The network for 'regulation of nitric oxide biosynthetic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of nitric oxide biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide.

Homo sapiens
Name Description Probability Func Analog Organism
EGFR epidermal growth factor receptor 0.999
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.977
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.851
IL1R1 interleukin 1 receptor, type I 0.775
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.750
IRAK2 interleukin-1 receptor-associated kinase 2 0.540
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.494
TICAM2 toll-like receptor adaptor molecule 2 0.298
IL1B interleukin 1, beta 0.251
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.246
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.244
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.244
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.234
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.199
TNIP1 TNFAIP3 interacting protein 1 0.196
INSR insulin receptor 0.189
KLF4 Kruppel-like factor 4 (gut) 0.170
IGF1R insulin-like growth factor 1 receptor 0.166
TNIP2 TNFAIP3 interacting protein 2 0.134
IL1RAP interleukin 1 receptor accessory protein 0.119
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 0.088
CAV1 caveolin 1, caveolae protein, 22kDa 0.083
NCF1 neutrophil cytosolic factor 1 0.080
ZFP36 zinc finger protein 36, C3H type, homolog (mouse) 0.079
KLF6 Kruppel-like factor 6 0.078
MAP3K8 mitogen-activated protein kinase kinase kinase 8 0.077
NOXA1 NADPH oxidase activator 1 0.074
IL8 interleukin 8 0.065
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 0.063
PRKCZ protein kinase C, zeta 0.057
IL10RA interleukin 10 receptor, alpha 0.056
BCAR1 breast cancer anti-estrogen resistance 1 0.056
DLG2 discs, large homolog 2 (Drosophila) 0.044
CTBP1 C-terminal binding protein 1 0.044
PKD1 polycystic kidney disease 1 (autosomal dominant) 0.044
REL v-rel reticuloendotheliosis viral oncogene homolog (avian) 0.043
BCL3 B-cell CLL/lymphoma 3 0.040
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.034
STAT5A signal transducer and activator of transcription 5A 0.034
DUSP1 dual specificity phosphatase 1 0.034
MPDZ multiple PDZ domain protein 0.033
CCL20 chemokine (C-C motif) ligand 20 0.030
LY96 lymphocyte antigen 96 0.030
IL1RN interleukin 1 receptor antagonist 0.029
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 0.029
IFNGR1 interferon gamma receptor 1 0.029
EGR2 early growth response 2 0.029
RELB v-rel reticuloendotheliosis viral oncogene homolog B 0.028
FOS FBJ murine osteosarcoma viral oncogene homolog 0.028
IL1R2 interleukin 1 receptor, type II 0.026
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.025
FOSL2 FOS-like antigen 2 0.025
TRPC1 transient receptor potential cation channel, subfamily C, member 1 0.024
BIRC3 baculoviral IAP repeat containing 3 0.024
SSTR2 somatostatin receptor 2 0.024
IL6ST interleukin 6 signal transducer (gp130, oncostatin M receptor) 0.023
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 0.023
JUNB jun B proto-oncogene 0.023
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.023
SH2D1A SH2 domain containing 1A 0.022
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 0.021
SOCS1 suppressor of cytokine signaling 1 0.021
GHR growth hormone receptor 0.021
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta 0.021
MCL1 myeloid cell leukemia sequence 1 (BCL2-related) 0.020
MATK megakaryocyte-associated tyrosine kinase 0.020
DDR2 discoidin domain receptor tyrosine kinase 2 0.019
MALT1 mucosa associated lymphoid tissue lymphoma translocation gene 1 0.019
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.019
MYLK2 myosin light chain kinase 2 0.019
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 0.019
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.018
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 0.018
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.018
PPP5C protein phosphatase 5, catalytic subunit 0.018
PARD6A par-6 partitioning defective 6 homolog alpha (C. elegans) 0.017
EPOR erythropoietin receptor 0.017
ICAM1 intercellular adhesion molecule 1 0.017
FYN FYN oncogene related to SRC, FGR, YES 0.016
DLG1 discs, large homolog 1 (Drosophila) 0.016
SH3RF1 SH3 domain containing ring finger 1 0.016
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.016
APP amyloid beta (A4) precursor protein 0.015
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.015
MAP2K4 mitogen-activated protein kinase kinase 4 0.015
PARD6B par-6 partitioning defective 6 homolog beta (C. elegans) 0.015
PLAUR plasminogen activator, urokinase receptor 0.015
IRS1 insulin receptor substrate 1 0.015
NAMPT nicotinamide phosphoribosyltransferase 0.015
SMAD3 SMAD family member 3 0.014
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 0.014
NFIL3 nuclear factor, interleukin 3 regulated 0.014
CARD11 caspase recruitment domain family, member 11 0.014
PARD3 par-3 partitioning defective 3 homolog (C. elegans) 0.014
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.013
PRKCD protein kinase C, delta 0.013
CXCL2 chemokine (C-X-C motif) ligand 2 0.012
IL6 interleukin 6 (interferon, beta 2) 0.012
FTH1 ferritin, heavy polypeptide 1 0.012
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.012
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.388
hep hemipterous 0.097
S6k RPS6-p70-protein kinase 0.065
Akt1 CG4006 gene product from transcript CG4006-RA 0.064
InR Insulin-like receptor 0.043
chico CG5686 gene product from transcript CG5686-RB 0.031
Dcr-2 Dicer-2 0.022
Atg1 Autophagy-specific gene 1 0.020
Tpi Triose phosphate isomerase 0.019
foxo forkhead box, sub-group O 0.018
drd drop dead 0.017
Pk61C Protein kinase 61C 0.016
sd scalloped 0.015
hth homothorax 0.014
spi spitz 0.013
Dredd Death related ced-3/Nedd2-like protein 0.012
scb scab 0.012
Ras85D Ras oncogene at 85D 0.011
Rheb CG1081 gene product from transcript CG1081-RA 0.011
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Mus musculus
Name Description Probability Func Analog Organism
Tlr4 toll-like receptor 4 0.866
Lyz2 lysozyme 2 0.754
Lepr leptin receptor 0.612
Nos2 nitric oxide synthase 2, inducible 0.608
Relb avian reticuloendotheliosis viral (v-rel) oncogene related B 0.564
Il6 interleukin 6 0.540
Nos1 nitric oxide synthase 1, neuronal 0.513
Tnf tumor necrosis factor 0.486
Klrk1 killer cell lectin-like receptor subfamily K, member 1 0.479
Myd88 myeloid differentiation primary response gene 88 0.478
Klra9 killer cell lectin-like receptor subfamily A, member 9 0.370
Ccr2 chemokine (C-C motif) receptor 2 0.355
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 0.269
Ccl2 chemokine (C-C motif) ligand 2 0.237
Vdr vitamin D receptor 0.233
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.212
Tlr2 toll-like receptor 2 0.176
Il10 interleukin 10 0.176
Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.147
Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.129
AF251705 cDNA sequence AF251705 0.122
H2-Q7 histocompatibility 2, Q region locus 7 0.117
Ncr1 natural cytotoxicity triggering receptor 1 0.098
Csf1 colony stimulating factor 1 (macrophage) 0.094
Socs1 suppressor of cytokine signaling 1 0.078
H2-D1 histocompatibility 2, D region locus 1 0.073
Mmp9 matrix metallopeptidase 9 0.071
Tgfb1 transforming growth factor, beta 1 0.071
Cd44 CD44 antigen 0.070
Cav1 caveolin 1, caveolae protein 0.070
Il1a interleukin 1 alpha 0.068
Ren1 renin 1 structural 0.063
Fasl Fas ligand (TNF superfamily, member 6) 0.063
H2-K1 histocompatibility 2, K1, K region 0.063
Pparg peroxisome proliferator activated receptor gamma 0.061
Insr insulin receptor 0.061
Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b 0.061
Pyhin1 pyrin and HIN domain family, member 1 0.054
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.052
Pten phosphatase and tensin homolog 0.049
Nos3 nitric oxide synthase 3, endothelial cell 0.048
Emr1 EGF-like module containing, mucin-like, hormone receptor-like sequence 1 0.048
B2m beta-2 microglobulin 0.046
Cd14 CD14 antigen 0.042
Map3k8 mitogen-activated protein kinase kinase kinase 8 0.041
Klrc1 killer cell lectin-like receptor subfamily C, member 1 0.038
Gzmk granzyme K 0.038
Klra3 killer cell lectin-like receptor, subfamily A, member 3 0.037
Lair1 leukocyte-associated Ig-like receptor 1 0.036
Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 0.035
Smad3 MAD homolog 3 (Drosophila) 0.035
Ptrf polymerase I and transcript release factor 0.033
Ar androgen receptor 0.032
Klra7 killer cell lectin-like receptor, subfamily A, member 7 0.032
Tapbp TAP binding protein 0.032
Ccr5 chemokine (C-C motif) receptor 5 0.030
Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member 1 0.030
Gzma granzyme A 0.030
Tap2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) 0.030
Bcar1 breast cancer anti-estrogen resistance 1 0.029
Gzmb granzyme B 0.029
Bcl3 B-cell leukemia/lymphoma 3 0.028
Dmd dystrophin, muscular dystrophy 0.028
Irg1 immunoresponsive gene 1 0.028
Slfn2 schlafen 2 0.028
Clec4e C-type lectin domain family 4, member e 0.028
Cxcl9 chemokine (C-X-C motif) ligand 9 0.027
Cxcl1 chemokine (C-X-C motif) ligand 1 0.027
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.026
Hspa8 heat shock protein 8 0.026
Stat6 signal transducer and activator of transcription 6 0.025
Nr3c1 nuclear receptor subfamily 3, group C, member 1 0.025
Ms4a4c membrane-spanning 4-domains, subfamily A, member 4C 0.024
Aoah acyloxyacyl hydrolase 0.024
Meox2 mesenchyme homeobox 2 0.024
Ccl3 chemokine (C-C motif) ligand 3 0.024
Il18rap interleukin 18 receptor accessory protein 0.024
Saa4 serum amyloid A 4 0.023
Gnas GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus 0.023
Klrd1 killer cell lectin-like receptor, subfamily D, member 1 0.023
Fpr3 formyl peptide receptor 3 0.023
Cxcl10 chemokine (C-X-C motif) ligand 10 0.023
Cxcl2 chemokine (C-X-C motif) ligand 2 0.023
Il7r interleukin 7 receptor 0.023
Slfn1 schlafen 1 0.023
Il1rn interleukin 1 receptor antagonist 0.023
Akt1 thymoma viral proto-oncogene 1 0.023
Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) 0.022
Klrb1b killer cell lectin-like receptor subfamily B member 1B 0.022
Asap1 ArfGAP with SH# domain, ankyrin repeat and PH domain1 0.022
Invs inversin 0.021
Nphp4 nephronophthisis 4 (juvenile) homolog (human) 0.021
Cblb Casitas B-lineage lymphoma b 0.020
Slc12a1 solute carrier family 12, member 1 0.020
Agtr1a angiotensin II receptor, type 1a 0.020
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.020
Tnfsf14 tumor necrosis factor (ligand) superfamily, member 14 0.020
F2rl2 coagulation factor II (thrombin) receptor-like 2 0.019
Clec4d C-type lectin domain family 4, member d 0.019
Slfn4 schlafen 4 0.019
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Rattus norvegicus
Name Description Probability Func Analog Organism
Slc2a3 solute carrier family 2 (facilitated glucose transporter), member 3 0.029
Htr2b 5-hydroxytryptamine (serotonin) receptor 2B 0.026
Serpina3k serine (or cysteine) peptidase inhibitor, clade A, member 3K 0.023
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.019
Ahsg alpha-2-HS-glycoprotein 0.019
Eef2 eukaryotic translation elongation factor 2 0.018
Arf6 ADP-ribosylation factor 6 0.015
Spp2 secreted phosphoprotein 2 0.014
Cx3cl1 chemokine (C-X3-C motif) ligand 1 0.014
Ccr2 chemokine (C-C motif) receptor 2 0.014
Gnb2 guanine nucleotide binding protein (G protein), beta polypeptide 2 0.013
Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member 1 0.013
Irs1 insulin receptor substrate 1 0.013
Irf1 interferon regulatory factor 1 0.013
C4bpa complement component 4 binding protein, alpha 0.013
Hsph1 heat shock 105/110 protein 1 0.012
Hspb1 heat shock protein 1 0.012
Cd2 Cd2 molecule 0.012
Fmnl1 formin-like 1 0.012
Arrb1 arrestin, beta 1 0.012
Alb albumin 0.012
Rgs14 regulator of G-protein signaling 14 0.011
Odf3b outer dense fiber of sperm tails 3B 0.011
Foxa3 forkhead box A3 0.011
Apoa5 apolipoprotein A-V 0.011
Ahnak AHNAK nucleoprotein 0.011
Mbl1 mannose-binding lectin (protein A) 1 0.011
Hist1h1a histone cluster 1, H1a 0.011
Hk1 hexokinase 1 0.011
Olr1 oxidized low density lipoprotein (lectin-like) receptor 1 0.011
Fga fibrinogen alpha chain 0.010
LOC293989 cytochrome P450-like 0.010
Agtr1a angiotensin II receptor, type 1a 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism