HTZ-1 0.062
pas-3 Protein PAS-3 0.061
pqn-65 Protein PQN-65 0.060
crt-1 Protein CRT-1 0.060
ZK507.6 Protein ZK507.6 0.059
tbb-2 Protein TBB-2 0.059
cpg-8 Protein CPG-8 0.059
F36D4.5 Protein F36D4.5 0.059
C52A10.1 Protein C52A10.1 0.058
Loading network...
Danio rerio
Name Description Probability Func Analog Organism
psmb1 proteasome (prosome, macropain) subunit, beta type, 1 0.965
psmd6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 0.956
psmc6 proteasome (prosome, macropain) 26S subunit, ATPase, 6 0.924
psmd12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 0.885
hspa5 heat shock protein 5 0.875
psmc1b proteasome (prosome, macropain) 26S subunit, ATPase, 1b 0.862
psmb4 proteasome (prosome, macropain) subunit, beta type, 4 0.857
psmb2 proteasome (prosome, macropain) subunit, beta type, 2 0.857
psmd4b proteasome (prosome, macropain) 26S subunit, non-ATPase, 4b 0.843
psmc2 proteasome (prosome, macropain) 26S subunit, ATPase 2 0.827
psma6a proteasome (prosome, macropain) subunit, alpha type, 6a 0.823
psma8 proteasome (prosome, macropain) subunit, alpha type, 8 0.811
zgc:92775 zgc:92775 0.771
rab1a RAB1A, member RAS oncogene family 0.768
psmb3 proteasome (prosome, macropain) subunit, beta type, 3 0.764
psmb7 proteasome (prosome, macropain) subunit, beta type, 7 0.732
ccnb1 cyclin B1 0.724
ywhabb tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide b 0.716
psma4 proteasome (prosome, macropain) subunit, alpha type, 4 0.685
ubin ataxin-1 ubiquitin-like interacting protein 0.678
psmd2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.648
LOC100330405 transmembrane protein 176B-like 0.645
ctsc cathepsin C 0.637
psmd11b proteasome (prosome, macropain) 216S subunit, non-ATPase, 11b 0.610
psmc5 proteasome (prosome, macropain) 26S subunit, ATPase, 5 0.595
psmd13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 0.590
ctsl1b cathepsin L, 1 b 0.587
ddx42 DEAD (Asp-Glu-Ala-Asp) box polypeptide 42 0.586
ck2b casein kinase 2 beta 0.586
syvn1 synovial apoptosis inhibitor 1, synoviolin 0.528
ctsz cathepsin Z 0.526
ube2l3a ubiquitin-conjugating enzyme E2L 3a 0.525
cct5 chaperonin containing TCP1, subunit 5 (epsilon) 0.505
psmc4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 0.493
dnajc3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.491
smndc1 survival motor neuron domain containing 1 0.490
si:rp71-45k5.4 si:rp71-45k5.4 0.490
chchd2 coiled-coil-helix-coiled-coil-helix domain containing 2 0.470
zgc:55813 zgc:55813 0.462
psmb5 proteasome (prosome, macropain) subunit, beta type, 5 0.443
xbp1 X-box binding protein 1 0.439
usp5 ubiquitin specific protease 5 0.431
ctsd cathepsin D 0.431
zgc:86903 zgc:86903 0.430
