The network for 'regulation of purine nucleotide catabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of purine nucleotide catabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of purine nucleotides.

Homo sapiens
Name Description Probability Func Analog Organism
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.999
PTK2 PTK2 protein tyrosine kinase 2 0.989
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.983
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 0.975
S100A6 S100 calcium binding protein A6 0.963
DNM2 dynamin 2 0.960
SH3KBP1 SH3-domain kinase binding protein 1 0.952
DNM1 dynamin 1 0.942
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.939
SFN stratifin 0.930
ITSN1 intersectin 1 (SH3 domain protein) 0.929
NCF2 neutrophil cytosolic factor 2 0.913
RAF1 v-raf-1 murine leukemia viral oncogene homolog 1 0.912
MTOR mechanistic target of rapamycin (serine/threonine kinase) 0.904
FGFR2 fibroblast growth factor receptor 2 0.900
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.890
BCAR1 breast cancer anti-estrogen resistance 1 0.889
LAMTOR1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 0.868
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.865
SNX9 sorting nexin 9 0.863
CBLB Cas-Br-M (murine) ecotropic retroviral transforming sequence b 0.858
ARRB1 arrestin, beta 1 0.850
GRB2 growth factor receptor-bound protein 2 0.849
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.846
TNNC1 troponin C type 1 (slow) 0.840
ILK integrin-linked kinase 0.832
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.830
GRB7 growth factor receptor-bound protein 7 0.822
RIN3 Ras and Rab interactor 3 0.819
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.790
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.787
NCKAP1 NCK-associated protein 1 0.777
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1 0.776
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11 0.764
TPM1 tropomyosin 1 (alpha) 0.753
RHOA ras homolog gene family, member A 0.750
FGFR1 fibroblast growth factor receptor 1 0.745
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 0.737
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1 0.724
PLCG1 phospholipase C, gamma 1 0.714
UNC119 unc-119 homolog (C. elegans) 0.704
S100A8 S100 calcium binding protein A8 0.701
GABARAPL1 GABA(A) receptor-associated protein like 1 0.693
S100A11 S100 calcium binding protein A11 0.684
RASA1 RAS p21 protein activator (GTPase activating protein) 1 0.677
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.676
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.662
ADRBK1 adrenergic, beta, receptor kinase 1 0.648
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A 0.633
MARK3 MAP/microtubule affinity-regulating kinase 3 0.609
ADAM15 ADAM metallopeptidase domain 15 0.608
ABI1 abl-interactor 1 0.601
HAP1 huntingtin-associated protein 1 0.595
FKBP4 FK506 binding protein 4, 59kDa 0.592
SKIL SKI-like oncogene 0.583
CNKSR2 connector enhancer of kinase suppressor of Ras 2 0.582
FOS FBJ murine osteosarcoma viral oncogene homolog 0.580
OCRL oculocerebrorenal syndrome of Lowe 0.577
TSC2 tuberous sclerosis 2 0.561
EGFR epidermal growth factor receptor 0.561
ANKRD28 ankyrin repeat domain 28 0.553
SH3RF1 SH3 domain containing ring finger 1 0.541
TBCD tubulin folding cofactor D 0.536
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.532
HRAS v-Ha-ras Harvey rat sarcoma viral oncogene homolog 0.530
MOBKL1B MOB1, Mps One Binder kinase activator-like 1B (yeast) 0.529
PSEN1 presenilin 1 0.528
TRAF5 TNF receptor-associated factor 5 0.526
HTT huntingtin 0.521
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.514
GSK3B glycogen synthase kinase 3 beta 0.510
JUN jun proto-oncogene 0.507
