The network for 'nitric oxide biosynthetic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

nitric oxide biosynthetic process

The chemical reactions and pathways resulting in the formation of nitric oxide, nitrogen monoxide (NO), a colorless gas only slightly soluble in water.

Homo sapiens
Name Description Probability Func Analog Organism
EGFR epidermal growth factor receptor 0.988
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.947
IL1R1 interleukin 1 receptor, type I 0.929
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.830
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.771
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.621
TICAM2 toll-like receptor adaptor molecule 2 0.553
IRAK2 interleukin-1 receptor-associated kinase 2 0.545
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.511
NOSTRIN nitric oxide synthase trafficker 0.342
NR0B1 nuclear receptor subfamily 0, group B, member 1 0.332
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.319
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein 0.206
KLF4 Kruppel-like factor 4 (gut) 0.193
IL1B interleukin 1, beta 0.167
IL1RAP interleukin 1 receptor accessory protein 0.162
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.159
SOCS3 suppressor of cytokine signaling 3 0.144
DLG2 discs, large homolog 2 (Drosophila) 0.140
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.108
STAT5A signal transducer and activator of transcription 5A 0.106
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.095
IL8 interleukin 8 0.078
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.078
TRAF6 TNF receptor-associated factor 6 0.076
VAC14 Vac14 homolog (S. cerevisiae) 0.074
NOXA1 NADPH oxidase activator 1 0.057
BCAR1 breast cancer anti-estrogen resistance 1 0.054
KLF6 Kruppel-like factor 6 0.050
CAV1 caveolin 1, caveolae protein, 22kDa 0.050
APP amyloid beta (A4) precursor protein 0.049
SSTR2 somatostatin receptor 2 0.047
TRPC1 transient receptor potential cation channel, subfamily C, member 1 0.047
DUSP1 dual specificity phosphatase 1 0.045
MYLK2 myosin light chain kinase 2 0.045
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.043
BCL2L1 BCL2-like 1 0.043
MPDZ multiple PDZ domain protein 0.042
IL10RA interleukin 10 receptor, alpha 0.040
CFLAR CASP8 and FADD-like apoptosis regulator 0.040
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.039
PKD1 polycystic kidney disease 1 (autosomal dominant) 0.036
MYD88 myeloid differentiation primary response gene (88) 0.035
PPP5C protein phosphatase 5, catalytic subunit 0.034
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 0.034
MAPT microtubule-associated protein tau 0.033
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.032
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.031
ESR1 estrogen receptor 1 0.031
IL1R2 interleukin 1 receptor, type II 0.030
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.029
IL1RN interleukin 1 receptor antagonist 0.029
BCL3 B-cell CLL/lymphoma 3 0.029
INSR insulin receptor 0.029
MATK megakaryocyte-associated tyrosine kinase 0.027
ALDOB aldolase B, fructose-bisphosphate 0.026
CDCP1 CUB domain containing protein 1 0.025
ZC3H12A zinc finger CCCH-type containing 12A 0.025
DLG4 discs, large homolog 4 (Drosophila) 0.025
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.025
DDR2 discoidin domain receptor tyrosine kinase 2 0.025
KCNA1 potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia) 0.024
PARD6A par-6 partitioning defective 6 homolog alpha (C. elegans) 0.023
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.023
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 0.022
LAT linker for activation of T cells 0.022
ZFP36 zinc finger protein 36, C3H type, homolog (mouse) 0.022
CTBP1 C-terminal binding protein 1 0.022
MXD1 MAX dimerization protein 1 0.021
NCF1 neutrophil cytosolic factor 1 0.021
CAV2 caveolin 2 0.020
PICK1 protein interacting with PRKCA 1 0.020
FYN FYN oncogene related to SRC, FGR, YES 0.020
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 0.019
CCL4 chemokine (C-C motif) ligand 4 0.018
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 0.018
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.018
CALCA calcitonin-related polypeptide alpha 0.018
TNIP1 TNFAIP3 interacting protein 1 0.018
LY96 lymphocyte antigen 96 0.017
MAP2K4 mitogen-activated protein kinase kinase 4 0.017
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta) 0.017
EHMT2 euchromatic histone-lysine N-methyltransferase 2 0.016
ACTB actin, beta 0.016
SSTR3 somatostatin receptor 3 0.016
SQSTM1 sequestosome 1 0.016
BAG3 BCL2-associated athanogene 3 0.016
SP1 Sp1 transcription factor 0.015
FOS FBJ murine osteosarcoma viral oncogene homolog 0.015
PECAM1 platelet/endothelial cell adhesion molecule 0.015
GHR growth hormone receptor 0.015
SMAD3 SMAD family member 3 0.014
DLG1 discs, large homolog 1 (Drosophila) 0.014
FOSL2 FOS-like antigen 2 0.014
EPOR erythropoietin receptor 0.014
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.014
EGR2 early growth response 2 0.014
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 0.014
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 0.013
IGF1R insulin-like growth factor 1 receptor 0.013
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
Loading network...
Danio rerio
Name Description Probability Func Analog Organism
chrna1 cholinergic receptor, nicotinic, alpha polypeptide 1 0.721
LOC799612 prolactin 2 0.508
hsp90a.1 heat shock protein 90-alpha 1 0.348
vangl2 vang-like 2 (van gogh, Drosophila) 0.316
smyhc1l slow myosin heavy chain 1, like 0.313
nos2a nitric oxide synthase 2a, inducible 0.304
acta1a actin, alpha 1a, skeletal muscle 0.301
tnnc1b troponin C type 1b (slow) 0.299
fabp11a fatty acid binding protein 11a 0.287
tp53bp2 tumor protein p53 binding protein, 2 0.222
myhz2 myosin, heavy polypeptide 2, fast muscle specific 0.222
elovl5 ELOVL family member 5, elongation of long chain fatty acids (yeast) 0.171
insrb insulin receptor b 0.168
grid2 glutamate receptor, ionotropic, delta 2 0.167
smyhc1 slow myosin heavy chain 1 0.163
nfkbiaa nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a 0.162
plcg1 phospholipase C, gamma 1 0.159
tlr3 toll-like receptor 3 0.150
mchr1b melanin-concentrating hormone receptor 1b 0.146
lmna lamin A 0.145
myhz1.1 myosin, heavy polypeptide 1.1, skeletal muscle 0.137
smad2 MAD homolog 2 (Drosophila) 0.124
rab11fip4a RAB11 family interacting protein 4 (class II) a 0.111
hspb1 heat shock protein, alpha-crystallin-related, 1 0.106
vdra vitamin D receptor a 0.101
tlr18 toll-like receptor 18 0.101
stc1l stanniocalcin 1, like 0.101
slc25a14 solute carrier family 25 (mitochondrial carrier, brain), member 14 0.093
hcrt hypocretin (orexin) neuropeptide precursor 0.088
tpma alpha-tropomyosin 0.088
kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 0.086
ca8 carbonic anhydrase VIII 0.081
nos2b nitric oxide synthase 2b, inducible 0.078
slc2a1a solute carrier family 2 (facilitated glucose transporter), member 1a 0.076
si:ch211-209p5.2 si:ch211-209p5.2 0.076
unc45b unc-45 homolog B (C. elegans) 0.075
erbb2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog 0.069
slc2a1b solute carrier family 2 (facilitated glucose transporter), member 1b 0.068
tirap toll-interleukin 1 receptor (TIR) domain containing adaptor protein 0.068
plxnb2a plexin b2a 0.068
lama1 laminin, alpha 1 0.067
smyd1b SET and MYND domain containing 1b 0.067
myog myogenin 0.066
tpm1 tropomyosin 1 (alpha) 0.066
ifnphi1 interferon phi 1 0.066
pard6gb par-6 partitioning defective 6 homolog gamma B (C. elegans) 0.065
furinb furin (paired basic amino acid cleaving enzyme) b 0.065
bon bonnie and clyde 0.065
tnnt3a troponin T3a, skeletal, fast 0.064
pth1a parathyroid hormone 1a 0.064
shmt2 serine hydroxymethyltransferase 2 (mitochondrial) 0.062
nrg1 neuregulin 1 0.062
myh6 myosin, heavy polypeptide 6, cardiac muscle, alpha 0.062
LOC100332193 growth hormone secretagogue receptor type 1-like 0.061
gapdhs glyceraldehyde-3-phosphate dehydrogenase, spermatogenic 0.061
LOC570775 protein argonaute-1-like 0.060
tnfa tumor necrosis factor a (TNF superfamily, member 2) 0.060
LOC100003330 melanocortin-2 receptor accessory protein 2-like 0.060
acvr1b activin A receptor, type IB 0.060
ripk2 receptor-interacting serine-threonine kinase 2 0.059
esr2b estrogen receptor 2b 0.059
fbn2b fibrillin 2b 0.058
il8 interleukin 8 0.058
abcc1 ATP-binding cassette, sub-family C, member 1 0.058
ghrl ghrelin/obestatin preprohormone 0.058
fhla four and a half LIM domains a 0.057
cxcr4a chemokine (C-X-C motif) receptor 4a 0.056
ptger4b prostaglandin E receptor 4 (subtype EP4) b 0.056
tnfsf10l2 tumor necrosis factor (ligand) superfamily, member 10 like 2 0.055
tnnc2 troponin C type 2 (fast) 0.055
insra insulin receptor a 0.055
tbx20 T-box 20 0.053
crfa31.2 IL-4RA-like protein 2 0.053
actc1a actin, alpha, cardiac muscle 1a 0.053
park7 parkinson disease (autosomal recessive, early onset) 7 0.051
ticam1 toll-like receptor adaptor molecule 1 0.051
mmp9 matrix metalloproteinase 9 0.050
cecr1a cat eye syndrome chromosome region, candidate 1a 0.050
ppp1r12a protein phosphatase 1, regulatory (inhibitor) subunit 12A 0.049
il6r interleukin 6 receptor 0.048
med12 mediator of RNA polymerase II transcription, subunit 12 homolog 0.048
furina furin (paired basic amino acid cleaving enzyme) a 0.047
slc25a27 solute carrier family 25, member 27 0.047
mao monoamine oxidase 0.047
sid4 secreted immunoglobulin domain 4 0.047
ptch2 patched 2 0.046
scrib scribbled homolog (Drosophila) 0.046
zgc:162270 zgc:162270 0.046
mapk3 mitogen-activated protein kinase 3 0.045
tph2 tryptophan hydroxylase 2 (tryptophan 5-monooxygenase) 0.045
elovl2 elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 2 0.045
mmp13a matrix metalloproteinase 13a 0.044
thraa thyroid hormone receptor alpha a 0.044
cyp19a1b cytochrome P450, family 19, subfamily A, polypeptide 1b 0.044
jam2a junctional adhesion molecule 2a 0.044
sat1b spermidine/spermine N1-acetyl transferase 1b 0.042
mapk4 mitogen-activated protein kinase 4 0.042
myf6 myogenic factor 6 0.042
ucp3 uncoupling protein 3 0.042
ryr1b ryanodine receptor 1b (skeletal) 0.042
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
FK506-bp2 FK506-binding protein 2 0.013
mrn marionette 0.010
Loading network...
Mus musculus
Name Description Probability Func Analog Organism
Nos2 nitric oxide synthase 2, inducible 0.974
Tlr4 toll-like receptor 4 0.931
Nos1 nitric oxide synthase 1, neuronal 0.929
Lepr leptin receptor 0.928
Lyz2 lysozyme 2 0.881
Ccr2 chemokine (C-C motif) receptor 2 0.848
Tlr2 toll-like receptor 2 0.694
Atxn1 ataxin 1 0.560
H2-D1 histocompatibility 2, D region locus 1 0.537
Myd88 myeloid differentiation primary response gene 88 0.490
Vdr vitamin D receptor 0.429
Cd44 CD44 antigen 0.405
Pparg peroxisome proliferator activated receptor gamma 0.389
Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b 0.386
Klra9 killer cell lectin-like receptor subfamily A, member 9 0.372
Esr1 estrogen receptor 1 (alpha) 0.364
Insr insulin receptor 0.340
B2m beta-2 microglobulin 0.339
Ccl2 chemokine (C-C motif) ligand 2 0.320
Ren1 renin 1 structural 0.290
Klrc1 killer cell lectin-like receptor subfamily C, member 1 0.259
Klrk1 killer cell lectin-like receptor subfamily K, member 1 0.249
Lep leptin 0.193
Mmp9 matrix metallopeptidase 9 0.191
Dmd dystrophin, muscular dystrophy 0.191
Tgfb1 transforming growth factor, beta 1 0.186
Ar androgen receptor 0.180
Il10 interleukin 10 0.178
Vhl von Hippel-Lindau tumor suppressor 0.173
Tnf tumor necrosis factor 0.169
Pten phosphatase and tensin homolog 0.168
Ptgs2 prostaglandin-endoperoxide synthase 2 0.167
Akt1 thymoma viral proto-oncogene 1 0.157
Ptrf polymerase I and transcript release factor 0.151
Apoe apolipoprotein E 0.146
Il6 interleukin 6 0.134
Relb avian reticuloendotheliosis viral (v-rel) oncogene related B 0.118
Agtr1a angiotensin II receptor, type 1a 0.110
Nr3c1 nuclear receptor subfamily 3, group C, member 1 0.110
Smad3 MAD homolog 3 (Drosophila) 0.109
Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member 1 0.106
Il1a interleukin 1 alpha 0.101
H2-K1 histocompatibility 2, K1, K region 0.101
Cd14 CD14 antigen 0.098
Gzma granzyme A 0.093
Lif leukemia inhibitory factor 0.089
Nos3 nitric oxide synthase 3, endothelial cell 0.089
Ncr1 natural cytotoxicity triggering receptor 1 0.086
F9 coagulation factor IX 0.086
Umod uromodulin 0.081
Ccr5 chemokine (C-C motif) receptor 5 0.081
Socs1 suppressor of cytokine signaling 1 0.072
Gcet2 germinal center expressed transcript 2 0.069
Aoah acyloxyacyl hydrolase 0.064
H2-Q7 histocompatibility 2, Q region locus 7 0.063
Gzmk granzyme K 0.060
Gnas GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus 0.058
Cav1 caveolin 1, caveolae protein 0.058
Pyhin1 pyrin and HIN domain family, member 1 0.056
Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.055
Fasl Fas ligand (TNF superfamily, member 6) 0.053
Msr1 macrophage scavenger receptor 1 0.052
Klra2 killer cell lectin-like receptor, subfamily A, member 2 0.051
Klrb1b killer cell lectin-like receptor subfamily B member 1B 0.049
Lair1 leukocyte-associated Ig-like receptor 1 0.048
Chordc1 cysteine and histidine-rich domain (CHORD)-containing, zinc-binding protein 1 0.048
Notch2 Notch gene homolog 2 (Drosophila) 0.046
H2-Q6 histocompatibility 2, Q region locus 6 0.046
Il7r interleukin 7 receptor 0.046
Saa4 serum amyloid A 4 0.043
Ghr growth hormone receptor 0.042
Ms4a4c membrane-spanning 4-domains, subfamily A, member 4C 0.042
Il1r1 interleukin 1 receptor, type I 0.042
Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 0.041
Plat plasminogen activator, tissue 0.041
Il2rg interleukin 2 receptor, gamma chain 0.039
Fpr1 formyl peptide receptor 1 0.039
Emr4 EGF-like module containing, mucin-like, hormone receptor-like sequence 4 0.039
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.039
Wt1 Wilms tumor 1 homolog 0.038
Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.038
Klrd1 killer cell lectin-like receptor, subfamily D, member 1 0.037
Klra7 killer cell lectin-like receptor, subfamily A, member 7 0.036
Socs3 suppressor of cytokine signaling 3 0.036
Map3k8 mitogen-activated protein kinase kinase kinase 8 0.036
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.035
Ccr6 chemokine (C-C motif) receptor 6 0.034
Itgb3 integrin beta 3 0.033
Clec4n C-type lectin domain family 4, member n 0.032
Slc12a1 solute carrier family 12, member 1 0.032
Hspa8 heat shock protein 8 0.032
Emr1 EGF-like module containing, mucin-like, hormone receptor-like sequence 1 0.031
Cp ceruloplasmin 0.031
Casp12 caspase 12 0.031
Tnfsf8 tumor necrosis factor (ligand) superfamily, member 8 0.031
Mat1a methionine adenosyltransferase I, alpha 0.030
Pilrb1 paired immunoglobin-like type 2 receptor beta 1 0.029
Thbd thrombomodulin 0.029
Ccr3 chemokine (C-C motif) receptor 3 0.029
Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 0.028
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
Hsph1 heat shock 105/110 protein 1 0.019
Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member 1 0.016
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.016
Nek9 NIMA (never in mitosis gene a)- related kinase 9 0.011
Loading network...
Saccharomyces cerevisiae
Name Description Probability Func Analog Organism