szl sizzled 0.427
ube2d1 ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast) 0.425
fstl1b follistatin-like 1b 0.423
mdm2 transformed 3T3 cell double minute 2 homolog (mouse) 0.422
wnt4a wingless-type MMTV integration site family, member 4a 0.416
cdc20 cell division cycle 20 homolog 0.412
vcp valosin containing protein 0.406
psmc3 proteasome (prosome, macropain) 26S subunit, ATPase, 3 0.404
orc1 origin recognition complex, subunit 1 0.403
npc1 Niemann-Pick disease, type C1 0.402
adrm1b adhesion regulating molecule 1b 0.396
tacc3 transforming, acidic coiled-coil containing protein 3 0.388
zgc:110116 zgc:110116 0.385
psmd3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 0.382
ccne cyclin E 0.382
psmb6 proteasome (prosome, macropain) subunit, beta type, 6 0.377
zgc:92765 zgc:92765 0.374
capn2b calpain 2, (m/II) large subunit b 0.373
ccnb2 cyclin B2 0.370
zgc:123326 zgc:123326 0.361
cdt1 chromatin licensing and DNA replication factor 1 0.360
ihha Indian hedgehog homolog a 0.359
max myc-associated factor X 0.356
sart3 squamous cell carcinoma antigen recognised by T cells 3 0.336
supt5h suppressor of Ty 5 homolog (S. cerevisiae) 0.336
gps1 G protein pathway suppressor 1 0.334
hyou1 hypoxia up-regulated 1 0.333
gmnn geminin, DNA replication inhibitor 0.329
psmc1a proteasome (prosome, macropain) 26S subunit, ATPase, 1a 0.323
psma5 proteasome (prosome, macropain) subunit, alpha type,5 0.321
ube2g2 ubiquitin-conjugating enzyme E2G 2 0.318
ciapin1 cytokine induced apoptosis inhibitor 1 0.302
tram1 translocating chain-associating membrane protein 1 0.299
plk1 polo-like kinase 1 (Drosophila) 0.294
ctsba cathepsin B, a 0.292
ncl1 nicalin 0.286
extl3 exostoses (multiple)-like 3 0.286
lancl1 LanC antibiotic synthetase component C-like 1 (bacterial) 0.286
rlf rearranged L-myc fusion 0.286
exoc3 exocyst complex component 3 0.284
eif4ebp2 eukaryotic translation initiation factor 4E binding protein 2 0.279
psmb8 proteasome (prosome, macropain) subunit, beta type, 8 0.279
kif23 kinesin family member 23 0.272
psma1 proteasome (prosome, macropain) subunit, alpha type, 1 0.269
psmd11a proteasome (prosome, macropain) 216S subunit, non-ATPase, 11a 0.269
pdap1 pdgfa associated protein 1 0.267
dnaja2l DnaJ (Hsp40) homolog, subfamily A, member 2, like 0.266
arf2 ADP-ribosylation factor 2 0.266
gro2 groucho 2 0.266
btg2 B-cell translocation gene 2 0.266
aurkb aurora kinase B 0.261
fbxw2 F-box and WD repeat domain containing 2 0.260
smad2 MAD homolog 2 (Drosophila) 0.258
slc2a10 solute carrier family 2 (facilitated glucose transporter), member 10 0.257
rnf40 ring finger protein 40 0.256
hspa4b heat shock protein 4b 0.255
Loading network...
