The network for 'hemopoiesis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

hemopoiesis

The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates.

Homo sapiens
Name Description Probability Func Analog Organism
GRB2 growth factor receptor-bound protein 2 1.000
TRAF1 TNF receptor-associated factor 1 0.998
JUN jun proto-oncogene 0.993
SMAD2 SMAD family member 2 0.992
LCK lymphocyte-specific protein tyrosine kinase 0.987
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.987
NCOR2 nuclear receptor corepressor 2 0.987
RUNX1 runt-related transcription factor 1 0.983
BIRC3 baculoviral IAP repeat containing 3 0.981
UBE2I ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 0.979
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.974
SYK spleen tyrosine kinase 0.972
IL4R interleukin 4 receptor 0.961
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.957
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.950
TP53 tumor protein p53 0.947
ICAM1 intercellular adhesion molecule 1 0.940
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.932
B2M beta-2-microglobulin 0.924
CCL4 chemokine (C-C motif) ligand 4 0.923
JUNB jun B proto-oncogene 0.918
CCR5 chemokine (C-C motif) receptor 5 0.918
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.918
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.912
TAL1 T-cell acute lymphocytic leukemia 1 0.911
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.903
IL2RB interleukin 2 receptor, beta 0.892
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.885
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 0.885
TRAF2 TNF receptor-associated factor 2 0.882
MLL myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) 0.882
VEGFA vascular endothelial growth factor A 0.879
CFLAR CASP8 and FADD-like apoptosis regulator 0.877
HIST1H2BD histone cluster 1, H2bd 0.874
CCL5 chemokine (C-C motif) ligand 5 0.873
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.869
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 0.866
NCOR1 nuclear receptor corepressor 1 0.866
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.861
CD86 CD86 molecule 0.859
HDAC3 histone deacetylase 3 0.858
NOTCH1 notch 1 0.856
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.853
CD40 CD40 molecule, TNF receptor superfamily member 5 0.846
KLF4 Kruppel-like factor 4 (gut) 0.841
BRCA1 breast cancer 1, early onset 0.838
EGFR epidermal growth factor receptor 0.834
IRF1 interferon regulatory factor 1 0.834
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.832
FGFR1 fibroblast growth factor receptor 1 0.823
TNF tumor necrosis factor 0.816
CCR7 chemokine (C-C motif) receptor 7 0.814
ESR1 estrogen receptor 1 0.806
SIN3A SIN3 homolog A, transcription regulator (yeast) 0.799
IL8 interleukin 8 0.795
CAV1 caveolin 1, caveolae protein, 22kDa 0.793
HIST1H3D histone cluster 1, H3d 0.793
HLA-C major histocompatibility complex, class I, C 0.787
ANXA1 annexin A1 0.786
SMAD3 SMAD family member 3 0.785
SLAMF1 signaling lymphocytic activation molecule family member 1 0.778
HDAC1 histone deacetylase 1 0.765
PBX1 pre-B-cell leukemia homeobox 1 0.762
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.758
GATA1 GATA binding protein 1 (globin transcription factor 1) 0.753
JAG1 jagged 1 0.753
PRPF38A PRP38 pre-mRNA processing factor 38 (yeast) domain containing A 0.750
MYC v-myc myelocytomatosis viral oncogene homolog (avian) 0.748
FOS FBJ murine osteosarcoma viral oncogene homolog 0.747
SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 0.739
LAT linker for activation of T cells 0.737
HIST1H2AE histone cluster 1, H2ae 0.737
CRK v-crk sarcoma virus CT10 oncogene homolog (avian) 0.732
IL10RA interleukin 10 receptor, alpha 0.731
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 0.726
FASLG Fas ligand (TNF superfamily, member 6) 0.721
XIAP X-linked inhibitor of apoptosis 0.718
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.714
VAV1 vav 1 guanine nucleotide exchange factor 0.712
SPI1 spleen focus forming virus (SFFV) proviral integration oncogene spi1 0.712
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain 0.710
HIST1H2BG histone cluster 1, H2bg 0.708
SH2D1A SH2 domain containing 1A 0.706
TCF12 transcription factor 12 0.692
HIST1H1C histone cluster 1, H1c 0.691
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.684
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.683
HLA-G major histocompatibility complex, class I, G 0.683
ZNF43 zinc finger protein 43 0.681
CXCL10 chemokine (C-X-C motif) ligand 10 0.666
HIPK2 homeodomain interacting protein kinase 2 0.658
GATA2 GATA binding protein 2 0.658
DAXX death-domain associated protein 0.652
CD80 CD80 molecule 0.641
TGFB1 transforming growth factor, beta 1 0.639
HLA-B major histocompatibility complex, class I, B 0.633
PPARA peroxisome proliferator-activated receptor alpha 0.632
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 0.628
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.612
RIPK2 receptor-interacting serine-threonine kinase 2 0.608
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
Loading network...
