The network for 'lymphocyte activation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

lymphocyte activation

A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor.

Homo sapiens
Name Description Probability Func Analog Organism
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 1.000
SYK spleen tyrosine kinase 1.000
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.998
CD3E CD3e molecule, epsilon (CD3-TCR complex) 0.995
EGFR epidermal growth factor receptor 0.994
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.992
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.989
CCL5 chemokine (C-C motif) ligand 5 0.986
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 0.983
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.983
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.983
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.974
LCK lymphocyte-specific protein tyrosine kinase 0.971
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.968
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.959
CD247 CD247 molecule 0.944
IL2RB interleukin 2 receptor, beta 0.943
IL2RG interleukin 2 receptor, gamma 0.930
PTPRC protein tyrosine phosphatase, receptor type, C 0.927
GRB2 growth factor receptor-bound protein 2 0.926
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.926
LYN v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.916
IRF4 interferon regulatory factor 4 0.912
BCL2 B-cell CLL/lymphoma 2 0.911
PLCG1 phospholipase C, gamma 1 0.904
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1 0.901
ITK IL2-inducible T-cell kinase 0.862
RB1 retinoblastoma 1 0.856
FGFR2 fibroblast growth factor receptor 2 0.854
SOCS3 suppressor of cytokine signaling 3 0.853
RUNX1 runt-related transcription factor 1 0.846
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.834
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.813
ICAM1 intercellular adhesion molecule 1 0.812
CCR5 chemokine (C-C motif) receptor 5 0.812
IRAK1 interleukin-1 receptor-associated kinase 1 0.805
IL1R1 interleukin 1 receptor, type I 0.804
BRCA1 breast cancer 1, early onset 0.799
CCR7 chemokine (C-C motif) receptor 7 0.790
BIRC3 baculoviral IAP repeat containing 3 0.789
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 0.783
SH2D1A SH2 domain containing 1A 0.765
CASP1 caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) 0.763
HCK hemopoietic cell kinase 0.749
IL10RA interleukin 10 receptor, alpha 0.748
GRB7 growth factor receptor-bound protein 7 0.745
NOTCH1 notch 1 0.744
PSEN1 presenilin 1 0.739
CD2 CD2 molecule 0.738
SLA Src-like-adaptor 0.730
HLA-DRA major histocompatibility complex, class II, DR alpha 0.730
CCL22 chemokine (C-C motif) ligand 22 0.715
NKG7 natural killer cell group 7 sequence 0.714
TRAF1 TNF receptor-associated factor 1 0.707
BCL2L1 BCL2-like 1 0.705
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 0.679
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain 0.674
IL12B interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) 0.669
FAS Fas (TNF receptor superfamily, member 6) 0.666
EP300 E1A binding protein p300 0.647
HLA-DMA major histocompatibility complex, class II, DM alpha 0.644
FLNA filamin A, alpha 0.643
NCOR2 nuclear receptor corepressor 2 0.643
FGFR1 fibroblast growth factor receptor 1 0.637
HLA-DMB major histocompatibility complex, class II, DM beta 0.637
IL4R interleukin 4 receptor 0.630
CD86 CD86 molecule 0.625
CDK6 cyclin-dependent kinase 6 0.619
