The network for 'pyrimidine containing compound metabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

pyrimidine containing compound metabolic process

The chemical reactions and pathways involving a pyrimidine-containing compound, i.e. any compound that contains pyrimidine or a formal derivative thereof.

Homo sapiens
Name Description Probability Func Analog Organism
NME1 non-metastatic cells 1, protein (NM23A) expressed in 0.440
ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase 0.100
NME3 non-metastatic cells 3, protein expressed in 0.068
NME4 non-metastatic cells 4, protein expressed in 0.043
NME2 non-metastatic cells 2, protein (NM23B) expressed in 0.040
SH3GL3 SH3-domain GRB2-like 3 0.028
POLR1C polymerase (RNA) I polypeptide C, 30kDa 0.025
MAPK3 mitogen-activated protein kinase 3 0.024
POLR2H polymerase (RNA) II (DNA directed) polypeptide H 0.022
SPG21 spastic paraplegia 21 (autosomal recessive, Mast syndrome) 0.020
NOP56 NOP56 ribonucleoprotein homolog (yeast) 0.019
PTPRO protein tyrosine phosphatase, receptor type, O 0.017
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor) 0.016
UCK2 uridine-cytidine kinase 2 0.016
GINS3 GINS complex subunit 3 (Psf3 homolog) 0.015
RPL38 ribosomal protein L38 0.014
MAPK14 mitogen-activated protein kinase 14 0.012
SH3GL2 SH3-domain GRB2-like 2 0.012
WDYHV1 WDYHV motif containing 1 0.011
ECH1 enoyl CoA hydratase 1, peroxisomal 0.011
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
nrf-5 Protein NRF-5 0.010
sar-1 Protein SAR-1 0.010
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Danio rerio
Name Description Probability Func Analog Organism
dhfr dihydrofolate reductase 0.314
mthfd1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 0.126
mki67ip mki67 (FHA domain) interacting nucleolar phosphoprotein (human) 0.123
mtr 5-methyltetrahydrofolate-homocysteine methyltransferase 0.105
ddx56 DEAD (Asp-Glu-Ala-Asp) box polypeptide 56 0.094
tyms thymidylate synthase 0.093
pold1 polymerase (DNA directed), delta 1, catalytic subunit 0.089
si:dkey-91i17.1 si:dkey-91i17.1 0.084
zgc:110847 zgc:110847 0.077
si:dkey-1h6.1 si:dkey-1h6.1 0.075
dnmt1 DNA (cytosine-5-)-methyltransferase 1 0.074
mapk3 mitogen-activated protein kinase 3 0.071
mthfd2l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like 0.068
slc25a32a solute carrier family 25, member 32a 0.066
rfc4 replication factor C (activator 1) 4 0.066
surf6 surfeit 6 0.065
pola2 polymerase (DNA directed), alpha 2 0.064
prim1 primase polypeptide 1 0.062
im:7148292 im:7148292 0.060
mthfd2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 0.058
nop58 NOP58 ribonucleoprotein homolog (yeast) 0.052
fbl fibrillarin 0.048
rrs1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 0.045
wdr75 WD repeat domain 75 0.045
zff9 zinc finger protein 9 0.044
nup43 nucleoporin 43 0.044
hspd1 heat shock 60kD protein 1 (chaperonin) 0.041
hells helicase, lymphoid-specific 0.039
rfc3 replication factor C (activator 1) 3 0.038
kpna2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) 0.038
aldh4a1 aldehyde dehydrogenase 4 family, member A1 0.036
ddx18 DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 0.033
trmt2a trm2 tRNA methyltransferase 2 homolog A (S. cerevisiae) 0.033
im:6898523 im:6898523 0.032
mcm5 MCM5 minichromosome maintenance deficient 5 (S. cerevisiae) 0.032
pgm3 phosphoglucomutase 3 0.031
zgc:56683 zgc:56683 0.030
pprc1 peroxisome proliferator-activated receptor gamma, coactivator-related 1 0.030
aldh7a1 aldehyde dehydrogenase 7 family, member A1 0.029
slc25a32b solute carrier family 25, member 32b 0.029
wdr12 WD repeat domain 12 0.027
rpl7l1 ribosomal protein L7-like 1 0.026
pdss1 prenyl (decaprenyl) diphosphate synthase, subunit 1 0.026
celsr1b cadherin EGF LAG seven-pass G-type receptor 1b 0.025
etf1 eukaryotic translation termination factor 1 0.025
bysl bystin-like 0.025
noc4l nucleolar complex associated 4 homolog (S. cerevisiae) 0.024
mapk12 mitogen-activated protein kinase 12 0.024
mre11a meiotic recombination 11 homolog A (S. cerevisiae) 0.023
impdh2 IMP (inosine monophosphate) dehydrogenase 2 0.023
zgc:112986 zgc:112986 0.022
mak16 MAK16 homolog (S. cerevisiae) 0.022
nol10 nucleolar protein 10 0.021
prdx2 peroxiredoxin 2 0.021
zgc:152830 zgc:152830 0.021
ncapg2 non-SMC condensin II complex, subunit G2 0.021
gins1 GINS complex subunit 1 (Psf1 homolog) 0.020
imp4 IMP4, U3 small nucleolar ribonucleoprotein, homolog (yeast) 0.020
noc3l nucleolar complex associated 3 homolog (S. cerevisiae) 0.020
mat1a methionine adenosyltransferase I, alpha 0.019
dpyd dihydropyrimidine dehydrogenase 0.019
msh6 mutS homolog 6 (E. coli) 0.019
pole2 polymerase (DNA directed), epsilon 2 0.019
polr1a polymerase (RNA) I polypeptide A 0.019
tomm40l translocase of outer mitochondrial membrane 40 homolog, like 0.018
dap3 death associated protein 3 0.018
ints6 integrator complex subunit 6 0.018
si:ch211-93f2.1 si:ch211-93f2.1 0.018
ahctf1 AT hook containing transcription factor 1 0.018
smc4 structural maintenance of chromosomes 4 0.017
LOC567547 5,10-methylenetetrahydrofolate reductase (NADPH)-like 0.017
smc2 structural maintenance of chromosomes 2 0.017
hist1h4l histone 1, H4, like 0.017
zgc:56429 zgc:56429 0.017
lap3 leucine aminopeptidase 3 0.017
snf8 SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae) 0.017
grwd1 glutamate-rich WD repeat containing 1 0.017
fen1 flap structure-specific endonuclease 1 0.017
si:dkey-25e12.5 si:dkey-25e12.5 0.017
nr1h5 nuclear receptor subfamily 1, group H, member 5 0.017
bicc2 bicaudal C homolog 2 0.017
slc10a2 solute carrier family 10 (sodium/bile acid cotransporter family), member 2 0.016
nfe2l1 nuclear factor, erythroid derived 2,-like 1 0.016
gart phosphoribosylglycinamide formyltransferase 0.016
pola1 polymerase (DNA directed), alpha 1 0.016
nasp nuclear autoantigenic sperm protein (histone-binding) 0.016
cyp4t8 cytochrome P450, family 4, subfamily T, polypeptide 8 0.016
cyfip2 cytoplasmic FMR1 interacting protein 2 0.016
mtx1b metaxin 1b 0.016
mapk6 mitogen-activated protein kinase 6 0.015
sypl2a synaptophysin-like 2a 0.015
pdia2 protein disulfide isomerase family A, member 2 0.015
si:ch211-89f7.4 si:ch211-89f7.4 0.015
srpr signal recognition particle receptor (docking protein) 0.015
sult1st3 sulfotransferase family 1, cytosolic sulfotransferase 3 0.015
acy3.2 aspartoacylase (aminocyclase) 3.2 0.015
rrm1 ribonucleotide reductase M1 polypeptide 0.015
slc9a3r1 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 0.015
mapk7 mitogen-activated protein kinase 7 0.015
ftcd formiminotransferase cyclodeaminase 0.015
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Chpt1 choline phosphotransferase 1 0.183
Gtf2a1 general transcription factor II A, 1 0.173
Mcm4 minichromosome maintenance deficient 4 homolog (S. cerevisiae) 0.108
Mapk1 mitogen-activated protein kinase 1 0.098
Tdg thymine DNA glycosylase 0.083
Tymp thymidine phosphorylase 0.075
Sykb spleen tyrosine kinase 0.074
Dusp6 dual specificity phosphatase 6 0.068
Atf2 activating transcription factor 2 0.058
Pea15a phosphoprotein enriched in astrocytes 15A 0.057
Mapk3 mitogen-activated protein kinase 3 0.045
Lbr lamin B receptor 0.044
Nup93 nucleoporin 93 0.041
Fads2 fatty acid desaturase 2 0.040
Igh immunoglobulin heavy chain complex 0.034
Hspa14 heat shock protein 14 0.031
Tfdp1 transcription factor Dp 1 0.030
Pafah1b2 platelet-activating factor acetylhydrolase, isoform 1b, subunit 2 0.024
Nprl3 nitrogen permease regulator-like 3 (S. cerevisiae) 0.023
Sp3 trans-acting transcription factor 3 0.022
Acad11 acyl-Coenzyme A dehydrogenase family, member 11 0.021
Cat catalase 0.021
Srm spermidine synthase 0.020
Sqstm1 sequestosome 1 0.019
Mcm7 minichromosome maintenance deficient 7 (S. cerevisiae) 0.019
Prdm1 PR domain containing 1, with ZNF domain 0.018
Ptpn22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 0.018
Siae sialic acid acetylesterase 0.018
Mut methylmalonyl-Coenzyme A mutase 0.016
Nupl1 nucleoporin like 1 0.016
Fen1 flap structure specific endonuclease 1 0.016
Snrnp40 small nuclear ribonucleoprotein 40 (U5) 0.015
Ivd isovaleryl coenzyme A dehydrogenase 0.015
D030056L22Rik RIKEN cDNA D030056L22 gene 0.015
Lancl2 LanC (bacterial lantibiotic synthetase component C)-like 2 0.014
Tiprl TIP41, TOR signalling pathway regulator-like (S. cerevisiae) 0.014
Esr1 estrogen receptor 1 (alpha) 0.014
Wdr77 WD repeat domain 77 0.013
Rpa1 replication protein A1 0.013
Ehhadh enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase 0.012
Acadm acyl-Coenzyme A dehydrogenase, medium chain 0.012
Ywhah tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide 0.012
Acadsb acyl-Coenzyme A dehydrogenase, short/branched chain 0.011
Mknk2 MAP kinase-interacting serine/threonine kinase 2 0.011
Ddx39 DEAD (Asp-Glu-Ala-Asp) box polypeptide 39 0.011
Fbxo8 F-box protein 8 0.010
Rora RAR-related orphan receptor alpha 0.010
Slc25a16 solute carrier family 25 (mitochondrial carrier, Graves disease autoantigen), member 16 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism
Ns5atp9 NS5A (hepatitis C virus) transactivated protein 9 0.038
Rfc3 replication factor C (activator 1) 3 0.031
Prim1 DNA primase, p49 subunit 0.031
Nhp2 NHP2 ribonucleoprotein homolog (yeast) 0.029
Dad1 defender against cell death 1 0.029
Ccnb1 cyclin B1 0.028
Mcm3 minichromosome maintenance complex component 3 0.024
Mcm6 minichromosome maintenance complex component 6 0.022
Dhfr dihydrofolate reductase 0.020
Mcm2 minichromosome maintenance complex component 2 0.018
Hypk Huntingtin interacting protein K 0.018
Pgam1 phosphoglycerate mutase 1 (brain) 0.018
Stmn1 stathmin 1 0.018
Mcm5 minichromosome maintenance complex component 5 0.018
Fen1 flap structure-specific endonuclease 1 0.017
Dnajc9 DnaJ (Hsp40) homolog, subfamily C, member 9 0.017
Mcm4 minichromosome maintenance complex component 4 0.017
Atp5g1 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C1 (subunit 9) 0.017
Cdca7 cell division cycle associated 7 0.016
Pdia6 protein disulfide isomerase family A, member 6 0.016
Rrm1 ribonucleotide reductase M1 0.016
Rsad2 radical S-adenosyl methionine domain containing 2 0.015
Psmd13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 0.015
Sec61b Sec61 beta subunit 0.015
Tomm6 translocase of outer mitochondrial membrane 6 homolog (yeast) 0.015
Rpl14 ribosomal protein L14 0.015
Snf8 SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae) 0.014
Ube2c ubiquitin-conjugating enzyme E2C 0.014
Chmp5 chromatin modifying protein 5 0.014
Trip13 thyroid hormone receptor interactor 13 0.014
Rfc4 replication factor C (activator 1) 4 0.013
Bscl2 Bernardinelli-Seip congenital lipodystrophy 2 homolog (human) 0.013
Fam173a family with sequence similarity 173, member A 0.012
Top2a topoisomerase (DNA) II alpha 0.012
Kifc1 kinesin family member C1 0.012
Tcf19 transcription factor 19 0.012
RGD620382 Nucleoside 2-deoxyribosyltransferase domain containing protein RGD620382 0.012
Ppil3 peptidylprolyl isomerase (cyclophilin)-like 3 0.012
Tk1 thymidine kinase 1, soluble 0.012
Timeless timeless homolog (Drosophila) 0.012
Grpel1 GrpE-like 1, mitochondrial 0.012
Bysl bystin-like 0.011
Tsen34 tRNA splicing endonuclease 34 homolog (S. cerevisiae) 0.011
Cox8a cytochrome c oxidase subunit VIIIa 0.011
RGD1562987 similar to cDNA sequence BC031181 0.011
Apex1 APEX nuclease (multifunctional DNA repair enzyme) 1 0.011
Adhfe1 alcohol dehydrogenase, iron containing, 1 0.011
Hspd1 heat shock protein 1 (chaperonin) 0.011
Isoc1 isochorismatase domain containing 1 0.010
Mad2l1 MAD2 mitotic arrest deficient-like 1 (yeast) 0.010
Hsd17b12 hydroxysteroid (17-beta) dehydrogenase 12 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
THI20 Thi20p 0.925
THI2 Thi2p 0.904
THI3 Thi3p 0.838
RRP1 Rrp1p 0.415
THI13 Thi13p 0.413
YNL010W hypothetical protein 0.289
THI5 Thi5p 0.264
URA5 Ura5p 0.261
DFR1 Dfr1p 0.227
PET18 Pet18p 0.200
THI12 Thi12p 0.179
THI73 Thi73p 0.178
THI21 Thi21p 0.175
PMI40 Pmi40p 0.164
ERB1 Erb1p 0.159
ALG14 Alg14p 0.145
DAS2 Das2p 0.144
YEL073C hypothetical protein 0.137
GUK1 Guk1p 0.134
TAD3 Tad3p 0.126
YAH1 Yah1p 0.123
RPB8 Rpb8p 0.117
INM1 Inm1p 0.113
THI11 Thi11p 0.113
SNZ2 Snz2p 0.107
MDN1 Mdn1p 0.107
BNA2 Bna2p 0.105
MNE1 Mne1p 0.104
DPH5 Dph5p 0.104
THI6 Thi6p 0.103
TUB3 Tub3p 0.099
IMD2 Imd2p 0.097
PRS1 Prs1p 0.093
PDC2 Pdc2p 0.092
YFL040W hypothetical protein 0.089
THG1 Thg1p 0.085
SIL1 Sil1p 0.083
GIT1 Git1p 0.082
YNL024C hypothetical protein 0.081
TMA20 Tma20p 0.078
FUS3 Fus3p 0.078
RMA1 Rma1p 0.078
SPE4 Spe4p 0.074
YMR321C hypothetical protein 0.074
URA3 Ura3p 0.072
SQT1 Sqt1p 0.067
HLR1 Hlr1p 0.066
NOP7 Nop7p 0.064
NUC1 Nuc1p 0.064
SNO3 Sno3p 0.062
YGK3 Ygk3p 0.060
KTI12 Kti12p 0.060
YDL157C hypothetical protein 0.060
SRD1 Srd1p 0.058
AAD14 Aad14p 0.057
YDR370C hypothetical protein 0.057
URA4 Ura4p 0.056
YPR127W hypothetical protein 0.056
YOL038C-A hypothetical protein 0.056
YGR201C hypothetical protein 0.055
NIP7 Nip7p 0.055
POM34 Pom34p 0.055
GYL1 Gyl1p 0.054
YPL245W hypothetical protein 0.053
YDR341C hypothetical protein 0.053
RBG2 Rbg2p 0.053
ZPS1 Zps1p 0.052
TCA17 Tca17p 0.052
YLR264C-A hypothetical protein 0.052
YIR035C hypothetical protein 0.051
YNL108C hypothetical protein 0.051
YLR042C hypothetical protein 0.051
IRC23 Irc23p 0.051
URA2 Ura2p 0.051
PSF2 Psf2p 0.050
SNO2 Sno2p 0.050
THI4 Thi4p 0.049
SSP1 Ssp1p 0.049
DBP5 Dbp5p 0.049
HTS1 Hts1p 0.049
ACM1 Acm1p 0.048
MF(ALPHA)2 Mf(alpha)2p 0.048
PCK1 Pck1p 0.048
ARP10 Arp10p 0.047
KTR5 Ktr5p 0.047
YEH2 Yeh2p 0.047
REX2 Rex2p 0.046
ADH2 Adh2p 0.046
CLB6 Clb6p 0.046
AIM20 Aim20p 0.046
YLR126C hypothetical protein 0.045
LEU2 Leu2p 0.045
SEN2 Sen2p 0.045
DTD1 Dtd1p 0.045
RKI1 Rki1p 0.045
YET2 Yet2p 0.044
YAR023C hypothetical protein 0.044
PMT3 Pmt3p 0.043
TAE1 Tae1p 0.042
YGR079W hypothetical protein 0.042