Homo sapiens
Name Description Probability Func Analog Organism
UBC ubiquitin C 1.000
TP53 tumor protein p53 1.000
UBE2D2 ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast) 1.000
UBE2D1 ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast) 1.000
RNF11 ring finger protein 11 1.000
VCP valosin containing protein 1.000
UBE2D3 ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast) 1.000
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 1.000
XIAP X-linked inhibitor of apoptosis 1.000
SKP1 S-phase kinase-associated protein 1 1.000
CDC20 cell division cycle 20 homolog (S. cerevisiae) 0.998
SKP2 S-phase kinase-associated protein 2 (p45) 0.998
CDC27 cell division cycle 27 homolog (S. cerevisiae) 0.998
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 0.998
CUL1 cullin 1 0.997
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 0.996
UBE3A ubiquitin protein ligase E3A 0.996
CUL3 cullin 3 0.996
UBE2N ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast) 0.995
PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6 0.995
PSMC2 proteasome (prosome, macropain) 26S subunit, ATPase, 2 0.995
ARIH2 ariadne homolog 2 (Drosophila) 0.992
COPS5 COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis) 0.990
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.989
RB1 retinoblastoma 1 0.988
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.986
CDK2 cyclin-dependent kinase 2 0.985
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2 0.984
PSMA1 proteasome (prosome, macropain) subunit, alpha type, 1 0.981
PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5 0.981
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 0.979
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.979
RBX1 ring-box 1, E3 ubiquitin protein ligase 0.976
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) 0.974
PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki) 0.974
PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1 0.973
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 0.968
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6 0.965
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 0.962
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.954
HSPA8 heat shock 70kDa protein 8 0.953
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.952
OTUB1 OTU domain, ubiquitin aldehyde binding 1 0.951
ANAPC4 anaphase promoting complex subunit 4 0.951
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.948
UBXN7 UBX domain protein 7 0.947
ZNRF1 zinc and ring finger 1 0.946
TRAF6 TNF receptor-associated factor 6 0.944
SMAD2 SMAD family member 2 0.944
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3 0.944
RNF5 ring finger protein 5 0.935
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2 0.933
TRIM39 tripartite motif containing 39 0.932
TCEB1 transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C) 0.930
PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5 0.928
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.924
SIAH1 seven in absentia homolog 1 (Drosophila) 0.923
PTK2 PTK2 protein tyrosine kinase 2 0.922
CCNB1 cyclin B1 0.919
UBQLN1 ubiquilin 1 0.918
PSMB6 proteasome (prosome, macropain) subunit, beta type, 6 0.914
CDC5L CDC5 cell division cycle 5-like (S. pombe) 0.906
SYVN1 synovial apoptosis inhibitor 1, synoviolin 0.902
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase 0.898
CSNK1E casein kinase 1, epsilon 0.897
ADRM1 adhesion regulating molecule 1 0.885
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 0.885
DCUN1D1 DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae) 0.884
RNF111 ring finger protein 111 0.880
MDM4 Mdm4 p53 binding protein homolog (mouse) 0.880
CCNA2 cyclin A2 0.876
FBXW11 F-box and WD repeat domain containing 11 0.872
RAD23B RAD23 homolog B (S. cerevisiae) 0.869
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.866
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.858
ANAPC11 anaphase promoting complex subunit 11 0.858
SQSTM1 sequestosome 1 0.840
UFD1L ubiquitin fusion degradation 1 like (yeast) 0.840
AMFR autocrine motility factor receptor 0.834
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.833
ARIH1 ariadne homolog, ubiquitin-conjugating enzyme E2 binding protein, 1 (Drosophila) 0.832
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.831
CBX5 chromobox homolog 5 0.828
GSK3B glycogen synthase kinase 3 beta 0.826
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.821
PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 0.818
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 0.817
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 0.811
USP9X ubiquitin specific peptidase 9, X-linked 0.810
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 0.802
DERL1 Der1-like domain family, member 1 0.802
RNF2 ring finger protein 2 0.801
UHRF2 ubiquitin-like with PHD and ring finger domains 2 0.801
MKRN1 makorin ring finger protein 1 0.801
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.794
MARCH7 membrane-associated ring finger (C3HC4) 7 0.792
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 0.788
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3 0.786
BRCA1 breast cancer 1, early onset 0.781
RFWD2 ring finger and WD repeat domain 2 0.776
Loading network...
Mus musculus
Name Description Probability Func Analog Organism
Trp53 transformation related protein 53 0.999
Ctnnb1 catenin (cadherin associated protein), beta 1 0.999
Pten phosphatase and tensin homolog 0.999
Axin1 axin 1 0.997
Ccnb1 cyclin B1 0.986
Gsk3b glycogen synthase kinase 3 beta 0.985
Mgea5 meningioma expressed antigen 5 (hyaluronidase) 0.981
Psma7 proteasome (prosome, macropain) subunit, alpha type 7 0.981
Cdk1 cyclin-dependent kinase 1 0.980
Vcp valosin containing protein 0.979
Psma1 proteasome (prosome, macropain) subunit, alpha type 1 0.973
Psmd4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 0.965
Psmb7 proteasome (prosome, macropain) subunit, beta type 7 0.930
Cdc20 cell division cycle 20 homolog (S. cerevisiae) 0.924
Map3k7 mitogen-activated protein kinase kinase kinase 7 0.921
Psma5 proteasome (prosome, macropain) subunit, alpha type 5 0.921
Skp1a S-phase kinase-associated protein 1A 0.917
Usp9x ubiquitin specific peptidase 9, X chromosome 0.902
Psma2 proteasome (prosome, macropain) subunit, alpha type 2 0.900
Ppp1cc protein phosphatase 1, catalytic subunit, gamma isoform 0.890
Fgfr1 fibroblast growth factor receptor 1 0.889
Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member 1 0.881
Mdm2 transformed mouse 3T3 cell double minute 2 0.881
Cyld cylindromatosis (turban tumor syndrome) 0.880
Ccna2 cyclin A2 0.880
Psma4 proteasome (prosome, macropain) subunit, alpha type 4 0.880
Prc1 protein regulator of cytokinesis 1 0.862
Kpna1 karyopherin (importin) alpha 1 0.856
Bub1b budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae) 0.843
Mbd3 methyl-CpG binding domain protein 3 0.843
Psmc3 proteasome (prosome, macropain) 26S subunit, ATPase 3 0.842
Rrm2 ribonucleotide reductase M2 0.842
Birc5 baculoviral IAP repeat-containing 5 0.836
Ccnb2 cyclin B2 0.833
Nedd4 neural precursor cell expressed, developmentally down-regulated 4 0.822
Psmc5 protease (prosome, macropain) 26S subunit, ATPase 5 0.818
Traf6 TNF receptor-associated factor 6 0.809
Psmb6 proteasome (prosome, macropain) subunit, beta type 6 0.798
Cul3 cullin 3 0.796
Skil SKI-like 0.793
Pax8 paired box gene 8 0.776
Psma3 proteasome (prosome, macropain) subunit, alpha type 3 0.770
Stat3 signal transducer and activator of transcription 3 0.767
Cry2 cryptochrome 2 (photolyase-like) 0.764
Aurka aurora kinase A 0.759
Ube2g1 ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, C. elegans) 0.756
Mis18bp1 MIS18 binding protein 1 0.753
Csnk1d casein kinase 1, delta 0.751
Bag6 BCL2-associated athanogene 6 0.748
Ncoa3 nuclear receptor coactivator 3 0.741
Usp22 ubiquitin specific peptidase 22 0.728
Kif20a kinesin family member 20A 0.722
Stub1 STIP1 homology and U-Box containing protein 1 0.720
App amyloid beta (A4) precursor protein 0.714
Rnf111 ring finger 111 0.714
Ikbkg inhibitor of kappaB kinase gamma 0.712
Bcl2 B-cell leukemia/lymphoma 2 0.703
Ranbp9 RAN binding protein 9 0.694
Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) 0.692
Tax1bp1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.691
Dyrk1a dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a 0.686
Psmc2 proteasome (prosome, macropain) 26S subunit, ATPase 2 0.682
Cdca8 cell division cycle associated 8 0.666
Adrm1 adhesion regulating molecule 1 0.653
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.653
Uba3 ubiquitin-like modifier activating enzyme 3 0.645
Gli3 GLI-Kruppel family member GLI3 0.642
Col1a1 collagen, type I, alpha 1 0.640
Ppp1ca protein phosphatase 1, catalytic subunit, alpha isoform 0.636
Ikbkb inhibitor of kappaB kinase beta 0.629
Cops2 COP9 (constitutive photomorphogenic) homolog, subunit 2 (Arabidopsis thaliana) 0.623
Grb2 growth factor receptor bound protein 2 0.622
Thra thyroid hormone receptor alpha 0.615
Mdm4 transformed mouse 3T3 cell double minute 4 0.612
Mki67 antigen identified by monoclonal antibody Ki 67 0.609
Pomp proteasome maturation protein 0.609
Apc adenomatosis polyposis coli 0.609
Rbl2 retinoblastoma-like 2 0.601
Asf1b ASF1 anti-silencing function 1 homolog B (S. cerevisiae) 0.594
Banf1 barrier to autointegration factor 1 0.588
Htt huntingtin 0.588
Cdca5 cell division cycle associated 5 0.582
Arid1b AT rich interactive domain 1B (SWI-like) 0.582
Ski ski sarcoma viral oncogene homolog (avian) 0.578
Hif1a hypoxia inducible factor 1, alpha subunit 0.573
Sirt1 sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae) 0.566
Ube2d3 ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast) 0.566
Per2 period homolog 2 (Drosophila) 0.565
C330027C09Rik RIKEN cDNA C330027C09 gene 0.562
Ncstn nicastrin 0.551
Cops5 COP9 (constitutive photomorphogenic) homolog, subunit 5 (Arabidopsis thaliana) 0.543
Runx2 runt related transcription factor 2 0.543
Psmd12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 0.540
Pias2 protein inhibitor of activated STAT 2 0.539
Psma6 proteasome (prosome, macropain) subunit, alpha type 6 0.534
Pik3ca phosphatidylinositol 3-kinase, catalytic, alpha polypeptide 0.528
Psen1 presenilin 1 0.523
Pcna proliferating cell nuclear antigen 0.518
Ccne1 cyclin E1 0.516
Aimp1 aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 0.514
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
Psma5 proteasome (prosome, macropain) subunit, alpha type 5 0.925
Psma3 proteasome (prosome, macropain) subunit, alpha type 3 0.876
Psmc2 proteasome (prosome, macropain) 26S subunit, ATPase 2 0.760
Psmb3 proteasome (prosome, macropain) subunit, beta type 3 0.724
Psma4 proteasome (prosome, macropain) subunit, alpha type 4 0.630
Dnaja2 DnaJ (Hsp40) homolog, subfamily A, member 2 0.592
Psmc1 proteasome (prosome, macropain) 26S subunit, ATPase, 1 0.549
Psma7 proteasome (prosome, macropain) subunit, alpha type 7 0.490
Sec61a1 Sec61 alpha 1 subunit (S. cerevisiae) 0.435
Psmd6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 0.362
Ppp1cb protein phosphatase 1, catalytic subunit, beta isoform 0.353
Psmb2 proteasome (prosome, macropain) subunit, beta type 2 0.330
Psmb6 proteasome (prosome, macropain) subunit, beta type 6 0.303
Psmb7 proteasome (prosome, macropain) subunit, beta type 7 0.294
Psmb4 proteasome (prosome, macropain) subunit, beta type 4 0.260
Psma2 proteasome (prosome, macropain) subunit, alpha type 2 0.246
Psme2 proteasome (prosome, macropain) activator subunit 2 0.241
Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 0.239
Psmd4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 0.156
Psmc4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 0.145
Psma6 proteasome (prosome, macropain) subunit, alpha type 6 0.145
Csnk1d casein kinase 1, delta 0.144
Zfand5 zinc finger, AN1-type domain 5 0.136
Psmd3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 0.131
Psmc5 proteasome (prosome, macropain) 26S subunit, ATPase, 5 0.121
Psmc3 proteasome (prosome, macropain) 26S subunit, ATPase 3 0.120
Canx calnexin 0.117
Psmd13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 0.114
Eef2 eukaryotic translation elongation factor 2 0.113
Cast calpastatin 0.101
Hspe1 heat shock protein 1 (chaperonin 10) 0.097
Cnbp CCHC-type zinc finger, nucleic acid binding protein 0.092
Dbp D site of albumin promoter (albumin D-box) binding protein 0.088
Psmb8 proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) 0.087
Psma1 proteasome (prosome, macropain) subunit, alpha type 1 0.087
Hprt1 hypoxanthine phosphoribosyltransferase 1 0.082
Ube2b ubiquitin-conjugating enzyme E2B (RAD6 homolog, S. cerevisiae) 0.082
Usf2 upstream transcription factor 2, c-fos interacting 0.080
Kif22 kinesin family member 22 0.078
Dctn4 dynactin 4 0.077
Oaz1 ornithine decarboxylase antizyme 1 0.074
Cdc37 cell division cycle 37 homolog (S. cerevisiae) 0.072
Txnl1 thioredoxin-like 1 0.071
Psmb10 proteasome (prosome, macropain) subunit, beta type 10 0.069
Nsfl1c NSFL1 (p97) cofactor (p47) 0.060
Serinc1 serine incorporator 1 0.058
Ube2i ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 0.056
Rad23b RAD23 homolog B (S. cerevisiae) 0.056
Pdia6 protein disulfide isomerase family A, member 6 0.050
Calr calreticulin 0.049
Hsph1 heat shock 105/110 protein 1 0.048
Psmd7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 0.046
Psmb5 proteasome (prosome, macropain) subunit, beta type 5 0.046
LOC362855 P55 0.045
Phax phosphorylated adaptor for RNA export 0.045
Cnot7 CCR4-NOT transcription complex, subunit 7 0.044
Rab21 RAB21, member RAS oncogene family 0.043
Tax1bp1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.042
Vcp valosin-containing protein 0.042
Akt1s1 AKT1 substrate 1 (proline-rich) 0.041
Ccnb1 cyclin B1 0.040
Psmb9 proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2) 0.039
Pcna proliferating cell nuclear antigen 0.039
Cmtm6 CKLF-like MARVEL transmembrane domain containing 6 0.039
Ubc ubiquitin C 0.038
Pdia4 protein disulfide isomerase family A, member 4 0.036
Wdr26 WD repeat domain 26 0.035
Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.035
Tspyl1 TSPY-like 1 0.035
Mgat2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase 0.034
Tor1aip2 torsin A interacting protein 2 0.034
Ptges3 prostaglandin E synthase 3 (cytosolic) 0.033
Acyp2 acylphosphatase 2, muscle type 0.033
Casp3 caspase 3 0.033
Rpn1 ribophorin I 0.032
Dnajb11 DnaJ (Hsp40) homolog, subfamily B, member 11 0.032
Prdx1 peroxiredoxin 1 0.031
Ppp1r2 protein phosphatase 1, regulatory (inhibitor) subunit 2 0.031
Vps35 vacuolar protein sorting 35 homolog (S. cerevisiae) 0.030
Vapa VAMP (vesicle-associated membrane protein)-associated protein A 0.030
Syngr2 synaptogyrin 2 0.030
Mllt4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.030
Sdcbp syndecan binding protein 0.030
Hyou1 hypoxia up-regulated 1 0.030
Nploc4 nuclear protein localization 4 homolog (S. cerevisiae) 0.030
Magi2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.029
Eif2s2 eukaryotic translation initiation factor 2, subunit 2 beta 0.029
Psmd8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 0.029
B2m beta-2 microglobulin 0.029
Ube2g1 ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast) 0.029
Parp14 poly (ADP-ribose) polymerase family, member 14 0.028
Eif5a eukaryotic translation initiation factor 5A 0.028
Foxm1 forkhead box M1 0.027
Serp1 stress-associated endoplasmic reticulum protein 1 0.027
Ufd1l ubiquitin fusion degradation 1 like (yeast) 0.027
Dlg1 discs, large homolog 1 (Drosophila) 0.026
Rbbp7 retinoblastoma binding protein 7 0.025
Lman1 lectin, mannose-binding, 1 0.025
Grin1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 0.025
Eif4a2 eukaryotic translation initiation factor 4A, isoform 2 0.025
Loading network...
Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
CDC48 Cdc48p 1.000
PRE1 Pre1p 0.988
PPH22 Pph22p 0.983
KAR2 Kar2p 0.982
RPT4 Rpt4p 0.968
DSK2 Dsk2p 0.965
RPT1 Rpt1p 0.959
RPN10 Rpn10p 0.958
PRE2 Pre2p 0.956
RPT3 Rpt3p 0.947
RPT6 Rpt6p 0.938
YPT1 Ypt1p 0.934
RAD23 Rad23p 0.924
ECM29 Ecm29p 0.913
UFD2 Ufd2p 0.907
HRD1 Hrd1p 0.895
RPT2 Rpt2p 0.892
PRE10 Pre10p 0.869
PRE6 Pre6p 0.845
CDC16 Cdc16p 0.842
MND2 Mnd2p 0.836
DOC1 Doc1p 0.836
CDC23 Cdc23p 0.828
FYV10 Fyv10p 0.826
OTU1 Otu1p 0.826
PUP2 Pup2p 0.825
PRE9 Pre9p 0.820
CDC53 Cdc53p 0.816
UFD4 Ufd4p 0.808
BRE5 Bre5p 0.808
UFD1 Ufd1p 0.802
VPS36 Vps36p 0.800
SCL1 Scl1p 0.798
RPN9 Rpn9p 0.784
UBP15 Ubp15p 0.782
MAD2 Mad2p 0.769
RPN12 Rpn12p 0.768
RPT5 Rpt5p 0.768
APC5 Apc5p 0.765
SCJ1 Scj1p 0.760
UBR1 Ubr1p 0.758
RPN11 Rpn11p 0.747
SKP1 Skp1p 0.745
UBC7 Ubc7p 0.744
PRE4 Pre4p 0.703
CDC27 Cdc27p 0.701
UBC4 Ubc4p 0.690
UBA1 Uba1p 0.668
RKR1 Rkr1p 0.666
DER1 Der1p 0.661
VID30 Vid30p 0.653
SWM1 Swm1p 0.649
RPN8 Rpn8p 0.645
HRD3 Hrd3p 0.637
ELC1 Elc1p 0.636
PRE7 Pre7p 0.630
SSE2 Sse2p 0.619
PPH21 Pph21p 0.594
PRE5 Pre5p 0.588
PRE8 Pre8p 0.586
GID7 Gid7p 0.586
UBX3 Ubx3p 0.572
PUP1 Pup1p 0.559
RPN6 Rpn6p 0.549
YDJ1 Ydj1p 0.547
UBC13 Ubc13p 0.547
MET30 Met30p 0.547
SWE1 Swe1p 0.546
APC2 Apc2p 0.541
MUB1 Mub1p 0.539
KAP114 Kap114p 0.534
KSP1 Ksp1p 0.533
RMD5 Rmd5p 0.529
MON2 Mon2p 0.523
RPN4 Rpn4p 0.523
UBX4 Ubx4p 0.522
RTS1 Rts1p 0.516
SSA1 Ssa1p 0.506
UBI4 Ubi4p 0.506
CDC4 Cdc4p 0.493
PTC1 Ptc1p 0.491
APC4 Apc4p 0.476
GPB2 Gpb2p 0.474
CDC26 Cdc26p 0.471
PRC1 Prc1p 0.462
SPT16 Spt16p 0.462
YBP2 Ybp2p 0.461
UBP3 Ubp3p 0.460
GRR1 Grr1p 0.457
LAG2 Lag2p 0.457
DFM1 Dfm1p 0.453
TRE1 Tre1p 0.450
RPN7 Rpn7p 0.441
HTA1 Hta1p 0.440
UFO1 Ufo1p 0.434
HSP82 Hsp82p 0.434
TIP41 Tip41p 0.433
APC11 Apc11p 0.431
SGT2 Sgt2p 0.429
RPN13 Rpn13p 0.429