TRAF3IP3 TRAF3 interacting protein 3 0.612
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 1 0.610
INSR insulin receptor 0.604
WAS Wiskott-Aldrich syndrome (eczema-thrombocytopenia) 0.592
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 0.585
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 0.584
SMAD7 SMAD family member 7 0.579
FASLG Fas ligand (TNF superfamily, member 6) 0.573
MS4A1 membrane-spanning 4-domains, subfamily A, member 1 0.572
VAV1 vav 1 guanine nucleotide exchange factor 0.563
LTA lymphotoxin alpha (TNF superfamily, member 1) 0.561
CCL4 chemokine (C-C motif) ligand 4 0.557
SASH3 SAM and SH3 domain containing 3 0.552
BTN3A3 butyrophilin, subfamily 3, member A3 0.542
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) 0.539
MYD88 myeloid differentiation primary response gene (88) 0.534
SIRT1 sirtuin 1 0.534
TGIF1 TGFB-induced factor homeobox 1 0.531
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 0.530
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 0.530
UBASH3B ubiquitin associated and SH3 domain containing B 0.527
CD3G CD3g molecule, gamma (CD3-TCR complex) 0.517
STAT4 signal transducer and activator of transcription 4 0.511
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 0.497
CXCL10 chemokine (C-X-C motif) ligand 10 0.493
TYROBP TYRO protein tyrosine kinase binding protein 0.492
HLA-F major histocompatibility complex, class I, F 0.488
SLAMF1 signaling lymphocytic activation molecule family member 1 0.483
DLG1 discs, large homolog 1 (Drosophila) 0.482
SH3BP2 SH3-domain binding protein 2 0.481
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 0.479
CD6 CD6 molecule 0.478
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
ikzf1 IKAROS family zinc finger 1 (Ikaros) 0.386
fgf3 fibroblast growth factor 3 0.331
mcm5 MCM5 minichromosome maintenance deficient 5 (S. cerevisiae) 0.320
mafba v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian) 0.308
fgf8a fibroblast growth factor 8 a 0.253
ets1a v-ets erythroblastosis virus E26 oncogene homolog 1a 0.233
egr2b early growth response 2b 0.222
mmp9 matrix metalloproteinase 9 0.197
hspa5 heat shock protein 5 0.176
cdx4 caudal type homeo box transcription factor 4 0.160
fgfr1b fibroblast growth factor receptor 1b 0.155
runx2a runt-related transcription factor 2a 0.124
gata1a GATA binding protein 1a 0.123
cxcr4b chemokine (C-X-C motif), receptor 4b 0.098
rspo3 R-spondin 3 homolog (Xenopus laevis) 0.097
dlc deltaC 0.091
tp63 tumor protein p63 0.088
il7r interleukin 7 receptor 0.076
sfrp5 secreted frizzled-related protein 5 0.075
wasb Wiskott-Aldrich syndrome (eczema-thrombocytopenia) b 0.068
cd63 Cd63 antigen 0.058
kita kit receptor a 0.055
nap1l1 nucleosome assembly protein 1, like 1 0.048
runx3 runt-related transcription factor 3 0.045
tp53 tumor protein p53 0.045
lcp1 lymphocyte cytosolic plastin 1 0.043
csrp1a cysteine and glycine-rich protein 1a 0.043
epha4a eph receptor A4a 0.042
tbx1 T-box 1 0.040
lmo4a LIM domain only 4a 0.040
chtf18 CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae) 0.039
nrp2b neuropilin 2b 0.037
mll myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) 0.037
capns1b calpain, small subunit 1 b 0.036
spi1 spleen focus forming virus (SFFV) proviral integration oncogene spi1 0.036
elk4 ELK4, ETS-domain protein 0.035
cmyb transcription factor cmyb 0.033
pglyrp5 peptidoglycan recognition protein 5 0.033
bmp2b bone morphogenetic protein 2b 0.032
cxcr4a chemokine (C-X-C motif) receptor 4a 0.032
