The network for 'interleukin 8 production' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

interleukin 8 production

The appearance of interleukin-8 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.

Homo sapiens
Name Description Probability Func Analog Organism
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.995
RIPK2 receptor-interacting serine-threonine kinase 2 0.986
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 0.973
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.966
BIRC3 baculoviral IAP repeat containing 3 0.950
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.918
MYD88 myeloid differentiation primary response gene (88) 0.914
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.908
C1QA complement component 1, q subcomponent, A chain 0.876
MAP3K3 mitogen-activated protein kinase kinase kinase 3 0.758
REL v-rel reticuloendotheliosis viral oncogene homolog (avian) 0.728
RELB v-rel reticuloendotheliosis viral oncogene homolog B 0.605
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.503
IL1R1 interleukin 1 receptor, type I 0.502
CASP1 caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) 0.402
PLAU plasminogen activator, urokinase 0.375
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein 0.371
NLRC4 NLR family, CARD domain containing 4 0.366
DLG1 discs, large homolog 1 (Drosophila) 0.336
ABI2 abl-interactor 2 0.302
ANXA1 annexin A1 0.284
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 0.231
CARD11 caspase recruitment domain family, member 11 0.220
S100A10 S100 calcium binding protein A10 0.212
VIM vimentin 0.211
CRP C-reactive protein, pentraxin-related 0.209
TNIP2 TNFAIP3 interacting protein 2 0.209
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma 0.190
C1QC complement component 1, q subcomponent, C chain 0.169
ZNF496 zinc finger protein 496 0.161
FCN2 ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin) 0.154
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.132
C1QB complement component 1, q subcomponent, B chain 0.130
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.130
RHOA ras homolog gene family, member A 0.127
MAP3K8 mitogen-activated protein kinase kinase kinase 8 0.125
SLMAP sarcolemma associated protein 0.123
FAS Fas (TNF receptor superfamily, member 6) 0.118
MAD2L2 MAD2 mitotic arrest deficient-like 2 (yeast) 0.116
KLF6 Kruppel-like factor 6 0.115
WFIKKN2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 0.111
ARRB1 arrestin, beta 1 0.106
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 0.103
PPP1R15A protein phosphatase 1, regulatory (inhibitor) subunit 15A 0.096
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.088
ITGB5 integrin, beta 5 0.088
MEFV Mediterranean fever 0.087
BMPR1B bone morphogenetic protein receptor, type IB 0.085
C9orf89 chromosome 9 open reading frame 89 0.078
IRAK1 interleukin-1 receptor-associated kinase 1 0.078
BCL3 B-cell CLL/lymphoma 3 0.073
DUSP1 dual specificity phosphatase 1 0.073
MPO myeloperoxidase 0.072
SH3D19 SH3 domain containing 19 0.071
TNIP1 TNFAIP3 interacting protein 1 0.070
ACTG1 actin, gamma 1 0.066
PYDC2 pyrin domain containing 2 0.061
TRADD TNFRSF1A-associated via death domain 0.061
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 0.061
GOLGA2 golgin A2 0.061
EMP1 epithelial membrane protein 1 0.061
TSC22D4 TSC22 domain family, member 4 0.059
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.058
NLRP3 NLR family, pyrin domain containing 3 0.057