Danio rerio
Name Description Probability Func Analog Organism
cmyb transcription factor cmyb 1.000
tal1 T-cell acute lymphocytic leukemia 1 0.999
gata1a GATA binding protein 1a 0.999
kdrl kinase insert domain receptor like 0.994
runx1 runt-related transcription factor 1 0.994
tfr1a transferrin receptor 1a 0.993
notch3 notch homolog 3 0.992
alas2 aminolevulinate, delta-, synthetase 2 0.991
bmp2b bone morphogenetic protein 2b 0.990
LOC566708 FL cytokine receptor-like 0.978
hbbe1.1 hemoglobin beta embryonic-1.1 0.968
plcg1 phospholipase C, gamma 1 0.962
dla deltaA 0.962
ikzf1 IKAROS family zinc finger 1 (Ikaros) 0.956
gata6 GATA-binding protein 6 0.950
mafba v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian) 0.948
cdx4 caudal type homeo box transcription factor 4 0.940
hbbe3 hemoglobin beta embryonic-3 0.936
tbx1 T-box 1 0.936
urod uroporphyrinogen decarboxylase 0.920
hoxd4a homeo box D4a 0.896
ets1a v-ets erythroblastosis virus E26 oncogene homolog 1a 0.895
smad5 MAD homolog 5 (Drosophila) 0.882
ccnd1 cyclin D1 0.879
hhex hematopoietically expressed homeobox 0.873
tgfb3 transforming growth factor, beta 3 0.871
hbae1 hemoglobin alpha embryonic-1 0.855
gdf6a growth differentiation factor 6a 0.850
LOC100151531 zinc finger protein Gfi-1b-like 0.847
gata5 GATA-binding protein 5 0.844
rag1 recombination activating gene 1 0.840
osr1 odd-skipped related 1 (Drosophila) 0.840
dlc deltaC 0.835
etv2 ets variant gene 2 0.833
f2r coagulation factor II (thrombin) receptor 0.831
hhip hedgehog interacting protein 0.822
dlb deltaB 0.820
pax2a paired box gene 2a 0.816
ptenb phosphatase and tensin homolog B (mutated in multiple advanced cancers 1) 0.811
pdcd2 programmed cell death 2 0.798
pitx2 paired-like homeodomain transcription factor 2 0.795
tll1 tolloid-like 1 0.782
trpv6 transient receptor potential cation channel, subfamily V, member 6 0.779
hand2 heart and neural crest derivatives expressed transcript 2 0.777
hbaa1 hemoglobin alpha adult-1 0.772
npm1 nucleophosmin 1 0.766
rpl36a ribosomal protein L36A 0.765
notch1a notch homolog 1a 0.759
slc4a1a solute carrier family 4, anion exchanger, member 1a 0.758
epb41 erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked) 0.757
fgf10a fibroblast growth factor 10a 0.757
ddx18 DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 0.751
dld deltaD 0.738
slc25a37 solute carrier family 25, member 37 0.734
gata2a GATA-binding protein 2a 0.725
hbae3 hemoglobin alpha embryonic-3 0.707
gsna gelsolin a 0.701
wnt2bb wingless-type MMTV integration site family, member 2Bb 0.684
cfl2l cofilin 2, like 0.681
rhag Rhesus blood group-associated glycoprotein 0.678
wnt7ba wingless-type MMTV integration site family, member 7Ba 0.670
atp2b1a ATPase, Ca++ transporting, plasma membrane 1a 0.665
tp53 tumor protein p53 0.664
met met proto-oncogene (hepatocyte growth factor receptor) 0.663
hnf1ba HNF1 homeobox Ba 0.662
rpl22l1 ribosomal protein L22-like 1 0.657
il7r interleukin 7 receptor 0.656
acvr1l activin A receptor, type I like 0.656
