IMP
Process View
The network for 'regulation of antigen receptor mediated signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.
Multiple Organisms
regulation of antigen receptor mediated signaling pathway
Any process that modulates the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B- or T cell.
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| LCK | lymphocyte-specific protein tyrosine kinase | 1.000 | |
| ZAP70 | zeta-chain (TCR) associated protein kinase 70kDa | 0.996 | |
| CD2 | CD2 molecule | 0.939 | |
| CD247 | CD247 molecule | 0.912 | |
| CD3E | CD3e molecule, epsilon (CD3-TCR complex) | 0.864 | |
| PTK2 | PTK2 protein tyrosine kinase 2 | 0.807 | |
| VAV1 | vav 1 guanine nucleotide exchange factor | 0.708 | |
| PSTPIP1 | proline-serine-threonine phosphatase interacting protein 1 | 0.586 | |
| CARD11 | caspase recruitment domain family, member 11 | 0.526 | |
| CBL | Cas-Br-M (murine) ecotropic retroviral transforming sequence | 0.395 | |
| MALT1 | mucosa associated lymphoid tissue lymphoma translocation gene 1 | 0.327 | |
| PIK3R1 | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | 0.287 | |
| NCK2 | NCK adaptor protein 2 | 0.259 | |
| MAPK1 | mitogen-activated protein kinase 1 | 0.258 | |
| PTPN22 | protein tyrosine phosphatase, non-receptor type 22 (lymphoid) | 0.258 | |
| PTPN6 | protein tyrosine phosphatase, non-receptor type 6 | 0.244 | |
| SYK | spleen tyrosine kinase | 0.231 | |
| GHR | growth hormone receptor | 0.227 | |
| LAT | linker for activation of T cells | 0.181 | |
| LPXN | leupaxin | 0.173 | |
| PTPN1 | protein tyrosine phosphatase, non-receptor type 1 | 0.157 | |
| TFF1 | trefoil factor 1 | 0.148 | |
| LCP2 | lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) | 0.137 | |
| LYN | v-yes-1 Yamaguchi sarcoma viral related oncogene homolog | 0.133 | |
| LAIR1 | leukocyte-associated immunoglobulin-like receptor 1 | 0.112 | |
| C9orf89 | chromosome 9 open reading frame 89 | 0.107 | |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | 0.101 | |
| HDAC7 | histone deacetylase 7 | 0.101 | |
| PXN | paxillin | 0.085 | |
| NCF1 | neutrophil cytosolic factor 1 | 0.081 | |
| PTPRC | protein tyrosine phosphatase, receptor type, C | 0.077 | |
| PRKCD | protein kinase C, delta | 0.073 | |
| TAB2 | TGF-beta activated kinase 1/MAP3K7 binding protein 2 | 0.059 | |
| WAS | Wiskott-Aldrich syndrome (eczema-thrombocytopenia) | 0.057 | |
| BCL10 | B-cell CLL/lymphoma 10 | 0.055 | |
| HOXA1 | homeobox A1 | 0.055 | |
| CD22 | CD22 molecule | 0.055 | |
| CDH5 | cadherin 5, type 2 (vascular endothelium) | 0.053 | |
| ILK | integrin-linked kinase | 0.049 | |
| PRKCQ | protein kinase C, theta | 0.048 | |
| TRAF6 | TNF receptor-associated factor 6 | 0.047 | |
| MICA | MHC class I polypeptide-related sequence A | 0.046 | |
| PLCG1 | phospholipase C, gamma 1 | 0.042 | |
| MAP2K1 | mitogen-activated protein kinase kinase 1 | 0.042 | |
| SH3BP2 | SH3-domain binding protein 2 | 0.038 | |
| GRB2 | growth factor receptor-bound protein 2 | 0.038 | |
| NCK1 | NCK adaptor protein 1 | 0.038 | |
| SEMA4D | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D | 0.037 | |
| PILRA | paired immunoglobin-like type 2 receptor alpha | 0.035 | |
| MAPK3 | mitogen-activated protein kinase 3 | 0.034 | |
| PLK3 | polo-like kinase 3 | 0.032 | |
| CD33 | CD33 molecule | 0.031 | |
| SH2D2A | SH2 domain containing 2A | 0.028 | |
| RABAC1 | Rab acceptor 1 (prenylated) | 0.027 | |
| PTPN11 | protein tyrosine phosphatase, non-receptor type 11 | 0.026 | |
| PHC2 | polyhomeotic homolog 2 (Drosophila) | 0.025 | |
| PRKCB | protein kinase C, beta | 0.024 | |
| SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | 0.024 | |
| CSF2RB | colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) | 0.024 | |
| FLT1 | fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) | 0.023 | |
