The network for 'hematopoietic stem cell differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

hematopoietic stem cell differentiation

The process in which a relatively unspecialized cell acquires specialized features of a hematopoietic stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells.

Name Description Probability Func Analog Organism
HDAC2 histone deacetylase 2 1.000
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.968
HOXB7 homeobox B7 0.931
HOXB5 homeobox B5 0.890
CCND1 cyclin D1 0.856
VAC14 Vac14 homolog (S. cerevisiae) 0.846
SF3A1 splicing factor 3a, subunit 1, 120kDa 0.842
HOXA10 homeobox A10 0.804
SIN3A SIN3 homolog A, transcription regulator (yeast) 0.726
RPS27 ribosomal protein S27 0.696
RBBP4 retinoblastoma binding protein 4 0.684
MKL1 megakaryoblastic leukemia (translocation) 1 0.678
HOXA4 homeobox A4 0.635
RUNX1 runt-related transcription factor 1 0.568
HOXB9 homeobox B9 0.488
HOXA7 homeobox A7 0.463
HOXB3 homeobox B3 0.430
HOXA5 homeobox A5 0.416
RBBP7 retinoblastoma binding protein 7 0.406
GATA2 GATA binding protein 2 0.382
WBP11 WW domain binding protein 11 0.375
PARP1 poly (ADP-ribose) polymerase 1 0.355
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.347
MYOD1 myogenic differentiation 1 0.330
PAX1 paired box 1 0.326
HOXB6 homeobox B6 0.314
CSNK2A1 casein kinase 2, alpha 1 polypeptide 0.309
RPS10 ribosomal protein S10 0.303
HOXC10 homeobox C10 0.242
HOXA6 homeobox A6 0.240
RPL37A ribosomal protein L37a 0.231
WHSC1L1 Wolf-Hirschhorn syndrome candidate 1-like 1 0.220
APLF aprataxin and PNKP like factor 0.212
ARFIP2 ADP-ribosylation factor interacting protein 2 0.209
MYOCD myocardin 0.199
NOTCH1 notch 1 0.167
UHRF2 ubiquitin-like with PHD and ring finger domains 2 0.166
HOXA2 homeobox A2 0.153
RPL39 ribosomal protein L39 0.150
HOXA11 homeobox A11 0.144
CCND2 cyclin D2 0.141
CYTH2 cytohesin 2 0.112
CCND3 cyclin D3 0.112
DHX30 DEAH (Asp-Glu-Ala-His) box polypeptide 30 0.112
RPS28 ribosomal protein S28 0.112
NCL nucleolin 0.101
HOXA1 homeobox A1 0.095
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.093
HOXC5 homeobox C5 0.086
HOXA3 homeobox A3 0.084
CDK6 cyclin-dependent kinase 6 0.083
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.083
NR2E3 nuclear receptor subfamily 2, group E, member 3 0.083
HOXB2 homeobox B2 0.078
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.076
WRN Werner syndrome, RecQ helicase-like 0.075
HOXC8 homeobox C8 0.074
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.073
HOXC6 homeobox C6 0.069
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.069
HDAC1 histone deacetylase 1 0.068
DMTF1 cyclin D binding myb-like transcription factor 1 0.067
RPA1 replication protein A1, 70kDa 0.066
TOP1 topoisomerase (DNA) I 0.065
HOXC11 homeobox C11 0.065
CD2BP2 CD2 (cytoplasmic tail) binding protein 2 0.065
HDGF hepatoma-derived growth factor 0.062
DDIT3 DNA-damage-inducible transcript 3 0.061
TNS1 tensin 1 0.061
NOTCH3 notch 3 0.060
TAL1 T-cell acute lymphocytic leukemia 1 0.060
FKBP1A FK506 binding protein 1A, 12kDa 0.060
KRT15 keratin 15 0.056
MOV10 Mov10, Moloney leukemia virus 10, homolog (mouse) 0.054
RPL27 ribosomal protein L27 0.051
CDK9 cyclin-dependent kinase 9 0.046
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 0.046
RPL38 ribosomal protein L38 0.044
CAV2 caveolin 2 0.044
RAB5C RAB5C, member RAS oncogene family 0.044
RBM5 RNA binding motif protein 5 0.044
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein) 0.043
NCOR2 nuclear receptor corepressor 2 0.043
RPA2 replication protein A2, 32kDa 0.042
MKL2 MKL/myocardin-like 2 0.042
BCL6 B-cell CLL/lymphoma 6 0.041
RPL41 ribosomal protein L41 0.039
MTA2 metastasis associated 1 family, member 2 0.038
SMAD6 SMAD family member 6 0.038
POU2F1 POU class 2 homeobox 1 0.038
PDX1 pancreatic and duodenal homeobox 1 0.038
C4orf14 chromosome 4 open reading frame 14 0.037
DHX58 DEXH (Asp-Glu-X-His) box polypeptide 58 0.037
IER5 immediate early response 5 0.037
SF3A2 splicing factor 3a, subunit 2, 66kDa 0.037
HOXB8 homeobox B8 0.036
JAG1 jagged 1 0.036
HOXC4 homeobox C4 0.035
GATA1 GATA binding protein 1 (globin transcription factor 1) 0.035
HOXB4 homeobox B4 0.034
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
Loading network...
Danio rerio
Name Description Probability Func Analog Organism
kdrl kinase insert domain receptor like 0.997
tbx16 T-box gene 16 0.987
atoh1b atonal homolog 1b 0.919
etv2 ets variant gene 2 0.882
dlc deltaC 0.877
tbx2a T-box gene 2a 0.836
runx1 runt-related transcription factor 1 0.774
ascl1a achaete-scute complex-like 1a (Drosophila) 0.738
tbx5a T-box 5a 0.737
mib mind bomb 0.693
hand2 heart and neural crest derivatives expressed transcript 2 0.634
ptf1a pancreas specific transcription factor, 1a 0.631
dld deltaD 0.614
hoxd4a homeo box D4a 0.612
pax2a paired box gene 2a 0.585
hnf1ba HNF1 homeobox Ba 0.536
myf5 myogenic factor 5 0.534
her1 hairy-related 1 0.533
tcf21 transcription factor 21 0.518
notch1a notch homolog 1a 0.495
fgf10a fibroblast growth factor 10a 0.457
cdh5 cadherin 5 0.430
fn1 fibronectin 1 0.419
med12 mediator of RNA polymerase II transcription, subunit 12 homolog 0.406
gfi1.1 growth factor independent 1.1 0.359
isl1 islet1 0.357
eve1 even-skipped-like1 0.356
wnt9a wingless-type MMTV integration site family, member 9A 0.341
LOC566708 FL cytokine receptor-like 0.326
dla deltaA 0.308
tbx15 T-box 15 0.299
wnt2bb wingless-type MMTV integration site family, member 2Bb 0.277
tbx1 T-box 1 0.256
myod1 myogenic differentiation 1 0.247
spns2 spinster homolog 2 (Drosophila) 0.240
ptch1 patched 1 0.239
jag2 jagged 2 0.227
sars seryl-tRNA synthetase 0.223
fgf8a fibroblast growth factor 8 a 0.222
neurog1 neurogenin 1 0.215
unc45a unc-45 homolog A (C. elegans) 0.215
ccm2 cerebral cavernous malformation 2 0.198
dlb deltaB 0.195
twist1a twist1a 0.187
tnnt3a troponin T3a, skeletal, fast 0.184
metap2 methionyl aminopeptidase 2 0.182
foxa3 forkhead box A3 0.170
LOC799612 prolactin 2 0.167
foxi1 forkhead box I1 0.166
cdkn1c cyclin-dependent kinase inhibitor 1C (p57, Kip2) 0.159
dact1 dapper homolog 1, antagonist of beta-catenin (xenopus) 0.157
krit1 KRIT1, ankyrin repeat containing 0.155
nos2b nitric oxide synthase 2b, inducible 0.154
tbx24 T-box 24 0.144
smyhc1l slow myosin heavy chain 1, like 0.144
wnt11 wingless-type MMTV integration site family, member 11 0.140
atoh1a atonal homolog 1a 0.138
her7 hairy and enhancer of split related-7 0.127
lama1 laminin, alpha 1 0.122
gja3 gap junction protein, alpha 3 0.120
hoxc4a homeo box C4a 0.118
cdx4 caudal type homeo box transcription factor 4 0.115
vcana versican a 0.115
snrnp70 small nuclear ribonucleoprotein 70 (U1) 0.111
lhx1a LIM homeobox 1a 0.110
tfr1a transferrin receptor 1a 0.107
dll4 delta-like 4 (Drosophila) 0.106
nkx2.3 NK2 transcription factor related 3 0.099
nos2a nitric oxide synthase 2a, inducible 0.099
vhl von Hippel-Lindau tumor suppressor 0.098
tbx18 T-box 18 0.098
sf3a3 splicing factor 3a, subunit 3 0.097
notch1b notch homolog 1b 0.095
st14a suppression of tumorigenicity 14 (colon carcinoma) a 0.093
hbbe3 hemoglobin beta embryonic-3 0.090
wnt8a wingless-type MMTV integration site family, member 8a 0.088
f2rl1.2 coagulation factor II (thrombin) receptor-like 1.2 0.088
neurod4 neurogenic differentiation 4 0.087
six2a sine oculis-related homeobox 2a 0.083
fzd10 frizzled homolog 10 0.080
tmem2 transmembrane protein 2 0.078
barx1 BarH-like homeobox 1 0.077
wnt3a wingless-type MMTV integration site family, member 3A 0.077
vegfc vascular endothelial growth factor c 0.076
pvalb2 parvalbumin 2 0.076
gcm2 glial cells missing homolog 2 (Drosophila) 0.075
jam2b junctional adhesion molecule 2b 0.072
otpb orthopedia homolog b 0.072
neurod6b neurogenic differentiation 6b 0.070
hoxd11a homeo box D11a 0.070
six4a sine oculis homeobox homolog 4a 0.070
dlx6a distal-less homeobox gene 6a 0.068
btk Bruton agammaglobulinemia tyrosine kinase 0.068
dmrt2a doublesex and mab-3 related transcription factor 2a 0.068
cmyb transcription factor cmyb 0.067
fbln1 fibulin 1 0.067
grem2 gremlin 2, cysteine knot superfamily 0.066
cyp26c1 cytochrome P450, family 26, subfamily C, polypeptide 1 0.062
met met proto-oncogene (hepatocyte growth factor receptor) 0.062
plcg1 phospholipase C, gamma 1 0.061
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
MED22 Mediator complex subunit 22 0.091
Dl Delta 0.088
RPA2 Replication protein A2 0.050
Rcd5 Reduction in Cnn dots 5 0.050
eIF-4E Eukaryotic initiation factor 4E 0.049
SMC2 CG10212 gene product from transcript CG10212-RA 0.041
CG11266 CG11266 gene product from transcript CG11266-RD 0.036
RpL34b Ribosomal protein L34b 0.035
Klp61F Kinesin-like protein at 61F 0.034
sgg shaggy 0.031
eIF3-S10 CG9805 gene product from transcript CG9805-RA 0.030
mRpL49 mitochondrial ribosomal protein L49 0.027
cyp33 cyclophilin-33 0.027
sti sticky 0.026
Saf-B Scaffold attachment factor B 0.026
CG9740 CG9740 gene product from transcript CG9740-RA 0.025
MED14 Mediator complex subunit 14 0.025
RpL31 Ribosomal protein L31 0.024
Tctp Translationally controlled tumor protein 0.024
Int6 Int6 homologue 0.023
CG5548 CG5548 gene product from transcript CG5548-RA 0.023
CG4364 CG4364 gene product from transcript CG4364-RA 0.022
CG9172 CG9172 gene product from transcript CG9172-RA 0.022
CG7181 CG7181 gene product from transcript CG7181-RA 0.021
CG7006 CG7006 gene product from transcript CG7006-RA 0.020
Spt6 CG12225 gene product from transcript CG12225-RA 0.020
CG9715 CG9715 gene product from transcript CG9715-RA 0.019
zf30C Zinc finger protein 30C 0.019
mRpL9 mitochondrial ribosomal protein L9 0.018
CG14482 CG14482 gene product from transcript CG14482-RA 0.018
Rpb10 CG13628 gene product from transcript CG13628-RA 0.018
CG7757 CG7757 gene product from transcript CG7757-RA 0.018
lola longitudinals lacking 0.017
CG11015 CG11015 gene product from transcript CG11015-RA 0.017
mtacp1 mitochondrial acyl carrier protein 1 0.017
CG5703 CG5703 gene product from transcript CG5703-RA 0.017
Rae1 CG9862 gene product from transcript CG9862-RA 0.017
Aos1 CG12276 gene product from transcript CG12276-RA 0.017
CG3909 CG3909 gene product from transcript CG3909-RA 0.016
CG3621 CG3621 gene product from transcript CG3621-RA 0.016
CG8485 CG8485 gene product from transcript CG8485-RA 0.016
rad50 CG6339 gene product from transcript CG6339-RD 0.016
Rpb5 CG11979 gene product from transcript CG11979-RA 0.016
Prx5 Peroxiredoxin 5 0.016
CG9350 CG9350 gene product from transcript CG9350-RA 0.016
gw gawky 0.015
CG12079 CG12079 gene product from transcript CG12079-RA 0.015
CG5859 CG5859 gene product from transcript CG5859-RA 0.014
bs blistered 0.014
CG14235 CG14235 gene product from transcript CG14235-RA 0.014
CoVa Cytochrome c oxidase subunit Va 0.014
CG3560 CG3560 gene product from transcript CG3560-RA 0.013
CG8386 CG8386 gene product from transcript CG8386-RA 0.013
CG12259 CG12259 gene product from transcript CG12259-RA 0.013
CG2862 CG2862 gene product from transcript CG2862-RA 0.013
SelG Selenoprotein G 0.013
Pdsw CG8844 gene product from transcript CG8844-RA 0.013
CG4646 CG4646 gene product from transcript CG4646-RA 0.013
CG10664 CG10664 gene product from transcript CG10664-RB 0.013
RpL18A Ribosomal protein L18A 0.013
EcR Ecdysone receptor 0.012
MBD-R2 CG10042 gene product from transcript CG10042-RB 0.012
sta stubarista 0.012
CG10267 CG10267 gene product from transcript CG10267-RB 0.012
cid centromere identifier 0.012
CG12400 CG12400 gene product from transcript CG12400-RA 0.012
RpL37a Ribosomal protein L37a 0.011
SmE Small ribonucleoprotein particle protein SmE 0.011
msps mini spindles 0.011
mop myopic 0.011
Ssb-c31a Single stranded-binding protein c31A 0.011
Neb-cGP CG15304 gene product from transcript CG15304-RA 0.011
CG6422 CG6422 gene product from transcript CG6422-RA 0.011
CG3192 CG3192 gene product from transcript CG3192-RA 0.011
Ef1beta Elongation factor 1 beta 0.011
Oscp Oligomycin sensitivity-conferring protein 0.011
CG2021 CG2021 gene product from transcript CG2021-RA 0.011
LSm7 CG13277 gene product from transcript CG13277-RA 0.011
CG14671 CG14671 gene product from transcript CG14671-RA 0.010
CG8460 CG8460 gene product from transcript CG8460-RA 0.010
CG3214 CG3214 gene product from transcript CG3214-RB 0.010
CG7630 CG7630 gene product from transcript CG7630-RA 0.010
CG9667 CG9667 gene product from transcript CG9667-RA 0.010
Clp Clipper 0.010
ND23 NADH:ubiquinone reductase 23kD subunit precursor 0.010
CG5362 CG5362 gene product from transcript CG5362-RA 0.010
Loading network...
Mus musculus
Name Description Probability Func Analog Organism
Neurod1 neurogenic differentiation 1 0.923
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.694
Notch1 Notch gene homolog 1 (Drosophila) 0.663
Ccnd1 cyclin D1 0.651
Kiss1 KiSS-1 metastasis-suppressor 0.578
Ccnd2 cyclin D2 0.350
Sfrp2 secreted frizzled-related protein 2 0.339
Otx2 orthodenticle homolog 2 (Drosophila) 0.310
Ptf1a pancreas specific transcription factor, 1a 0.309
Uncx UNC homeobox 0.292
Myl2 myosin, light polypeptide 2, regulatory, cardiac, slow 0.274
Tcf15 transcription factor 15 0.227
Rbpj recombination signal binding protein for immunoglobulin kappa J region 0.213
Dsg4 desmoglein 4 0.202
Gata1 GATA binding protein 1 0.190
Tal1 T-cell acute lymphocytic leukemia 1 0.188
Pdx1 pancreatic and duodenal homeobox 1 0.187
Pax6 paired box gene 6 0.172
Gfra3 glial cell line derived neurotrophic factor family receptor alpha 3 0.117
Hand2 heart and neural crest derivatives expressed transcript 2 0.113
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.101
Neurog2 neurogenin 2 0.097
Onecut1 one cut domain, family member 1 0.093
Shh sonic hedgehog 0.092
Gata4 GATA binding protein 4 0.090
Mecom MDS1 and EVI1 complex locus 0.088
Hoxc5 homeobox C5 0.087
Efna2 ephrin A2 0.086
Socs1 suppressor of cytokine signaling 1 0.085
Isl1 ISL1 transcription factor, LIM/homeodomain 0.080
Gsc goosecoid homeobox 0.080
Srebf2 sterol regulatory element binding factor 2 0.078
Notch2 Notch gene homolog 2 (Drosophila) 0.069
Hoxb5 homeobox B5 0.066
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.065
En1 engrailed 1 0.064
Dlx2 distal-less homeobox 2 0.062
Crb2 crumbs homolog 2 (Drosophila) 0.062
Insm1 insulinoma-associated 1 0.059
Prph peripherin 0.057
Pax3 paired box gene 3 0.056
Myog myogenin 0.054
Cbfa2t3 core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human) 0.052
Hes1 hairy and enhancer of split 1 (Drosophila) 0.051
Foxf1a forkhead box F1a 0.047
Nkx3-2 NK3 homeobox 2 0.047
Tlx3 T-cell leukemia, homeobox 3 0.046
Smu1 smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans) 0.045
Tcfap2a transcription factor AP-2, alpha 0.045
Hoxc6 homeobox C6 0.045
Six5 sine oculis-related homeobox 5 homolog (Drosophila) 0.045
Anapc4 anaphase promoting complex subunit 4 0.045
Hoxd13 homeobox D13 0.043
Hba-x hemoglobin X, alpha-like embryonic chain in Hba complex 0.042
Hand1 heart and neural crest derivatives expressed transcript 1 0.041
Smn1 survival motor neuron 1 0.041
Nhlh1 nescient helix loop helix 1 0.041
Rim4 recombination induced mutation 4 0.040
Lep leptin 0.040
Sin3a transcriptional regulator, SIN3A (yeast) 0.038
Nkx6-1 NK6 homeobox 1 0.038
Tbx5 T-box 5 0.037
Has2 hyaluronan synthase 2 0.037
Cpsf3 cleavage and polyadenylation specificity factor 3 0.036
Tnfrsf4 tumor necrosis factor receptor superfamily, member 4 0.036
Foxd3 forkhead box D3 0.035
Hoxa11 homeobox A11 0.035
Des desmin 0.034
Shox2 short stature homeobox 2 0.034
Lfng LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 0.034
Nbn nibrin 0.034
Nkx2-9 NK2 transcription factor related, locus 9 (Drosophila) 0.034
Foxd2 forkhead box D2 0.033
Gpr50 G-protein-coupled receptor 50 0.032
Myh7 myosin, heavy polypeptide 7, cardiac muscle, beta 0.031
Igdcc3 immunoglobulin superfamily, DCC subclass, member 3 0.031
Il21r interleukin 21 receptor 0.031
Meox2 mesenchyme homeobox 2 0.031
Hoxb1 homeobox B1 0.031
Nkx1-2 NK1 transcription factor related, locus 2 (Drosophila) 0.031
Epor erythropoietin receptor 0.031
Nrarp Notch-regulated ankyrin repeat protein 0.031
Phldb2 pleckstrin homology-like domain, family B, member 2 0.031
Dok1 docking protein 1 0.030
Fgf15 fibroblast growth factor 15 0.030
Lhx5 LIM homeobox protein 5 0.029
Tcf3 transcription factor 3 0.029
Pafah1b2 platelet-activating factor acetylhydrolase, isoform 1b, subunit 2 0.029
Mab21l2 mab-21-like 2 (C. elegans) 0.028
Ttn titin 0.028
Pitx1 paired-like homeodomain transcription factor 1 0.028
Pou4f2 POU domain, class 4, transcription factor 2 0.028
Hoxa5 homeobox A5 0.028
Mybpc3 myosin binding protein C, cardiac 0.028
Lhx6 LIM homeobox protein 6 0.028
Col22a1 collagen, type XXII, alpha 1 0.027
Madcam1 mucosal vascular addressin cell adhesion molecule 1 0.027
Isl2 insulin related protein 2 (islet 2) 0.027
Ccl4 chemokine (C-C motif) ligand 4 0.027
Dab1 disabled homolog 1 (Drosophila) 0.026
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
Loading network...
Saccharomyces cerevisiae
Name Description Probability Func Analog Organism