hdr hematopoietic death receptor 0.652
mef2ca myocyte enhancer factor 2ca 0.648
ndr2 nodal-related 2 0.648
mll myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) 0.643
tpm4 tropomyosin 4 0.636
aplnrb apelin receptor b 0.631
cebpa CCAAT/enhancer binding protein (C/EBP), alpha 0.625
fras1 Fraser syndrome 1 0.625
cpox coproporphyrinogen oxidase 0.622
tbx6 T-box gene 6 0.609
nrarpa notch-regulated ankyrin repeat protein a 0.604
tbx24 T-box 24 0.602
rpl11 ribosomal protein L11 0.600
fgf3 fibroblast growth factor 3 0.583
klf4 Kruppel-like factor 4 0.562
cdh5 cadherin 5 0.561
fgf8a fibroblast growth factor 8 a 0.560
tmem88a transmembrane protein 88 a 0.557
pkp1 plakophilin 1 0.555
ldb2a LIM-domain binding factor 2a 0.551
igf1rb insulin-like growth factor 1b receptor 0.547
spry4 sprouty (Drosophila) homolog 4 0.544
sox2 SRY-box containing gene 2 0.540
spint1a serine peptidase inhibitor, Kunitz type 1 a 0.538
fn1 fibronectin 1 0.537
sulf1 sulfatase 1 0.527
znfl2a zinc finger-like gene 2a 0.523
tie1 endothelium-specific receptor tyrosine kinase 1 0.516
trim33 tripartite motif-containing 33 0.514
haus3 HAUS augmin-like complex, subunit 3 0.510
cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.507
foxi1 forkhead box I1 0.505
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
dpp decapentaplegic 0.976
tkv thickveins 0.908
Rac1 CG2248 gene product from transcript CG2248-RA 0.905
N Notch 0.879
ci cubitus interruptus 0.876
shn schnurri 0.859
Sin3A CG8815 gene product from transcript CG8815-RC 0.768
Tl Toll 0.760
drk downstream of receptor kinase 0.737
da daughterless 0.719
rap retina aberrant in pattern 0.710
rho rhomboid 0.664
Pvr PDGF- and VEGF-receptor related 0.583
nmo nemo 0.571
twi twist 0.571
put punt 0.477
Atg1 Autophagy-specific gene 1 0.461
srp serpent 0.459
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.431
dome domeless 0.430
Src64B Src oncogene at 64B 0.390
cup CG11181 gene product from transcript CG11181-RB 0.372
CtBP C-terminal Binding Protein 0.371
dom domino 0.366
bsk basket 0.326
Smox Smad on X 0.325
aop anterior open 0.321
Rala Ras-related protein 0.311
Rel Relish 0.304
ct cut 0.301
corto CG2530 gene product from transcript CG2530-RA 0.298
E(spl) Enhancer of split 0.296
Dad Daughters against dpp 0.290
krz kurtz 0.286
Dsor1 Downstream of raf1 0.272
Dcr-2 Dicer-2 0.264
os outstretched 0.252
fs(1)N female sterile (1) Nasrat 0.245
argos CG4531 gene product from transcript CG4531-RA 0.242
ush u-shaped 0.221
scb scab 0.218
mys myospheroid 0.203
tsr twinstar 0.199
ap apterous 0.198
rl rolled 0.194
pum pumilio 0.188
robo roundabout 0.188
Hcf Host cell factor 0.185
InR Insulin-like receptor 0.182
rin rasputin 0.182
if inflated 0.175
klu klumpfuss 0.175
Ptp69D Protein tyrosine phosphatase 69D 0.174
sd scalloped 0.169
rst roughest 0.168
osa CG7467 gene product from transcript CG7467-RD 0.158
zfh1 Zn finger homeodomain 1 0.151
Rac2 CG8556 gene product from transcript CG8556-RA 0.149
Imp IGF-II mRNA-binding protein 0.147
pic piccolo 0.142
tai taiman 0.137
RpL7A Ribosomal protein L7A 0.136
dos daughter of sevenless 0.136
lz lozenge 0.134
p120ctn Adherens junction protein p120 0.134
G-oalpha47A G protein oalpha 47A 0.130
Hsf Heat shock factor 0.127
tefu telomere fusion 0.127
Rab11 Rab-protein 11 0.126
Mnn1 Menin 1 0.124
S6kII RPS6-protein kinase-II 0.122
HLHmdelta E(spl) region transcript mdelta 0.122
ed echinoid 0.119
Dcp-1 Death caspase-1 0.119
Mrtf Myocardin-related transcription factor 0.119
HLHm3 E(spl) region transcript m3 0.117
Egfr Epidermal growth factor receptor 0.117
HLHmgamma E(spl) region transcript mgamma 0.115
mbc myoblast city 0.115
fas faint sausage 0.110
rpr reaper 0.109
wg wingless 0.107
tin tinman 0.106
kis kismet 0.105
dm diminutive 0.103
hipk homeodomain interacting protein kinase 0.100
unc-13 CG2999 gene product from transcript CG2999-RA 0.097
fw furrowed 0.096
crb crumbs 0.096
Mad Mothers against dpp 0.096
CG5794 CG5794 gene product from transcript CG5794-RB 0.095
babo baboon 0.094
slp1 sloppy paired 1 0.094
kuz kuzbanian 0.092
CG10414 CG10414 gene product from transcript CG10414-RA 0.092
debcl death executioner Bcl-2 homologue 0.089
Traf4 TNF-receptor-associated factor 4 0.089
RASSF8 CG5053 gene product from transcript CG5053-RA 0.088
sxc super sex combs 0.088
for foraging 0.088
Loading network...
Mus musculus
Name Description Probability Func Analog Organism
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
Dusp1 dual specificity phosphatase 1 0.419
Fgr Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 0.192
Cd74 Cd74 molecule, major histocompatibility complex, class II invariant chain 0.188
Ccl5 chemokine (C-C motif) ligand 5 0.182
Cd4 Cd4 molecule 0.173
Slco2b1 solute carrier organic anion transporter family, member 2b1 0.169
Jak1 Janus kinase 1 0.166
Cd37 CD37 molecule 0.139
Cd2 Cd2 molecule 0.108
Csf1r colony stimulating factor 1 receptor 0.092
RT1-Ba RT1 class II, locus Ba 0.090
Rgs1 regulator of G-protein signaling 1 0.090
Dusp6 dual specificity phosphatase 6 0.078
Ccl4 chemokine (C-C motif) ligand 4 0.076
Cd247 Cd247 molecule 0.073
Itpkb inositol 1,4,5-trisphosphate 3-kinase B 0.070
Hck hemopoietic cell kinase 0.070
LOC287167 globin, alpha 0.070
Prrx1 paired related homeobox 1 0.069
Barhl2 BarH-like homeobox 2 0.068
Cfp complement factor properdin 0.067
Acacb acetyl-Coenzyme A carboxylase beta 0.067
Zfp36 zinc finger protein 36 0.066
Utrn utrophin 0.063
Il2rb interleukin 2 receptor, beta 0.061
Igh-6 immunoglobulin heavy chain 6 0.061
Lyz2 lysozyme 2 0.061
Smad1 SMAD family member 1 0.059
Bmp6 bone morphogenetic protein 6 0.057
Mylk2 myosin light chain kinase 2 0.057
Tgfbr3 transforming growth factor, beta receptor III 0.057
Nfya nuclear transcription factor-Y alpha 0.056
Gzmk granzyme K 0.055
Tgfbr2 transforming growth factor, beta receptor II 0.055
Alox5 arachidonate 5-lipoxygenase 0.053
Ptpn18 protein tyrosine phosphatase, non-receptor type 18 0.052
Olr837 olfactory receptor 837 0.050
Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.050
Cdkn2b cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 0.049
Gdnf glial cell derived neurotrophic factor 0.049
Cd86 CD86 molecule 0.048
RT1-Da RT1 class II, locus Da 0.047
RT1-Db1 RT1 class II, locus Db1 0.046
Fos FBJ osteosarcoma oncogene 0.044
Fcer1g Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide 0.044
Btg2 BTG family, member 2 0.044
Laptm5 lysosomal protein transmembrane 5 0.044
Sec14l3 SEC14-like 3 (S. cerevisiae) 0.043
LOC689064 beta-globin 0.042
Inpp5d inositol polyphosphate-5-phosphatase D 0.042
Hbb-b1 hemoglobin, beta adult major chain 0.042
Acap1 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 0.042
Tcrb T-cell receptor beta chain 0.042
Mmp14 matrix metallopeptidase 14 (membrane-inserted) 0.041
Gja5 gap junction protein, alpha 5 0.041
Jak2 Janus kinase 2 0.041
Cd5 Cd5 molecule 0.039
Prf1 perforin 1 (pore forming protein) 0.039
Apol3 apolipoprotein L, 3 0.039
Faslg Fas ligand (TNF superfamily, member 6) 0.038
Lcp2 lymphocyte cytosolic protein 2 0.037
Apbb1ip amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein 0.037
LOC100134871 beta globin minor gene 0.036
Stat4 signal transducer and activator of transcription 4 0.035
Junb jun B proto-oncogene 0.035
Myo1f myosin IF 0.034
Smad7 SMAD family member 7 0.033
Serpinb1a serine (or cysteine) proteinase inhibitor, clade B, member 1a 0.033
Ccr5 chemokine (C-C motif) receptor 5 0.033
Man2b1 mannosidase, alpha, class 2B, member 1 0.033
Grb2 growth factor receptor bound protein 2 0.033
Zfp36l2 zinc finger protein 36, C3H type-like 2 0.033
Ly6b lymphocyte antigen 6 complex, locus B 0.033
Flt4 fms-related tyrosine kinase 4 0.032
Tcof1 Treacher Collins-Franceschetti syndrome 1 homolog (human) 0.032
LOC687711 similar to small nuclear ribonucleoprotein D3 0.032
Tap2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) 0.032
Egfr epidermal growth factor receptor 0.032
C1qa complement component 1, q subcomponent, A chain 0.031
Dcaf7 DDB1 and CUL4 associated factor 7 0.031
Slc10a2 solute carrier family 10 (sodium/bile acid cotransporter family), member 2 0.030
Errfi1 ERBB receptor feedback inhibitor 1 0.030
Abi3 ABI family, member 3 0.030
Cd180 CD180 molecule 0.030
Klf6 Kruppel-like factor 6 0.030
Cxcr3 chemokine (C-X-C motif) receptor 3 0.029
Nkg7 natural killer cell group 7 sequence 0.029
Grm5 glutamate receptor, metabotropic 5 0.029
Csf2rb colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 0.029
Mcpt3 mast cell peptidase 3 0.029
Cfd complement factor D (adipsin) 0.028
Akap1 A kinase (PRKA) anchor protein 1 0.028
Pip prolactin induced protein 0.028
Map4k1 mitogen activated protein kinase kinase kinase kinase 1 0.028
Cebpa CCAAT/enhancer binding protein (C/EBP), alpha 0.028
Prkch protein kinase C, eta 0.027
Prlh prolactin releasing hormone 0.027
Serpini2 serine (or cysteine) peptidase inhibitor, clade I, member 2 0.027
Sirpa signal-regulatory protein alpha 0.027
Dmd dystrophin 0.027
Loading network...
Saccharomyces cerevisiae
Name Description Probability Func Analog Organism