| ITGAL | integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) | 0.021 | |
| RPS6KA2 | ribosomal protein S6 kinase, 90kDa, polypeptide 2 | 0.021 | |
| RRBP1 | ribosome binding protein 1 homolog 180kDa (dog) | 0.021 | |
| MEST | mesoderm specific transcript homolog (mouse) | 0.021 | |
| PRKCA | protein kinase C, alpha | 0.019 | |
| FGR | Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog | 0.018 | |
| CDC42EP1 | CDC42 effector protein (Rho GTPase binding) 1 | 0.017 | |
| GORASP1 | golgi reassembly stacking protein 1, 65kDa | 0.017 | |
| GIT2 | G protein-coupled receptor kinase interacting ArfGAP 2 | 0.017 | |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.016 | |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.015 | |
| TRIP6 | thyroid hormone receptor interactor 6 | 0.015 | |
| RAPGEF1 | Rap guanine nucleotide exchange factor (GEF) 1 | 0.015 | |
| HCLS1 | hematopoietic cell-specific Lyn substrate 1 | 0.015 | |
| DPPA4 | developmental pluripotency associated 4 | 0.015 | |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.015 | |
| THAP2 | THAP domain containing, apoptosis associated protein 2 | 0.014 | |
| TRIM9 | tripartite motif containing 9 | 0.014 | |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | 0.013 | |
| VCL | vinculin | 0.013 | |
| BTN2A1 | butyrophilin, subfamily 2, member A1 | 0.013 | |
| CRK | v-crk sarcoma virus CT10 oncogene homolog (avian) | 0.013 | |
| SQSTM1 | sequestosome 1 | 0.013 | |
| FHL2 | four and a half LIM domains 2 | 0.012 | |
| MED15 | mediator complex subunit 15 | 0.012 | |
| BTN3A1 | butyrophilin, subfamily 3, member A1 | 0.012 | |
| PHF21A | PHD finger protein 21A | 0.012 | |
| SRC | v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | 0.012 | |
| BTN2A2 | butyrophilin, subfamily 2, member A2 | 0.011 | |
| MS4A1 | membrane-spanning 4-domains, subfamily A, member 1 | 0.011 | |
| DPYSL4 | dihydropyrimidinase-like 4 | 0.011 | |
| BBS10 | Bardet-Biedl syndrome 10 | 0.011 | |
| ITGB2 | integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) | 0.011 | |
| MAPK14 | mitogen-activated protein kinase 14 | 0.011 | |
| RRAS2 | related RAS viral (r-ras) oncogene homolog 2 | 0.010 |
Loading network...
Mus musculus
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| Inpp5d | inositol polyphosphate-5-phosphatase D | 1.000 | |
| Grb2 | growth factor receptor bound protein 2 | 1.000 | |
| Cbl | Casitas B-lineage lymphoma | 0.999 | |
| Cd19 | CD19 antigen | 0.998 | |
| Ptprc | protein tyrosine phosphatase, receptor type, C | 0.998 | |
| Cd22 | CD22 antigen | 0.988 | |
| Ikzf1 | IKAROS family zinc finger 1 | 0.986 | |
| Fyn | Fyn proto-oncogene | 0.985 | |
| Cd79a | CD79A antigen (immunoglobulin-associated alpha) | 0.967 | |
| Sykb | spleen tyrosine kinase | 0.965 | |
| Tnf | tumor necrosis factor | 0.947 | |
| Fgr | Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog | 0.866 | |
| Vav1 | vav 1 oncogene | 0.866 | |
| Icos | inducible T-cell co-stimulator | 0.851 | |
| Cd80 | CD80 antigen | 0.835 | |
| Igh | immunoglobulin heavy chain complex | 0.833 | |
| Ccr5 | chemokine (C-C motif) receptor 5 | 0.815 | |
| Fcgr2b | Fc receptor, IgG, low affinity IIb | 0.741 | |
| Il4 | interleukin 4 | 0.736 | |
| Src | Rous sarcoma oncogene | 0.698 | |
| Shc1 | src homology 2 domain-containing transforming protein C1 | 0.692 | |
| Prkce | protein kinase C, epsilon | 0.653 | |
| Slamf1 | signaling lymphocytic activation molecule family member 1 | 0.651 | |
| Flt1 | FMS-like tyrosine kinase 1 | 0.649 | |
| Pdcd1 | programmed cell death 1 | 0.644 | |
| Prkcd | protein kinase C, delta | 0.632 | |
| Jak2 | Janus kinase 2 | 0.626 | |
| Prdm1 | PR domain containing 1, with ZNF domain | 0.617 | |
| Pik3cg | phosphoinositide-3-kinase, catalytic, gamma polypeptide | 0.615 | |
| Lyz2 | lysozyme 2 | 0.613 | |
| Cdh5 | cadherin 5 | 0.602 | |
| Cd40 | CD40 antigen | 0.602 | |
| Ccr6 | chemokine (C-C motif) receptor 6 | 0.590 | |
| Tnfrsf4 | tumor necrosis factor receptor superfamily, member 4 | 0.568 | |
| Btk | Bruton agammaglobulinemia tyrosine kinase | 0.548 | |
| Sh3kbp1 | SH3-domain kinase binding protein 1 | 0.548 | |
| Cd44 | CD44 antigen | 0.520 | |
| Foxp3 | forkhead box P3 | 0.519 | |
| Pik3r1 | phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha) | 0.503 | |
| Cd7 | CD7 antigen | 0.489 | |
| Ifng | interferon gamma | 0.488 | |
| Lyn | Yamaguchi sarcoma viral (v-yes-1) oncogene homolog | 0.486 | |
| Cd4 | CD4 antigen | 0.483 | |
| Pik3cd | phosphatidylinositol 3-kinase catalytic delta polypeptide | 0.480 | |
| Ptk2 | PTK2 protein tyrosine kinase 2 | 0.478 | |
| Cd8a | CD8 antigen, alpha chain | 0.474 | |
| Ccr1 | chemokine (C-C motif) receptor 1 | 0.470 | |
| Ldb3 | LIM domain binding 3 | 0.457 | |
| Rc3h1 | RING CCCH (C3H) domains 1 | 0.435 | |
| Cd180 | CD180 antigen | 0.414 | |
| Lat | linker for activation of T cells | 0.396 | |
| Dok1 | docking protein 1 | 0.393 | |
| Ccr7 | chemokine (C-C motif) receptor 7 | 0.392 | |
| Pou2af1 | POU domain, class 2, associating factor 1 | 0.385 | |
| Fasl | Fas ligand (TNF superfamily, member 6) | 0.357 | |
| Ptpre | protein tyrosine phosphatase, receptor type, E | 0.355 | |
| S100a4 | S100 calcium binding protein A4 | 0.349 | |
| Cd5 | CD5 antigen | 0.337 | |
| Klrk1 | killer cell lectin-like receptor subfamily K, member 1 | 0.329 | |
| Fcer1g | Fc receptor, IgE, high affinity I, gamma polypeptide | 0.328 | |
| Igk | immunoglobulin kappa chain complex | 0.325 | |
| Itga4 | integrin alpha 4 | 0.323 | |
| Tnfrsf9 | tumor necrosis factor receptor superfamily, member 9 | 0.313 | |
| Gab2 | growth factor receptor bound protein 2-associated protein 2 | 0.313 | |
| Fas | Fas (TNF receptor superfamily member 6) | 0.311 | |
| Fcrla | Fc receptor-like A | 0.308 | |
| Hcls1 | hematopoietic cell specific Lyn substrate 1 | 0.296 | |
| Slamf6 | SLAM family member 6 | 0.289 | |
| Plcg1 | phospholipase C, gamma 1 | 0.288 | |
| Il2rb | interleukin 2 receptor, beta chain | 0.278 | |
| Ccr8 | chemokine (C-C motif) receptor 8 | 0.271 | |
| Nfatc1 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 | 0.269 | |
| Lair1 | leukocyte-associated Ig-like receptor 1 | 0.269 | |
| Wipf1 | WAS/WASL interacting protein family, member 1 | 0.265 | |
| Itgal | integrin alpha L | 0.257 | |
| Cd28 | CD28 antigen | 0.257 | |
| Gab1 | growth factor receptor bound protein 2-associated protein 1 | 0.253 | |
| Ncoa3 | nuclear receptor coactivator 3 | 0.251 | |
| Il18rap | interleukin 18 receptor accessory protein | 0.245 | |
| Klrd1 | killer cell lectin-like receptor, subfamily D, member 1 | 0.244 | |
| Tbx21 | T-box 21 | 0.237 | |
| Cxcr2 | chemokine (C-X-C motif) receptor 2 | 0.233 | |
| Itgax | integrin alpha X | 0.220 | |
| Il2rg | interleukin 2 receptor, gamma chain | 0.219 | |
| Ifnar1 | interferon (alpha and beta) receptor 1 | 0.213 | |
| Itk | IL2-inducible T-cell kinase | 0.199 | |
| Kdr | kinase insert domain protein receptor | 0.198 | |
| Cxcr6 | chemokine (C-X-C motif) receptor 6 | 0.196 | |
| Grin2b | glutamate receptor, ionotropic, NMDA2B (epsilon 2) | 0.191 | |
| Xcr1 | chemokine (C motif) receptor 1 | 0.189 | |
| Tlr2 | toll-like receptor 2 | 0.184 | |
| Il10 | interleukin 10 | 0.183 | |
| Ptpn6 | protein tyrosine phosphatase, non-receptor type 6 | 0.181 | |
| Tnfrsf13c | tumor necrosis factor receptor superfamily, member 13c | 0.174 | |
| Itgb2 | integrin beta 2 | 0.173 | |
| Cd247 | CD247 antigen | 0.168 | |
| Ccl2 | chemokine (C-C motif) ligand 2 | 0.165 | |
| Pdcd1lg2 | programmed cell death 1 ligand 2 | 0.165 | |
| Ccl3 | chemokine (C-C motif) ligand 3 | 0.164 | |
| Apaf1 | apoptotic peptidase activating factor 1 | 0.164 |