erbb3b v-erb-b2 erythroblastic leukemia viral oncogene homolog 3b 0.031
cbfb core-binding factor, beta subunit 0.030
dld deltaD 0.028
cldne claudin e 0.028
tlr2 toll-like receptor 2 0.028
hspa9 heat shock protein 9 0.028
wnt1 wingless-type MMTV integration site family, member 1 0.027
zgc:64115 zgc:64115 0.027
sb:cb472 sb:cb472 0.027
zgc:64051 zgc:64051 0.026
crip2 cysteine-rich protein 2 0.026
anxa1a annexin A1a 0.025
rpl7a ribosomal protein L7a 0.025
lft1 lefty1 0.025
odc1 ornithine decarboxylase 1 0.025
jak3 Janus kinase 3 (a protein tyrosine kinase, leukocyte) 0.024
ippk inositol 1,3,4,5,6-pentakisphosphate 2-kinase 0.024
twist1a twist1a 0.024
si:ch211-215h6.2 si:ch211-215h6.2 0.024
zfp36l1a zinc finger protein 36, C3H type-like 1a 0.023
fzd8a frizzled homolog 8a 0.023
wnt3 wingless-type MMTV integration site family, member 3 0.023
plagl2 pleiomorphic adenoma gene-like 2 0.022
spry2 sprouty homolog 2 0.022
si:dkey-27i16.2 si:dkey-27i16.2 0.022
coro1a coronin, actin binding protein, 1A 0.022
pcdh18b protocadherin 18b 0.021
btk Bruton agammaglobulinemia tyrosine kinase 0.021
irx7 iroquois homeobox protein 7 0.021
foxa2 forkhead box A2 0.020
ryk receptor-like tyrosine kinase 0.020
chd chordin 0.020
ighm immunoglobulin heavy constant mu and immunoglobulin heavy constant mu 0.020
pola2 polymerase (DNA directed), alpha 2 0.020
impdh1b inosine 5'-phosphate dehydrogenase 1b 0.020
tlr3 toll-like receptor 3 0.019
raraa retinoic acid receptor, alpha a 0.019
zgc:56039 zgc:56039 0.019
ccnd1 cyclin D1 0.019
axin2 axin 2 (conductin, axil) 0.018
rac2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) 0.018
dag1 dystroglycan 1 0.018
hsd17b2 hydroxysteroid (17-beta) dehydrogenase 2 0.018
myca myelocytomatosis oncogene a 0.018
cd8a CD8 antigen, alpha polypeptide 0.018
mt2 metallothionein 2 0.018
camk2g1 calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma 1 0.018
rpl23a ribosomal protein L23a 0.018
her1 hairy-related 1 0.018
osr1 odd-skipped related 1 (Drosophila) 0.017
pfn1 profilin 1 0.017
lef1 lymphocyte enhancer binding factor 1 0.016
polr2d polymerase (RNA) II (DNA directed) polypeptide D 0.016
tnfa tumor necrosis factor a (TNF superfamily, member 2) 0.016
LOC100003514 protein kinase C alpha type-like 0.016
otx1b orthodenticle homolog 1b 0.016
rtn1a reticulon 1a 0.016
dnmt4 DNA (cytosine-5-)-methyltransferase 4 0.016
pax5 paired box gene 5 0.016
efna2 ephrin A2 0.016
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
RT1-Ba RT1 class II, locus Ba 0.777
Cd247 Cd247 molecule 0.761
RT1-Da RT1 class II, locus Da 0.720
St8sia4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 0.700
Ptafr platelet-activating factor receptor 0.658
Cd2 Cd2 molecule 0.646
Gzmk granzyme K 0.599
Anxa2 annexin A2 0.531
Il1b interleukin 1 beta 0.502
Cd74 Cd74 molecule, major histocompatibility complex, class II invariant chain 0.498
Fgr Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 0.405
Cd5 Cd5 molecule 0.403
Arhgap4 Rho GTPase activating protein 4 0.358
Ptprc protein tyrosine phosphatase, receptor type, C 0.350
Ccr5 chemokine (C-C motif) receptor 5 0.334
Lcp2 lymphocyte cytosolic protein 2 0.324
Laptm5 lysosomal protein transmembrane 5 0.300
Bin2 bridging integrator 2 0.275
Cd37 CD37 molecule 0.263
Slc5a2 solute carrier family 5 (sodium/glucose cotransporter), member 2 0.222
Mvp major vault protein 0.218
Pik3cd phosphoinositide-3-kinase, catalytic, delta polypeptide 0.213
Sell selectin L 0.204
Plcg2 phospholipase C, gamma 2 0.198
Ptger4 prostaglandin E receptor 4 (subtype EP4) 0.189
Ciita class II, major histocompatibility complex, transactivator 0.188
Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.184
Rassf5 Ras association (RalGDS/AF-6) domain family member 5 0.182
Cd86 CD86 molecule 0.180
Cd3g CD3 molecule, gamma 0.173
Spn sialophorin 0.172
Ccl5 chemokine (C-C motif) ligand 5 0.162
Il10 interleukin 10 0.149
Prf1 perforin 1 (pore forming protein) 0.142
Csf1 colony stimulating factor 1 (macrophage) 0.141
Nkg7 natural killer cell group 7 sequence 0.141
Fgfr2 fibroblast growth factor receptor 2 0.139
Ctsl1 cathepsin L1 0.138
Grin2a glutamate receptor, ionotropic, N-methyl D-aspartate 2A 0.138
Slc8a3 solute carrier family 8 (sodium/calcium exchanger), member 3 0.133
Acap1 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 0.133
Ccr2 chemokine (C-C motif) receptor 2 0.132
Il2rb interleukin 2 receptor, beta 0.132
Casp1 caspase 1 0.131
Reg3g regenerating islet-derived 3 gamma 0.131
Cxcr4 chemokine (C-X-C motif) receptor 4 0.130
Cxcr3 chemokine (C-X-C motif) receptor 3 0.129
Il2ra interleukin 2 receptor, alpha 0.127
Ets1 v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) 0.126
Cd4 Cd4 molecule 0.125
Clec9a C-type lectin domain family 9, member a 0.122
RT1-Db1 RT1 class II, locus Db1 0.121
Slfn2 schlafen 2 0.115
Syt8 synaptotagmin VIII 0.115
Il6st interleukin 6 signal transducer 0.112
Ptger2 prostaglandin E receptor 2 (subtype EP2) 0.107
Inpp5d inositol polyphosphate-5-phosphatase D 0.106
Gimap4 GTPase, IMAP family member 4 0.106
Ly86 lymphocyte antigen 86 0.104
Creb1 cAMP responsive element binding protein 1 0.102
Hck hemopoietic cell kinase 0.098
Il1r1 interleukin 1 receptor, type I 0.096
Myo1f myosin IF 0.093
Gfra2 GDNF family receptor alpha 2 0.093
Ctsb cathepsin B 0.090
Gpr114 G protein-coupled receptor 114 0.090
Lypd3 Ly6/Plaur domain containing 3 0.088
Lyz2 lysozyme 2 0.087
Hspe1 heat shock protein 1 (chaperonin 10) 0.086
Acvr1b activin A receptor, type IB 0.085
Ccl4 chemokine (C-C motif) ligand 4 0.083
RGD1559588 similar to cell surface receptor FDFACT 0.082
Prss27 protease, serine 27 0.080
Mmp10 matrix metallopeptidase 10 0.078
Inhbe inhibin beta E 0.077
Hcst hematopoietic cell signal transducer 0.077
Cmtm3 CKLF-like MARVEL transmembrane domain containing 3 0.076
Itgad integrin, alpha D 0.076
Fcgr3a Fc fragment of IgG, low affinity IIIa, receptor 0.076
Vcam1 vascular cell adhesion molecule 1 0.073
Plek pleckstrin 0.071
Pde3a phosphodiesterase 3A, cGMP inhibited 0.071
Tnfrsf14 tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) 0.070
Il18 interleukin 18 0.069
Sh2d2a SH2 domain protein 2A 0.069
Ripk1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.069
Slc28a3 solute carrier family 28 (sodium-coupled nucleoside transporter), member 3 0.069
Il1rn interleukin 1 receptor antagonist 0.069
Gckr glucokinase (hexokinase 4) regulator 0.069
Mylk2 myosin light chain kinase 2 0.069
Nos3 nitric oxide synthase 3, endothelial cell 0.068
Cfp complement factor properdin 0.068
Zbp1 Z-DNA binding protein 1 0.068
Calcr calcitonin receptor 0.067
Tnfrsf4 tumor necrosis factor receptor superfamily, member 4 0.066
Atp2a3 ATPase, Ca++ transporting, ubiquitous 0.066
Fcrla Fc receptor-like A 0.066
Mgat5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.064
Map4k1 mitogen activated protein kinase kinase kinase kinase 1 0.063
Gata6 GATA binding protein 6 0.063
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism