IMP
Process View
The network for 'negative regulation of b cell receptor signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.
Multiple Organisms
negative regulation of b cell receptor signaling pathway
Any process that stops, prevents, or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B cell.
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| PTK2 | PTK2 protein tyrosine kinase 2 | 0.986 | |
| TRIP6 | thyroid hormone receptor interactor 6 | 0.868 | |
| TFF1 | trefoil factor 1 | 0.809 | |
| LAIR1 | leukocyte-associated immunoglobulin-like receptor 1 | 0.799 | |
| BCAR1 | breast cancer anti-estrogen resistance 1 | 0.680 | |
| LPXN | leupaxin | 0.622 | |
| PILRA | paired immunoglobin-like type 2 receptor alpha | 0.581 | |
| FHL2 | four and a half LIM domains 2 | 0.540 | |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.530 | |
| PHC2 | polyhomeotic homolog 2 (Drosophila) | 0.502 | |
| HOXA1 | homeobox A1 | 0.490 | |
| CD33 | CD33 molecule | 0.431 | |
| NCK2 | NCK adaptor protein 2 | 0.316 | |
| GIT2 | G protein-coupled receptor kinase interacting ArfGAP 2 | 0.281 | |
| LCP2 | lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) | 0.225 | |
| PECAM1 | platelet/endothelial cell adhesion molecule | 0.187 | |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | 0.183 | |
| SRC | v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | 0.161 | |
| PXN | paxillin | 0.152 | |
| PHF21A | PHD finger protein 21A | 0.152 | |
| ILK | integrin-linked kinase | 0.149 | |
| BBS10 | Bardet-Biedl syndrome 10 | 0.149 | |
| ITGA7 | integrin, alpha 7 | 0.126 | |
| EPOR | erythropoietin receptor | 0.123 | |
| CSF2RB | colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) | 0.109 | |
| FN1 | fibronectin 1 | 0.099 | |
| SYK | spleen tyrosine kinase | 0.098 | |
| CBL | Cas-Br-M (murine) ecotropic retroviral transforming sequence | 0.089 | |
| VCL | vinculin | 0.078 | |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.065 | |
| PTPN11 | protein tyrosine phosphatase, non-receptor type 11 | 0.053 | |
| VAV1 | vav 1 guanine nucleotide exchange factor | 0.053 | |
| CDC42EP1 | CDC42 effector protein (Rho GTPase binding) 1 | 0.048 | |
| ITGA4 | integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) | 0.042 | |
| SIGLEC7 | sialic acid binding Ig-like lectin 7 | 0.041 | |
| ROS1 | c-ros oncogene 1 , receptor tyrosine kinase | 0.040 | |
| SH3BP2 | SH3-domain binding protein 2 | 0.039 | |
| POM121 | POM121 membrane glycoprotein | 0.038 | |
| SIGLEC10 | sialic acid binding Ig-like lectin 10 | 0.037 | |
| PARVB | parvin, beta | 0.037 | |
| ZNF426 | zinc finger protein 426 | 0.032 | |
| CRKL | v-crk sarcoma virus CT10 oncogene homolog (avian)-like | 0.032 | |
| LYN | v-yes-1 Yamaguchi sarcoma viral related oncogene homolog | 0.031 | |
| PTPN23 | protein tyrosine phosphatase, non-receptor type 23 | 0.031 | |
| PARVA | parvin, alpha | 0.030 | |
| CD22 | CD22 molecule | 0.028 | |
| GRB2 | growth factor receptor-bound protein 2 | 0.026 | |
| RNF5 | ring finger protein 5 | 0.025 | |
| SLC11A1 | solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 | 0.025 | |
| CNN1 | calponin 1, basic, smooth muscle | 0.024 | |
| ZNF331 | zinc finger protein 331 | 0.024 | |
| SH2D2A | SH2 domain containing 2A | 0.023 | |
| KIR2DL3 | killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3 | 0.023 | |
| KIR2DL1 | killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1 | 0.023 | |
| CRK | v-crk sarcoma virus CT10 oncogene homolog (avian) | 0.022 | |
| CD72 | CD72 molecule | 0.022 | |
| DBNL | drebrin-like | 0.020 | |
| FBP1 | fructose-1,6-bisphosphatase 1 | 0.020 | |
| GIT1 | G protein-coupled receptor kinase interacting ArfGAP 1 | 0.019 | |
| PTK2B | PTK2B protein tyrosine kinase 2 beta | 0.019 | |
| HK3 | hexokinase 3 (white cell) | 0.018 | |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.018 | |
| CSK | c-src tyrosine kinase | 0.017 | |
| CYTH4 | cytohesin 4 | 0.017 | |
| FGR | Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog | 0.016 | |
| FCGR2B | Fc fragment of IgG, low affinity IIb, receptor (CD32) | 0.016 | |
| MYL9 | myosin, light chain 9, regulatory | 0.016 | |
| INPP5D | inositol polyphosphate-5-phosphatase, 145kDa | 0.016 | |
| EHD2 | EH-domain containing 2 | 0.016 | |
| TGFB1I1 | transforming growth factor beta 1 induced transcript 1 | 0.015 | |
| KCNMB1 | potassium large conductance calcium-activated channel, subfamily M, beta member 1 | 0.015 | |
| DMBT1 | deleted in malignant brain tumors 1 | 0.015 | |
| AR | androgen receptor | 0.015 | |
| CAV2 | caveolin 2 | 0.014 | |
| HES1 | hairy and enhancer of split 1, (Drosophila) | 0.014 | |
| SIRPA | signal-regulatory protein alpha | 0.013 | |
| APOBR | apolipoprotein B receptor | 0.013 | |
| DPEP2 | dipeptidase 2 | 0.013 | |
| LILRA2 | leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2 | 0.013 | |
| CD247 | CD247 molecule | 0.013 | |
| ABO | ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) | 0.013 | |
| TLN1 | talin 1 | 0.013 | |
| RAPGEF1 | Rap guanine nucleotide exchange factor (GEF) 1 | 0.013 | |
| RHOU | ras homolog gene family, member U | 0.012 | |
| CD3E | CD3e molecule, epsilon (CD3-TCR complex) | 0.012 | |
| GAB1 | GRB2-associated binding protein 1 | 0.011 | |
| KIT | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog | 0.011 | |
| BTLA | B and T lymphocyte associated | 0.011 | |
| ITGA6 | integrin, alpha 6 | 0.011 | |
| PSTPIP1 | proline-serine-threonine phosphatase interacting protein 1 | 0.011 | |
| ENG | endoglin | 0.011 | |
| CATSPER1 | cation channel, sperm associated 1 | 0.010 | |
| THAP2 | THAP domain containing, apoptosis associated protein 2 | 0.010 | |
| CTGF | connective tissue growth factor | 0.010 |
Loading network...
Mus musculus
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| Inpp5d | inositol polyphosphate-5-phosphatase D | 0.953 | |
| Cd22 | CD22 antigen | 0.625 | |
| Trp53 | transformation related protein 53 | 0.604 | |
| Grb2 | growth factor receptor bound protein 2 | 0.440 | |
| Lyn | Yamaguchi sarcoma viral (v-yes-1) oncogene homolog | 0.380 | |
| Nf1 | neurofibromatosis 1 | 0.261 | |
| Cd79a | CD79A antigen (immunoglobulin-associated alpha) | 0.251 | |
| Itgb1 | integrin beta 1 (fibronectin receptor beta) | 0.208 | |
| Cbl | Casitas B-lineage lymphoma | 0.179 | |
| Flt1 | FMS-like tyrosine kinase 1 | 0.155 | |
| Shc1 | src homology 2 domain-containing transforming protein C1 | 0.149 | |
| Vav1 | vav 1 oncogene | 0.140 | |
| Ptpn6 | protein tyrosine phosphatase, non-receptor type 6 | 0.140 | |
| Igh | immunoglobulin heavy chain complex | 0.140 | |
| Egfr | epidermal growth factor receptor | 0.125 | |
| Homer1 | homer homolog 1 (Drosophila) | 0.120 | |
| Vegfa | vascular endothelial growth factor A | 0.116 | |
| Lepr | leptin receptor | 0.105 | |
| Shank2 | SH3/ankyrin domain gene 2 | 0.104 | |
| Blnk | B-cell linker | 0.097 | |
| Parvg | parvin, gamma | 0.096 | |
| Btk | Bruton agammaglobulinemia tyrosine kinase | 0.091 | |
| Nos3 | nitric oxide synthase 3, endothelial cell | 0.083 | |
| Cd72 | CD72 antigen | 0.075 | |
| Cd19 | CD19 antigen | 0.072 | |
| Dok1 | docking protein 1 | 0.071 | |
| Rxra | retinoid X receptor alpha | 0.067 | |
| Plcg2 | phospholipase C, gamma 2 | 0.066 | |
| Erbb2 | v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) | 0.066 | |
| Cd37 | CD37 antigen | 0.060 | |
| Nfkb2 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 | 0.060 | |
| Spag8 | sperm associated antigen 8 | 0.058 | |
| Sos1 | son of sevenless homolog 1 (Drosophila) | 0.058 | |
| Camk2a | calcium/calmodulin-dependent protein kinase II alpha | 0.057 | |
| Plekhh2 | pleckstrin homology domain containing, family H (with MyTH4 domain) member 2 | 0.056 | |
| Ikzf3 | IKAROS family zinc finger 3 | 0.055 | |
| Bcar1 | breast cancer anti-estrogen resistance 1 | 0.054 | |
| Jup | junction plakoglobin | 0.053 | |
| Fgfr2 | fibroblast growth factor receptor 2 | 0.051 | |
| Gab2 | growth factor receptor bound protein 2-associated protein 2 | 0.050 | |
| Dynlt1b | dynein light chain Tctex-type 1D | 0.050 | |
| Sfpi1 | SFFV proviral integration 1 | 0.048 | |
| Src | Rous sarcoma oncogene | 0.046 | |
| Traf3ip2 | TRAF3 interacting protein 2 | 0.046 | |
| Myl9 | myosin, light polypeptide 9, regulatory | 0.044 | |
| Tnfrsf13b | tumor necrosis factor receptor superfamily, member 13b | 0.044 | |
| Vhl | von Hippel-Lindau tumor suppressor | 0.043 | |
| Slamf1 | signaling lymphocytic activation molecule family member 1 | 0.043 | |
| Smtn | smoothelin | 0.040 | |
| Dok3 | docking protein 3 | 0.040 | |
| Fas | Fas (TNF receptor superfamily member 6) | 0.040 | |
| Npdc1 | neural proliferation, differentiation and control gene 1 | 0.039 | |
| Erbb3 | v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) | 0.038 | |
| Cnn1 | calponin 1 | 0.036 | |
| Ptk2 | PTK2 protein tyrosine kinase 2 | 0.036 | |
| Epas1 | endothelial PAS domain protein 1 | 0.036 | |
| Pstpip1 | proline-serine-threonine phosphatase-interacting protein 1 | 0.035 | |
| Grm1 | glutamate receptor, metabotropic 1 | 0.035 | |
| Dlg2 | discs, large homolog 2 (Drosophila) | 0.034 | |
| Ntf3 | neurotrophin 3 | 0.034 | |
| Arhgef25 | Rho guanine nucleotide exchange factor (GEF) 25 | 0.033 | |
| Tagln | transgelin | 0.033 | |
| Isl1 | ISL1 transcription factor, LIM/homeodomain | 0.032 | |
| Prkcb | protein kinase C, beta | 0.032 | |
| Lmna | lamin A | 0.031 | |
| Atxn1 | ataxin 1 | 0.031 | |
| Dnm1 | dynamin 1 | 0.031 | |
| Tnfrsf13c | tumor necrosis factor receptor superfamily, member 13c | 0.031 | |
| Grin2b | glutamate receptor, ionotropic, NMDA2B (epsilon 2) | 0.031 | |
| Dscaml1 | Down syndrome cell adhesion molecule-like 1 | 0.031 | |
| Zfpm2 | zinc finger protein, multitype 2 | 0.030 | |
| Emp2 | epithelial membrane protein 2 | 0.030 | |
| Nbl1 | neuroblastoma, suppression of tumorigenicity 1 | 0.030 | |
| Dlgap1 | discs, large (Drosophila) homolog-associated protein 1 | 0.029 | |
| Epb4.1l2 | erythrocyte protein band 4.1-like 2 | 0.029 | |
| Ikzf1 | IKAROS family zinc finger 1 | 0.029 | |
| Arc | activity regulated cytoskeletal-associated protein | 0.029 | |
| Dvl2 | dishevelled 2, dsh homolog (Drosophila) | 0.028 | |
| Adam19 | a disintegrin and metallopeptidase domain 19 (meltrin beta) | 0.028 | |
| Hey2 | hairy/enhancer-of-split related with YRPW motif 2 | 0.027 | |
| Ldlr | low density lipoprotein receptor | 0.027 | |
| Dsg1a | desmoglein 1 alpha | 0.027 | |
| Ptk2b | PTK2 protein tyrosine kinase 2 beta | 0.027 | |
| Tnf | tumor necrosis factor | 0.027 | |
| Acta2 | actin, alpha 2, smooth muscle, aorta | 0.026 | |
| Pik3cd | phosphatidylinositol 3-kinase catalytic delta polypeptide | 0.026 | |
| Kdr | kinase insert domain protein receptor | 0.026 | |
| Vav2 | vav 2 oncogene | 0.026 | |
| Fstl3 | follistatin-like 3 | 0.026 | |
| Cd79b | CD79B antigen | 0.025 | |
| Nes | nestin | 0.025 | |
| Cnr2 | cannabinoid receptor 2 (macrophage) | 0.025 | |
| Prkch | protein kinase C, eta | 0.025 | |
| Col1a1 | collagen, type I, alpha 1 | 0.024 | |
| Dot1l | DOT1-like, histone H3 methyltransferase (S. cerevisiae) | 0.024 | |
| Hcls1 | hematopoietic cell specific Lyn substrate 1 | 0.024 | |
| Pou2af1 | POU domain, class 2, associating factor 1 | 0.024 | |
| Grik2 | glutamate receptor, ionotropic, kainate 2 (beta 2) | 0.024 | |
| Prkcdbp | protein kinase C, delta binding protein | 0.023 | |
| Ppp6r2 | protein phosphatase 6, regulatory subunit 2 | 0.022 |