S100A11 S100 calcium binding protein A11 0.057
MARCO macrophage receptor with collagenous structure 0.055
TRAF1 TNF receptor-associated factor 1 0.055
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 0.055
TLR4 toll-like receptor 4 0.054
DBP D site of albumin promoter (albumin D-box) binding protein 0.054
JUN jun proto-oncogene 0.054
KLF4 Kruppel-like factor 4 (gut) 0.052
TLR2 toll-like receptor 2 0.051
TRAF6 TNF receptor-associated factor 6 0.050
S100A9 S100 calcium binding protein A9 0.048
CFLAR CASP8 and FADD-like apoptosis regulator 0.048
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.046
ANXA4 annexin A4 0.045
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 0.045
HDAC7 histone deacetylase 7 0.045
IL1R2 interleukin 1 receptor, type II 0.044
BCL2A1 BCL2-related protein A1 0.042
ORM1 orosomucoid 1 0.042
CFL1 cofilin 1 (non-muscle) 0.041
GNMT glycine N-methyltransferase 0.041
CYBB cytochrome b-245, beta polypeptide 0.040
IFNGR1 interferon gamma receptor 1 0.038
CD14 CD14 molecule 0.037
CASP10 caspase 10, apoptosis-related cysteine peptidase 0.037
SQSTM1 sequestosome 1 0.037
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta 0.037
IGSF6 immunoglobulin superfamily, member 6 0.036
CAMP cathelicidin antimicrobial peptide 0.036
IRAK2 interleukin-1 receptor-associated kinase 2 0.036
SMAD3 SMAD family member 3 0.035
BIRC2 baculoviral IAP repeat containing 2 0.035
SLC15A3 solute carrier family 15, member 3 0.035
PTAFR platelet-activating factor receptor 0.035
SPRR2A small proline-rich protein 2A 0.034
ATF3 activating transcription factor 3 0.033
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Myd88 myeloid differentiation primary response gene 88 0.994
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.983
Casp1 caspase 1 0.935
Ticam1 toll-like receptor adaptor molecule 1 0.811
Lhx1 LIM homeobox protein 1 0.677
Map3k8 mitogen-activated protein kinase kinase kinase 8 0.596
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.570
Tlr2 toll-like receptor 2 0.569
Nlrp3 NLR family, pyrin domain containing 3 0.542
Dact1 dapper homolog 1, antagonist of beta-catenin (xenopus) 0.469
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.456
Gbp5 guanylate binding protein 5 0.435
Cyld cylindromatosis (turban tumor syndrome) 0.401
Cd14 CD14 antigen 0.373
Traf3 TNF receptor-associated factor 3 0.303
Arrb2 arrestin, beta 2 0.295
Pik3ap1 phosphoinositide-3-kinase adaptor protein 1 0.289
Dysf dysferlin 0.273
Otx1 orthodenticle homolog 1 (Drosophila) 0.264
Map3k3 mitogen-activated protein kinase kinase kinase 3 0.248
Tlr4 toll-like receptor 4 0.242
Socs3 suppressor of cytokine signaling 3 0.233
Pax8 paired box gene 8 0.207
Casp8 caspase 8 0.203
Slc34a2 solute carrier family 34 (sodium phosphate), member 2 0.196
T brachyury 0.188
Litaf LPS-induced TN factor 0.178
Klf2 Kruppel-like factor 2 (lung) 0.170
Hif1a hypoxia inducible factor 1, alpha subunit 0.170
Anxa3 annexin A3 0.166
Sftpb surfactant associated protein B 0.164
Fzd8 frizzled homolog 8 (Drosophila) 0.162
Tnf tumor necrosis factor 0.155
Fzd10 frizzled homolog 10 (Drosophila) 0.153
Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 0.152
Wnt3a wingless-related MMTV integration site 3A 0.152
Ikbkg inhibitor of kappaB kinase gamma 0.151
Klf6 Kruppel-like factor 6 0.150
Treml1 triggering receptor expressed on myeloid cells-like 1 0.146
Mmp8 matrix metallopeptidase 8 0.143
Cd44 CD44 antigen 0.137
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.137
Ripk1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.136
Socs1 suppressor of cytokine signaling 1 0.134
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 0.134
Acan aggrecan 0.129
Asprv1 aspartic peptidase, retroviral-like 1 0.129
Porcn porcupine homolog (Drosophila) 0.121
Emx2 empty spiracles homolog 2 (Drosophila) 0.119
Pax2 paired box gene 2 0.116
Cxcl1 chemokine (C-X-C motif) ligand 1 0.116
Atf3 activating transcription factor 3 0.115
3110079O15Rik RIKEN cDNA 3110079O15 gene 0.114
Il1r1 interleukin 1 receptor, type I 0.113
Nupr1 nuclear protein 1 0.112
Ager advanced glycosylation end product-specific receptor 0.112
Osmr oncostatin M receptor 0.112
Wnt10a wingless related MMTV integration site 10a 0.111
Anxa2 annexin A2 0.111
Plaur plasminogen activator, urokinase receptor 0.111
Fut7 fucosyltransferase 7 0.111
Trp73 transformation related protein 73 0.109
Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.108
Il1a interleukin 1 alpha 0.108
Wnt10b wingless related MMTV integration site 10b 0.107
Lgals3 lectin, galactose binding, soluble 3 0.105
Itgb2l integrin beta 2-like 0.102
Lcn2 lipocalin 2 0.099
Rarg retinoic acid receptor, gamma 0.098
Il18 interleukin 18 0.097
Ms4a3 membrane-spanning 4-domains, subfamily A, member 3 0.097
Itch itchy, E3 ubiquitin protein ligase 0.096
Foxn4 forkhead box N4 0.095
Slpi secretory leukocyte peptidase inhibitor 0.094
Mgmt O-6-methylguanine-DNA methyltransferase 0.093
Pou3f1 POU domain, class 3, transcription factor 1 0.092
Fgf18 fibroblast growth factor 18 0.092
Fas Fas (TNF receptor superfamily member 6) 0.091
5830411N06Rik RIKEN cDNA 5830411N06 gene 0.090
Cebpd CCAAT/enhancer binding protein (C/EBP), delta 0.089
Amh anti-Mullerian hormone 0.089
Foxa2 forkhead box A2 0.089
Fgf8 fibroblast growth factor 8 0.089
Foxl2 forkhead box L2 0.089
Ngp neutrophilic granule protein 0.088
Traf2 TNF receptor-associated factor 2 0.087
Il13ra1 interleukin 13 receptor, alpha 1 0.086
Dync1h1 dynein cytoplasmic 1 heavy chain 1 0.086
Klf3 Kruppel-like factor 3 (basic) 0.086
Kl klotho 0.083
Krt86 keratin 86 0.083
Wnt5b wingless-related MMTV integration site 5B 0.082
Nobox NOBOX oogenesis homeobox 0.082
Gdnf glial cell line derived neurotrophic factor 0.082
Emx1 empty spiracles homolog 1 (Drosophila) 0.082
Plscr1 phospholipid scramblase 1 0.080
Inhbb inhibin beta-B 0.080
Cp ceruloplasmin 0.078
Cd177 CD177 antigen 0.077
Gli2 GLI-Kruppel family member GLI2 0.076
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Rattus norvegicus
Name Description Probability Func Analog Organism
C5ar1 complement component 5a receptor 1 0.034
Ccl2 chemokine (C-C motif) ligand 2 0.022
Olr1 oxidized low density lipoprotein (lectin-like) receptor 1 0.020
Mgat2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase 0.018
Lilrb4 leukocyte immunoglobulin-like receptor, subfamily B, member 4 0.017
Ccl3 chemokine (C-C motif) ligand 3 0.014
Plod2 procollagen lysine, 2-oxoglutarate 5-dioxygenase 2 0.013
Myd88 myeloid differentiation primary response gene 88 0.013
Pla1a phospholipase A1 member A 0.013
Atf3 activating transcription factor 3 0.012
Casp1 caspase 1 0.012
Bet1 blocked early in transport 1 homolog (S. cerevisiae) 0.012
Hck hemopoietic cell kinase 0.011
Snap23 synaptosomal-associated protein 23 0.011
Igsf6 immunoglobulin superfamily, member 6 0.011
Cxcl1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.011
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism