The network for 'positive regulation of tumor necrosis factor superfamily cytokine production' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of tumor necrosis factor superfamily cytokine production

Any process that activates or increases the frequency, rate or extent of tumor necrosis factor superfamily cytokine production.

Homo sapiens
Name Description Probability Func Analog Organism
BIRC3 baculoviral IAP repeat containing 3 1.000
TRAF1 TNF receptor-associated factor 1 0.999
RIPK2 receptor-interacting serine-threonine kinase 2 0.999
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.998
TRAF2 TNF receptor-associated factor 2 0.995
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein 0.985
BIRC2 baculoviral IAP repeat containing 2 0.966
TRAF3 TNF receptor-associated factor 3 0.959
TRADD TNFRSF1A-associated via death domain 0.932
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.918
MYD88 myeloid differentiation primary response gene (88) 0.901
CASP1 caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) 0.831
TLR2 toll-like receptor 2 0.810
CXCL10 chemokine (C-X-C motif) ligand 10 0.795
SYK spleen tyrosine kinase 0.794
CCL5 chemokine (C-C motif) ligand 5 0.750
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 0.673
TLR4 toll-like receptor 4 0.655
IL8 interleukin 8 0.609
IL12B interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) 0.604
CXCL2 chemokine (C-X-C motif) ligand 2 0.575
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.559
CXCL3 chemokine (C-X-C motif) ligand 3 0.488
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 0.478
CXCL11 chemokine (C-X-C motif) ligand 11 0.476
TNF tumor necrosis factor 0.447
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.439
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.429
CXCL9 chemokine (C-X-C motif) ligand 9 0.414
NLRC4 NLR family, CARD domain containing 4 0.402
IRAK3 interleukin-1 receptor-associated kinase 3 0.391
TRAF5 TNF receptor-associated factor 5 0.384
IDE insulin-degrading enzyme 0.353
IL23A interleukin 23, alpha subunit p19 0.290
TICAM2 toll-like receptor adaptor molecule 2 0.281
FAS Fas (TNF receptor superfamily, member 6) 0.276
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited) 0.275
CCL4 chemokine (C-C motif) ligand 4 0.252
IRAK2 interleukin-1 receptor-associated kinase 2 0.213
CCL8 chemokine (C-C motif) ligand 8 0.213
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.207
CCR1 chemokine (C-C motif) receptor 1 0.203
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 0.198
CXCL6 chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) 0.179
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.150
IL1B interleukin 1, beta 0.146
CXCL5 chemokine (C-X-C motif) ligand 5 0.145
FASLG Fas ligand (TNF superfamily, member 6) 0.144
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.135
MAFA v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian) 0.135
MEFV Mediterranean fever 0.130
CASP10 caspase 10, apoptosis-related cysteine peptidase 0.102
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 0.101
CCL20 chemokine (C-C motif) ligand 20 0.096
SETD8 SET domain containing (lysine methyltransferase) 8 0.092
PLEK pleckstrin 0.087
CFLAR CASP8 and FADD-like apoptosis regulator 0.082
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) 0.082
CCR7 chemokine (C-C motif) receptor 7 0.081
IRAK1 interleukin-1 receptor-associated kinase 1 0.080
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.077
CD33 CD33 molecule 0.076
CYBB cytochrome b-245, beta polypeptide 0.073
CCR2 chemokine (C-C motif) receptor 2 0.066
CCL2 chemokine (C-C motif) ligand 2 0.065
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) 0.064
MARK2 MAP/microtubule affinity-regulating kinase 2 0.063
CD48 CD48 molecule 0.059
PF4 platelet factor 4 0.055
SLA Src-like-adaptor 0.053
PYDC2 pyrin domain containing 2 0.052
CXCR3 chemokine (C-X-C motif) receptor 3 0.052
CD163 CD163 molecule 0.052
RIPK3 receptor-interacting serine-threonine kinase 3 0.048
LAIR1 leukocyte-associated immunoglobulin-like receptor 1 0.048
SOD2 superoxide dismutase 2, mitochondrial 0.047
S100A12 S100 calcium binding protein A12 0.047
IRAK4 interleukin-1 receptor-associated kinase 4 0.046
CSF2RA colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) 0.046
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 0.046
EPOR erythropoietin receptor 0.046
SOCS1 suppressor of cytokine signaling 1 0.045
NOD2 nucleotide-binding oligomerization domain containing 2 0.044
DPP4 dipeptidyl-peptidase 4 0.042
TLR1 toll-like receptor 1 0.041
BLNK B-cell linker 0.040
CXCR6 chemokine (C-X-C motif) receptor 6 0.040
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 0.040
MMP9 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) 0.040
INPP5D inositol polyphosphate-5-phosphatase, 145kDa 0.038
UBD ubiquitin D 0.037
GATA2 GATA binding protein 2 0.037
FYB FYN binding protein 0.037
S100A9 S100 calcium binding protein A9 0.035
CLEC7A C-type lectin domain family 7, member A 0.035
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 0.035
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) 0.034
TFEC transcription factor EC 0.034
S100A8 S100 calcium binding protein A8 0.034
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.033
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Tlr4 toll-like receptor 4 0.999
Cd44 CD44 antigen 0.986
Lyz2 lysozyme 2 0.984
Ccr2 chemokine (C-C motif) receptor 2 0.981
Ccl2 chemokine (C-C motif) ligand 2 0.912
Ccr1 chemokine (C-C motif) receptor 1 0.867
Ifng interferon gamma 0.843
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.842
Klrk1 killer cell lectin-like receptor subfamily K, member 1 0.811
Myd88 myeloid differentiation primary response gene 88 0.777
Casp1 caspase 1 0.745
Klra9 killer cell lectin-like receptor subfamily A, member 9 0.714
Clec4n C-type lectin domain family 4, member n 0.708
C3ar1 complement component 3a receptor 1 0.659
Cd180 CD180 antigen 0.639
Ncr1 natural cytotoxicity triggering receptor 1 0.633
Gzma granzyme A 0.625
Tnf tumor necrosis factor 0.587
Foxp3 forkhead box P3 0.501
Cd7 CD7 antigen 0.491
Blk B lymphoid kinase 0.439
Fcrla Fc receptor-like A 0.438
AF251705 cDNA sequence AF251705 0.432
Fasl Fas ligand (TNF superfamily, member 6) 0.391
Klrb1c killer cell lectin-like receptor subfamily B member 1C 0.383
Fcer1g Fc receptor, IgE, high affinity I, gamma polypeptide 0.373
Il18rap interleukin 18 receptor accessory protein 0.371
Flt3 FMS-like tyrosine kinase 3 0.367
Ccr3 chemokine (C-C motif) receptor 3 0.366
Cxcr3 chemokine (C-X-C motif) receptor 3 0.360
Apoe apolipoprotein E 0.354
Prf1 perforin 1 (pore forming protein) 0.340
Klrg1 killer cell lectin-like receptor subfamily G, member 1 0.339
Cd40 CD40 antigen 0.327
Adam19 a disintegrin and metallopeptidase domain 19 (meltrin beta) 0.325
Gzmk granzyme K 0.312
Ikzf1 IKAROS family zinc finger 1 0.309
Ctsw cathepsin W 0.306
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.304
Ubd ubiquitin D 0.302
Klrd1 killer cell lectin-like receptor, subfamily D, member 1 0.301
Mmp8 matrix metallopeptidase 8 0.301
Ccl3 chemokine (C-C motif) ligand 3 0.301
Ccl7 chemokine (C-C motif) ligand 7 0.299
Il2rb interleukin 2 receptor, beta chain 0.293
Il6 interleukin 6 0.293
Ptprc protein tyrosine phosphatase, receptor type, C 0.290
Emr1 EGF-like module containing, mucin-like, hormone receptor-like sequence 1 0.282
Xcl1 chemokine (C motif) ligand 1 0.272
Klrb1b killer cell lectin-like receptor subfamily B member 1B 0.270
Emx2 empty spiracles homolog 2 (Drosophila) 0.270
Fas Fas (TNF receptor superfamily member 6) 0.267
Cd300ld CD300 molecule-like family member d 0.266
Prnp prion protein 0.258
Cd209b CD209b antigen 0.257
Tlr2 toll-like receptor 2 0.257
Ear2 eosinophil-associated, ribonuclease A family, member 2 0.248
Clec4d C-type lectin domain family 4, member d 0.244
Il10 interleukin 10 0.235
Ifngr1 interferon gamma receptor 1 0.234
Ccr6 chemokine (C-C motif) receptor 6 0.233
Gzmb granzyme B 0.220
Ccr5 chemokine (C-C motif) receptor 5 0.211
Siglec1 sialic acid binding Ig-like lectin 1, sialoadhesin 0.206
Msr1 macrophage scavenger receptor 1 0.202
Ccl8 chemokine (C-C motif) ligand 8 0.197
Itgax integrin alpha X 0.193
Ifnar1 interferon (alpha and beta) receptor 1 0.191
Ccl4 chemokine (C-C motif) ligand 4 0.189
Slpi secretory leukocyte peptidase inhibitor 0.187
Cd96 CD96 antigen 0.186
Cd14 CD14 antigen 0.183
Nfatc4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 0.170
Fpr2 formyl peptide receptor 2 0.149
Igk immunoglobulin kappa chain complex 0.148
Casp8 caspase 8 0.141
Il1b interleukin 1 beta 0.139
Ntf3 neurotrophin 3 0.136
Xcr1 chemokine (C motif) receptor 1 0.133
Ccl9 chemokine (C-C motif) ligand 9 0.131
Clec7a C-type lectin domain family 7, member a 0.127
Il7r interleukin 7 receptor 0.124
Icos inducible T-cell co-stimulator 0.123
Mmp9 matrix metallopeptidase 9 0.122
C3 complement component 3 0.122
Folr2 folate receptor 2 (fetal) 0.121
Bex6 brain expressed gene 6 0.118
Irg1 immunoresponsive gene 1 0.117
H2-Ob histocompatibility 2, O region beta locus 0.115
Mmp12 matrix metallopeptidase 12 0.114
Ccl6 chemokine (C-C motif) ligand 6 0.109
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.109
Cd33 CD33 antigen 0.106
Havcr2 hepatitis A virus cellular receptor 2 0.103
Socs1 suppressor of cytokine signaling 1 0.102
Il2ra interleukin 2 receptor, alpha chain 0.100
Ccl24 chemokine (C-C motif) ligand 24 0.100
Pdcd1lg2 programmed cell death 1 ligand 2 0.099
Pax2 paired box gene 2 0.098
Nfatc3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 0.096
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Rattus norvegicus
Name Description Probability Func Analog Organism
Ccl3 chemokine (C-C motif) ligand 3 0.466
Igsf6 immunoglobulin superfamily, member 6 0.390
Il1b interleukin 1 beta 0.389
Ccr2 chemokine (C-C motif) receptor 2 0.241
Plau plasminogen activator, urokinase 0.221
Cxcl1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.218
C5ar1 complement component 5a receptor 1 0.192
Ccl4 chemokine (C-C motif) ligand 4 0.188
Cxcl10 chemokine (C-X-C motif) ligand 10 0.169
Hmox1 heme oxygenase (decycling) 1 0.134
Klrd1 killer cell lectin-like receptor, subfamily D, member 1 0.132
Olr1 oxidized low density lipoprotein (lectin-like) receptor 1 0.120
Litaf lipopolysaccharide-induced TNF factor 0.118
Mmp12 matrix metallopeptidase 12 0.110
Ccl7 chemokine (C-C motif) ligand 7 0.092
Rgs1 regulator of G-protein signaling 1 0.090
Ccl2 chemokine (C-C motif) ligand 2 0.082
Xcl1 chemokine (C motif) ligand 1 0.078
Cd14 CD14 molecule 0.071
Il2rb interleukin 2 receptor, beta 0.064
Cfd complement factor D (adipsin) 0.063
Cxcl2 chemokine (C-X-C motif) ligand 2 0.059
St8sia4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 0.056
Cd86 CD86 molecule 0.054
Il6 interleukin 6 0.053
Tlr2 toll-like receptor 2 0.050
Ltbr lymphotoxin beta receptor (TNFR superfamily, member 3) 0.049
Cd8a CD8a molecule 0.048
Il1a interleukin 1 alpha 0.047
Plscr1 phospholipid scramblase 1 0.046
Cd40 CD40 molecule, TNF receptor superfamily member 5 0.043
Fcn1 ficolin (collagen/fibrinogen domain containing) 1 0.039
Ccl20 chemokine (C-C motif) ligand 20 0.035
Ccr5 chemokine (C-C motif) receptor 5 0.035
Folr2 folate receptor 2 (fetal) 0.033
Icam1 intercellular adhesion molecule 1 0.030
Reg3b regenerating islet-derived 3 beta 0.029
Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.029
Cd53 Cd53 molecule 0.028
Xdh xanthine dehydrogenase 0.026
Ifitm1 interferon induced transmembrane protein 1 0.025
Lpl lipoprotein lipase 0.024
Sell selectin L 0.024
P2ry14 purinergic receptor P2Y, G-protein coupled, 14 0.024
Timp1 TIMP metallopeptidase inhibitor 1 0.023
Clec9a C-type lectin domain family 9, member a 0.022
Smad1 SMAD family member 1 0.022
Slpi secretory leukocyte peptidase inhibitor 0.022
Arl11 ADP-ribosylation factor-like 11 0.022
C1qc complement component 1, q subcomponent, C chain 0.021
Bcl2a1d B-cell leukemia/lymphoma 2 related protein A1d 0.020
Pla2g2a phospholipase A2, group IIA (platelets, synovial fluid) 0.020
Nkg7 natural killer cell group 7 sequence 0.020
Cd38 CD38 molecule 0.018
Serpina3n serine (or cysteine) peptidase inhibitor, clade A, member 3N 0.017
Adam17 ADAM metallopeptidase domain 17 0.017
Cd247 Cd247 molecule 0.017
Fcgr2a Fc fragment of IgG, low affinity IIa, receptor (CD32) 0.016
Olr1082 olfactory receptor 1082 0.016
Hpgds hematopoietic prostaglandin D synthase 0.015
Itgam integrin, alpha M 0.014
Ch25h cholesterol 25-hydroxylase 0.014
Hck hemopoietic cell kinase 0.014
Ier3 immediate early response 3 0.014
Map3k8 mitogen-activated protein kinase kinase kinase 8 0.014
Il8rb interleukin 8 receptor, beta 0.013
Ccl5 chemokine (C-C motif) ligand 5 0.013
Adamts4 ADAM metallopeptidase with thrombospondin type 1 motif, 4 0.013
Il1r2 interleukin 1 receptor, type II 0.013
Fstl3 follistatin-like 3 (secreted glycoprotein) 0.012
Cxcl3 chemokine (C-X-C motif) ligand 3 0.012
Lilrb4 leukocyte immunoglobulin-like receptor, subfamily B, member 4 0.012
Stat3 signal transducer and activator of transcription 3 0.012
Nox4 NADPH oxidase 4 0.012
Clec2d C-type lectin domain family 2, member d 0.012
Mefv Mediterranean fever 0.011
Bcl3 B-cell CLL/lymphoma 3 0.011
P2ry6 pyrimidinergic receptor P2Y, G-protein coupled, 6 0.011
Sele selectin E 0.011
Cmtm2a CKLF-like MARVEL transmembrane domain containing 2A 0.011
Tlr7 toll-like receptor 7 0.011
Rab32 RAB32, member RAS oncogene family 0.011
Ciita class II, major histocompatibility complex, transactivator 0.011
Bloc1s1 biogenesis of lysosomal organelles complex-1, subunit 1 0.011
Ccl22 chemokine (C-C motif) ligand 22 0.010
Acsl1 acyl-CoA synthetase long-chain family member 1 0.010
Cdh17 cadherin 17 0.010
Adrb2 adrenergic, beta-2-, receptor, surface 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism