IMP
Process View
The network for 'positive thymic t cell selection' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.
Multiple Organisms
positive thymic t cell selection
The process of sparing immature T cells in the thymus which react with self-MHC protein complexes with low affinity levels from apoptotic death.
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| LCK | lymphocyte-specific protein tyrosine kinase | 0.999 | |
| CD247 | CD247 molecule | 0.994 | |
| CD3E | CD3e molecule, epsilon (CD3-TCR complex) | 0.973 | |
| LAT | linker for activation of T cells | 0.876 | |
| HLA-DMB | major histocompatibility complex, class II, DM beta | 0.822 | |
| HLA-DRA | major histocompatibility complex, class II, DR alpha | 0.734 | |
| PTPN22 | protein tyrosine phosphatase, non-receptor type 22 (lymphoid) | 0.668 | |
| HLA-DPA1 | major histocompatibility complex, class II, DP alpha 1 | 0.489 | |
| HLA-DRB1 | major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 1 | 0.484 | |
| VAV1 | vav 1 guanine nucleotide exchange factor | 0.359 | |
| SH2D1A | SH2 domain containing 1A | 0.301 | |
| STRADA | STE20-related kinase adaptor alpha | 0.239 | |
| HLA-DQA1 | major histocompatibility complex, class II, DQ alpha 1 | 0.180 | |
| CD74 | CD74 molecule, major histocompatibility complex, class II invariant chain | 0.178 | |
| MKL1 | megakaryoblastic leukemia (translocation) 1 | 0.148 | |
| SH2D2A | SH2 domain containing 2A | 0.144 | |
| CXCR4 | chemokine (C-X-C motif) receptor 4 | 0.114 | |
| GHR | growth hormone receptor | 0.113 | |
| HLA-DPB1 | major histocompatibility complex, class II, DP beta 1 | 0.112 | |
| SYK | spleen tyrosine kinase | 0.102 | |
| STRADB | STE20-related kinase adaptor beta | 0.095 | |
| LCP2 | lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) | 0.081 | |
| PTPN6 | protein tyrosine phosphatase, non-receptor type 6 | 0.055 | |
| HLA-DRB5 | major histocompatibility complex, class II, DR beta 5 | 0.049 | |
| WAS | Wiskott-Aldrich syndrome (eczema-thrombocytopenia) | 0.049 | |
| CD2 | CD2 molecule | 0.049 | |
| ITGAL | integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) | 0.048 | |
| PRKCQ | protein kinase C, theta | 0.043 | |
| CD8A | CD8a molecule | 0.042 | |
| CD52 | CD52 molecule | 0.041 | |
| SH3BP2 | SH3-domain binding protein 2 | 0.034 | |
| SEMA4D | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D | 0.028 | |
| MYOCD | myocardin | 0.028 | |
| MKL2 | MKL/myocardin-like 2 | 0.025 | |
| ITGB2 | integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) | 0.024 | |
| PIK3R1 | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | 0.024 | |
| HCLS1 | hematopoietic cell-specific Lyn substrate 1 | 0.021 | |
| CBL | Cas-Br-M (murine) ecotropic retroviral transforming sequence | 0.019 | |
| CD3D | CD3d molecule, delta (CD3-TCR complex) | 0.018 | |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.018 | |
| PTPRB | protein tyrosine phosphatase, receptor type, B | 0.014 | |
| ITGA1 | integrin, alpha 1 | 0.013 | |
| HLA-DQB1 | major histocompatibility complex, class II, DQ beta 1 | 0.013 | |
| FCGR2A | Fc fragment of IgG, low affinity IIa, receptor (CD32) | 0.012 | |
| BTK | Bruton agammaglobulinemia tyrosine kinase | 0.012 | |
| CD7 | CD7 molecule | 0.012 | |
| TYROBP | TYRO protein tyrosine kinase binding protein | 0.012 | |
| HLA-DRB4 | major histocompatibility complex, class II, DR beta 4 | 0.012 | |
| LRMP | lymphoid-restricted membrane protein | 0.011 | |
| TRAT1 | T cell receptor associated transmembrane adaptor 1 | 0.011 | |
| CD3G | CD3g molecule, gamma (CD3-TCR complex) | 0.010 |
Loading network...
Mus musculus
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| H2-Aa | histocompatibility 2, class II antigen A, alpha | 0.999 | |
| Cd74 | CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) | 0.992 | |
| H2-Ab1 | histocompatibility 2, class II antigen A, beta 1 | 0.979 | |
| Cd247 | CD247 antigen | 0.973 | |
| H2-Eb1 | histocompatibility 2, class II antigen E beta | 0.950 | |
| Fyn | Fyn proto-oncogene | 0.898 | |
| Lck | lymphocyte protein tyrosine kinase | 0.799 | |
| Lat | linker for activation of T cells | 0.397 | |
| Fgfr2 | fibroblast growth factor receptor 2 | 0.332 | |
| H2-DMa | histocompatibility 2, class II, locus DMa | 0.266 | |
| Ptpn22 | protein tyrosine phosphatase, non-receptor type 22 (lymphoid) | 0.198 | |
| H2-DMb2 | histocompatibility 2, class II, locus Mb2 | 0.169 | |
| Efnb2 | ephrin B2 | 0.121 | |
| Cd28 | CD28 antigen | 0.107 | |
| Itk | IL2-inducible T-cell kinase | 0.103 | |
| Sox9 | SRY-box containing gene 9 | 0.090 | |
| Fas | Fas (TNF receptor superfamily member 6) | 0.081 | |
| Cd3e | CD3 antigen, epsilon polypeptide | 0.070 | |
| Cd22 | CD22 antigen | 0.061 | |
| Ptprc | protein tyrosine phosphatase, receptor type, C | 0.061 | |
| Vav1 | vav 1 oncogene | 0.060 | |
| Efna1 | ephrin A1 | 0.059 | |
| Ciita | class II transactivator | 0.057 | |
| Srebf2 | sterol regulatory element binding factor 2 | 0.053 | |
| Ptprcap | protein tyrosine phosphatase, receptor type, C polypeptide-associated protein | 0.053 | |
| Gli3 | GLI-Kruppel family member GLI3 | 0.053 | |
| Foxc2 | forkhead box C2 | 0.052 | |
| Cd2 | CD2 antigen | 0.050 | |
| Cxcr4 | chemokine (C-X-C motif) receptor 4 | 0.050 | |
| Irf8 | interferon regulatory factor 8 | 0.048 | |
| Cd8a | CD8 antigen, alpha chain | 0.046 | |
| Itgax | integrin alpha X | 0.042 | |
| B2m | beta-2 microglobulin | 0.040 | |
| Kras | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog | 0.037 | |
| Rhoh | ras homolog gene family, member H | 0.035 | |
| Grb2 | growth factor receptor bound protein 2 | 0.035 | |
| Cdkn1b | cyclin-dependent kinase inhibitor 1B | 0.034 | |
| Jak1 | Janus kinase 1 | 0.033 | |
| Ccl5 | chemokine (C-C motif) ligand 5 | 0.033 | |
| Ctnnb1 | catenin (cadherin associated protein), beta 1 | 0.031 | |
| Sh2d1a | SH2 domain protein 1A | 0.029 | |
| Prkcq | protein kinase C, theta | 0.029 | |
| Cxcr3 | chemokine (C-X-C motif) receptor 3 | 0.025 | |
| Ctsw | cathepsin W | 0.024 | |
| Abcg1 | ATP-binding cassette, sub-family G (WHITE), member 1 | 0.024 | |
| H2-Oa | histocompatibility 2, O region alpha locus | 0.023 | |
| Ntf3 | neurotrophin 3 | 0.022 | |
| Sh2d2a | SH2 domain protein 2A | 0.021 | |
| Cd37 | CD37 antigen | 0.020 | |
| Foxc1 | forkhead box C1 | 0.020 | |
| Fcgr2b | Fc receptor, IgG, low affinity IIb | 0.020 | |
| Cd5 | CD5 antigen | 0.020 | |
| Rela | v-rel reticuloendotheliosis viral oncogene homolog A (avian) | 0.019 | |
| Nsf | N-ethylmaleimide sensitive fusion protein | 0.019 | |
| Cd8b1 | CD8 antigen, beta chain 1 | 0.019 | |
| Cd83 | CD83 antigen | 0.019 | |
| Cytip | cytohesin 1 interacting protein | 0.018 | |
| Cd6 | CD6 antigen | 0.018 | |
| Stat3 | signal transducer and activator of transcription 3 | 0.017 | |
| Cd27 | CD27 antigen | 0.017 | |
| Was | Wiskott-Aldrich syndrome homolog (human) | 0.017 | |
| Cbl | Casitas B-lineage lymphoma | 0.016 | |
| Wipf1 | WAS/WASL interacting protein family, member 1 | 0.016 | |
| Pag1 | phosphoprotein associated with glycosphingolipid microdomains 1 | 0.016 | |
| Map4k4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.016 | |
| Rbms1 | RNA binding motif, single stranded interacting protein 1 | 0.016 | |
| Traf3 | TNF receptor-associated factor 3 | 0.016 | |
| Lyz2 | lysozyme 2 | 0.016 | |
| Ltb | lymphotoxin B | 0.015 | |
| Rac2 | RAS-related C3 botulinum substrate 2 | 0.015 | |
| Tcra | T-cell receptor alpha chain | 0.015 | |
| Stat4 | signal transducer and activator of transcription 4 | 0.015 | |
| Il27ra | interleukin 27 receptor, alpha | 0.015 | |
| Gzma | granzyme A | 0.015 | |
| Cd79a | CD79A antigen (immunoglobulin-associated alpha) | 0.014 | |
| Gimap4 | GTPase, IMAP family member 4 | 0.014 | |
| Il16 | interleukin 16 | 0.014 | |
| Itgae | integrin alpha E, epithelial-associated | 0.014 | |
| Il2rb | interleukin 2 receptor, beta chain | 0.014 | |
| Cd4 | CD4 antigen | 0.014 | |
| Cd3d | CD3 antigen, delta polypeptide | 0.013 | |
| Cd3g | CD3 antigen, gamma polypeptide | 0.013 | |
| Klrd1 | killer cell lectin-like receptor, subfamily D, member 1 | 0.013 | |
| Dock2 | dedicator of cyto-kinesis 2 | 0.013 | |
| Rassf5 | Ras association (RalGDS/AF-6) domain family member 5 | 0.013 | |
| Ly86 | lymphocyte antigen 86 | 0.013 | |
| Itgb2 | integrin beta 2 | 0.013 | |
| Arhgap9 | Rho GTPase activating protein 9 | 0.012 | |
| Cd96 | CD96 antigen | 0.012 | |
| Stk10 | serine/threonine kinase 10 | 0.012 | |
| H2-K1 | histocompatibility 2, K1, K region | 0.012 | |
| Acap1 | ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 | 0.012 | |
| Elf1 | E74-like factor 1 | 0.012 | |
| Ptprn | protein tyrosine phosphatase, receptor type, N | 0.012 | |
| Ptk2b | PTK2 protein tyrosine kinase 2 beta | 0.012 | |
| Igj | immunoglobulin joining chain | 0.012 | |
| Pld4 | phospholipase D family, member 4 | 0.012 | |
| Cd79b | CD79B antigen | 0.012 | |
| Hey2 | hairy/enhancer-of-split related with YRPW motif 2 | 0.011 | |
| Il6st | interleukin 6 signal transducer | 0.011 |