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.505
LAMTOR2 late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 0.486
TFG TRK-fused gene 0.483
S100B S100 calcium binding protein B 0.481
ZMYND11 zinc finger, MYND-type containing 11 0.468
FMNL1 formin-like 1 0.466
CCR5 chemokine (C-C motif) receptor 5 0.462
C19orf50 chromosome 19 open reading frame 50 0.452
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.451
MPRIP myosin phosphatase Rho interacting protein 0.447
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.443
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 0.440
ARL2 ADP-ribosylation factor-like 2 0.438
RALB v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein) 0.436
MYCBP2 MYC binding protein 2 0.429
THOC4 THO complex 4 0.426
RHEB Ras homolog enriched in brain 0.425
RAB5A RAB5A, member RAS oncogene family 0.418
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.418
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) 0.417
BCR breakpoint cluster region 0.407
TJP2 tight junction protein 2 (zona occludens 2) 0.406
TOR1A torsin family 1, member A (torsin A) 0.405
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha 0.403
WAS Wiskott-Aldrich syndrome (eczema-thrombocytopenia) 0.395
RICTOR RPTOR independent companion of MTOR, complex 2 0.390
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta 0.389
LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila) 0.381
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
sem-5 Protein SEM-5 0.585
unc-45 Protein UNC-45 0.370
snf-1 Protein SNF-1 0.219
zyg-9 Protein ZYG-9 0.217
spdl-1 Protein SPDL-1 0.205
lag-1 Protein LAG-1 0.192
tpxl-1 Protein TPXL-1 0.187
CELE_F47G4.4 Protein F47G4.4 0.168
egl-13 Protein EGL-13 0.160
unc-53 Protein UNC-53 0.157
zoo-1 Protein ZOO-1 0.151
hda-1 Protein HDA-1 0.142
pak-1 Protein PAK-1 0.141
dnj-27 Protein DNJ-27 0.131
egl-18 Protein EGL-18 0.129
gpr-2 Protein GPR-2 0.123
sup-17 Protein SUP-17 0.117
lin-10 Protein LIN-10 0.107
cyld-1 Protein CYLD-1 0.104
cks-1 Protein CKS-1 0.099
goa-1 Protein GOA-1 0.098
rig-6 Protein RIG-6 0.097
gpr-1 Protein GPR-1 0.092
sad-1 Protein SAD-1 0.089
T21B6.3 Protein T21B6.3 0.089
zfp-1 Protein ZFP-1 0.088
CELE_F25B4.5 Protein F25B4.5 0.087
larp-5 Protein LARP-5 0.086
Y55F3BR.8 Protein Y55F3BR.8 0.083
hmr-1 Protein HMR-1 0.082
bet-2 Protein BET-2 0.081
tmc-2 Protein TMC-2 0.081
rme-4 Protein RME-4 0.080
rpb-7 Protein RPB-7 0.076
rsbp-1 Protein RSBP-1 0.075
rhgf-2 Protein RHGF-2 0.074
F13H6.1 Protein F13H6.1 0.072
mtm-9 Protein MTM-9 0.072
ptp-1 Protein PTP-1 0.071
elt-6 Protein ELT-6 0.068
CELE_T10D4.6 Protein T10D4.6 0.068
C53C9.2 Protein C53C9.2 0.068
C11E4.6 Protein C11E4.6 0.067
W05F2.6 Protein W05F2.6 0.067
ttx-1 Protein TTX-1 0.067
eef-1A.1 Protein EEF-1A.1 0.064
sax-3 Protein SAX-3 0.064
gar-3 Protein GAR-3 0.064
unc-71 Protein UNC-71 0.062
pat-3 Protein PAT-3 0.062
myo-2 Protein MYO-2 0.061
acr-2 Protein ACR-2 0.061
lin-2 Protein LIN-2 0.060
syd-9 Protein SYD-9 0.058
T14B1.1 Protein T14B1.1 0.058
unc-80 Protein UNC-80 0.058
madf-5 Protein MADF-5 0.056
etr-1 Protein ETR-1 0.056
lin-45 Protein LIN-45 0.055
unc-79 Protein UNC-79 0.054
unc-54 Protein UNC-54 0.052
gly-7 Protein GLY-7 0.051
gei-8 Protein GEI-8 0.051
egl-36 Protein EGL-36 0.050
F35G2.1 Protein F35G2.1 0.050
unc-26 Protein UNC-26 0.049
gsa-1 Protein GSA-1 0.049
unc-59 Protein UNC-59 0.047
drr-2 Protein DRR-2 0.046
F49E10.4 Protein F49E10.4 0.045
pde-4 Protein PDE-4 0.045
dgk-4 Protein DGK-4 0.045
pdk-1 Protein PDK-1 0.045
rps-2 Protein RPS-2 0.044
C46C11.1 Protein C46C11.1 0.044
chc-1 Protein CHC-1 0.044
pkg-1 Protein PKG-1 0.044
myo-1 Protein MYO-1 0.044
skn-1 Protein SKN-1 0.043
zfp-3 Protein ZFP-3 0.043
egl-27 Protein EGL-27 0.043
mrck-1 Protein MRCK-1 0.043
pat-12 Protein PAT-12 0.043
pqn-47 Protein PQN-47 0.042
CELE_Y69A2AR.28 Protein Y69A2AR.28 0.042
sel-12 Protein SEL-12 0.042
hmg-1.1 Protein HMG-1.1 0.042
unc-15 Protein UNC-15 0.042
lpd-3 Protein LPD-3 0.042
atg-11 Protein ATG-11 0.041
tbb-4 Protein TBB-4 0.041
ptp-4 Protein PTP-4 0.041
sto-4 Protein STO-4 0.040
stim-1 Protein STIM-1 0.040
CELE_F08D12.1 Protein F08D12.1 0.040
afd-1 Protein AFD-1 0.040
lev-11 Protein LEV-11 0.040
sym-4 Protein SYM-4 0.040
R11A8.7 Protein R11A8.7 0.039
C06G1.5 Protein C06G1.5 0.039
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Danio rerio
Name Description Probability Func Analog Organism
tnni2a.4 troponin I, skeletal, fast 2a.4 0.801
tpm4 tropomyosin 4 0.500
tnnc1b troponin C type 1b (slow) 0.475
tnnt3b troponin T3b, skeletal, fast 0.369
tnni1al troponin I, skeletal, slow like 0.238
bida BH3 interacting domain death agonist 0.231
depdc1a DEP domain containing 1a 0.226
hspa4a heat shock protein 4a 0.218
tnni1b troponin I, skeletal, slow b 0.208
smyhc2 slow myosin heavy chain 2 0.197
cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.164
gapdh glyceraldehyde-3-phosphate dehydrogenase 0.159
gnaia guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a 0.145
dclk2 doublecortin-like kinase 2 0.142
rtcd1 RNA terminal phosphate cyclase domain 1 0.141
ilk integrin linked kinase 0.139
actn3b actinin alpha 3b 0.137
ptprk protein tyrosine phosphatase, receptor type, K 0.133
mcm6 MCM6 minichromosome maintenance deficient 6, mitotin (S. cerevisiae) 0.132
pvalb4 parvalbumin 4 0.128
ahctf1 AT hook containing transcription factor 1 0.125
pvalb2 parvalbumin 2 0.124
psen1 presenilin 1 0.119
hsp90a.2 heat shock protein 90-alpha 2 0.118
nme2b.2 non-metastatic cells 2b.2, protein (NM23B) expressed in 0.116
rtn1a reticulon 1a 0.115
si:rp71-39b20.7 si:rp71-39b20.7 0.113
tp73 tumor protein p73 0.112
trpv4 transient receptor potential cation channel, subfamily V, member 4 0.111
actc1a actin, alpha, cardiac muscle 1a 0.111
ldb3b LIM domain binding 3b 0.111
pvalb1 parvalbumin 1 0.109
stau1 staufen, RNA binding protein, homolog 1 (Drosophila) 0.108
optc opticin 0.107
myhz1.2 myosin, heavy polypeptide 1.2, skeletal muscle 0.107
flt1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.106
tpm3 tropomyosin 3 0.103
vamp2 vesicle-associated membrane protein 2 0.103
clic4 chloride intracellular channel 4 0.102
yes1 v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 0.101
gna14 guanine nucleotide binding protein (G protein), alpha 14 0.101
tm9sf2 transmembrane 9 superfamily member 2 0.101
kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.099
gclc glutamate-cysteine ligase, catalytic subunit 0.097
eomesa eomesodermin homolog a 0.096
zbtb4 zinc finger and BTB domain containing 4 0.096
pacsin3 protein kinase C and casein kinase substrate in neurons 3 0.095
tie1 endothelium-specific receptor tyrosine kinase 1 0.095
ube2d1 ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast) 0.095
pparg peroxisome proliferator activated receptor gamma 0.094
jun jun proto-oncogene 0.093
s100v2 S100 calcium binding protein V2 0.093
vdrb vitamin D receptor b 0.093
prkcbp1l protein kinase C binding protein 1, like 0.092
tnnc2 troponin C type 2 (fast) 0.092
dnaja DnaJ (Hsp40) homolog, subfamily A member 0.090
rras related RAS viral (r-ras) oncogene homolog 0.090
adrb2a adrenergic receptor, beta 2a 0.090
myhz2 myosin, heavy polypeptide 2, fast muscle specific 0.090
rxrbb retinoid x receptor, beta b 0.089
slc25a4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 0.089
acvr1b activin A receptor, type IB 0.088
iqgap1 IQ motif containing GTPase activating protein 1 0.088
zgc:113625 zgc:113625 0.087
stc1l stanniocalcin 1, like 0.087
sb:cb730 sb:cb730 0.087
neb nebulin 0.087
cfl2l cofilin 2, like 0.085
pvrl1b poliovirus receptor-related 1b 0.085
smyhc1 slow myosin heavy chain 1 0.084
s100t S100 calcium binding protein T 0.084
pafah1b1a platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit a 0.083
nrarpa notch-regulated ankyrin repeat protein a 0.083
acsl4a acyl-CoA synthetase long-chain family member 4a 0.083
ptgs2a prostaglandin-endoperoxide synthase 2a 0.082
hspd1 heat shock 60kD protein 1 (chaperonin) 0.081
lingo1b leucine rich repeat and Ig domain containing 1b 0.081
acvr2a activin receptor IIa 0.081
cmlc1 cardiac myosin light chain-1 0.081
cacnb1 calcium channel, voltage-dependent, beta 1 subunit 0.080
myhz1.1 myosin, heavy polypeptide 1.1, skeletal muscle 0.080
casq2 calsequestrin 2 0.080
zgc:55259 zgc:55259 0.079
slmapb sarcolemma associated protein b 0.079
dnaja1l DnaJ (Hsp40) homolog, subfamily A, member 1, like 0.079
mylz2 myosin, light polypeptide 2, skeletal muscle 0.078
gngt2b guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2b 0.078
zgc:56466 zgc:56466 0.078
tpm1 tropomyosin 1 (alpha) 0.078
mat2a methionine adenosyltransferase II, alpha 0.078
tnnt2a troponin T2a, cardiac 0.077
rps6ka3a ribosomal protein S6 kinase, polypeptide 3a 0.077
cnn2 calponin 2 0.077
rab1a RAB1A, member RAS oncogene family 0.076
tgif1 TGFB-induced factor homeobox 1 0.076
hif1ab hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) b 0.075
ttyh2l tweety homolog 2, like 0.075
adrb3a adrenergic receptor, beta 3a 0.074
gria4b glutamate receptor, ionotropic, AMPA 4b 0.073
rhoub ras homolog gene family, member Ub 0.073
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.682
Pkn Protein kinase related to protein kinase N 0.361
nwk nervous wreck 0.276
CG8155 CG8155 gene product from transcript CG8155-RA 0.271
Wnk CG7177 gene product from transcript CG7177-RA 0.262
trio CG18214 gene product from transcript CG18214-RA 0.254
Rheb CG1081 gene product from transcript CG1081-RA 0.245
Pk61C Protein kinase 61C 0.241
puc puckered 0.240
cno canoe 0.234
stg string 0.223
Fak56D Focal Adhesion Kinase 0.212
NaCP60E Na channel protein 60E 0.206
CG6509 CG6509 gene product from transcript CG6509-RB 0.205
sax saxophone 0.191
wupA wings up A 0.189
Hrs Hepatocyte growth factor regulated tyrosine kinase substrate 0.178
shot short stop 0.165
rok Rho-kinase 0.164
drk downstream of receptor kinase 0.164
Prp31 CG6876 gene product from transcript CG6876-RA 0.151
Stat92E Signal-transducer and activator of transcription protein at 92E 0.145
Khc Kinesin heavy chain 0.141
mbc myoblast city 0.139
gek genghis khan 0.132
cenG1A centaurin gamma 1A 0.117
RhoGAP68F CG6811 gene product from transcript CG6811-RA 0.117
Su(H) Suppressor of Hairless 0.115
ninaC neither inactivation nor afterpotential C 0.106
Gug Grunge 0.105
PTP-ER Protein tyrosine phosphatase-ERK/Enhancer of Ras1 0.102
Dab Disabled 0.102
CycA Cyclin A 0.102
Mad Mothers against dpp 0.102
CG7158 CG7158 gene product from transcript CG7158-RA 0.101
Hem HEM-protein 0.101
CG3573 CG3573 gene product from transcript CG3573-RA 0.091
l(2)k16918 lethal (2) k16918 0.091
ari-2 ariadne 2 0.090
flw flapwing 0.090
Pten CG5671 gene product from transcript CG5671-RB 0.090
synj synaptojanin 0.088
unc-104 CG8566 gene product from transcript CG8566-RB 0.087
Sos Son of sevenless 0.084
Pak PAK-kinase 0.078
dos daughter of sevenless 0.078
stai stathmin 0.076
rl rolled 0.073
CG8334 CG8334 gene product from transcript CG8334-RA 0.072
lgs legless 0.072
dys dysfusion 0.071
raps rapsynoid 0.071
mts microtubule star 0.070
Tre1 trapped in endoderm-1 0.068
CG11033 CG11033 gene product from transcript CG11033-RB 0.067
plexB plexin B 0.067
sec6 CG5341 gene product from transcript CG5341-RA 0.067
msps mini spindles 0.067
yrt yurt 0.067
DAAM Dishevelled Associated Activator of Morphogenesis 0.066
Mkp3 Mitogen-activated protein kinase phosphatase 3 0.065
siz schizo 0.064
sls sallimus 0.063
Tor Target of rapamycin 0.062
jumu jumeau 0.061
mask multiple ankyrin repeats single KH domain 0.061
Hr96 Hormone receptor-like in 96 0.060
Plc21C Phospholipase C at 21C 0.059
Jra Jun-related antigen 0.058
baz bazooka 0.058
Ank2 Ankyrin 2 0.057
Smg1 CG32743 gene product from transcript CG32743-RA 0.056
Eip63E Ecdysone-induced protein 63E 0.055
Tak1 TGF-beta activated kinase 1 0.054
Zn72D CG5215 gene product from transcript CG5215-RB 0.053
cpx complexin 0.052
psidin phagocyte signaling impaired 0.051
Rala Ras-related protein 0.051
Mlp84B Muscle LIM protein at 84B 0.051
CG1233 CG1233 gene product from transcript CG1233-RB 0.051
Caki Calcium/calmodulin-dependent protein kinase 0.050
pod1 CG4532 gene product from transcript CG4532-RF 0.049
Nmnat Nicotinamide mononucleotide adenylyltransferase 0.049
Sbf SET domain binding factor 0.048
Mtl Mig-2-like 0.047
neur neuralized 0.047
Smox Smad on X 0.047
p120ctn Adherens junction protein p120 0.046
pyd polychaetoid 0.046
Dip3 Dorsal interacting protein 3 0.045
Rtnl1 CG33113 gene product from transcript CG33113-RF 0.045
CG1021 CG1021 gene product from transcript CG1021-RE 0.045
G-ialpha65A G protein alphai subunit 65A 0.045
Myo31DF Myosin 31DF 0.045
CG5798 CG5798 gene product from transcript CG5798-RA 0.044
neuroligin CG13772 gene product from transcript CG13772-RA 0.044
Abi Abelson interacting protein 0.044
trp transient receptor potential 0.044
Flo-2 flotillin 2 0.043
Rho1 CG8416 gene product from transcript CG8416-RB 0.043
Loading network...
Mus musculus
Name Description Probability Func Analog Organism
Ephb2 Eph receptor B2 0.984
Efnb2 ephrin B2 0.981
Epha4 Eph receptor A4 0.977
Braf Braf transforming gene 0.914
Sema6a sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A 0.911
Nf1 neurofibromatosis 1 0.893
Rac1 RAS-related C3 botulinum substrate 1 0.881
Kl klotho 0.875
Ilk integrin linked kinase 0.855
Itsn1 intersectin 1 (SH3 domain protein 1A) 0.842
Sox10 SRY-box containing gene 10 0.833
Ntrk3 neurotrophic tyrosine kinase, receptor, type 3 0.829
Ret ret proto-oncogene 0.797
Plxna1 plexin A1 0.775
Arrb2 arrestin, beta 2 0.763
Mtor mechanistic target of rapamycin (serine/threonine kinase) 0.749
Pafah1b1 platelet-activating factor acetylhydrolase, isoform 1b, subunit 1 0.736
Cdc42 cell division cycle 42 homolog (S. cerevisiae) 0.720
Arhgef7 Rho guanine nucleotide exchange factor (GEF7) 0.699
Myl2 myosin, light polypeptide 2, regulatory, cardiac, slow 0.693
Lrrk2 leucine-rich repeat kinase 2 0.693
Adrb1 adrenergic receptor, beta 1 0.693
Plxnb1 plexin B1 0.618
Gfra2 glial cell line derived neurotrophic factor family receptor alpha 2 0.615
Arhgef11 Rho guanine nucleotide exchange factor (GEF) 11 0.615
Adrbk1 adrenergic receptor kinase, beta 1 0.614
Chrm1 cholinergic receptor, muscarinic 1, CNS 0.613
Wnt5a wingless-related MMTV integration site 5A 0.606
Prkce protein kinase C, epsilon 0.596
Ctnnb1 catenin (cadherin associated protein), beta 1 0.584
Ptk2b PTK2 protein tyrosine kinase 2 beta 0.572
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.569
Ntf3 neurotrophin 3 0.563
Bmpr2 bone morphogenic protein receptor, type II (serine/threonine kinase) 0.563
Vav1 vav 1 oncogene 0.542
Spry4 sprouty homolog 4 (Drosophila) 0.535
Dlg4 discs, large homolog 4 (Drosophila) 0.531
Grin2b glutamate receptor, ionotropic, NMDA2B (epsilon 2) 0.529
Ldb3 LIM domain binding 3 0.516
Lepr leptin receptor 0.505
Srsf9 serine/arginine-rich splicing factor 9 0.503
Dock1 dedicator of cytokinesis 1 0.502
Rictor RPTOR independent companion of MTOR, complex 2 0.497
Bcl2 B-cell leukemia/lymphoma 2 0.484
Wnt7a wingless-related MMTV integration site 7A 0.462
Ndel1 nuclear distribution gene E-like homolog 1 (A. nidulans) 0.446
Arpc4 actin related protein 2/3 complex, subunit 4 0.441
Banf1 barrier to autointegration factor 1 0.438
Grb2 growth factor receptor bound protein 2 0.437
Ppp1r9b protein phosphatase 1, regulatory subunit 9B 0.421
Hrc histidine rich calcium binding protein 0.417
Pde1b phosphodiesterase 1B, Ca2+-calmodulin dependent 0.409
Sh3bp1 SH3-domain binding protein 1 0.408
Mkl1 MKL (megakaryoblastic leukemia)/myocardin-like 1 0.399
Epha1 Eph receptor A1 0.399
Ccr2 chemokine (C-C motif) receptor 2 0.398
Npy2r neuropeptide Y receptor Y2 0.396
Pnpla2 patatin-like phospholipase domain containing 2 0.382
Rasgrp2 RAS, guanyl releasing protein 2 0.381
Prkcc protein kinase C, gamma 0.375
Epb4.1l2 erythrocyte protein band 4.1-like 2 0.374
Selplg selectin, platelet (p-selectin) ligand 0.370
Kifc2 kinesin family member C2 0.363
Git1 G protein-coupled receptor kinase-interactor 1 0.349
Shc3 src homology 2 domain-containing transforming protein C3 0.348
Hdac7 histone deacetylase 7 0.344
Wdr1 WD repeat domain 1 0.343
Arhgef12 Rho guanine nucleotide exchange factor (GEF) 12 0.342
Cdc42ep1 CDC42 effector protein (Rho GTPase binding) 1 0.340
Erh enhancer of rudimentary homolog (Drosophila) 0.338
Src Rous sarcoma oncogene 0.334
Spna2 spectrin alpha 2 0.333
Arrb1 arrestin, beta 1 0.330
Wipf1 WAS/WASL interacting protein family, member 1 0.327
Mcm5 minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae) 0.319
Scn5a sodium channel, voltage-gated, type V, alpha 0.318
Ptpn13 protein tyrosine phosphatase, non-receptor type 13 0.314
Mapkap1 mitogen-activated protein kinase associated protein 1 0.312
Cdh6 cadherin 6 0.311
Drd2 dopamine receptor D2 0.310
Vdr vitamin D receptor 0.308
Tnni2 troponin I, skeletal, fast 2 0.304
Asap1 ArfGAP with SH# domain, ankyrin repeat and PH domain1 0.303
Tnnt3 troponin T3, skeletal, fast 0.301
Kalrn kalirin, RhoGEF kinase 0.297
Syn2 synapsin II 0.289
Vasp vasodilator-stimulated phosphoprotein 0.288
Hmha1 histocompatibility (minor) HA-1 0.286
Efna1 ephrin A1 0.280
Pxn paxillin 0.273
Cnr1 cannabinoid receptor 1 (brain) 0.269
Nrbp2 nuclear receptor binding protein 2 0.266
Magi1 membrane associated guanylate kinase, WW and PDZ domain containing 1 0.262
Lsm2 LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) 0.261
Stim2 stromal interaction molecule 2 0.259
Ly6h lymphocyte antigen 6 complex, locus H 0.258
Adam11 a disintegrin and metallopeptidase domain 11 0.257
Ltb lymphotoxin B 0.255
Mtap2 microtubule-associated protein 2 0.254
Rtkn rhotekin 0.247
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
Tagln transgelin 0.846
Acta2 smooth muscle alpha-actin 0.562
Myl9 myosin, light chain 9, regulatory 0.480
Pja2 praja 2, RING-H2 motif containing 0.316
Kcnab2 potassium voltage-gated channel, shaker-related subfamily, beta member 2 0.303
Hk1 hexokinase 1 0.298
Homer1 homer homolog 1 (Drosophila) 0.244
Anxa2 annexin A2 0.235
Actg2 actin, gamma 2, smooth muscle, enteric 0.166
Sptan1 spectrin, alpha, non-erythrocytic 1 0.152
Dapk3 death-associated protein kinase 3 0.151
Amph amphiphysin 0.144
Gng7 guanine nucleotide binding protein (G protein), gamma 7 0.133
Gabrb3 gamma-aminobutyric acid (GABA) A receptor, beta 3 0.127
Cnksr2 connector enhancer of kinase suppressor of Ras 2 0.126
Epas1 endothelial PAS domain protein 1 0.111
Flna filamin A, alpha 0.110
Gria2 glutamate receptor, ionotropic, AMPA 2 0.109
Prkch protein kinase C, eta 0.098
Cfp complement factor properdin 0.097
Rfng RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 0.096
Shank2 SH3 and multiple ankyrin repeat domains 2 0.094
Ola1 Obg-like ATPase 1 0.093
Ctnnd2 catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein) 0.092
Stk39 serine/threonine kinase 39, STE20/SPS1 homolog (yeast) 0.090
Stxbp5 syntaxin binding protein 5 (tomosyn) 0.090
Sstr1 somatostatin receptor 1 0.084
Picalm phosphatidylinositol binding clathrin assembly protein 0.081
Adora2a adenosine A2a receptor 0.081
Pik3r2 phosphoinositide-3-kinase, regulatory subunit 2 (beta) 0.081
Csrp1 cysteine and glycine-rich protein 1 0.080
A1i3 alpha-1-inhibitor III 0.079
Camk4 calcium/calmodulin-dependent protein kinase IV 0.078
Gipc1 GIPC PDZ domain containing family, member 1 0.074
Sdc3 syndecan 3 0.073
Tgfbr2 transforming growth factor, beta receptor II 0.071
Pum1 pumilio homolog 1 (Drosophila) 0.070
Mcam melanoma cell adhesion molecule 0.069
Accn1 amiloride-sensitive cation channel 1, neuronal 0.069
Ephb1 Eph receptor B1 0.067
Ppp2ca protein phosphatase 2, catalytic subunit, alpha isoform 0.066
Dnaja4 DnaJ (Hsp40) homolog, subfamily A, member 4 0.066
Gabra4 gamma-aminobutyric acid (GABA) A receptor, alpha 4 0.066
Syn1 synapsin I 0.066
Kcnq3 potassium voltage-gated channel, KQT-like subfamily, member 3 0.066
Gabrg1 gamma-aminobutyric acid (GABA) A receptor, gamma 1 0.065
Lpcat4 lysophosphatidylcholine acyltransferase 4 0.065
Cacna1c calcium channel, voltage-dependent, L type, alpha 1C subunit 0.064
Rab3il1 RAB3A interacting protein (rabin3)-like 1 0.064
Cacnb4 calcium channel, voltage-dependent, beta 4 subunit 0.063
Fgfr1 Fibroblast growth factor receptor 1 0.063
Scn3b sodium channel, voltage-gated, type III, beta 0.062
Dnm1 dynamin 1 0.061
Kit v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 0.061
Sel1l sel-1 suppressor of lin-12-like (C. elegans) 0.061
Mgat5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.061
Trappc2 trafficking protein particle complex 2 0.059
Abcc8 ATP-binding cassette, subfamily C (CFTR/MRP), member 8 0.059
St8sia3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 0.058
Sh3gl2 SH3-domain GRB2-like 2 0.057
Myh7 myosin, heavy chain 7, cardiac muscle, beta 0.056
Nckap1 NCK-associated protein 1 0.056
Ryr2 ryanodine receptor 2, cardiac 0.055
Pik3cd phosphoinositide-3-kinase, catalytic, delta polypeptide 0.054
Atp4b ATPase, H+/K+ exchanging, beta polypeptide 0.054
Vav1 vav 1 guanine nucleotide exchange factor 0.053
Syt7 synaptotagmin VII 0.053
Pfn1 profilin 1 0.053
Clcn2 chloride channel 2 0.053
Gucy1b3 guanylate cyclase 1, soluble, beta 3 0.053
Syt4 synaptotagmin IV 0.053
Flnb filamin, beta 0.053
Lin7b lin-7 homolog b (C. elegans) 0.053
Chrm1 cholinergic receptor, muscarinic 1 0.052
Btg1 B-cell translocation gene 1, anti-proliferative 0.052
Kcnab1 potassium voltage-gated channel, shaker-related subfamily, beta member 1 0.052
Myo1c myosin IC 0.052
Pls3 plastin 3 (T-isoform) 0.051
Agap3 ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 0.051
Pi4ka phosphatidylinositol 4-kinase, catalytic, alpha 0.051
Snca synuclein, alpha (non A4 component of amyloid precursor) 0.050
Gria1 glutamate receptor, ionotropic, AMPA 1 0.050
Snap25 synaptosomal-associated protein 25 0.050
Npr3 natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C) 0.050
Jak2 Janus kinase 2 0.049
N5 DNA binding protein N5 0.049
Cck cholecystokinin 0.049
Lcp2 lymphocyte cytosolic protein 2 0.048
Vsnl1 visinin-like 1 0.048
Fam108a1 family with sequence similarity 108, member A1 0.048
Sept10 septin 10 0.048
Robo2 roundabout homolog 2 (Drosophila) 0.047
Dync1h1 dynein cytoplasmic 1 heavy chain 1 0.047
Vamp3 vesicle-associated membrane protein 3 0.047
Tpm2 tropomyosin 2, beta 0.046
Chrm3 cholinergic receptor, muscarinic 3 0.046
Cdk5 cyclin-dependent kinase 5 0.046
Dgkz diacylglycerol kinase zeta 0.046
Rhoa ras homolog gene family, member A 0.046
Svop SV2 related protein 0.046
Loading network...
Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
STE5 Ste5p 0.453
GYL1 Gyl1p 0.259
RHO1 Rho1p 0.247
STE11 Ste11p 0.205
SUI3 Sui3p 0.156
GDI1 Gdi1p 0.147
FAR1 Far1p 0.146
STE4 Ste4p 0.146
ROM2 Rom2p 0.139
SEC16 Sec16p 0.120
TRS65 Trs65p 0.112
STI1 Sti1p 0.096
AVO1 Avo1p 0.095
CDC24 Cdc24p 0.095
MKK1 Mkk1p 0.094
YPT53 Ypt53p 0.079
VPS15 Vps15p 0.078
TOM1 Tom1p 0.072
STE20 Ste20p 0.061
KEL1 Kel1p 0.061
MDS3 Mds3p 0.057
MON1 Mon1p 0.057
FUS2 Fus2p 0.057
MRC1 Mrc1p 0.056
GCD6 Gcd6p 0.055
FIR1 Fir1p 0.055
PTP2 Ptp2p 0.054
GIC2 Gic2p 0.054
HYP2 Hyp2p 0.052
TSC11 Tsc11p 0.051
BET3 Bet3p 0.051
MSB3 Msb3p 0.050
VTA1 Vta1p 0.049
BEM3 Bem3p 0.046
PEP5 Pep5p 0.046
STT4 Stt4p 0.046
SSK1 Ssk1p 0.045
KOG1 Kog1p 0.044
FKH1 Fkh1p 0.043
CHS1 Chs1p 0.042
STE2 Ste2p 0.042
SAR1 Sar1p 0.042
PKC1 Pkc1p 0.042
ATG20 Atg20p 0.041
SLH1 Slh1p 0.040
MRS6 Mrs6p 0.039
HCH1 Hch1p 0.039
SEC53 Sec53p 0.039
MBF1 Mbf1p 0.039
YNL108C hypothetical protein 0.038
MKK2 Mkk2p 0.038
MCM3 Mcm3p 0.038
TMN3 Tmn3p 0.038
BUD14 Bud14p 0.037
PAR32 Par32p 0.037
SOG2 Sog2p 0.037
VPS5 Vps5p 0.037
YPP1 Ypp1p 0.037
TCP1 Tcp1p 0.037
YPT52 Ypt52p 0.037
SSK2 Ssk2p 0.037
BST1 Bst1p 0.036
CHS5 Chs5p 0.036
TOR1 Tor1p 0.036
YDJ1 Ydj1p 0.036
CCZ1 Ccz1p 0.036
SSA4 Ssa4p 0.036
YIR035C hypothetical protein 0.036
ORC2 Orc2p 0.035
SLT2 Slt2p 0.035
NOP10 Nop10p 0.035
CDC50 Cdc50p 0.035
YJL144W hypothetical protein 0.035
SPA2 Spa2p 0.035
INP52 Inp52p 0.035
SEC23 Sec23p 0.035
BUL1 Bul1p 0.034
SPR6 Spr6p 0.034
ITR2 Itr2p 0.034
COX13 Cox13p 0.034
TAO3 Tao3p 0.034
TSC10 Tsc10p 0.033
IST1 Ist1p 0.033
SSL2 Ssl2p 0.032
NEO1 Neo1p 0.032
CWC23 Cwc23p 0.032
GLO3 Glo3p 0.032
YDR186C hypothetical protein 0.032
RGA2 Rga2p 0.032
DBF4 Dbf4p 0.032
SFB2 Sfb2p 0.031
PMI40 Pmi40p 0.031
APM4 Apm4p 0.031
BIT61 Bit61p 0.031
ARP10 Arp10p 0.030
RAT1 Rat1p 0.030
AKL1 Akl1p 0.030
INP53 Inp53p 0.030
URA6 Ura6p 0.030
AAP1 Aap1p 0.030